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The map label for this gene is maeB [C]

Identifier: 238917371

GI number: 238917371

Start: 1501455

End: 1502609

Strand: Direct

Name: maeB [C]

Synonym: EUBELI_01448

Alternate gene names: 238917371

Gene position: 1501455-1502609 (Clockwise)

Preceding gene: 238917369

Following gene: 238917372

Centisome position: 70.02

GC content: 41.73

Gene sequence:

>1155_bases
ATGACTAATGCAGAGAAAGCCTTACAGCTCCATGAAGAGTGGAATGGTAAATTTGAAACAACTCCTAAAATGAAGATTCA
GACAAGAGAAGATCTTGCTCTTGCTTATACTCCTGGTGTAGCAGAACCTTGCAAGGTTATTGCCAAGGACAAAGAAGCAG
CTTATAAGTACACTATCAAGTCTAACACTATCGCTGTTGTATCTGACGGAAGTGCTGTACTTGGACTCGGTAATATCGGT
GCTCATGCCGCTATGCCTGTTATGGAAGGAAAAGCTGTTCTTTTCAAAGAATTTGGTAACGTTAATGCTGTGCCTGTCTG
CCTTGATACACAGGACACAGAAGAAATCATCAAAACTGTAGTTAATATTGCACCTGCATTTGGCGGTATCAATCTTGAAG
ATATATCAGCTCCAAGATGTTTTGAAATCGAGACAAGACTTAAAGAGCTTCTGGACATACCTGTATTCCATGATGACCAG
CATGGTACAGCTATCGTTGTATTAGCAGGTATTATTAATGGACTTAAAGTTACAGGCAAGACTAAAGAAGATTGCCAGGT
AGTAGTCAACGGTGCCGGTTCTGCCGGAGTTGCTATCACAAAGCTTCTTCTTACATATGGTTTTAAGCATGTAACAATGT
GTGATAAGTCTGGTATCCTTTCTAAGGCTTCAGAAGGTCTTAACTGGATGCAGCAGTCAATGATGGAAGTAACTAACCTT
GAGAACAAGACTGGTTCTTTAGCTGATGCACTCCGTGGTGCAGATATATTTGTCGGAGTTTCTGCTCCTAACATCGTTAC
AGCAGACATGGTTAAGACTATGAATAAAGATGCTATTATATTTGCAATGGCCAACCCTGTTCCAGAGATTATGCCAGATG
TTGCCAAGGCAGCCGGTGCCAGAGTTGTTGGTACAGGCCGTTCTGATTTTCCTAATCAGGTTAATAATGTAATCGCTTTC
CCTGGCATTTTCAAGGGTGCTCTCGAAGGACGTGCCAGACAGATAACTGAAGACATGAAGCTTGCTGCTGCGCTTGCAAT
TGCTAATCTTGTTCCAGATGACGAAGTAAGTGATGTTAACATCCTTCCAGAAGCATTTGACCCAAGAGTTGCTGATGTCG
TAAGTAAAGCTGTAATCGACCATATAGAGAAGTAA

Upstream 100 bases:

>100_bases
CTAAAAGAAAAGACTAAAAATGCTTTTTTTAGTCAGAGCAATATGTTATTATATATAATGCTGTTAAAAGCACTAATTAT
TGAAAGGAAGATTAGATATC

Downstream 100 bases:

>100_bases
TTATGCTTCCATATTATTATTCTGTAAGTGAATATCTTAAAGACACTTATGGTAAGAAATTATACAAATTAAGTCTTTCC
GGAAACATGACATGTCCCAA

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME [H]

Number of amino acids: Translated: 384; Mature: 383

Protein sequence:

>384_residues
MTNAEKALQLHEEWNGKFETTPKMKIQTREDLALAYTPGVAEPCKVIAKDKEAAYKYTIKSNTIAVVSDGSAVLGLGNIG
AHAAMPVMEGKAVLFKEFGNVNAVPVCLDTQDTEEIIKTVVNIAPAFGGINLEDISAPRCFEIETRLKELLDIPVFHDDQ
HGTAIVVLAGIINGLKVTGKTKEDCQVVVNGAGSAGVAITKLLLTYGFKHVTMCDKSGILSKASEGLNWMQQSMMEVTNL
ENKTGSLADALRGADIFVGVSAPNIVTADMVKTMNKDAIIFAMANPVPEIMPDVAKAAGARVVGTGRSDFPNQVNNVIAF
PGIFKGALEGRARQITEDMKLAAALAIANLVPDDEVSDVNILPEAFDPRVADVVSKAVIDHIEK

Sequences:

>Translated_384_residues
MTNAEKALQLHEEWNGKFETTPKMKIQTREDLALAYTPGVAEPCKVIAKDKEAAYKYTIKSNTIAVVSDGSAVLGLGNIG
AHAAMPVMEGKAVLFKEFGNVNAVPVCLDTQDTEEIIKTVVNIAPAFGGINLEDISAPRCFEIETRLKELLDIPVFHDDQ
HGTAIVVLAGIINGLKVTGKTKEDCQVVVNGAGSAGVAITKLLLTYGFKHVTMCDKSGILSKASEGLNWMQQSMMEVTNL
ENKTGSLADALRGADIFVGVSAPNIVTADMVKTMNKDAIIFAMANPVPEIMPDVAKAAGARVVGTGRSDFPNQVNNVIAF
PGIFKGALEGRARQITEDMKLAAALAIANLVPDDEVSDVNILPEAFDPRVADVVSKAVIDHIEK
>Mature_383_residues
TNAEKALQLHEEWNGKFETTPKMKIQTREDLALAYTPGVAEPCKVIAKDKEAAYKYTIKSNTIAVVSDGSAVLGLGNIGA
HAAMPVMEGKAVLFKEFGNVNAVPVCLDTQDTEEIIKTVVNIAPAFGGINLEDISAPRCFEIETRLKELLDIPVFHDDQH
GTAIVVLAGIINGLKVTGKTKEDCQVVVNGAGSAGVAITKLLLTYGFKHVTMCDKSGILSKASEGLNWMQQSMMEVTNLE
NKTGSLADALRGADIFVGVSAPNIVTADMVKTMNKDAIIFAMANPVPEIMPDVAKAAGARVVGTGRSDFPNQVNNVIAFP
GIFKGALEGRARQITEDMKLAAALAIANLVPDDEVSDVNILPEAFDPRVADVVSKAVIDHIEK

Specific function: In addition to the NAD-dependent oxidative decarboxylation of L-malate, the enzyme catalyzes the decarboxylation of oxaloacetate [H]

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=359, Percent_Identity=25.9052924791086, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI62420882, Length=358, Percent_Identity=26.536312849162, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI62420880, Length=358, Percent_Identity=26.536312849162, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI239049447, Length=358, Percent_Identity=26.536312849162, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI4505145, Length=359, Percent_Identity=25.0696378830084, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1788806, Length=398, Percent_Identity=45.9798994974874, Blast_Score=337, Evalue=7e-94,
Organism=Escherichia coli, GI87081919, Length=433, Percent_Identity=24.0184757505774, Blast_Score=74, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=353, Percent_Identity=29.1784702549575, Blast_Score=89, Evalue=9e-19,
Organism=Drosophila melanogaster, GI78707242, Length=411, Percent_Identity=25.0608272506083, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78707238, Length=411, Percent_Identity=25.0608272506083, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI78707240, Length=411, Percent_Identity=25.0608272506083, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI21356279, Length=357, Percent_Identity=24.0896358543417, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI281362674, Length=357, Percent_Identity=24.0896358543417, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI281362672, Length=357, Percent_Identity=24.0896358543417, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24646388, Length=409, Percent_Identity=23.4718826405868, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24646386, Length=409, Percent_Identity=23.4718826405868, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281363505, Length=354, Percent_Identity=24.2937853107345, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI78707236, Length=354, Percent_Identity=24.2937853107345, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI281363503, Length=354, Percent_Identity=24.2937853107345, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI78707232, Length=354, Percent_Identity=24.2937853107345, Blast_Score=79, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M [H]

EC number: =1.1.1.38 [H]

Molecular weight: Translated: 40929; Mature: 40797

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNAEKALQLHEEWNGKFETTPKMKIQTREDLALAYTPGVAEPCKVIAKDKEAAYKYTIK
CCCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHCCCCCEEEEEEE
SNTIAVVSDGSAVLGLGNIGAHAAMPVMEGKAVLFKEFGNVNAVPVCLDTQDTEEIIKTV
CCEEEEEECCCEEEEECCCCCHHHCHHHCCCCCEEHHCCCCCEEEEEECCCCHHHHHHHH
VNIAPAFGGINLEDISAPRCFEIETRLKELLDIPVFHDDQHGTAIVVLAGIINGLKVTGK
HHHHHHCCCCCHHHCCCCCEEEHHHHHHHHHCCCCEECCCCCCEEEEEEHHHCCEEECCC
TKEDCQVVVNGAGSAGVAITKLLLTYGFKHVTMCDKSGILSKASEGLNWMQQSMMEVTNL
CCCCCEEEEECCCCCHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
ENKTGSLADALRGADIFVGVSAPNIVTADMVKTMNKDAIIFAMANPVPEIMPDVAKAAGA
CCCCCHHHHHHCCCEEEEECCCCCEEHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
RVVGTGRSDFPNQVNNVIAFPGIFKGALEGRARQITEDMKLAAALAIANLVPDDEVSDVN
EEEECCCCCCCHHHHCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ILPEAFDPRVADVVSKAVIDHIEK
CCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNAEKALQLHEEWNGKFETTPKMKIQTREDLALAYTPGVAEPCKVIAKDKEAAYKYTIK
CCHHHHHHHHHHHCCCCCCCCCEEEEECCCEEEEECCCCCHHHHHHHCCCCCEEEEEEE
SNTIAVVSDGSAVLGLGNIGAHAAMPVMEGKAVLFKEFGNVNAVPVCLDTQDTEEIIKTV
CCEEEEEECCCEEEEECCCCCHHHCHHHCCCCCEEHHCCCCCEEEEEECCCCHHHHHHHH
VNIAPAFGGINLEDISAPRCFEIETRLKELLDIPVFHDDQHGTAIVVLAGIINGLKVTGK
HHHHHHCCCCCHHHCCCCCEEEHHHHHHHHHCCCCEECCCCCCEEEEEEHHHCCEEECCC
TKEDCQVVVNGAGSAGVAITKLLLTYGFKHVTMCDKSGILSKASEGLNWMQQSMMEVTNL
CCCCCEEEEECCCCCHHHHHHHHHHHCCHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHC
ENKTGSLADALRGADIFVGVSAPNIVTADMVKTMNKDAIIFAMANPVPEIMPDVAKAAGA
CCCCCHHHHHHCCCEEEEECCCCCEEHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
RVVGTGRSDFPNQVNNVIAFPGIFKGALEGRARQITEDMKLAAALAIANLVPDDEVSDVN
EEEECCCCCCCHHHHCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ILPEAFDPRVADVVSKAVIDHIEK
CCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2644282 [H]