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The map label for this gene is hemZ [H]

Identifier: 238925275

GI number: 238925275

Start: 2810644

End: 2812236

Strand: Reverse

Name: hemZ [H]

Synonym: EUBREC_2929

Alternate gene names: 238925275

Gene position: 2812236-2810644 (Counterclockwise)

Preceding gene: 238925276

Following gene: 238925274

Centisome position: 81.52

GC content: 49.28

Gene sequence:

>1593_bases
ATGATAGTAGTAGTATTTAATAAACCGGATTTTGAATATGATGTGCACTCACTGCTCAAGGAGTTCTTCCCTCAGGAGGA
TGTGCAGATGTACTATAGCTGCCCACCGGATGAGGTGGAGGGGAAAAACTTAGCCTGCACACACCACGAGATGACAGATG
ATGGCGTAAAGGAATTTGCGGATGCCTCACAGGTATTTAAGATAGACTATGTGGGCGATGAAATTGCAGTGGAGTGGACG
CTGAATAGAGCCGGCGGAAATAATTCCATGACAGGTGAGATGCAGCAAACCGACGAAAGTGACATTAAAACAGCCGGAGA
AAGTATCTGCACAAAAATATCCGTAGACAGCGCAGAACGCAAGGAGACCAAAAACCGCCTCAAGCTCGCCCTGTATTCCA
TGATAGAAAAGGGCACAGGAAAGAGCCTTCCGTGGGGCACACTCTCAGGCATCAGACCGACCAAGATAGCCATGAAGTGC
ATAGAGGACGGCATGAGCGATAAGGAAACCTACGACTATCTGAAGGAAACCTACCTCGCAAGCGATGAGAAAATCGACCT
CTCAATAGGCATAGCAAAGCGTGAGAAGGCACTGCTCGACAAGGTGGACTATGACAACGGCTACAGCCTGTACATAGGCA
TACCATTCTGCCCGAGCACCTGTGCATACTGCTCGTTTACCTCATACCCGCTGGGTGTGTGGAAAAACCGCGTAGACGAT
TACCTCGATGCACTCGAGAAGGAGATAGACTACACAGCACAGAAGTTCTACCACAAAAAGCTAAACTCCATCTACATAGG
AGGCGGTACACCGACCACACTAAGCCCTGCACAGCTTGACAGGCTTATCAGAAAAATCAAATGCAGCTTTGATTTAAAGG
ACTGCCTGGAATTTACCGTGGAGGCAGGCAGACCGGACTCCATCACGAGAGAAAAACTCCTGGCACTAAAGAAAAACGGC
ATCAGCCGTATATCAGTCAATCCGCAGACCATGAAGCAGCAGACGCTTGATATAATAGGAAGACACCACACAGTAGACGA
TACGATACAAAGCTTCAAGCTCGCGCGTGAGCTGGGCTTTGACAACATAAATATGGACCTCATCATAGGCCTTCCCGAGG
AAACACTCGATGATGTAAGGCACACAATGGAGCTGGTGAAGGATATGGCACCTGACAACGTCACTATCCACTCACTCGCA
GTAAAGCGAGCTGCACGACTCACCATCTTCAAGGACCGCTACAGCGATATGCAGATGGTCAACACTCAGGAGCATATGGA
TCTCTGCGCAGCCTACTGTAAGCAGATGGGGCTTGAGCCATACTACCTCTACAGGCAGAAGGGCATGGCAGGCAATATGG
AAAACGTGGGCTATGCGGCAAAGGGCAAGGCCGGCGTATACAACATACTGATCATGGAGGAAAAACAGACTATTGTAGCC
TGCGGAGCTGGAGCAAGCACCAAGCGTGTCTGGCCCGTACCGAATCCGGATGGCACACACCGCATCGACAGATGCGAGAA
TGTCAAGGATGTAGGGCAGTATATCACAAGGATTGATGAGATGATAGAGAGAAAGCAGAGGCTGTTTGACTAA

Upstream 100 bases:

>100_bases
TGAAGGAAAAAATCATGACACTGCCTGAGCATACAGAGGTGTACCCGGGCCACAACGACACAACAACCATAGAAAACGAG
AGGATGTATAACCCTTACTT

Downstream 100 bases:

>100_bases
AAGTTGATGGTAAAAATTAATGGAAAATCAAAAATTAGATACAATTATATTCCGGAAAACGGCATTATCAAAGGATGAGT
TGAATCGTATATATAAATAT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 530; Mature: 530

Protein sequence:

>530_residues
MIVVVFNKPDFEYDVHSLLKEFFPQEDVQMYYSCPPDEVEGKNLACTHHEMTDDGVKEFADASQVFKIDYVGDEIAVEWT
LNRAGGNNSMTGEMQQTDESDIKTAGESICTKISVDSAERKETKNRLKLALYSMIEKGTGKSLPWGTLSGIRPTKIAMKC
IEDGMSDKETYDYLKETYLASDEKIDLSIGIAKREKALLDKVDYDNGYSLYIGIPFCPSTCAYCSFTSYPLGVWKNRVDD
YLDALEKEIDYTAQKFYHKKLNSIYIGGGTPTTLSPAQLDRLIRKIKCSFDLKDCLEFTVEAGRPDSITREKLLALKKNG
ISRISVNPQTMKQQTLDIIGRHHTVDDTIQSFKLARELGFDNINMDLIIGLPEETLDDVRHTMELVKDMAPDNVTIHSLA
VKRAARLTIFKDRYSDMQMVNTQEHMDLCAAYCKQMGLEPYYLYRQKGMAGNMENVGYAAKGKAGVYNILIMEEKQTIVA
CGAGASTKRVWPVPNPDGTHRIDRCENVKDVGQYITRIDEMIERKQRLFD

Sequences:

>Translated_530_residues
MIVVVFNKPDFEYDVHSLLKEFFPQEDVQMYYSCPPDEVEGKNLACTHHEMTDDGVKEFADASQVFKIDYVGDEIAVEWT
LNRAGGNNSMTGEMQQTDESDIKTAGESICTKISVDSAERKETKNRLKLALYSMIEKGTGKSLPWGTLSGIRPTKIAMKC
IEDGMSDKETYDYLKETYLASDEKIDLSIGIAKREKALLDKVDYDNGYSLYIGIPFCPSTCAYCSFTSYPLGVWKNRVDD
YLDALEKEIDYTAQKFYHKKLNSIYIGGGTPTTLSPAQLDRLIRKIKCSFDLKDCLEFTVEAGRPDSITREKLLALKKNG
ISRISVNPQTMKQQTLDIIGRHHTVDDTIQSFKLARELGFDNINMDLIIGLPEETLDDVRHTMELVKDMAPDNVTIHSLA
VKRAARLTIFKDRYSDMQMVNTQEHMDLCAAYCKQMGLEPYYLYRQKGMAGNMENVGYAAKGKAGVYNILIMEEKQTIVA
CGAGASTKRVWPVPNPDGTHRIDRCENVKDVGQYITRIDEMIERKQRLFD
>Mature_530_residues
MIVVVFNKPDFEYDVHSLLKEFFPQEDVQMYYSCPPDEVEGKNLACTHHEMTDDGVKEFADASQVFKIDYVGDEIAVEWT
LNRAGGNNSMTGEMQQTDESDIKTAGESICTKISVDSAERKETKNRLKLALYSMIEKGTGKSLPWGTLSGIRPTKIAMKC
IEDGMSDKETYDYLKETYLASDEKIDLSIGIAKREKALLDKVDYDNGYSLYIGIPFCPSTCAYCSFTSYPLGVWKNRVDD
YLDALEKEIDYTAQKFYHKKLNSIYIGGGTPTTLSPAQLDRLIRKIKCSFDLKDCLEFTVEAGRPDSITREKLLALKKNG
ISRISVNPQTMKQQTLDIIGRHHTVDDTIQSFKLARELGFDNINMDLIIGLPEETLDDVRHTMELVKDMAPDNVTIHSLA
VKRAARLTIFKDRYSDMQMVNTQEHMDLCAAYCKQMGLEPYYLYRQKGMAGNMENVGYAAKGKAGVYNILIMEEKQTIVA
CGAGASTKRVWPVPNPDGTHRIDRCENVKDVGQYITRIDEMIERKQRLFD

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=203, Percent_Identity=25.615763546798, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI87082341, Length=234, Percent_Identity=29.4871794871795, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789325, Length=207, Percent_Identity=29.951690821256, Blast_Score=110, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 60069; Mature: 60069

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVVFNKPDFEYDVHSLLKEFFPQEDVQMYYSCPPDEVEGKNLACTHHEMTDDGVKEFA
CEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEECCCCCHHHHHHHH
DASQVFKIDYVGDEIAVEWTLNRAGGNNSMTGEMQQTDESDIKTAGESICTKISVDSAER
CHHHEEEEEECCCEEEEEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHEECCCCHHH
KETKNRLKLALYSMIEKGTGKSLPWGTLSGIRPTKIAMKCIEDGMSDKETYDYLKETYLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCC
SDEKIDLSIGIAKREKALLDKVDYDNGYSLYIGIPFCPSTCAYCSFTSYPLGVWKNRVDD
CCCCEEEEEECHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHH
YLDALEKEIDYTAQKFYHKKLNSIYIGGGTPTTLSPAQLDRLIRKIKCSFDLKDCLEFTV
HHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
EAGRPDSITREKLLALKKNGISRISVNPQTMKQQTLDIIGRHHTVDDTIQSFKLARELGF
CCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
DNINMDLIIGLPEETLDDVRHTMELVKDMAPDNVTIHSLAVKRAARLTIFKDRYSDMQMV
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHEEEHHCCCCHHHH
NTQEHMDLCAAYCKQMGLEPYYLYRQKGMAGNMENVGYAAKGKAGVYNILIMEEKQTIVA
CCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHCCCCCCCCCCEEEEEEEECCCEEEE
CGAGASTKRVWPVPNPDGTHRIDRCENVKDVGQYITRIDEMIERKQRLFD
ECCCCCCCEECCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIVVVFNKPDFEYDVHSLLKEFFPQEDVQMYYSCPPDEVEGKNLACTHHEMTDDGVKEFA
CEEEEECCCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEECCCCCHHHHHHHH
DASQVFKIDYVGDEIAVEWTLNRAGGNNSMTGEMQQTDESDIKTAGESICTKISVDSAER
CHHHEEEEEECCCEEEEEEEEECCCCCCCCCCCHHHCCHHHHHHHHHHHHHEECCCCHHH
KETKNRLKLALYSMIEKGTGKSLPWGTLSGIRPTKIAMKCIEDGMSDKETYDYLKETYLA
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHCC
SDEKIDLSIGIAKREKALLDKVDYDNGYSLYIGIPFCPSTCAYCSFTSYPLGVWKNRVDD
CCCCEEEEEECHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHCCCCCCHHHHHHHHHH
YLDALEKEIDYTAQKFYHKKLNSIYIGGGTPTTLSPAQLDRLIRKIKCSFDLKDCLEFTV
HHHHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHH
EAGRPDSITREKLLALKKNGISRISVNPQTMKQQTLDIIGRHHTVDDTIQSFKLARELGF
CCCCCCCHHHHHHHHHHHCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCC
DNINMDLIIGLPEETLDDVRHTMELVKDMAPDNVTIHSLAVKRAARLTIFKDRYSDMQMV
CCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHEEEHHCCCCHHHH
NTQEHMDLCAAYCKQMGLEPYYLYRQKGMAGNMENVGYAAKGKAGVYNILIMEEKQTIVA
CCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHCCCCCCCCCCEEEEEEEECCCEEEE
CGAGASTKRVWPVPNPDGTHRIDRCENVKDVGQYITRIDEMIERKQRLFD
ECCCCCCCEECCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 10568751 [H]