BacMap

Definition	Eubacterium rectale ATCC 33656, complete genome.
Accession	NC_012781
Length	3,449,685

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The map label for this gene is ppiB [H]

Identifier: 238925281

GI number: 238925281

Start: 2818736

End: 2819257

Strand: Reverse

Name: ppiB [H]

Synonym: EUBREC_2935

Alternate gene names: 238925281

Gene position: 2819257-2818736 (Counterclockwise)

Preceding gene: 238925282

Following gene: 238925280

Centisome position: 81.73

GC content: 49.04

Gene sequence:

>522_bases
ATGGCACAGAATCCAATCGTAACAATCACAATGGAAAACGGCGATGTAATCAAGGCGGAGCTTTATCCGGAAATCGCACC
AAACACAGTAAACAACTTTATCAGCTTAATCAATCACAACTTCTATGACGGAGTATGCTTCCACCGTGTAATCAAGGGCT
TCATGCTCCAGGGCGGAGATCCGGACGGAAACGGCACAGGCGGTCCTGGCTATGAAATCAAGGGCGAGTTCACACACAAC
GGCTTCAAAAATGACTTAAAGCACACAGCCGGTGTACTTTCAATGGCACGTACCATGATACCTGACTCAGCAGGCAGCCA
GTTCTTCATCATGCATCAGGATGCACCACATCTCGACGGTGAGTATGCGGCATTCGGCAAAGTAATCGAGGGCATGGATG
TGGTAAACAAGATCGCAGAGGTGCGCACAGACTACATGGACAAACCACTTGAGGCTCAGGTCATGAAGACAGTTACAGTT
GAGACCTTCGGAGTGGACTATCCGGAGCCGGAGACAGTTTAA

Upstream 100 bases:

>100_bases
GGTAAAATCAATCGGGTAGAAATTAATTCGATATTTAATTATTGCGAGGAATGGATATTCTCCAAGCCTCATAATATTAT
AAAAGAAAGAGAGAAAAATA

Downstream 100 bases:

>100_bases
TGATAATAATTATTGATGAGGCAAGCGCAAAACTTGCCTCTTTTTACTATCATGACGAGATATTCAAGCCACAGTGGAAG
TGCGCAGCCGATATGTCATC

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MAQNPIVTITMENGDVIKAELYPEIAPNTVNNFISLINHNFYDGVCFHRVIKGFMLQGGDPDGNGTGGPGYEIKGEFTHN
GFKNDLKHTAGVLSMARTMIPDSAGSQFFIMHQDAPHLDGEYAAFGKVIEGMDVVNKIAEVRTDYMDKPLEAQVMKTVTV
ETFGVDYPEPETV

Sequences:

>Translated_173_residues
MAQNPIVTITMENGDVIKAELYPEIAPNTVNNFISLINHNFYDGVCFHRVIKGFMLQGGDPDGNGTGGPGYEIKGEFTHN
GFKNDLKHTAGVLSMARTMIPDSAGSQFFIMHQDAPHLDGEYAAFGKVIEGMDVVNKIAEVRTDYMDKPLEAQVMKTVTV
ETFGVDYPEPETV
>Mature_172_residues
AQNPIVTITMENGDVIKAELYPEIAPNTVNNFISLINHNFYDGVCFHRVIKGFMLQGGDPDGNGTGGPGYEIKGEFTHNG
FKNDLKHTAGVLSMARTMIPDSAGSQFFIMHQDAPHLDGEYAAFGKVIEGMDVVNKIAEVRTDYMDKPLEAQVMKTVTVE
TFGVDYPEPETV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=150, Percent_Identity=42, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI19557636, Length=156, Percent_Identity=41.025641025641, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI24308049, Length=149, Percent_Identity=40.9395973154362, Blast_Score=100, Evalue=9e-22,
Organism=Homo sapiens, GI4758950, Length=137, Percent_Identity=47.4452554744526, Blast_Score=96, Evalue=1e-20,
Organism=Homo sapiens, GI4505991, Length=136, Percent_Identity=47.7941176470588, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI6631100, Length=160, Percent_Identity=38.125, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI5454154, Length=160, Percent_Identity=39.375, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI42560244, Length=147, Percent_Identity=37.4149659863946, Blast_Score=89, Evalue=2e-18,
Organism=Homo sapiens, GI22547212, Length=156, Percent_Identity=39.7435897435897, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI7657473, Length=156, Percent_Identity=39.7435897435897, Blast_Score=85, Evalue=3e-17,
Organism=Homo sapiens, GI10863927, Length=125, Percent_Identity=47.2, Blast_Score=84, Evalue=8e-17,
Organism=Homo sapiens, GI64276486, Length=162, Percent_Identity=36.4197530864198, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI22547215, Length=156, Percent_Identity=39.7435897435897, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI45439316, Length=144, Percent_Identity=39.5833333333333, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI303305009, Length=144, Percent_Identity=39.5833333333333, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI5174637, Length=144, Percent_Identity=39.5833333333333, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI5031987, Length=145, Percent_Identity=44.1379310344828, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI310127646, Length=134, Percent_Identity=40.2985074626866, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI310114371, Length=134, Percent_Identity=40.2985074626866, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI310119221, Length=134, Percent_Identity=40.2985074626866, Blast_Score=78, Evalue=4e-15,
Organism=Homo sapiens, GI4826932, Length=148, Percent_Identity=39.8648648648649, Blast_Score=77, Evalue=6e-15,
Organism=Homo sapiens, GI310110104, Length=128, Percent_Identity=43.75, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI256017253, Length=127, Percent_Identity=42.5196850393701, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI221139811, Length=127, Percent_Identity=42.5196850393701, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI256017251, Length=127, Percent_Identity=42.5196850393701, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI310129267, Length=128, Percent_Identity=42.96875, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310120620, Length=128, Percent_Identity=42.96875, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI20911035, Length=138, Percent_Identity=35.5072463768116, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI178057341, Length=127, Percent_Identity=41.7322834645669, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI209417936, Length=127, Percent_Identity=41.7322834645669, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI30102944, Length=127, Percent_Identity=41.7322834645669, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI219842199, Length=127, Percent_Identity=41.7322834645669, Blast_Score=71, Evalue=4e-13,
Organism=Homo sapiens, GI150418007, Length=129, Percent_Identity=41.8604651162791, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI169163387, Length=100, Percent_Identity=47, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI169164185, Length=97, Percent_Identity=48.4536082474227, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI169163623, Length=97, Percent_Identity=48.4536082474227, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI310127745, Length=130, Percent_Identity=37.6923076923077, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI310119290, Length=130, Percent_Identity=37.6923076923077, Blast_Score=64, Evalue=7e-11,
Organism=Homo sapiens, GI310114540, Length=130, Percent_Identity=37.6923076923077, Blast_Score=64, Evalue=8e-11,
Organism=Escherichia coli, GI1789763, Length=146, Percent_Identity=43.8356164383562, Blast_Score=97, Evalue=4e-22,
Organism=Escherichia coli, GI1786736, Length=169, Percent_Identity=39.0532544378698, Blast_Score=96, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=42.5925925925926, Blast_Score=115, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI71980594, Length=155, Percent_Identity=42.5806451612903, Blast_Score=111, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI71980590, Length=148, Percent_Identity=43.2432432432432, Blast_Score=107, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17551284, Length=155, Percent_Identity=42.5806451612903, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17551282, Length=155, Percent_Identity=42.5806451612903, Blast_Score=100, Evalue=7e-22,
Organism=Caenorhabditis elegans, GI17506311, Length=145, Percent_Identity=42.0689655172414, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17506307, Length=137, Percent_Identity=46.7153284671533, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17552780, Length=141, Percent_Identity=44.6808510638298, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17552782, Length=145, Percent_Identity=44.8275862068966, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17532641, Length=128, Percent_Identity=39.0625, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71997782, Length=157, Percent_Identity=41.4012738853503, Blast_Score=86, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17566266, Length=145, Percent_Identity=42.0689655172414, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17559074, Length=158, Percent_Identity=40.5063291139241, Blast_Score=85, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17565860, Length=150, Percent_Identity=41.3333333333333, Blast_Score=84, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17552784, Length=153, Percent_Identity=39.2156862745098, Blast_Score=81, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17532643, Length=161, Percent_Identity=37.888198757764, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=130, Percent_Identity=40.7692307692308, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI32563659, Length=152, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6321848, Length=140, Percent_Identity=46.4285714285714, Blast_Score=91, Evalue=9e-20,
Organism=Saccharomyces cerevisiae, GI6320359, Length=128, Percent_Identity=44.53125, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6323562, Length=128, Percent_Identity=45.3125, Blast_Score=82, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6323246, Length=170, Percent_Identity=38.8235294117647, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320510, Length=156, Percent_Identity=41.025641025641, Blast_Score=78, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322492, Length=183, Percent_Identity=31.1475409836066, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17986117, Length=162, Percent_Identity=43.2098765432099, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19922376, Length=142, Percent_Identity=40.1408450704225, Blast_Score=113, Evalue=7e-26,
Organism=Drosophila melanogaster, GI20130249, Length=155, Percent_Identity=43.2258064516129, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24652460, Length=136, Percent_Identity=38.9705882352941, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24650807, Length=144, Percent_Identity=38.1944444444444, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI17136360, Length=147, Percent_Identity=40.8163265306122, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24664125, Length=128, Percent_Identity=46.09375, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357783, Length=128, Percent_Identity=46.09375, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21357249, Length=147, Percent_Identity=34.0136054421769, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI45549139, Length=128, Percent_Identity=45.3125, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI17647301, Length=126, Percent_Identity=41.2698412698413, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24586038, Length=164, Percent_Identity=37.1951219512195, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19922912, Length=149, Percent_Identity=40.2684563758389, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355677, Length=172, Percent_Identity=30.2325581395349, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 19003; Mature: 18872

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQNPIVTITMENGDVIKAELYPEIAPNTVNNFISLINHNFYDGVCFHRVIKGFMLQGGD
CCCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
PDGNGTGGPGYEIKGEFTHNGFKNDLKHTAGVLSMARTMIPDSAGSQFFIMHQDAPHLDG
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
EYAAFGKVIEGMDVVNKIAEVRTDYMDKPLEAQVMKTVTVETFGVDYPEPETV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AQNPIVTITMENGDVIKAELYPEIAPNTVNNFISLINHNFYDGVCFHRVIKGFMLQGGD
CCCCEEEEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
PDGNGTGGPGYEIKGEFTHNGFKNDLKHTAGVLSMARTMIPDSAGSQFFIMHQDAPHLDG
CCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCC
EYAAFGKVIEGMDVVNKIAEVRTDYMDKPLEAQVMKTVTVETFGVDYPEPETV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9317025; 9665876 [H]