Click here to switch to the map view.

The map label for this gene is panB [H]

Identifier: 238893120

GI number: 238893120

Start: 951511

End: 952302

Strand: Reverse

Name: panB [H]

Synonym: KP1_0968

Alternate gene names: 238893120

Gene position: 952302-951511 (Counterclockwise)

Preceding gene: 238893121

Following gene: 238893119

Centisome position: 18.14

GC content: 60.98

Gene sequence:

>792_bases
ATGAAACCGACCACCATTGCCCTGCTGCAGAAATGCAAACAGGAAAAGAAGCGCTTTGCCACCATTACCGCCTACGATCA
CAGCTTCGCGAAGCTGTTCGCCGATGAAGGCATAAATGTGCTGCTGGTAGGCGACTCGCTGGGAATGACGGTGCAGGGTC
ACGACTCCACCCTGCCGGTTACCGTGGAAGATATCGCCTATCACACCCGCGCCGTCCGCCGCGGCGCGCCAAACAGCCTG
CTGCTTGCCGACCTGCCGTTCATGGCCTATGCCACCCCCGAGCAGACCTTTGCAAATGCCGCCATCGTGATGCGCGCTGG
CGCCAATATGGTCAAACTCGAGGGCGGCGCCTGGCTGGCCGACACCGTGAGGATGCTGGCGGAGCGCGCGGTGCCGGTTT
GCGGCCATCTTGGCCTGACGCCGCAGTCGGTGAACGTATTCGGTGGGTATAAAGTGCAGGGTCGCGGCGATGCGGCGCAG
ACCCTGTTTGAAGACGCGTTAGCGCTGGAGGCGGCGGGTGCGCAGCTGTTGGTCCTGGAGTGCGTGCCGGTTGAACTGGC
GAAGCGCATCACCGACGCTCTGACCATTCCAGTGATCGGCATCGGCGCGGGCAATGTCACCGACGGGCAAATCCTCGTGA
TGCATGACGCTTTCGGCATTACCGGCGGCCACATTCCTAAATTTGCCAAGAATTTCCTTGCCGAAGCGGGCGACATCCGC
GCCGCGGTGCGGCAGTATATTGCCGAAGTCGAATCCGGAGTCTATCCGGGCGAAGAACACAGTTTCCATTAA

Upstream 100 bases:

>100_bases
ATTTGCGGCGATCGTCGTAATCGGTTGCCCAAAATCATTGCCCCTCTGAATGCTGCTGTTAGAATGCCGGTTAATATGAC
TTTCATCATCAGGAAATGTT

Downstream 100 bases:

>100_bases
GGAGTCTTGTTGTGCTGATTATTGAATCCGTACTGCTGCTGCGGCAGCATATCCGCCGTCTGCGTCAGGAAGGTAAGCGT
ATCGCGTTGGTCCCGACGAT

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 263; Mature: 263

Protein sequence:

>263_residues
MKPTTIALLQKCKQEKKRFATITAYDHSFAKLFADEGINVLLVGDSLGMTVQGHDSTLPVTVEDIAYHTRAVRRGAPNSL
LLADLPFMAYATPEQTFANAAIVMRAGANMVKLEGGAWLADTVRMLAERAVPVCGHLGLTPQSVNVFGGYKVQGRGDAAQ
TLFEDALALEAAGAQLLVLECVPVELAKRITDALTIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAEAGDIR
AAVRQYIAEVESGVYPGEEHSFH

Sequences:

>Translated_263_residues
MKPTTIALLQKCKQEKKRFATITAYDHSFAKLFADEGINVLLVGDSLGMTVQGHDSTLPVTVEDIAYHTRAVRRGAPNSL
LLADLPFMAYATPEQTFANAAIVMRAGANMVKLEGGAWLADTVRMLAERAVPVCGHLGLTPQSVNVFGGYKVQGRGDAAQ
TLFEDALALEAAGAQLLVLECVPVELAKRITDALTIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAEAGDIR
AAVRQYIAEVESGVYPGEEHSFH
>Mature_263_residues
MKPTTIALLQKCKQEKKRFATITAYDHSFAKLFADEGINVLLVGDSLGMTVQGHDSTLPVTVEDIAYHTRAVRRGAPNSL
LLADLPFMAYATPEQTFANAAIVMRAGANMVKLEGGAWLADTVRMLAERAVPVCGHLGLTPQSVNVFGGYKVQGRGDAAQ
TLFEDALALEAAGAQLLVLECVPVELAKRITDALTIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAEAGDIR
AAVRQYIAEVESGVYPGEEHSFH

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=264, Percent_Identity=89.3939393939394, Blast_Score=484, Evalue=1e-138,
Organism=Saccharomyces cerevisiae, GI6319653, Length=255, Percent_Identity=37.2549019607843, Blast_Score=173, Evalue=3e-44,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 28028; Mature: 28028

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPTTIALLQKCKQEKKRFATITAYDHSFAKLFADEGINVLLVGDSLGMTVQGHDSTLPV
CCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCE
TVEDIAYHTRAVRRGAPNSLLLADLPFMAYATPEQTFANAAIVMRAGANMVKLEGGAWLA
EHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCHHHHHCEEEEEECCCCEEEECCCCCHH
DTVRMLAERAVPVCGHLGLTPQSVNVFGGYKVQGRGDAAQTLFEDALALEAAGAQLLVLE
HHHHHHHHHCCCHHCCCCCCCCCEEEEECEEEECCCHHHHHHHHHHHHHHHCCCEEEEEE
CVPVELAKRITDALTIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAEAGDIR
ECCHHHHHHHHHHHEEEEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHH
AAVRQYIAEVESGVYPGEEHSFH
HHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKPTTIALLQKCKQEKKRFATITAYDHSFAKLFADEGINVLLVGDSLGMTVQGHDSTLPV
CCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHCCCCEEEEEECCCCEEEECCCCCCCE
TVEDIAYHTRAVRRGAPNSLLLADLPFMAYATPEQTFANAAIVMRAGANMVKLEGGAWLA
EHHHHHHHHHHHHCCCCCCEEEECCCCCEECCCHHHHHCEEEEEECCCCEEEECCCCCHH
DTVRMLAERAVPVCGHLGLTPQSVNVFGGYKVQGRGDAAQTLFEDALALEAAGAQLLVLE
HHHHHHHHHCCCHHCCCCCCCCCEEEEECEEEECCCHHHHHHHHHHHHHHHCCCEEEEEE
CVPVELAKRITDALTIPVIGIGAGNVTDGQILVMHDAFGITGGHIPKFAKNFLAEAGDIR
ECCHHHHHHHHHHHEEEEEEECCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHCCHHHH
AAVRQYIAEVESGVYPGEEHSFH
HHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA