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The map label for this gene is speA [H]

Identifier: 238896471

GI number: 238896471

Start: 4451196

End: 4453184

Strand: Reverse

Name: speA [H]

Synonym: KP1_4649

Alternate gene names: 238896471

Gene position: 4453184-4451196 (Counterclockwise)

Preceding gene: 238896480

Following gene: 238896470

Centisome position: 84.85

GC content: 60.18

Gene sequence:

>1989_bases
TTGAGGTTCGCTATGTCTGACGACATGTCTATGGTTTCGCCTTCGTCAGCAGGCGAACACGGTGTACTACGTTCCATGCA
GGAGGTAGCGATGAGCTCCCAGGAAGCCAGCAAGATGCTGCGTACTTATAATATTGCCTGGTGGGGCAATAACTATTATG
ACGTCAACGAACTGGGCCACATCAGCGTTTGCCCGGATCCGGACGTCCCGGAAGCGCGCGTTGACCTCGCGGAATTAGTC
AAAGCCCGCGAGGCGCAAGGGCAGCGCTTGCCGGCGCTGTTCTGCTTCCCGCAGATCCTGCAGCACCGCCTGCGCTCGAT
CAACGCCGCCTTCAAACGCGCGCGTGAATCGTATGGCTATAACGGCGATTACTTCCTCGTCTACCCGATCAAGGTTAACC
AGCACCGTCGCGTGATTGAATCGCTGATCCATTCCGGCGAGCCGTTGGGCCTGGAAGCCGGTTCGAAAGCGGAACTGATG
GCCGTGCTGGCGCACGCCGGGATGACCCGCAGCGTCATCGTCTGTAATGGTTATAAAGACCGCGAATATATCCGTCTGGC
GCTGGTGGGCGAGAAGATGGGCCACAAGGTCTATCTGGTCATTGAGAAGATGTCCGAGATCGCTATCGTACTGGAAGAGG
CCGAGCGCCTGAACGTGGTGCCGCGCCTCGGCGTGCGTGCGCGTCTGGCCTCGCAGGGCTCCGGTAAATGGCAGTCCTCC
GGCGGCGAGAAGTCCAAGTTCGGCCTCGCAGCGACCCAGGTGCTGCAACTGGTCGAAATTCTGCGCGAGGCAGGCCATCT
TGAGAGCCTGCAACTGCTGCACTTCCACCTCGGTTCGCAGATGGCTAACATTCGCGATATCGCCACCGGCGTGCGTGAAT
CGGCGCGTTTCTACGTCGAACTGCATAAGCTGGGCGTCAATATTCAGTGCTTCGACGTCGGCGGCGGCCTGGGCGTGGAC
TATGAAGGCACCCGCTCGCAGTCCGATTGCTCGGTGAACTACGGTCTGAACGAATACGCCAACAATATCATCTGGGCGAT
CGGCGATGCCTGCGAAGAGAATGGCCTGCCGCACCCGACGGTGATCACCGAGTCCGGCCGCGCGGTGACCGCGCACCATA
CCGTGCTGGTTTCCAACATCATCGGCGTTGAGCGTAACGAATACACCGAGGCGACCCCGCCGGCGGAAGACGCTGCGCGT
CCGCTGCAGAGCATGTGGGAAACCTGGCTGGAGATGCACGAGACCGGCAACCGCCGCTCGCTGCGCGAATGGCTGCACGA
CAGCCAGATGGACCTGCACGATATCCACATCGGCTACTCCTCAGGCACCTTCAACCTGCAGGAGCGCGCGTGGGCGGAAC
AGCTGTATCTGAACATGTGCCATGAGGTGCAGAAGCAGCTCGACCCGAGCAACCGCGCCCATCGTCCCATCATCGATGAG
CTGCAGGAGCGAATGGCGGATAAAATCTACGTCAACTTCTCGTTGTTCCAGTCGATGCCGGATGCCTGGGGGATCGATCA
GCTGTTCCCGGTGATGCCGCTGGAAGGGCTGAACAAGTCGCCGGAGCGCCGCGCGGTGCTGCTGGACATCACCTGCGATT
CCGATGGCGCCATCGATCACTACGTGGACGGCGACGGGATCGCCACCACCATGCCGATGCCGGAATACGACCCGGAGAAC
CCGCCGATGCTGGGCTTCTTCATGGTTGGCGCCTATCAGGAGATCCTCGGCAACATGCACAACCTGTTCGGCGATACCGA
GGCGGTGGACGTGTTCGTCTTCCCTGACGGCAGCGTTGAGGTTGAGCTGTCCGACGAGGGCGATACCGTAGCGGATATGC
TGCAGTATGTGCAGCTGGATCCGAACACGCTGCTGACCCAGTTCCGCGATCAGGTGAAAAATACCGGTCTGGACGATGCG
CTGCAGCAGCAGTTCCTCGAGGAGTTCGAGGCGGGACTGTACGGCTATACTTATCTGGAAGACGAGTAG

Upstream 100 bases:

>100_bases
AAAACCAGCAGATAGTGCTGGGCTTTAGGACTGTTCATGGGTTGTTATCGCATCTTTGGACTGCGATAGTAGTTAACTGT
CTTACACTTATTATTAAAAA

Downstream 100 bases:

>100_bases
CCGCTGATGCCCGGTGGCGCTGCGCTGACCGGGCCTGCGTATGTCGGCCGGATAAGGCGAAGCCGTCATCCGGCAGCATG
CGATACTCACTTGAACCCGT

Product: arginine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 662; Mature: 662

Protein sequence:

>662_residues
MRFAMSDDMSMVSPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGHISVCPDPDVPEARVDLAELV
KAREAQGQRLPALFCFPQILQHRLRSINAAFKRARESYGYNGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELM
AVLAHAGMTRSVIVCNGYKDREYIRLALVGEKMGHKVYLVIEKMSEIAIVLEEAERLNVVPRLGVRARLASQGSGKWQSS
GGEKSKFGLAATQVLQLVEILREAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVD
YEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITESGRAVTAHHTVLVSNIIGVERNEYTEATPPAEDAAR
PLQSMWETWLEMHETGNRRSLREWLHDSQMDLHDIHIGYSSGTFNLQERAWAEQLYLNMCHEVQKQLDPSNRAHRPIIDE
LQERMADKIYVNFSLFQSMPDAWGIDQLFPVMPLEGLNKSPERRAVLLDITCDSDGAIDHYVDGDGIATTMPMPEYDPEN
PPMLGFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVEVELSDEGDTVADMLQYVQLDPNTLLTQFRDQVKNTGLDDA
LQQQFLEEFEAGLYGYTYLEDE

Sequences:

>Translated_662_residues
MRFAMSDDMSMVSPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGHISVCPDPDVPEARVDLAELV
KAREAQGQRLPALFCFPQILQHRLRSINAAFKRARESYGYNGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELM
AVLAHAGMTRSVIVCNGYKDREYIRLALVGEKMGHKVYLVIEKMSEIAIVLEEAERLNVVPRLGVRARLASQGSGKWQSS
GGEKSKFGLAATQVLQLVEILREAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVD
YEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITESGRAVTAHHTVLVSNIIGVERNEYTEATPPAEDAAR
PLQSMWETWLEMHETGNRRSLREWLHDSQMDLHDIHIGYSSGTFNLQERAWAEQLYLNMCHEVQKQLDPSNRAHRPIIDE
LQERMADKIYVNFSLFQSMPDAWGIDQLFPVMPLEGLNKSPERRAVLLDITCDSDGAIDHYVDGDGIATTMPMPEYDPEN
PPMLGFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVEVELSDEGDTVADMLQYVQLDPNTLLTQFRDQVKNTGLDDA
LQQQFLEEFEAGLYGYTYLEDE
>Mature_662_residues
MRFAMSDDMSMVSPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGHISVCPDPDVPEARVDLAELV
KAREAQGQRLPALFCFPQILQHRLRSINAAFKRARESYGYNGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELM
AVLAHAGMTRSVIVCNGYKDREYIRLALVGEKMGHKVYLVIEKMSEIAIVLEEAERLNVVPRLGVRARLASQGSGKWQSS
GGEKSKFGLAATQVLQLVEILREAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVELHKLGVNIQCFDVGGGLGVD
YEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPTVITESGRAVTAHHTVLVSNIIGVERNEYTEATPPAEDAAR
PLQSMWETWLEMHETGNRRSLREWLHDSQMDLHDIHIGYSSGTFNLQERAWAEQLYLNMCHEVQKQLDPSNRAHRPIIDE
LQERMADKIYVNFSLFQSMPDAWGIDQLFPVMPLEGLNKSPERRAVLLDITCDSDGAIDHYVDGDGIATTMPMPEYDPEN
PPMLGFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVEVELSDEGDTVADMLQYVQLDPNTLLTQFRDQVKNTGLDDA
LQQQFLEEFEAGLYGYTYLEDE

Specific function: Catalyzes the biosynthesis of agmatine from arginine [H]

COG id: COG1166

COG function: function code E; Arginine decarboxylase (spermidine biosynthesis)

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789307, Length=658, Percent_Identity=95.1367781155015, Blast_Score=1304, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002985
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 74305; Mature: 74305

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFAMSDDMSMVSPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGH
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEECCCCCE
ISVCPDPDVPEARVDLAELVKAREAQGQRLPALFCFPQILQHRLRSINAAFKRARESYGY
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKD
CCCEEEEEEEEECHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCC
REYIRLALVGEKMGHKVYLVIEKMSEIAIVLEEAERLNVVPRLGVRARLASQGSGKWQSS
CCEEEEEEECHHHCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCC
GGEKSKFGLAATQVLQLVEILREAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVE
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LHKLGVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPT
EEHHCCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHHCCEEEEECCHHHHCCCCCCE
VITESGRAVTAHHTVLVSNIIGVERNEYTEATPPAEDAARPLQSMWETWLEMHETGNRRS
EEECCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
LREWLHDSQMDLHDIHIGYSSGTFNLQERAWAEQLYLNMCHEVQKQLDPSNRAHRPIIDE
HHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LQERMADKIYVNFSLFQSMPDAWGIDQLFPVMPLEGLNKSPERRAVLLDITCDSDGAIDH
HHHHHHHHEEEEHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCE
YVDGDGIATTMPMPEYDPENPPMLGFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVE
EECCCCCEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEE
VELSDEGDTVADMLQYVQLDPNTLLTQFRDQVKNTGLDDALQQQFLEEFEAGLYGYTYLE
EEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEC
DE
CC
>Mature Secondary Structure
MRFAMSDDMSMVSPSSAGEHGVLRSMQEVAMSSQEASKMLRTYNIAWWGNNYYDVNELGH
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCCEEECCCCCE
ISVCPDPDVPEARVDLAELVKAREAQGQRLPALFCFPQILQHRLRSINAAFKRARESYGY
EEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NGDYFLVYPIKVNQHRRVIESLIHSGEPLGLEAGSKAELMAVLAHAGMTRSVIVCNGYKD
CCCEEEEEEEEECHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEECCCCC
REYIRLALVGEKMGHKVYLVIEKMSEIAIVLEEAERLNVVPRLGVRARLASQGSGKWQSS
CCEEEEEEECHHHCCEEEEEEEHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCC
GGEKSKFGLAATQVLQLVEILREAGHLESLQLLHFHLGSQMANIRDIATGVRESARFYVE
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEE
LHKLGVNIQCFDVGGGLGVDYEGTRSQSDCSVNYGLNEYANNIIWAIGDACEENGLPHPT
EEHHCCEEEEEECCCCCCCCCCCCCCCCCCEEECCHHHHHCCEEEEECCHHHHCCCCCCE
VITESGRAVTAHHTVLVSNIIGVERNEYTEATPPAEDAARPLQSMWETWLEMHETGNRRS
EEECCCCEEEHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHH
LREWLHDSQMDLHDIHIGYSSGTFNLQERAWAEQLYLNMCHEVQKQLDPSNRAHRPIIDE
HHHHHCCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHH
LQERMADKIYVNFSLFQSMPDAWGIDQLFPVMPLEGLNKSPERRAVLLDITCDSDGAIDH
HHHHHHHHEEEEHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCE
YVDGDGIATTMPMPEYDPENPPMLGFFMVGAYQEILGNMHNLFGDTEAVDVFVFPDGSVE
EECCCCCEEECCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCEE
VELSDEGDTVADMLQYVQLDPNTLLTQFRDQVKNTGLDDALQQQFLEEFEAGLYGYTYLE
EEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEC
DE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12384590; 12704152 [H]