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The map label for this gene is cbh [H]

Identifier: 238922415

GI number: 238922415

Start: 610983

End: 611972

Strand: Reverse

Name: cbh [H]

Synonym: EUBELI_20651

Alternate gene names: 238922415

Gene position: 611972-610983 (Counterclockwise)

Preceding gene: 238922416

Following gene: 238922414

Centisome position: 97.64

GC content: 43.23

Gene sequence:

>990_bases
ATGTGTACAGCAGCAACTTACAAAACAAAAGATTTTTATATGGGCAGAACGCTTGATTATGAATTTTCCTATGGGGAACA
GATCACGATAACGCCAAGAAATTACGAATTTGATTTCCGGTTTGCCGGGAAGATAAAAAGCCATTATGCTTTGATCGGAA
TGGCATTTGTTGCAGAAGGTTATCCGCTTTATTATGATGCTGTTAATGAAAAAGGCCTTGGAATGGCAGGTCTTAATTTT
GTCGGCAATGCGGCATATGAAGAGGCTTTGCCGGAAGATGAAACAGAAGTCAGCCAGGTGGCACAGTTCGAGTTCATCCC
ATGGATCCTTACACAGTGTGCTACTGTAGCAGAGGCGAGAGAGAAGCTGGCAGCAATGAGACTGACAGGTACAGCATTCA
GTGAACAGCTGCCGACAGCACAGCTTCACTGGATCATTGCAGACAAAGACTCCTGTATCGTTGTTGAGTCTATGAAGGAT
GGGCTGCATGTATATGATAATCCGGTAGGAGTGCTTACCAATAATCCACCATTCCCGAGTCAGATGTTTGCACTGAATAA
TTATGCCGGAGTATCCAGAAAACAGCCGGAGAGTACTTTTGCAGGAGTATTACAGCTTGATGCATATAGCAGAGGAATGG
GTGGAATGGGAATACCTGGAGATCTTTCCAGCCAGTCAAGATTTGTGAAAGTTGCCTTTACAAAATTAAATTCGATCTCC
GGTGAAGAAGAGGATGAGAGTGTAAGCCAGTTCTTCCATATCTTAGGATCCGTAGATCAGCAGCGTGGATGCTGTGAGGT
GACAGAAGGCAAATATGAGATCACGATATACACGTCCTGTTGTAATACAGCAAAAGGTATTTATTATTATACGACTTATG
ATAATCATCAGATCACAGCGGTTGACATGCATGCGGAAAATCTGGATTCAGATCAGCTGATCTGTTATCCGCTTCTGTCC
AAGGGCGAAGTCAGATGGCAGAATAAATAA

Upstream 100 bases:

>100_bases
CGAAAAGTACCGCACAGGACGGAGTGCATATTTACGGATCGGACAGTTGTTTATGAGATTGTTTGCAGGACTATTATAGC
AGAAAGAAGAGGTGTTCGAT

Downstream 100 bases:

>100_bases
TACGAAAATGCACGGAGAAAGCATAACGCAGAACAACAGGAGGAAAGACCATGAAAGAAGTTAAAACACCGAAAAAACCA
CTGGCATATTATTATGGGAT

Product: choloylglycine hydrolase

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MCTAATYKTKDFYMGRTLDYEFSYGEQITITPRNYEFDFRFAGKIKSHYALIGMAFVAEGYPLYYDAVNEKGLGMAGLNF
VGNAAYEEALPEDETEVSQVAQFEFIPWILTQCATVAEAREKLAAMRLTGTAFSEQLPTAQLHWIIADKDSCIVVESMKD
GLHVYDNPVGVLTNNPPFPSQMFALNNYAGVSRKQPESTFAGVLQLDAYSRGMGGMGIPGDLSSQSRFVKVAFTKLNSIS
GEEEDESVSQFFHILGSVDQQRGCCEVTEGKYEITIYTSCCNTAKGIYYYTTYDNHQITAVDMHAENLDSDQLICYPLLS
KGEVRWQNK

Sequences:

>Translated_329_residues
MCTAATYKTKDFYMGRTLDYEFSYGEQITITPRNYEFDFRFAGKIKSHYALIGMAFVAEGYPLYYDAVNEKGLGMAGLNF
VGNAAYEEALPEDETEVSQVAQFEFIPWILTQCATVAEAREKLAAMRLTGTAFSEQLPTAQLHWIIADKDSCIVVESMKD
GLHVYDNPVGVLTNNPPFPSQMFALNNYAGVSRKQPESTFAGVLQLDAYSRGMGGMGIPGDLSSQSRFVKVAFTKLNSIS
GEEEDESVSQFFHILGSVDQQRGCCEVTEGKYEITIYTSCCNTAKGIYYYTTYDNHQITAVDMHAENLDSDQLICYPLLS
KGEVRWQNK
>Mature_329_residues
MCTAATYKTKDFYMGRTLDYEFSYGEQITITPRNYEFDFRFAGKIKSHYALIGMAFVAEGYPLYYDAVNEKGLGMAGLNF
VGNAAYEEALPEDETEVSQVAQFEFIPWILTQCATVAEAREKLAAMRLTGTAFSEQLPTAQLHWIIADKDSCIVVESMKD
GLHVYDNPVGVLTNNPPFPSQMFALNNYAGVSRKQPESTFAGVLQLDAYSRGMGGMGIPGDLSSQSRFVKVAFTKLNSIS
GEEEDESVSQFFHILGSVDQQRGCCEVTEGKYEITIYTSCCNTAKGIYYYTTYDNHQITAVDMHAENLDSDQLICYPLLS
KGEVRWQNK

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 36763; Mature: 36763

Theoretical pI: Translated: 4.48; Mature: 4.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCTAATYKTKDFYMGRTLDYEFSYGEQITITPRNYEFDFRFAGKIKSHYALIGMAFVAEG
CCCCCEECCCCEECCCEEEEEECCCCEEEEECCCEEEEEEEECCCCCHHHHEEHHHHHCC
YPLYYDAVNEKGLGMAGLNFVGNAAYEEALPEDETEVSQVAQFEFIPWILTQCATVAEAR
CEEEEECCCCCCCCEECCHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLAAMRLTGTAFSEQLPTAQLHWIIADKDSCIVVESMKDGLHVYDNPVGVLTNNPPFPS
HHHHHHEEECCHHHHCCCCEEEEEEEECCCCEEEEECCCCCCEEECCCEEEEECCCCCCH
QMFALNNYAGVSRKQPESTFAGVLQLDAYSRGMGGMGIPGDLSSQSRFVKVAFTKLNSIS
HHEEECCCCCCCCCCCCHHHHHEEEEEHHHCCCCCCCCCCCCCCCCCEEEEEEEEHHCCC
GEEEDESVSQFFHILGSVDQQRGCCEVTEGKYEITIYTSCCNTAKGIYYYTTYDNHQITA
CCCCHHHHHHHHHHHCCCCCCCCCEEECCCEEEEEEEEECCCCCCCEEEEEEECCCEEEE
VDMHAENLDSDQLICYPLLSKGEVRWQNK
EEEECCCCCCCCEEEEEECCCCEEEECCC
>Mature Secondary Structure
MCTAATYKTKDFYMGRTLDYEFSYGEQITITPRNYEFDFRFAGKIKSHYALIGMAFVAEG
CCCCCEECCCCEECCCEEEEEECCCCEEEEECCCEEEEEEEECCCCCHHHHEEHHHHHCC
YPLYYDAVNEKGLGMAGLNFVGNAAYEEALPEDETEVSQVAQFEFIPWILTQCATVAEAR
CEEEEECCCCCCCCEECCHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLAAMRLTGTAFSEQLPTAQLHWIIADKDSCIVVESMKDGLHVYDNPVGVLTNNPPFPS
HHHHHHEEECCHHHHCCCCEEEEEEEECCCCEEEEECCCCCCEEECCCEEEEECCCCCCH
QMFALNNYAGVSRKQPESTFAGVLQLDAYSRGMGGMGIPGDLSSQSRFVKVAFTKLNSIS
HHEEECCCCCCCCCCCCHHHHHEEEEEHHHCCCCCCCCCCCCCCCCCEEEEEEEEHHCCC
GEEEDESVSQFFHILGSVDQQRGCCEVTEGKYEITIYTSCCNTAKGIYYYTTYDNHQITA
CCCCHHHHHHHHHHHCCCCCCCCCEEECCCEEEEEEEEECCCCCCCEEEEEEECCCEEEE
VDMHAENLDSDQLICYPLLSKGEVRWQNK
EEEECCCCCCCCEEEEEECCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1476424; 12566566 [H]