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The map label for this gene is lacR [H]

Identifier: 238924391

GI number: 238924391

Start: 1919111

End: 1920004

Strand: Direct

Name: lacR [H]

Synonym: EUBREC_2032

Alternate gene names: 238924391

Gene position: 1919111-1920004 (Clockwise)

Preceding gene: 238924387

Following gene: 238924401

Centisome position: 55.63

GC content: 37.02

Gene sequence:

>894_bases
ATGCATAAAATGCTACAATACAAGCGGAGGTGTATAATGTATATTAACACGGGATATTTGAATCATTCACATAAAGATTT
TAAAGATAAAAGCCGCCCTCTGATTGTAGGAAGCTGCGGAACCTATCGCCTGTCACAGCATCCTAAGATGCCTACATACA
GGCCCAGAGGAAGACTGGATTACCAGATTATATACATATCATCCGGTCTTGTTCATTTCCACTTTGACAATCCTGAAAAT
GAGACAATCATTCCAGCAGGACATATAGTGTTATTTCGCCCAAAAGAGCTTCAAAAATATGAATTTTATGGTAAGGATAA
GACTCAGATATATTGGCTTCACTTTACCGGAAGCGACGTAAAAAACACTTTAAGAAAATACGGATTTACAGACAATAAAA
GAGTCTTTAATGTTGGAACATCTCTTGAATATGAACAGGTTTTCAAAAGGATTATTACAGAGCTTCAAAGATGTCAGGAC
AATTATGAGGAAATGCTCATGCTTTTGCTACGACACCTTTTGATTATATTTAACCGTAAAATAACAACTGAGCATGTAAT
CAGAAATGAATTCCTTGACAGCCAGATGGATACAGCAATTACATATTTCAATACAAACTACAACCGCTCTATTAACGTGG
AGGAATATGCTTCATCAATTGGTATGAGCATAAGCTGGTTTATCAGGAGCTTTCGGAAATATACCGGTAATACACCAGTA
CAATTTCTCACAGCACTAAGGATGACAAACGCACAGGTGCTGCTTGAAACGACATCCTACTCTATAAACGAGATTGCAGG
CATTGTCGGATACAATAATCCACTATACTTCAGTCGATTATTCCATAAACAAAAAGGCTGTTCTCCTTCTGAATACAGAG
CCAGAAATACATAA

Upstream 100 bases:

>100_bases
CTACAGTTTCACAGCTATTTGACTCAATTCCATTTGAAACGTAATCAATACACAATATCATGCTCTAAACATTTTGTCCA
TAAATATAAATAGACAAAAC

Downstream 100 bases:

>100_bases
TAAAAAGACAAAAGCAATATTATAATGCCAATTTTTTCCTATACTTATCTTTTTAATGAATGACTAACAGATTGTAAAAG
AATAATCCTTATCAGTCTCC

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 297; Mature: 297

Protein sequence:

>297_residues
MHKMLQYKRRCIMYINTGYLNHSHKDFKDKSRPLIVGSCGTYRLSQHPKMPTYRPRGRLDYQIIYISSGLVHFHFDNPEN
ETIIPAGHIVLFRPKELQKYEFYGKDKTQIYWLHFTGSDVKNTLRKYGFTDNKRVFNVGTSLEYEQVFKRIITELQRCQD
NYEEMLMLLLRHLLIIFNRKITTEHVIRNEFLDSQMDTAITYFNTNYNRSINVEEYASSIGMSISWFIRSFRKYTGNTPV
QFLTALRMTNAQVLLETTSYSINEIAGIVGYNNPLYFSRLFHKQKGCSPSEYRARNT

Sequences:

>Translated_297_residues
MHKMLQYKRRCIMYINTGYLNHSHKDFKDKSRPLIVGSCGTYRLSQHPKMPTYRPRGRLDYQIIYISSGLVHFHFDNPEN
ETIIPAGHIVLFRPKELQKYEFYGKDKTQIYWLHFTGSDVKNTLRKYGFTDNKRVFNVGTSLEYEQVFKRIITELQRCQD
NYEEMLMLLLRHLLIIFNRKITTEHVIRNEFLDSQMDTAITYFNTNYNRSINVEEYASSIGMSISWFIRSFRKYTGNTPV
QFLTALRMTNAQVLLETTSYSINEIAGIVGYNNPLYFSRLFHKQKGCSPSEYRARNT
>Mature_297_residues
MHKMLQYKRRCIMYINTGYLNHSHKDFKDKSRPLIVGSCGTYRLSQHPKMPTYRPRGRLDYQIIYISSGLVHFHFDNPEN
ETIIPAGHIVLFRPKELQKYEFYGKDKTQIYWLHFTGSDVKNTLRKYGFTDNKRVFNVGTSLEYEQVFKRIITELQRCQD
NYEEMLMLLLRHLLIIFNRKITTEHVIRNEFLDSQMDTAITYFNTNYNRSINVEEYASSIGMSISWFIRSFRKYTGNTPV
QFLTALRMTNAQVLLETTSYSINEIAGIVGYNNPLYFSRLFHKQKGCSPSEYRARNT

Specific function: Transcriptional regulator of the lacPH genes for lactose utilization [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787987, Length=92, Percent_Identity=36.9565217391304, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1786251, Length=224, Percent_Identity=25.8928571428571, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003313
- InterPro:   IPR018062
- InterPro:   IPR018060 [H]

Pfam domain/function: PF02311 AraC_binding; PF00165 HTH_AraC [H]

EC number: NA

Molecular weight: Translated: 35226; Mature: 35226

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS01124 HTH_ARAC_FAMILY_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKMLQYKRRCIMYINTGYLNHSHKDFKDKSRPLIVGSCGTYRLSQHPKMPTYRPRGRLD
CCHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCE
YQIIYISSGLVHFHFDNPENETIIPAGHIVLFRPKELQKYEFYGKDKTQIYWLHFTGSDV
EEEEEEECCEEEEEECCCCCCEEEECCCEEEECCCHHHHEEECCCCCCEEEEEEEECHHH
KNTLRKYGFTDNKRVFNVGTSLEYEQVFKRIITELQRCQDNYEEMLMLLLRHLLIIFNRK
HHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ITTEHVIRNEFLDSQMDTAITYFNTNYNRSINVEEYASSIGMSISWFIRSFRKYTGNTPV
CCHHHHHHHHHHHHHHHHEEEEEECCCCCEECHHHHHHHHCCHHHHHHHHHHHHCCCCHH
QFLTALRMTNAQVLLETTSYSINEIAGIVGYNNPLYFSRLFHKQKGCSPSEYRARNT
HHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCCCC
>Mature Secondary Structure
MHKMLQYKRRCIMYINTGYLNHSHKDFKDKSRPLIVGSCGTYRLSQHPKMPTYRPRGRLD
CCHHHHHHCEEEEEEECCCCCCCCCCCCCCCCCEEEECCCCEEECCCCCCCCCCCCCCCE
YQIIYISSGLVHFHFDNPENETIIPAGHIVLFRPKELQKYEFYGKDKTQIYWLHFTGSDV
EEEEEEECCEEEEEECCCCCCEEEECCCEEEECCCHHHHEEECCCCCCEEEEEEEECHHH
KNTLRKYGFTDNKRVFNVGTSLEYEQVFKRIITELQRCQDNYEEMLMLLLRHLLIIFNRK
HHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ITTEHVIRNEFLDSQMDTAITYFNTNYNRSINVEEYASSIGMSISWFIRSFRKYTGNTPV
CCHHHHHHHHHHHHHHHHEEEEEECCCCCEECHHHHHHHHCCHHHHHHHHHHHHCCCCHH
QFLTALRMTNAQVLLETTSYSINEIAGIVGYNNPLYFSRLFHKQKGCSPSEYRARNT
HHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9573174 [H]