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The map label for this gene is creC [H]

Identifier: 238892985

GI number: 238892985

Start: 792616

End: 794040

Strand: Direct

Name: creC [H]

Synonym: KP1_0816

Alternate gene names: 238892985

Gene position: 792616-794040 (Clockwise)

Preceding gene: 238892984

Following gene: 238892986

Centisome position: 15.1

GC content: 61.75

Gene sequence:

>1425_bases
ATGCGCATCGGCATGCGCCTGCTGCTGGGCTATTTTCTTATCGTCGCGATCGCCGCGTGGTTTGTGCTGTCGATCTTTGT
CCAGGAAGTGAAGCCGGGCGTGCGCCGGGCGACAGAGGGGACCCTCAATGATACCGCTACCCTGTTGGCGGCGCTGGCGC
GTGAGGATCTGCTGGCGGCAAACCCGCAGCAGGGCAGGCTGGCGCAGGCCTTTCACCAGCTCAACCAGCAGCCGCTCAAC
GCCAATATTGGCGGAATTAAAAAGGTACGTAATGAGTACCGCGTCTATCTGACCGATGCCCGGGGCAAGGTGGTGTTTGA
CTCCAGCGGGCAGGCGACAGGGCAGGACTATTCGCGCTGGAACGATGTCTGGCTCACCCTGCGCGGCCAGTACGGCGCGC
GCAGTACGCGCAGCGATCCGCATGATGAAGCCAGCTCGGTGATGTATATCGCCGCGCCGGTGATGGATAAGGGGCGGATT
ATCGGCGTGCTGAGCGTCGGTAAACCCAACCAGGCGATGACGCCGGTCATTAAGCGCAGCGAGCGGCGGATCCTCTGGGC
CGGCGGCGCCCTGCTGGGCATTGCGCTGTTGATTGGCGGCGGCGTCGTCTGGTGGATCAATTTCTCTATCGGCAAGCTGG
TGCGCTATGCGGACTCGGTGACCGCTGAGCGCCCGCTGCCGCTGCCGGAGGTTGGCAGCAGCGAATTGCGCAAGCTGGCC
CAGGCTCTGGAGAGCATGCGGGTAAAGCTCGAAGGTAAGAATGCCATCGAAAACTATGTCTATGACCTGACCCATGAACT
GAAAAGCCCGCTGGCGGCCATCCGCGGCGCGGCGGAGATCCTGCGCGAAGGGCCGCCGCCTGAGGTGGCGGCGCGGTTTA
CTGATAATATCCTCGCGCAAAACACCCGGATGCAACTGCTGGTGGAGCGGCTGCTCCAGCAGGCGAGACTGGAAAGCCGG
CTGGAGATAAAGCAGCATCCGGTGTCGATAGATGCGCTATACCAACGGCTGACGGAGGAGCGCAACATCGCTCTGGCGGC
GAAAGCTATCACCCTGCGCTGGCGGGAGAGTGGGATGCTGGTCAATGGCGATGGCGAGCTGTTGGCCCAGGCGCTGGGTA
ATCTGCTCGACAACGCGATTGACTTTACCCCCCAGGGCGGTGAGATCGCCCTGGCTGCGGAGAAGCGAAATGAAGAGGTG
CAATTGAGCGTTATCGACAACGGGTGCGGTATTCCGGATTATGCCCTGGAACGAATCTTTGAGCGATTCTATTCGCTGCC
GCGCGAAGACGGCCATAAGAGCAGCGGCCTTGGACTGGCGTTCGTTCGTGAAGTCGCGCGCCTGCATCACGGCGATATCA
ATCTGCACAATCGGCCCGAAGGCGGCGTGGTCGCCACGCTGCGACTTCACCGTCCCTTCACATAG

Upstream 100 bases:

>100_bases
CCCATATCAAAACCCTGCGCGCTAAGCTGCGGGCTGTGAATCCTGAAAAGGCGCCAATCAATACCCATCGCGGTATGGGC
TACAGCCTGGGGCGCGGCTG

Downstream 100 bases:

>100_bases
CTTCAAATTCTCCCCACACAGCCGTCCTATTGTGAGGCCATCACGATAGGGAGAAAGGCTATGTTGAAATCACCGTTATT
CTGGAAAATCACCACGTTAA

Product: sensory histidine kinase CreC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 474; Mature: 474

Protein sequence:

>474_residues
MRIGMRLLLGYFLIVAIAAWFVLSIFVQEVKPGVRRATEGTLNDTATLLAALAREDLLAANPQQGRLAQAFHQLNQQPLN
ANIGGIKKVRNEYRVYLTDARGKVVFDSSGQATGQDYSRWNDVWLTLRGQYGARSTRSDPHDEASSVMYIAAPVMDKGRI
IGVLSVGKPNQAMTPVIKRSERRILWAGGALLGIALLIGGGVVWWINFSIGKLVRYADSVTAERPLPLPEVGSSELRKLA
QALESMRVKLEGKNAIENYVYDLTHELKSPLAAIRGAAEILREGPPPEVAARFTDNILAQNTRMQLLVERLLQQARLESR
LEIKQHPVSIDALYQRLTEERNIALAAKAITLRWRESGMLVNGDGELLAQALGNLLDNAIDFTPQGGEIALAAEKRNEEV
QLSVIDNGCGIPDYALERIFERFYSLPREDGHKSSGLGLAFVREVARLHHGDINLHNRPEGGVVATLRLHRPFT

Sequences:

>Translated_474_residues
MRIGMRLLLGYFLIVAIAAWFVLSIFVQEVKPGVRRATEGTLNDTATLLAALAREDLLAANPQQGRLAQAFHQLNQQPLN
ANIGGIKKVRNEYRVYLTDARGKVVFDSSGQATGQDYSRWNDVWLTLRGQYGARSTRSDPHDEASSVMYIAAPVMDKGRI
IGVLSVGKPNQAMTPVIKRSERRILWAGGALLGIALLIGGGVVWWINFSIGKLVRYADSVTAERPLPLPEVGSSELRKLA
QALESMRVKLEGKNAIENYVYDLTHELKSPLAAIRGAAEILREGPPPEVAARFTDNILAQNTRMQLLVERLLQQARLESR
LEIKQHPVSIDALYQRLTEERNIALAAKAITLRWRESGMLVNGDGELLAQALGNLLDNAIDFTPQGGEIALAAEKRNEEV
QLSVIDNGCGIPDYALERIFERFYSLPREDGHKSSGLGLAFVREVARLHHGDINLHNRPEGGVVATLRLHRPFT
>Mature_474_residues
MRIGMRLLLGYFLIVAIAAWFVLSIFVQEVKPGVRRATEGTLNDTATLLAALAREDLLAANPQQGRLAQAFHQLNQQPLN
ANIGGIKKVRNEYRVYLTDARGKVVFDSSGQATGQDYSRWNDVWLTLRGQYGARSTRSDPHDEASSVMYIAAPVMDKGRI
IGVLSVGKPNQAMTPVIKRSERRILWAGGALLGIALLIGGGVVWWINFSIGKLVRYADSVTAERPLPLPEVGSSELRKLA
QALESMRVKLEGKNAIENYVYDLTHELKSPLAAIRGAAEILREGPPPEVAARFTDNILAQNTRMQLLVERLLQQARLESR
LEIKQHPVSIDALYQRLTEERNIALAAKAITLRWRESGMLVNGDGELLAQALGNLLDNAIDFTPQGGEIALAAEKRNEEV
QLSVIDNGCGIPDYALERIFERFYSLPREDGHKSSGLGLAFVREVARLHHGDINLHNRPEGGVVATLRLHRPFT

Specific function: Member of the two-component regulatory system CreC/CreB involved in catabolic regulation. CreC may function as a membrane- associated protein kinase that phosphorylates CreB in response to environmental signals. CreC can also phosphorylate PhoB [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=474, Percent_Identity=72.5738396624473, Blast_Score=694, Evalue=0.0,
Organism=Escherichia coli, GI1788393, Length=247, Percent_Identity=30.7692307692308, Blast_Score=102, Evalue=6e-23,
Organism=Escherichia coli, GI1786912, Length=216, Percent_Identity=33.3333333333333, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=29.7169811320755, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI48994928, Length=224, Percent_Identity=27.6785714285714, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87082128, Length=249, Percent_Identity=28.5140562248996, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788549, Length=214, Percent_Identity=28.5046728971963, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1790551, Length=304, Percent_Identity=26.9736842105263, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789403, Length=482, Percent_Identity=26.3485477178423, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI145693157, Length=240, Percent_Identity=25.4166666666667, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788713, Length=247, Percent_Identity=26.7206477732794, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=26.1603375527426, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=210, Percent_Identity=28.0952380952381, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790300, Length=217, Percent_Identity=29.4930875576037, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=265, Percent_Identity=25.2830188679245, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 52437; Mature: 52437

Theoretical pI: Translated: 9.50; Mature: 9.50

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGMRLLLGYFLIVAIAAWFVLSIFVQEVKPGVRRATEGTLNDTATLLAALAREDLLAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
NPQQGRLAQAFHQLNQQPLNANIGGIKKVRNEYRVYLTDARGKVVFDSSGQATGQDYSRW
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEEEECCCEEEECCCCCCCCCHHHCC
NDVWLTLRGQYGARSTRSDPHDEASSVMYIAAPVMDKGRIIGVLSVGKPNQAMTPVIKRS
CCEEEEEECCCCCCCCCCCCCCHHCCEEEEEECCCCCCCEEEEEECCCCCCHHCHHHHCC
ERRILWAGGALLGIALLIGGGVVWWINFSIGKLVRYADSVTAERPLPLPEVGSSELRKLA
CCEEEEECHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNAIENYVYDLTHELKSPLAAIRGAAEILREGPPPEVAARFTDNILAQ
HHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
NTRMQLLVERLLQQARLESRLEIKQHPVSIDALYQRLTEERNIALAAKAITLRWRESGML
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEEEEEEEEECCCEE
VNGDGELLAQALGNLLDNAIDFTPQGGEIALAAEKRNEEVQLSVIDNGCGIPDYALERIF
ECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHH
ERFYSLPREDGHKSSGLGLAFVREVARLHHGDINLHNRPEGGVVATLRLHRPFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MRIGMRLLLGYFLIVAIAAWFVLSIFVQEVKPGVRRATEGTLNDTATLLAALAREDLLAA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
NPQQGRLAQAFHQLNQQPLNANIGGIKKVRNEYRVYLTDARGKVVFDSSGQATGQDYSRW
CCCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCEEEEEEECCCEEEECCCCCCCCCHHHCC
NDVWLTLRGQYGARSTRSDPHDEASSVMYIAAPVMDKGRIIGVLSVGKPNQAMTPVIKRS
CCEEEEEECCCCCCCCCCCCCCHHCCEEEEEECCCCCCCEEEEEECCCCCCHHCHHHHCC
ERRILWAGGALLGIALLIGGGVVWWINFSIGKLVRYADSVTAERPLPLPEVGSSELRKLA
CCEEEEECHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
QALESMRVKLEGKNAIENYVYDLTHELKSPLAAIRGAAEILREGPPPEVAARFTDNILAQ
HHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHC
NTRMQLLVERLLQQARLESRLEIKQHPVSIDALYQRLTEERNIALAAKAITLRWRESGML
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCEEEEEEEEEEEEECCCEE
VNGDGELLAQALGNLLDNAIDFTPQGGEIALAAEKRNEEVQLSVIDNGCGIPDYALERIF
ECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCHHHHHHHH
ERFYSLPREDGHKSSGLGLAFVREVARLHHGDINLHNRPEGGVVATLRLHRPFT
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3531171; 7610040; 9278503; 2835585; 2228961 [H]