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The map label for this gene is map [H]

Identifier: 238894715

GI number: 238894715

Start: 2599670

End: 2600440

Strand: Reverse

Name: map [H]

Synonym: KP1_2721

Alternate gene names: 238894715

Gene position: 2600440-2599670 (Counterclockwise)

Preceding gene: 238894716

Following gene: 238894713

Centisome position: 49.55

GC content: 56.55

Gene sequence:

>771_bases
ATCATTAAAACCGCCGACGAACTCGCCCGGCAGCGCCATGCCGGCCAGCTGCTGGCGTCAGTGTTTGATATGCTGGATAC
TTTTATCGTTCCCGGCGTAACGACGATGGCGATTAACGATCGAGTGGAAGATTTTATCGTCAACCAGCTGCACGCCCGCC
CGGCCAGCAAGGGGCAATACGATTTTCCCTATGTGTTGAACACTTCCATTAACGATGTGGTGTGCCACGGGATCCCCAAA
GCGACCGAACATCTGCGCTCCGGGATGATTGTTAACGTCGATATCACCCTCGAGAAAGCGGGCATGATTGCCGACTCCAG
TAAGATGTACCTGATAGGCGATGTCTCCCCGCTGGCCCGCCGGCTGGTAAAGACTACCTATGAAGCGATGTGGAAAGGCA
TTGAGGTGGTGAAGCCTGGCGCGACGCTGGGCGATATTGGCCACGCTATTCAGCGCTGGGTGGAGGAACATGGCTATAGC
GTGGTCAGAGAATATTGCGGTCACGGCGTCGGTCAGGAAATGCATGAGGAACCGCAGGTGCTGCATTATGGCCGCCCCGG
AGAAGGCGCCGTGCTGCAGGAAGGCATGGTGTTCACCATTGAGCCGATGGTCAACCAGGGCGACAGCCGTATCAAAACCA
AAAAAGATGGCTGGACGGTGGTTACCCGCGATAAAAAACTCTCCGCGCAATGGGAGCACACCGTGGCCGTCACCGCCAAC
GGTTTTGAGGTGCTGACGTTACGCGACGATGAACAGTCGCGGATCCGCTGA

Upstream 100 bases:

>100_bases
ATGAGCGAACTCTACCCTGAGCTTAACCACCAGCAGATCAAACTGCTGATGCTGAAATCCGGCTCTGACCGTCTGCTGGA
GGTGATCAATGCCATCAATA

Downstream 100 bases:

>100_bases
GTTGCTTCCCTTTCTCTATGACGGTGGGCCGCTTTCCGATCCCGGAGCTCGCTTGGGCGCCAGACGACACCTGATTCTGC
CGCCGGGCGGCGGCAATAAT

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MIKTADELARQRHAGQLLASVFDMLDTFIVPGVTTMAINDRVEDFIVNQLHARPASKGQYDFPYVLNTSINDVVCHGIPK
ATEHLRSGMIVNVDITLEKAGMIADSSKMYLIGDVSPLARRLVKTTYEAMWKGIEVVKPGATLGDIGHAIQRWVEEHGYS
VVREYCGHGVGQEMHEEPQVLHYGRPGEGAVLQEGMVFTIEPMVNQGDSRIKTKKDGWTVVTRDKKLSAQWEHTVAVTAN
GFEVLTLRDDEQSRIR

Sequences:

>Translated_256_residues
MIKTADELARQRHAGQLLASVFDMLDTFIVPGVTTMAINDRVEDFIVNQLHARPASKGQYDFPYVLNTSINDVVCHGIPK
ATEHLRSGMIVNVDITLEKAGMIADSSKMYLIGDVSPLARRLVKTTYEAMWKGIEVVKPGATLGDIGHAIQRWVEEHGYS
VVREYCGHGVGQEMHEEPQVLHYGRPGEGAVLQEGMVFTIEPMVNQGDSRIKTKKDGWTVVTRDKKLSAQWEHTVAVTAN
GFEVLTLRDDEQSRIR
>Mature_256_residues
MIKTADELARQRHAGQLLASVFDMLDTFIVPGVTTMAINDRVEDFIVNQLHARPASKGQYDFPYVLNTSINDVVCHGIPK
ATEHLRSGMIVNVDITLEKAGMIADSSKMYLIGDVSPLARRLVKTTYEAMWKGIEVVKPGATLGDIGHAIQRWVEEHGYS
VVREYCGHGVGQEMHEEPQVLHYGRPGEGAVLQEGMVFTIEPMVNQGDSRIKTKKDGWTVVTRDKKLSAQWEHTVAVTAN
GFEVLTLRDDEQSRIR

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=42.1052631578947, Blast_Score=196, Evalue=1e-50,
Organism=Homo sapiens, GI40385867, Length=245, Percent_Identity=33.0612244897959, Blast_Score=151, Evalue=5e-37,
Organism=Escherichia coli, GI1786364, Length=250, Percent_Identity=49.6, Blast_Score=264, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI71996291, Length=220, Percent_Identity=42.7272727272727, Blast_Score=177, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6323273, Length=249, Percent_Identity=39.7590361445783, Blast_Score=186, Evalue=3e-48,
Organism=Drosophila melanogaster, GI21355531, Length=249, Percent_Identity=37.3493975903614, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24583427, Length=247, Percent_Identity=34.0080971659919, Blast_Score=150, Evalue=6e-37,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 28557; Mature: 28557

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKTADELARQRHAGQLLASVFDMLDTFIVPGVTTMAINDRVEDFIVNQLHARPASKGQY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCCCC
DFPYVLNTSINDVVCHGIPKATEHLRSGMIVNVDITLEKAGMIADSSKMYLIGDVSPLAR
CCCEEECCCCCHHHHCCCCHHHHHHHCCCEEEEEEEEECCCCEECCCCEEEEECCCHHHH
RLVKTTYEAMWKGIEVVKPGATLGDIGHAIQRWVEEHGYSVVREYCGHGVGQEMHEEPQV
HHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCE
LHYGRPGEGAVLQEGMVFTIEPMVNQGDSRIKTKKDGWTVVTRDKKLSAQWEHTVAVTAN
EECCCCCCCCEECCCEEEEEECCCCCCCCCCEECCCCCEEEEECCCCCCCCCEEEEEEEC
GFEVLTLRDDEQSRIR
CEEEEEEECCHHHHCC
>Mature Secondary Structure
MIKTADELARQRHAGQLLASVFDMLDTFIVPGVTTMAINDRVEDFIVNQLHARPASKGQY
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHCCCCCCCCC
DFPYVLNTSINDVVCHGIPKATEHLRSGMIVNVDITLEKAGMIADSSKMYLIGDVSPLAR
CCCEEECCCCCHHHHCCCCHHHHHHHCCCEEEEEEEEECCCCEECCCCEEEEECCCHHHH
RLVKTTYEAMWKGIEVVKPGATLGDIGHAIQRWVEEHGYSVVREYCGHGVGQEMHEEPQV
HHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCE
LHYGRPGEGAVLQEGMVFTIEPMVNQGDSRIKTKKDGWTVVTRDKKLSAQWEHTVAVTAN
EECCCCCCCCEECCCEEEEEECCCCCCCCCCEECCCCCEEEEECCCCCCCCCEEEEEEEC
GFEVLTLRDDEQSRIR
CEEEEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]