Click here to switch to the map view.

The map label for this gene is pheA [H]

Identifier: 238896043

GI number: 238896043

Start: 4012101

End: 4013261

Strand: Direct

Name: pheA [H]

Synonym: KP1_4175

Alternate gene names: 238896043

Gene position: 4012101-4013261 (Clockwise)

Preceding gene: 238896042

Following gene: 238896047

Centisome position: 76.44

GC content: 58.91

Gene sequence:

>1161_bases
ATGACCGAGGAAAACCCATTACTGGCGCTGCGCGATAAGATAAGCGCCCTGGACGAGAAGCTGCTTGCTCTGCTGGCGGA
GCGCCGCGGACTGGCTGTTGAGGTTGGAAAAGCCAAACTGGCCTCCCATCGTCCGGTGCGTGATATTGACCGCGAACGCG
ATCTGCTGGAGCGCCTGATGACTATCGGCAAGCGCCATAATCTGGATGCGCACTATATCACCCGCCTGTTCCAGCTGATT
ATCGAAGACTCTGTTCTTACCCAGCAAACCCTGCTGCAGCAGCATCTGAATAAAATTAACCCGCATTCGGCCCGCGTGGC
GTTCCTCGGTCCCAAGGGCTCTTACTCGCATCTGGCGGCGCGTCAGTACGCCGCTCGCCACTTTGAGCAGTTTATTGAGA
GCGGCTGCGCGAAGTTCGCCGATATTTTTAATCAGGTAGAAACCGGCCAGGCCGATTACGCGGTGGTGCCGATTGAAAAC
ACCAGCTCCGGCGGGATCAACGACGTCTACGATCTGCTGCAGCACACCAGCCTGTCGATCGTTGGCGAGCTGACGATCCC
TATCGATCATTGCGTACTGGTGAGCACCTCGACGGATGCCGATAAAATTCAGACCGTTTACAGCCATCCGCAGCCGTTCC
AGCAGTGCAGCCAGTACCTGAGCCGCTACCCGCACTGGAAGATTGAGTATACCGAGAGCACCTCGGCGGCAATGGAAAAA
GTGGCGCAGGCGAACTCCCCGGTCGTCGCGGCCCTGGGTAGCGAAGCGGGCGGCGCTCTGTATGGTCTGCAGGTGCTGGA
GCACTGCCAGGCCAACCAGACGCAGAACATCACGCGCTTCCTCGTCCTGGCGCGCAAAGCGGTGAACGTCTCCGATCAGG
TGCCGGCCAAGACCACGCTGTTAATGGCGACCGGTCAGCAGGCGGGCGCCCTGGTGGAAGCCCTGCTGGTGCTGCGCAAC
CACAATCTGATCATGACCAAACTGGAATCCCGCCCGATCCACGGCAATCCCTGGGAAGAGATGTTTTATCTCGATATTCA
GGCCAACCTGGATTCGCTGCCCATGCGCAAGGCGCTGAAGGAGCTGGCGGATATCACCCGCTCCATGAAGGTCCTCGGCT
GCTACCCTAGCGAAAACGTGGTCCCGGTGGATCCGGTTTAA

Upstream 100 bases:

>100_bases
CCGGGAGGCAATTCGTCGTATAAGAAAGAATGCGAAGACGAACAATAAGGCCTCCCACCCGGGAGGCCTTTTTTATTTGA
TAACAACAAAGGCAACATCT

Downstream 100 bases:

>100_bases
CATTCGCGGAACGGTAATTTCTTCATCCCTGCCACCGCTACCGGCAGGGTGAAGATGGCGCCTGACAGCGGATACTGCGC
CAGCTCATCGTCCTCCATGT

Product: bifunctional chorismate mutase/prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTEENPLLALRDKISALDEKLLALLAERRGLAVEVGKAKLASHRPVRDIDRERDLLERLMTIGKRHNLDAHYITRLFQLI
IEDSVLTQQTLLQQHLNKINPHSARVAFLGPKGSYSHLAARQYAARHFEQFIESGCAKFADIFNQVETGQADYAVVPIEN
TSSGGINDVYDLLQHTSLSIVGELTIPIDHCVLVSTSTDADKIQTVYSHPQPFQQCSQYLSRYPHWKIEYTESTSAAMEK
VAQANSPVVAALGSEAGGALYGLQVLEHCQANQTQNITRFLVLARKAVNVSDQVPAKTTLLMATGQQAGALVEALLVLRN
HNLIMTKLESRPIHGNPWEEMFYLDIQANLDSLPMRKALKELADITRSMKVLGCYPSENVVPVDPV

Sequences:

>Translated_386_residues
MTEENPLLALRDKISALDEKLLALLAERRGLAVEVGKAKLASHRPVRDIDRERDLLERLMTIGKRHNLDAHYITRLFQLI
IEDSVLTQQTLLQQHLNKINPHSARVAFLGPKGSYSHLAARQYAARHFEQFIESGCAKFADIFNQVETGQADYAVVPIEN
TSSGGINDVYDLLQHTSLSIVGELTIPIDHCVLVSTSTDADKIQTVYSHPQPFQQCSQYLSRYPHWKIEYTESTSAAMEK
VAQANSPVVAALGSEAGGALYGLQVLEHCQANQTQNITRFLVLARKAVNVSDQVPAKTTLLMATGQQAGALVEALLVLRN
HNLIMTKLESRPIHGNPWEEMFYLDIQANLDSLPMRKALKELADITRSMKVLGCYPSENVVPVDPV
>Mature_385_residues
TEENPLLALRDKISALDEKLLALLAERRGLAVEVGKAKLASHRPVRDIDRERDLLERLMTIGKRHNLDAHYITRLFQLII
EDSVLTQQTLLQQHLNKINPHSARVAFLGPKGSYSHLAARQYAARHFEQFIESGCAKFADIFNQVETGQADYAVVPIENT
SSGGINDVYDLLQHTSLSIVGELTIPIDHCVLVSTSTDADKIQTVYSHPQPFQQCSQYLSRYPHWKIEYTESTSAAMEKV
AQANSPVVAALGSEAGGALYGLQVLEHCQANQTQNITRFLVLARKAVNVSDQVPAKTTLLMATGQQAGALVEALLVLRNH
NLIMTKLESRPIHGNPWEEMFYLDIQANLDSLPMRKALKELADITRSMKVLGCYPSENVVPVDPV

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain [H]

Homologues:

Organism=Escherichia coli, GI1788951, Length=385, Percent_Identity=89.3506493506493, Blast_Score=720, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6324013, Length=324, Percent_Identity=26.8518518518519, Blast_Score=107, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010952
- InterPro:   IPR001086
- InterPro:   IPR018528 [H]

Pfam domain/function: PF01817 CM_2; PF00800 PDT [H]

EC number: =5.4.99.5; =4.2.1.51 [H]

Molecular weight: Translated: 42911; Mature: 42779

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00857 PREPHENATE_DEHYDR_1 ; PS00858 PREPHENATE_DEHYDR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEENPLLALRDKISALDEKLLALLAERRGLAVEVGKAKLASHRPVRDIDRERDLLERLM
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCCCCHHHHHHHHHHHHHHH
TIGKRHNLDAHYITRLFQLIIEDSVLTQQTLLQQHLNKINPHSARVAFLGPKGSYSHLAA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHH
RQYAARHFEQFIESGCAKFADIFNQVETGQADYAVVPIENTSSGGINDVYDLLQHTSLSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHE
VGELTIPIDHCVLVSTSTDADKIQTVYSHPQPFQQCSQYLSRYPHWKIEYTESTSAAMEK
EEEEEECCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHH
VAQANSPVVAALGSEAGGALYGLQVLEHCQANQTQNITRFLVLARKAVNVSDQVPAKTTL
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEE
LMATGQQAGALVEALLVLRNHNLIMTKLESRPIHGNPWEEMFYLDIQANLDSLPMRKALK
EEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHEEEEEEECCCCCCHHHHHHH
ELADITRSMKVLGCYPSENVVPVDPV
HHHHHHHHHHHEEECCCCCEECCCCC
>Mature Secondary Structure 
TEENPLLALRDKISALDEKLLALLAERRGLAVEVGKAKLASHRPVRDIDRERDLLERLM
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHCCCCHHHHHHHHHHHHHHH
TIGKRHNLDAHYITRLFQLIIEDSVLTQQTLLQQHLNKINPHSARVAFLGPKGSYSHLAA
HHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHHH
RQYAARHFEQFIESGCAKFADIFNQVETGQADYAVVPIENTSSGGINDVYDLLQHTSLSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCHHE
VGELTIPIDHCVLVSTSTDADKIQTVYSHPQPFQQCSQYLSRYPHWKIEYTESTSAAMEK
EEEEEECCCCEEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEECCCHHHHHHH
VAQANSPVVAALGSEAGGALYGLQVLEHCQANQTQNITRFLVLARKAVNVSDQVPAKTTL
HHHCCCCEEEEECCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCEEE
LMATGQQAGALVEALLVLRNHNLIMTKLESRPIHGNPWEEMFYLDIQANLDSLPMRKALK
EEECCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHEEEEEEECCCCCCHHHHHHH
ELADITRSMKVLGCYPSENVVPVDPV
HHHHHHHHHHHEEECCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]