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The map label for this gene is cueR [H]

Identifier: 238893453

GI number: 238893453

Start: 1298666

End: 1299076

Strand: Direct

Name: cueR [H]

Synonym: KP1_1344

Alternate gene names: 238893453

Gene position: 1298666-1299076 (Clockwise)

Preceding gene: 238893449

Following gene: 238893456

Centisome position: 24.74

GC content: 58.64

Gene sequence:

>411_bases
ATGAATATCAGCGATGTGGCGAAAAAAACCGGCTTAACCAGCAAAGCGATTCGTTTTTATGAAGAGAAGGGGCTGGTGAC
GCCGCCGTTGCGGAGCGAAAACGGCTACCGCACCTATAGTCAGCAGCATCTCGATGAGCTGACGCTGCTGCGCCAGGCGC
GGCAGGTGGGGTTTAACCTGGAAGAGTGCCGCGAACTGGTGGCCCTGTTCAACGACCCGTCGCGGCACAGCGCCGATGTG
AAAAAACGCACGCTGGAGAAAGTGGCGGATATCGAGAACCATATCCGCGAGCTGCAAAATATGCGCGCGCACCTGCTGGC
GCTGGCCGAATCCTGCCCCGGCGACGACAGCGCGGAGTGCCCGATTATCGATAATCTTTCCGGCTGCTGCCATCGCAAGG
CGCAGGCTTAA

Upstream 100 bases:

>100_bases
CTCCTGAATAATTTTCCGGTCAACGATTGACCAGAACCACTCTTTCATCGAGTATTAAGAAGGTTAAACCTTCCAGCAAG
GGGAAGGTCAAGGAGAAAAA

Downstream 100 bases:

>100_bases
CGGACGGCGGGTCTGATTCGTAGCGTAATCCCTTCTACGGCAATCACTTCAACCTTGCTGCCCGCCGCGAAGTCTTCATC
GGCAATCACCGGCCAGGAGC

Product: copper responsive transcription regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 136; Mature: 136

Protein sequence:

>136_residues
MNISDVAKKTGLTSKAIRFYEEKGLVTPPLRSENGYRTYSQQHLDELTLLRQARQVGFNLEECRELVALFNDPSRHSADV
KKRTLEKVADIENHIRELQNMRAHLLALAESCPGDDSAECPIIDNLSGCCHRKAQA

Sequences:

>Translated_136_residues
MNISDVAKKTGLTSKAIRFYEEKGLVTPPLRSENGYRTYSQQHLDELTLLRQARQVGFNLEECRELVALFNDPSRHSADV
KKRTLEKVADIENHIRELQNMRAHLLALAESCPGDDSAECPIIDNLSGCCHRKAQA
>Mature_136_residues
MNISDVAKKTGLTSKAIRFYEEKGLVTPPLRSENGYRTYSQQHLDELTLLRQARQVGFNLEECRELVALFNDPSRHSADV
KKRTLEKVADIENHIRELQNMRAHLLALAESCPGDDSAECPIIDNLSGCCHRKAQA

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=134, Percent_Identity=84.3283582089552, Blast_Score=238, Evalue=9e-65,
Organism=Escherichia coli, GI1789687, Length=138, Percent_Identity=34.7826086956522, Blast_Score=85, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15350; Mature: 15350

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISDVAKKTGLTSKAIRFYEEKGLVTPPLRSENGYRTYSQQHLDELTLLRQARQVGFNL
CCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
EECRELVALFNDPSRHSADVKKRTLEKVADIENHIRELQNMRAHLLALAESCPGDDSAEC
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIIDNLSGCCHRKAQA
CCCCCHHHHHHHCCCC
>Mature Secondary Structure
MNISDVAKKTGLTSKAIRFYEEKGLVTPPLRSENGYRTYSQQHLDELTLLRQARQVGFNL
CCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
EECRELVALFNDPSRHSADVKKRTLEKVADIENHIRELQNMRAHLLALAESCPGDDSAEC
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIIDNLSGCCHRKAQA
CCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]