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The map label for this gene is vanR [H]

Identifier: 238922318

GI number: 238922318

Start: 521949

End: 522650

Strand: Reverse

Name: vanR [H]

Synonym: EUBELI_20554

Alternate gene names: 238922318

Gene position: 522650-521949 (Counterclockwise)

Preceding gene: 238922319

Following gene: 238922317

Centisome position: 83.39

GC content: 38.89

Gene sequence:

>702_bases
ATGTACTGGCTGGGAGGGAATATGACCAAGATACTTATATTGGAAGATGATGATTTTATAAGGCAGCAGCTTGCAGGAAT
ATTACAGGAAAAAGGATATTCAGTTGTGGAAGCGGCAAGCGTAGGACAGTTTAATAAAATATATGAACAGGAAGAAGCTA
CAATAGATGTATTCTTGTTAGATGTATATCTGCCTGATGGCAATGGATTTGATGTCTGCAGGAAAATAAGAGAACACGGA
AGCCAGATAATAATATTTTTAACATCGTGTGATGATGAAGACAGTATTATTAAAGGACTTGACTGCGGCGGTGATGATTA
TGTTGTGAAGCCGTTCAGGGTTGCAGAACTTGTATCAAGAATAATGGCTAATGTTAGAAGAATATCAGGTGGCACAGACA
TTTATAAAGATGGAACACTTACGGTAGATTTCAGGAATAAATCAGTCACACATGCAGATAAACAGATATGCGTGTCACCG
ACAGAATTTCATGTGTTAGAGATACTTATAAACAACAAGGGACTTATTGTAAGAAGAGATACATTTTTCCAGAAAATGTG
GGACAGATACGGAACATTTGTAGAGGATAATACGCTGACAGTTACTGTGAGCAGGCTAAAGACAAAGCTTGGAAACCGTG
AGGACGGCAGAGCTTATATAGAGACGATCCGCGGAATCGGCTACCGGTGGAAGATTAATTGA

Upstream 100 bases:

>100_bases
GCAAAGGTGCTGTCATAAGGGTACAGATACCAAGATATGTTCTTAAGAGAAAGGCTGAATTGTAAGATATGTGTAAGGTT
AGTGCATTACAATATAGAAA

Downstream 100 bases:

>100_bases
GTTGTAAGGTTTTTGTAAGGTTGGCATGATAAGGTATATACATAAATCTTACAGGGGGTACTTGAGTGAATGTTTTAAAG
ATTACTTTCAAAAGTATAAG

Product: two-component system, OmpR family, response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MYWLGGNMTKILILEDDDFIRQQLAGILQEKGYSVVEAASVGQFNKIYEQEEATIDVFLLDVYLPDGNGFDVCRKIREHG
SQIIIFLTSCDDEDSIIKGLDCGGDDYVVKPFRVAELVSRIMANVRRISGGTDIYKDGTLTVDFRNKSVTHADKQICVSP
TEFHVLEILINNKGLIVRRDTFFQKMWDRYGTFVEDNTLTVTVSRLKTKLGNREDGRAYIETIRGIGYRWKIN

Sequences:

>Translated_233_residues
MYWLGGNMTKILILEDDDFIRQQLAGILQEKGYSVVEAASVGQFNKIYEQEEATIDVFLLDVYLPDGNGFDVCRKIREHG
SQIIIFLTSCDDEDSIIKGLDCGGDDYVVKPFRVAELVSRIMANVRRISGGTDIYKDGTLTVDFRNKSVTHADKQICVSP
TEFHVLEILINNKGLIVRRDTFFQKMWDRYGTFVEDNTLTVTVSRLKTKLGNREDGRAYIETIRGIGYRWKIN
>Mature_233_residues
MYWLGGNMTKILILEDDDFIRQQLAGILQEKGYSVVEAASVGQFNKIYEQEEATIDVFLLDVYLPDGNGFDVCRKIREHG
SQIIIFLTSCDDEDSIIKGLDCGGDDYVVKPFRVAELVSRIMANVRRISGGTDIYKDGTLTVDFRNKSVTHADKQICVSP
TEFHVLEILINNKGLIVRRDTFFQKMWDRYGTFVEDNTLTVTVSRLKTKLGNREDGRAYIETIRGIGYRWKIN

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786599, Length=230, Percent_Identity=30, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=29.8245614035088, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1786784, Length=229, Percent_Identity=33.1877729257642, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=32.4444444444444, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=27.3913043478261, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790863, Length=230, Percent_Identity=31.7391304347826, Blast_Score=103, Evalue=9e-24,
Organism=Escherichia coli, GI1789809, Length=228, Percent_Identity=28.5087719298246, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=28, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI87082012, Length=220, Percent_Identity=30.9090909090909, Blast_Score=100, Evalue=6e-23,
Organism=Escherichia coli, GI1790552, Length=230, Percent_Identity=32.1739130434783, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=29.0178571428571, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=28.1385281385281, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1787229, Length=209, Percent_Identity=27.2727272727273, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=29.6610169491525, Blast_Score=78, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26609; Mature: 26609

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYWLGGNMTKILILEDDDFIRQQLAGILQEKGYSVVEAASVGQFNKIYEQEEATIDVFLL
CEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEHHCCCHHHHHHHHCCCEEEEEEE
DVYLPDGNGFDVCRKIREHGSQIIIFLTSCDDEDSIIKGLDCGGDDYVVKPFRVAELVSR
EEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCHHEECCCCCCCCEEECCHHHHHHHHH
IMANVRRISGGTDIYKDGTLTVDFRNKSVTHADKQICVSPTEFHVLEILINNKGLIVRRD
HHHHHHHCCCCCCEEECCEEEEEECCCCCCCCCCEEECCCCCEEEEEEEECCCCEEEEHH
TFFQKMWDRYGTFVEDNTLTVTVSRLKTKLGNREDGRAYIETIRGIGYRWKIN
HHHHHHHHHHCCEEECCEEEEEHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEC
>Mature Secondary Structure
MYWLGGNMTKILILEDDDFIRQQLAGILQEKGYSVVEAASVGQFNKIYEQEEATIDVFLL
CEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCCEEEHHCCCHHHHHHHHCCCEEEEEEE
DVYLPDGNGFDVCRKIREHGSQIIIFLTSCDDEDSIIKGLDCGGDDYVVKPFRVAELVSR
EEEECCCCCHHHHHHHHHCCCEEEEEEECCCCCCHHEECCCCCCCCEEECCHHHHHHHHH
IMANVRRISGGTDIYKDGTLTVDFRNKSVTHADKQICVSPTEFHVLEILINNKGLIVRRD
HHHHHHHCCCCCCEEECCEEEEEECCCCCCCCCCEEECCCCCEEEEEEEECCCCEEEEHH
TFFQKMWDRYGTFVEDNTLTVTVSRLKTKLGNREDGRAYIETIRGIGYRWKIN
HHHHHHHHHHCCEEECCEEEEEHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]