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The map label for this gene is aroP [H]

Identifier: 238893093

GI number: 238893093

Start: 920135

End: 921505

Strand: Reverse

Name: aroP [H]

Synonym: KP1_0938

Alternate gene names: 238893093

Gene position: 921505-920135 (Counterclockwise)

Preceding gene: 238893100

Following gene: 238893092

Centisome position: 17.56

GC content: 58.5

Gene sequence:

>1371_bases
ATGGAAGGTCAACAGCACGGCGATCGGCTGAAGCGCGGCCTGAAAAACCGTCACATTCAGCTCATCGCGCTGGGCGGGGC
TATCGGCACCGGCCTGTTTCTGGGGAGCGCGTCCGTCATTCAGTCCGCCGGCCCGGGTATCATTCTTGGTTACGCTATCG
CCGGTTTTATCGCTTTCCTGATCATGCGTCAGCTGGGCGAAATGGTGGTGGAAGAGCCGGTGGCCGGCTCATTTAGCCAC
TTTGCTTACAAATACTGGGGCGGTTTTGCCGGCTTCGCCTCCGGCTGGAACTACTGGGTACTGTATGTCCTGGTGGCCAT
GGCGGAACTGACCGCCGTTGGCAAATATATCCAGTTCTGGTGGCCGGAAATCCCTACCTGGGCCTCGGCGGCGGTCTTCT
TCATCGCCATCAACGCCATTAACCTGACCAATGTCAAAGTGTTCGGTGAAATGGAATTCTGGTTCGCGATTATCAAAGTG
GTCGCCGTAGTGGCGATGATTTTGTTCGGCGGCTGGCTGCTGTTCAGCGGCAACGGCGGCCCGCAGGCGACGGTACGTAA
CCTGTGGGACCAGGGGGGCTTCCTGCCGCACGGCTTTTACGGGCTGGTGATGATGATGGCGATCATCATGTTCTCCTTTG
GCGGCCTGGAGCTGGTGGGGATCACCGCCGCGGAAGCGGATAATCCGGAGCAAAGCATTCCTAAAGCCACCAATCAGGTT
ATTTACCGTATTCTGATCTTCTATGTTGGTTCGCTGGCGGTGCTGCTCTCCCTGCTGCCGTGGACCCGCGTCACCGCGGA
CACCAGTCCGTTCGTCCTGATCTTCCATGAACTTGGCGATACGCTGGTGGCAAACGCTCTGAACGTGGTGGTGCTGACGG
CAGCGCTGTCGGTTTATAACAGCTGCGTCTACTGCAACAGCCGTATGCTGTTCGGCCTTGCTCAGCAGGGCAACGCGCCA
AAAGCGCTGCTCAGCGTCGACAAACGCGGCGTGCCGGTGAATACCATTCTCGTCTCGGCCCTGGTCACTGCGCTGTGCGT
GCTGATCAACTACCTGGCGCCTGAATCTGCTTTCGGTCTGCTGATGGCGCTGGTGGTCTCGGCCCTGGTCATCAACTGGG
CGATGATCAGCCTCGCGCATATGAAATTCCGTCGTGCCAAAAAGCAGCAGGGCGTGGTCACGCGTTTCCCGGCCCTCTTC
TATCCGCTGGGCAACTGGCTGTGCCTGCTGTTTATGGCGGCGGTGCTGGTGATTATGCTGATGACCCCGGGGATGGCGAT
TTCCGTCTGGCTGATCCCGGTATGGATTGCGGTGCTGGGCGTGGGCTACCTGTTTAAAGAGAAAGCCGCCGCCACCATAA
AAGCACAATAA

Upstream 100 bases:

>100_bases
CGCCCAAATTTTCGCTGGCTATGCTTTCAGGCAGGGACAGCAGTGAAGCAGCAACCTGACGGATGACGTACACAAAAAAT
AACCACACACGAGGTTTCAT

Downstream 100 bases:

>100_bases
TACATCTCATCAATACTTCACTTTGCTCTGCGCCCTCCCCTGAATAATGGGTGCAGAGCATTGTTATCTGCTTCACACTT
TCCCCTCCATAGCTTATTTA

Product: aromatic amino acid transporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MEGQQHGDRLKRGLKNRHIQLIALGGAIGTGLFLGSASVIQSAGPGIILGYAIAGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGGFAGFASGWNYWVLYVLVAMAELTAVGKYIQFWWPEIPTWASAAVFFIAINAINLTNVKVFGEMEFWFAIIKV
VAVVAMILFGGWLLFSGNGGPQATVRNLWDQGGFLPHGFYGLVMMMAIIMFSFGGLELVGITAAEADNPEQSIPKATNQV
IYRILIFYVGSLAVLLSLLPWTRVTADTSPFVLIFHELGDTLVANALNVVVLTAALSVYNSCVYCNSRMLFGLAQQGNAP
KALLSVDKRGVPVNTILVSALVTALCVLINYLAPESAFGLLMALVVSALVINWAMISLAHMKFRRAKKQQGVVTRFPALF
YPLGNWLCLLFMAAVLVIMLMTPGMAISVWLIPVWIAVLGVGYLFKEKAAATIKAQ

Sequences:

>Translated_456_residues
MEGQQHGDRLKRGLKNRHIQLIALGGAIGTGLFLGSASVIQSAGPGIILGYAIAGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGGFAGFASGWNYWVLYVLVAMAELTAVGKYIQFWWPEIPTWASAAVFFIAINAINLTNVKVFGEMEFWFAIIKV
VAVVAMILFGGWLLFSGNGGPQATVRNLWDQGGFLPHGFYGLVMMMAIIMFSFGGLELVGITAAEADNPEQSIPKATNQV
IYRILIFYVGSLAVLLSLLPWTRVTADTSPFVLIFHELGDTLVANALNVVVLTAALSVYNSCVYCNSRMLFGLAQQGNAP
KALLSVDKRGVPVNTILVSALVTALCVLINYLAPESAFGLLMALVVSALVINWAMISLAHMKFRRAKKQQGVVTRFPALF
YPLGNWLCLLFMAAVLVIMLMTPGMAISVWLIPVWIAVLGVGYLFKEKAAATIKAQ
>Mature_456_residues
MEGQQHGDRLKRGLKNRHIQLIALGGAIGTGLFLGSASVIQSAGPGIILGYAIAGFIAFLIMRQLGEMVVEEPVAGSFSH
FAYKYWGGFAGFASGWNYWVLYVLVAMAELTAVGKYIQFWWPEIPTWASAAVFFIAINAINLTNVKVFGEMEFWFAIIKV
VAVVAMILFGGWLLFSGNGGPQATVRNLWDQGGFLPHGFYGLVMMMAIIMFSFGGLELVGITAAEADNPEQSIPKATNQV
IYRILIFYVGSLAVLLSLLPWTRVTADTSPFVLIFHELGDTLVANALNVVVLTAALSVYNSCVYCNSRMLFGLAQQGNAP
KALLSVDKRGVPVNTILVSALVTALCVLINYLAPESAFGLLMALVVSALVINWAMISLAHMKFRRAKKQQGVVTRFPALF
YPLGNWLCLLFMAAVLVIMLMTPGMAISVWLIPVWIAVLGVGYLFKEKAAATIKAQ

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=292, Percent_Identity=22.9452054794521, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI258645169, Length=430, Percent_Identity=22.5581395348837, Blast_Score=72, Evalue=9e-13,
Organism=Homo sapiens, GI181337167, Length=291, Percent_Identity=25.085910652921, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614005, Length=431, Percent_Identity=22.0417633410673, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI258614003, Length=431, Percent_Identity=22.0417633410673, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1786302, Length=456, Percent_Identity=93.640350877193, Blast_Score=868, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=430, Percent_Identity=64.8837209302326, Blast_Score=583, Evalue=1e-168,
Organism=Escherichia coli, GI1790653, Length=454, Percent_Identity=39.8678414096916, Blast_Score=334, Evalue=6e-93,
Organism=Escherichia coli, GI1786602, Length=450, Percent_Identity=42.8888888888889, Blast_Score=332, Evalue=2e-92,
Organism=Escherichia coli, GI48994972, Length=431, Percent_Identity=39.907192575406, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI87081915, Length=388, Percent_Identity=38.4020618556701, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI87081708, Length=438, Percent_Identity=35.6164383561644, Blast_Score=277, Evalue=1e-75,
Organism=Escherichia coli, GI1789017, Length=432, Percent_Identity=36.8055555555556, Blast_Score=273, Evalue=2e-74,
Organism=Escherichia coli, GI1788480, Length=408, Percent_Identity=35.2941176470588, Blast_Score=249, Evalue=4e-67,
Organism=Caenorhabditis elegans, GI17531343, Length=380, Percent_Identity=25.2631578947368, Blast_Score=79, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=35.0678733031674, Blast_Score=240, Evalue=3e-64,
Organism=Saccharomyces cerevisiae, GI6324061, Length=438, Percent_Identity=32.8767123287671, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6324924, Length=455, Percent_Identity=32.967032967033, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=33.4170854271357, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6321053, Length=429, Percent_Identity=31.4685314685315, Blast_Score=206, Evalue=7e-54,
Organism=Saccharomyces cerevisiae, GI6322892, Length=431, Percent_Identity=34.338747099768, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6320717, Length=406, Percent_Identity=31.7733990147783, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6319824, Length=402, Percent_Identity=31.3432835820896, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324990, Length=416, Percent_Identity=31.0096153846154, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324059, Length=440, Percent_Identity=32.7272727272727, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6321629, Length=408, Percent_Identity=30.8823529411765, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6320251, Length=405, Percent_Identity=29.1358024691358, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6319543, Length=398, Percent_Identity=30.1507537688442, Blast_Score=179, Evalue=9e-46,
Organism=Saccharomyces cerevisiae, GI6319542, Length=406, Percent_Identity=28.5714285714286, Blast_Score=171, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6322967, Length=396, Percent_Identity=29.7979797979798, Blast_Score=167, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6319608, Length=416, Percent_Identity=28.6057692307692, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6324981, Length=396, Percent_Identity=28.7878787878788, Blast_Score=149, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320364, Length=521, Percent_Identity=25.1439539347409, Blast_Score=124, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24667468, Length=404, Percent_Identity=23.2673267326733, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI221512776, Length=375, Percent_Identity=21.3333333333333, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24666159, Length=370, Percent_Identity=21.3513513513514, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49552; Mature: 49552

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGQQHGDRLKRGLKNRHIQLIALGGAIGTGLFLGSASVIQSAGPGIILGYAIAGFIAFL
CCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCHHHHHCCCCCEEHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGGFAGFASGWNYWVLYVLVAMAELTAVGKYIQFW
HHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
WPEIPTWASAAVFFIAINAINLTNVKVFGEMEFWFAIIKVVAVVAMILFGGWLLFSGNGG
CCCCCCHHHHHHHHHHHEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
PQATVRNLWDQGGFLPHGFYGLVMMMAIIMFSFGGLELVGITAAEADNPEQSIPKATNQV
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILIFYVGSLAVLLSLLPWTRVTADTSPFVLIFHELGDTLVANALNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHHH
SCVYCNSRMLFGLAQQGNAPKALLSVDKRGVPVNTILVSALVTALCVLINYLAPESAFGL
HHHHCCCHHHEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LMALVVSALVINWAMISLAHMKFRRAKKQQGVVTRFPALFYPLGNWLCLLFMAAVLVIML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTPGMAISVWLIPVWIAVLGVGYLFKEKAAATIKAQ
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEGQQHGDRLKRGLKNRHIQLIALGGAIGTGLFLGSASVIQSAGPGIILGYAIAGFIAFL
CCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCHHHHHCCCCCEEHHHHHHHHHHHH
IMRQLGEMVVEEPVAGSFSHFAYKYWGGFAGFASGWNYWVLYVLVAMAELTAVGKYIQFW
HHHHHHHHHHHCCCCCCHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHH
WPEIPTWASAAVFFIAINAINLTNVKVFGEMEFWFAIIKVVAVVAMILFGGWLLFSGNGG
CCCCCCHHHHHHHHHHHEEEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCEEEEECCCC
PQATVRNLWDQGGFLPHGFYGLVMMMAIIMFSFGGLELVGITAAEADNPEQSIPKATNQV
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCHHHCCHHHHHH
IYRILIFYVGSLAVLLSLLPWTRVTADTSPFVLIFHELGDTLVANALNVVVLTAALSVYN
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCEEEHHHHCHHHHHHHHHHHHHHHHHHHHH
SCVYCNSRMLFGLAQQGNAPKALLSVDKRGVPVNTILVSALVTALCVLINYLAPESAFGL
HHHHCCCHHHEEECCCCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LMALVVSALVINWAMISLAHMKFRRAKKQQGVVTRFPALFYPLGNWLCLLFMAAVLVIML
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTPGMAISVWLIPVWIAVLGVGYLFKEKAAATIKAQ
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]