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The map label for this gene is dapA [H]

Identifier: 238917510

GI number: 238917510

Start: 1640612

End: 1641538

Strand: Reverse

Name: dapA [H]

Synonym: EUBELI_01589

Alternate gene names: 238917510

Gene position: 1641538-1640612 (Counterclockwise)

Preceding gene: 238917511

Following gene: 238917509

Centisome position: 76.56

GC content: 40.67

Gene sequence:

>927_bases
ATGTACATAATAATAGCTGTTAACAGCGGAAAGAAGGATGGTATGTCAGTATTTACCGGAGCCGGTGTAGCGATTATTAC
ACCAATGAAAGCTAATGGAGAAGTTAATTATGATAAGCTTGGAGAATTCCTTGATTACCAGATTAATAACTCAACAGATG
CAATTATTATCTGTGGAACAACAGGAGAGGCATCAACACTTACACATGAGGAGCATGTAGAAACAATTAGATTTGCTGCT
GATTATGTAAAGAAAAGAGTTCCTGTTATTGCAGGAACAGGTTCTAACTGCACAGAAACAGCTGTATGGCTTTCACAGGA
AGCACAGAAGGCAGGAGTTGATGGATGTCTTGTAGTTACACCATATTATAATAAAGCAACACAGAAGGGCCTTATCCAGC
ACTATACAGCGGTTGCGAAGTCAGTAGACCTTCCTATCATTATGTATAATGTTCCTGGAAGAACAGGCTGCAATATCCAG
CCAGAGACAGCAGCCAAGCTTGCTAAGGATGTTGACAATATCGTTGCTATCAAAGCTGCAACAGGTAATCTTGCACAGGA
GAGCAAGACAATGGCATTAGCTGAGGGAAGACTTGATATGTACTCAGGTGAAGACGGACTTATTGTTCCTCTTATGTCAA
TTGGAGCAAAGGGTGTAATTTCAGTATTATCTAATGTTGCTCCTAAGCAGACACATGATATCTGCGCTACATTTGCAGCA
GGAGATGTTGCTAAGGCTGCACAGTTACAGTTTAAGGCATTAGAACTTGTAGATGCATTATTCTGCGAGGTTAATCCAAT
TCCTGTTAAGCATGCACTTAACCTTATGGGATGGGATATGGGACCACTCAGAAGCCCATTATGCGAGATGGAAGAGGCTA
ACCTTGAGAGATTAAAGAAAGCAATGGTTAACTACGGAATACTTTAA

Upstream 100 bases:

>100_bases
TATTACTATGATTTCTTTAAGAGCCAGTCTGTTTGAGCAGATTGGCTCTTCTATGTTGTTGAGCTACCCACATAGGTAGC
GATGAGAATAGACAGGAATC

Downstream 100 bases:

>100_bases
TTGACAGGAGAATGAACATGACAAGAATAATTATGCATGGCTGTAACGGCCATATGGGACAGGTTATTACAGGAATAGTT
GCTAATGATGCTAATGCACA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MYIIIAVNSGKKDGMSVFTGAGVAIITPMKANGEVNYDKLGEFLDYQINNSTDAIIICGTTGEASTLTHEEHVETIRFAA
DYVKKRVPVIAGTGSNCTETAVWLSQEAQKAGVDGCLVVTPYYNKATQKGLIQHYTAVAKSVDLPIIMYNVPGRTGCNIQ
PETAAKLAKDVDNIVAIKAATGNLAQESKTMALAEGRLDMYSGEDGLIVPLMSIGAKGVISVLSNVAPKQTHDICATFAA
GDVAKAAQLQFKALELVDALFCEVNPIPVKHALNLMGWDMGPLRSPLCEMEEANLERLKKAMVNYGIL

Sequences:

>Translated_308_residues
MYIIIAVNSGKKDGMSVFTGAGVAIITPMKANGEVNYDKLGEFLDYQINNSTDAIIICGTTGEASTLTHEEHVETIRFAA
DYVKKRVPVIAGTGSNCTETAVWLSQEAQKAGVDGCLVVTPYYNKATQKGLIQHYTAVAKSVDLPIIMYNVPGRTGCNIQ
PETAAKLAKDVDNIVAIKAATGNLAQESKTMALAEGRLDMYSGEDGLIVPLMSIGAKGVISVLSNVAPKQTHDICATFAA
GDVAKAAQLQFKALELVDALFCEVNPIPVKHALNLMGWDMGPLRSPLCEMEEANLERLKKAMVNYGIL
>Mature_308_residues
MYIIIAVNSGKKDGMSVFTGAGVAIITPMKANGEVNYDKLGEFLDYQINNSTDAIIICGTTGEASTLTHEEHVETIRFAA
DYVKKRVPVIAGTGSNCTETAVWLSQEAQKAGVDGCLVVTPYYNKATQKGLIQHYTAVAKSVDLPIIMYNVPGRTGCNIQ
PETAAKLAKDVDNIVAIKAATGNLAQESKTMALAEGRLDMYSGEDGLIVPLMSIGAKGVISVLSNVAPKQTHDICATFAA
GDVAKAAQLQFKALELVDALFCEVNPIPVKHALNLMGWDMGPLRSPLCEMEEANLERLKKAMVNYGIL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=287, Percent_Identity=26.8292682926829, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI13540533, Length=282, Percent_Identity=25.886524822695, Blast_Score=79, Evalue=6e-15,
Organism=Escherichia coli, GI1788823, Length=295, Percent_Identity=42.7118644067797, Blast_Score=242, Evalue=2e-65,
Organism=Escherichia coli, GI1786463, Length=290, Percent_Identity=32.7586206896552, Blast_Score=145, Evalue=3e-36,
Organism=Escherichia coli, GI87082415, Length=303, Percent_Identity=30.6930693069307, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI1789620, Length=284, Percent_Identity=25.3521126760563, Blast_Score=94, Evalue=1e-20,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32927; Mature: 32927

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2 ; PS00189 LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYIIIAVNSGKKDGMSVFTGAGVAIITPMKANGEVNYDKLGEFLDYQINNSTDAIIICGT
CEEEEEECCCCCCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHCEEECCCCCEEEEEEC
TGEASTLTHEEHVETIRFAADYVKKRVPVIAGTGSNCTETAVWLSQEAQKAGVDGCLVVT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEE
PYYNKATQKGLIQHYTAVAKSVDLPIIMYNVPGRTGCNIQPETAAKLAKDVDNIVAIKAA
CCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHEEEEEEC
TGNLAQESKTMALAEGRLDMYSGEDGLIVPLMSIGAKGVISVLSNVAPKQTHDICATFAA
CCCCHHHHHHHHHHCCCEEEECCCCCEEEEHHHCCHHHHHHHHHHCCCCHHHHHHHHHHC
GDVAKAAQLQFKALELVDALFCEVNPIPVKHALNLMGWDMGPLRSPLCEMEEANLERLKK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHH
AMVNYGIL
HHHHCCCC
>Mature Secondary Structure
MYIIIAVNSGKKDGMSVFTGAGVAIITPMKANGEVNYDKLGEFLDYQINNSTDAIIICGT
CEEEEEECCCCCCCCEEEECCCEEEEEEECCCCCCCHHHHHHHHCEEECCCCCEEEEEEC
TGEASTLTHEEHVETIRFAADYVKKRVPVIAGTGSNCTETAVWLSQEAQKAGVDGCLVVT
CCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEE
PYYNKATQKGLIQHYTAVAKSVDLPIIMYNVPGRTGCNIQPETAAKLAKDVDNIVAIKAA
CCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHEEEEEEC
TGNLAQESKTMALAEGRLDMYSGEDGLIVPLMSIGAKGVISVLSNVAPKQTHDICATFAA
CCCCHHHHHHHHHHCCCEEEECCCCCEEEEHHHCCHHHHHHHHHHCCCCHHHHHHHHHHC
GDVAKAAQLQFKALELVDALFCEVNPIPVKHALNLMGWDMGPLRSPLCEMEEANLERLKK
CCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCHHHCHHHHHHHHHHHHHHH
AMVNYGIL
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA