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The map label for this gene is apt [H]

Identifier: 238893439

GI number: 238893439

Start: 1280374

End: 1280958

Strand: Direct

Name: apt [H]

Synonym: KP1_1327

Alternate gene names: 238893439

Gene position: 1280374-1280958 (Clockwise)

Preceding gene: 238893438

Following gene: 238893440

Centisome position: 24.39

GC content: 56.58

Gene sequence:

>585_bases
GTGGGTAATACCGTTTCAATCAGGCATACACTTATGACCGCAACTGCACAGCAGCTTGAATATCTGAAGAACAGCATCCA
GAGTATCGAGGATTATCCAAAACCTGGCATTCTTTTCCGCGATGTCACCAGCTTACTGGAAGACCCGAAGGCCTACGCGC
TTAGCATTGAACTGCTGACCGAGCGCTACAAAAACGCGGGTATTACCAAAGTGGTAGGGACTGAGGCGCGTGGCTTCCTG
TTCGGCGCACCGGTTGCGCTGGCGCTGGGCGTGGGCTTTGTTCCGGTACGCAAGCCGCGTAAGTTGCCGCGTGAAACCAT
TGCCGAGACCTATGAGCTGGAGTATGGCACCGATCAGCTGGAGATCCACGTTGACGCCATTAAACCGGGCGATAAAGTGC
TGGTGGTTGACGATCTGCTGGCGACCGGCGGCACTATCGACGCCACGGTCAAACTGATCCGCCGCCTCGGCGGCGAAGTG
CACGATGCCGCTTTCATTATCAATCTCTTCGATCTGGGCGGCGAACAGCGCCTGGAGAAGCTGGGGATCCACTGCTACAG
TCTGGTGCCGTTCCCGGGCCACTAA

Upstream 100 bases:

>100_bases
TGCAATTGTTGCCGACAGCCAGTAAATTCTGGCGTTTTCGAGCGCGGGCAAGCCTGGTCAAAGGTTAAACAAATGTTTCT
TTGGCCCCTTTTGCACGCCC

Downstream 100 bases:

>100_bases
GCAAATCCCTCCACATAGCCTCGCCGATCGGGCGGGGCTGTGATAGCATGACCCCTTCGTGATTTCACCTTCCAGCGTTT
CAGAGCCAGCCCATGAGTTA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MGNTVSIRHTLMTATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLTERYKNAGITKVVGTEARGFL
FGAPVALALGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIDATVKLIRRLGGEV
HDAAFIINLFDLGGEQRLEKLGIHCYSLVPFPGH

Sequences:

>Translated_194_residues
MGNTVSIRHTLMTATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLTERYKNAGITKVVGTEARGFL
FGAPVALALGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIDATVKLIRRLGGEV
HDAAFIINLFDLGGEQRLEKLGIHCYSLVPFPGH
>Mature_193_residues
GNTVSIRHTLMTATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLTERYKNAGITKVVGTEARGFLF
GAPVALALGVGFVPVRKPRKLPRETIAETYELEYGTDQLEIHVDAIKPGDKVLVVDDLLATGGTIDATVKLIRRLGGEVH
DAAFIINLFDLGGEQRLEKLGIHCYSLVPFPGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=165, Percent_Identity=42.4242424242424, Blast_Score=137, Evalue=4e-33,
Organism=Homo sapiens, GI71773201, Length=130, Percent_Identity=44.6153846153846, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1786675, Length=183, Percent_Identity=92.896174863388, Blast_Score=342, Evalue=1e-95,
Organism=Caenorhabditis elegans, GI17509087, Length=159, Percent_Identity=44.0251572327044, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=169, Percent_Identity=40.2366863905325, Blast_Score=111, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=171, Percent_Identity=35.672514619883, Blast_Score=89, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17136334, Length=168, Percent_Identity=42.2619047619048, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 21287; Mature: 21156

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNTVSIRHTLMTATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLT
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHEEHHHHHH
ERYKNAGITKVVGTEARGFLFGAPVALALGVGFVPVRKPRKLPRETIAETYELEYGTDQL
HHHHCCCCEEEECCCCCCEEECCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEE
EIHVDAIKPGDKVLVVDDLLATGGTIDATVKLIRRLGGEVHDAAFIINLFDLGGEQRLEK
EEEEEEECCCCEEEEEEHHHHCCCCHHHHHHHHHHHCCCHHHHHHEEHHHHCCCHHHHHH
LGIHCYSLVPFPGH
HCCEEEEECCCCCC
>Mature Secondary Structure 
GNTVSIRHTLMTATAQQLEYLKNSIQSIEDYPKPGILFRDVTSLLEDPKAYALSIELLT
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHEEHHHHHH
ERYKNAGITKVVGTEARGFLFGAPVALALGVGFVPVRKPRKLPRETIAETYELEYGTDQL
HHHHCCCCEEEECCCCCCEEECCHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEE
EIHVDAIKPGDKVLVVDDLLATGGTIDATVKLIRRLGGEVHDAAFIINLFDLGGEQRLEK
EEEEEEECCCCEEEEEEHHHHCCCCHHHHHHHHHHHCCCHHHHHHEEHHHHCCCHHHHHH
LGIHCYSLVPFPGH
HCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA