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The map label for this gene is folP [H]

Identifier: 238896684

GI number: 238896684

Start: 4664227

End: 4665075

Strand: Reverse

Name: folP [H]

Synonym: KP1_4896

Alternate gene names: 238896684

Gene position: 4665075-4664227 (Counterclockwise)

Preceding gene: 238896685

Following gene: 238896683

Centisome position: 88.88

GC content: 56.65

Gene sequence:

>849_bases
ATGAAACTTGTAGCCCAGGGCTCAACCCTCGATCTCTCTCACCCCCACGTGATGGGTATTCTAAATGTGACGCCTGACTC
CTTCTCCGATGGCGGCGCCCATAATTCGCTGATTGAGGCGGTGAAGCATGCCAATCTGATGATCAACGCCGGCGCGACCA
TCATTGATATCGGCGGTGAATCGACGCGGCCAGGGGCGGCTGAGGTTAGTGTGGAAGAGGAGCTTGCGCGGGTGATACCG
GTGGTTGAAGCCATTGCCCAGCGCTTTGAGGTATGGATCTCAGTGGATACCTCCAAGGCGGAGGTTATTCGCCAATCGGC
CAGGGCCGGGGCGCATATCATCAACGATATTCGTTCGCTGACCGAGCCCGGCGCGCTGCAGGCCGCCGCGGAAACCGGAC
TGCCGGTGTGTCTGATGCATATGCAGGGACAACCAAAAACCATGCAGGAGGCGCCGAAGTATGAGGACGTCTTCGCCGAT
GTTGAGCGTTTTTTTAATGAGCACATTGTGCGCTGCGAACAGGCGGGGATCGCAAAAGAAAAATTGCTGCTCGACCCGGG
ATTCGGTTTCGGTAAAAATCTCTCCCACAATTACCAACTGTTGGCCAGGCTTGGGGAGTTTCATCACTTTGGTCTGCCGC
TGCTGGTCGGTATGTCACGTAAGTCGATGGTAGGTCAGTTGCTGAACGTCGGGCCGTCGGAGCGGCTGAACGGCAGCCTG
GCGTGTGCCGTCATTGCAGCAATGCAGGGCGCGCAGATTATCCGCGTCCATGATGTCAAAGAAACGGTAGAAGCGCTGCG
CGTGGTGGAAGCCACCCTCGCCGCTAAGGGAAAAAAACGTTATGAGTAA

Upstream 100 bases:

>100_bases
CAAGTAAGCTACCGCTGTTGATGCTTGTTTAACCTTAAAACCCCGGGCGTCCGCTCCGGGGTTTTTCTTTTTTAACCTCT
TCAGTCTCAGGGATTTTGTG

Downstream 100 bases:

>100_bases
CCGCAAGTATTTTGGCACCGATGGTATTCGTGGCCGCGTCGGCGATGCGCCGATCACTCCGGAGTTTGTGCTCAAGCTGG
GCTGGGCGGCGGGCAAAGTG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 282; Mature: 282

Protein sequence:

>282_residues
MKLVAQGSTLDLSHPHVMGILNVTPDSFSDGGAHNSLIEAVKHANLMINAGATIIDIGGESTRPGAAEVSVEEELARVIP
VVEAIAQRFEVWISVDTSKAEVIRQSARAGAHIINDIRSLTEPGALQAAAETGLPVCLMHMQGQPKTMQEAPKYEDVFAD
VERFFNEHIVRCEQAGIAKEKLLLDPGFGFGKNLSHNYQLLARLGEFHHFGLPLLVGMSRKSMVGQLLNVGPSERLNGSL
ACAVIAAMQGAQIIRVHDVKETVEALRVVEATLAAKGKKRYE

Sequences:

>Translated_282_residues
MKLVAQGSTLDLSHPHVMGILNVTPDSFSDGGAHNSLIEAVKHANLMINAGATIIDIGGESTRPGAAEVSVEEELARVIP
VVEAIAQRFEVWISVDTSKAEVIRQSARAGAHIINDIRSLTEPGALQAAAETGLPVCLMHMQGQPKTMQEAPKYEDVFAD
VERFFNEHIVRCEQAGIAKEKLLLDPGFGFGKNLSHNYQLLARLGEFHHFGLPLLVGMSRKSMVGQLLNVGPSERLNGSL
ACAVIAAMQGAQIIRVHDVKETVEALRVVEATLAAKGKKRYE
>Mature_282_residues
MKLVAQGSTLDLSHPHVMGILNVTPDSFSDGGAHNSLIEAVKHANLMINAGATIIDIGGESTRPGAAEVSVEEELARVIP
VVEAIAQRFEVWISVDTSKAEVIRQSARAGAHIINDIRSLTEPGALQAAAETGLPVCLMHMQGQPKTMQEAPKYEDVFAD
VERFFNEHIVRCEQAGIAKEKLLLDPGFGFGKNLSHNYQLLARLGEFHHFGLPLLVGMSRKSMVGQLLNVGPSERLNGSL
ACAVIAAMQGAQIIRVHDVKETVEALRVVEATLAAKGKKRYE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=282, Percent_Identity=89.0070921985816, Blast_Score=524, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6324073, Length=331, Percent_Identity=26.8882175226586, Blast_Score=123, Evalue=3e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30427; Mature: 30427

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVAQGSTLDLSHPHVMGILNVTPDSFSDGGAHNSLIEAVKHANLMINAGATIIDIGGE
CCEEECCCEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEECCCEEEECCCC
STRPGAAEVSVEEELARVIPVVEAIAQRFEVWISVDTSKAEVIRQSARAGAHIINDIRSL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
TEPGALQAAAETGLPVCLMHMQGQPKTMQEAPKYEDVFADVERFFNEHIVRCEQAGIAKE
CCCCHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
KLLLDPGFGFGKNLSHNYQLLARLGEFHHFGLPLLVGMSRKSMVGQLLNVGPSERLNGSL
HEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCHHCCCHH
ACAVIAAMQGAQIIRVHDVKETVEALRVVEATLAAKGKKRYE
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKLVAQGSTLDLSHPHVMGILNVTPDSFSDGGAHNSLIEAVKHANLMINAGATIIDIGGE
CCEEECCCEEECCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCEEEECCCEEEECCCC
STRPGAAEVSVEEELARVIPVVEAIAQRFEVWISVDTSKAEVIRQSARAGAHIINDIRSL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
TEPGALQAAAETGLPVCLMHMQGQPKTMQEAPKYEDVFADVERFFNEHIVRCEQAGIAKE
CCCCHHHHHHHCCCCEEEEECCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
KLLLDPGFGFGKNLSHNYQLLARLGEFHHFGLPLLVGMSRKSMVGQLLNVGPSERLNGSL
HEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHCCCCHHCCCHH
ACAVIAAMQGAQIIRVHDVKETVEALRVVEATLAAKGKKRYE
HHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]