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The map label for this gene is mutX [H]

Identifier: 238922339

GI number: 238922339

Start: 542367

End: 542828

Strand: Reverse

Name: mutX [H]

Synonym: EUBELI_20575

Alternate gene names: 238922339

Gene position: 542828-542367 (Counterclockwise)

Preceding gene: 238922340

Following gene: 238922338

Centisome position: 86.61

GC content: 41.13

Gene sequence:

>462_bases
ATGATAACTACAACTTTATGTTATATAGAGAAGGACGGGAAGTATCTTATGCTTCACAGAGTGAAAAAGCATAATGATAT
TAATGAAGGTAAATGGATTGGAGTAGGCGGACATGCTGAGAATCAGGAGACTCCTGAGGAATGTCTTGTGCGTGAGGTAA
AGGAAGAAACAGGTCTTACGCTTACTTCATACAGATTCCGCGGGCTTGTAACATTTATAAGTAATGAATGTGAGCCAGAG
CTTATGTGTGTATTTACGGCAGATGGCTTTACAGGTGAGCTTATTGAATGTGATGAAGGAGAACTGGCTTGGGTTGATAA
AGAAGAAGTTCCCGAGCTTCCGACATGGGAGGGTGACAGGGTATTTCTTAACCTTCTTCTTTCGGGGGAGGAGAGATTTT
TCTCGATAAAGCTTAAGTATGAAGGCAGCAGACTTGTGGAAAAACAGGTCAATCTGTATTAA

Upstream 100 bases:

>100_bases
AATGAAAAACTTGACGCACTTGCGAAAGCAGATGCAGAGGCAATAATTGAATCTATAAGGTGAATTTGATTGAAAAAATC
GGACATGAAAGGTAGAATTG

Downstream 100 bases:

>100_bases
AATACAGATTTGAATATATTTACAGATGGAGTAATTTAGCAGCAATGCTTGACAAGTTCAAGAATATGGGGTGGAAGAAA
TTCTATCTCATATATGCAAT

Product: mutator MutT (7,8-dihydro-8-oxoguanine-triphosphatase)

Products: CMP; diphosphate [C]

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 153; Mature: 153

Protein sequence:

>153_residues
MITTTLCYIEKDGKYLMLHRVKKHNDINEGKWIGVGGHAENQETPEECLVREVKEETGLTLTSYRFRGLVTFISNECEPE
LMCVFTADGFTGELIECDEGELAWVDKEEVPELPTWEGDRVFLNLLLSGEERFFSIKLKYEGSRLVEKQVNLY

Sequences:

>Translated_153_residues
MITTTLCYIEKDGKYLMLHRVKKHNDINEGKWIGVGGHAENQETPEECLVREVKEETGLTLTSYRFRGLVTFISNECEPE
LMCVFTADGFTGELIECDEGELAWVDKEEVPELPTWEGDRVFLNLLLSGEERFFSIKLKYEGSRLVEKQVNLY
>Mature_153_residues
MITTTLCYIEKDGKYLMLHRVKKHNDINEGKWIGVGGHAENQETPEECLVREVKEETGLTLTSYRFRGLVTFISNECEPE
LMCVFTADGFTGELIECDEGELAWVDKEEVPELPTWEGDRVFLNLLLSGEERFFSIKLKYEGSRLVEKQVNLY

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 17659; Mature: 17659

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITTTLCYIEKDGKYLMLHRVKKHNDINEGKWIGVGGHAENQETPEECLVREVKEETGLT
CCEEEEEEEECCCCEEEEEEEHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCE
LTSYRFRGLVTFISNECEPELMCVFTADGFTGELIECDEGELAWVDKEEVPELPTWEGDR
EEEHHHHEEEEEECCCCCCEEEEEEECCCCCCCEEECCCCCEEEECHHHCCCCCCCCCCE
VFLNLLLSGEERFFSIKLKYEGSRLVEKQVNLY
EEEEEEECCCCEEEEEEEEECCCEEEHHHCCCC
>Mature Secondary Structure
MITTTLCYIEKDGKYLMLHRVKKHNDINEGKWIGVGGHAENQETPEECLVREVKEETGLT
CCEEEEEEEECCCCEEEEEEEHHCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCE
LTSYRFRGLVTFISNECEPELMCVFTADGFTGELIECDEGELAWVDKEEVPELPTWEGDR
EEEHHHHEEEEEECCCCCCEEEEEEECCCCCCCEEECCCCCEEEECHHHCCCCCCCCCCE
VFLNLLLSGEERFFSIKLKYEGSRLVEKQVNLY
EEEEEEECCCCEEEEEEEEECCCEEEHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: CTP; H2O [C]

Specific reaction: CTP + H2O = CMP + diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170394; 11463916; 8163538 [H]