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The map label for this gene is argI [H]

Identifier: 238892743

GI number: 238892743

Start: 530827

End: 531831

Strand: Reverse

Name: argI [H]

Synonym: KP1_0539

Alternate gene names: 238892743

Gene position: 531831-530827 (Counterclockwise)

Preceding gene: 238892746

Following gene: 238892741

Centisome position: 10.13

GC content: 60.0

Gene sequence:

>1005_bases
ATGTCTGCGTTTTACCAGAAGCATTTTTTAAAGTTACTCGATTTTACGCCTGCAGAAATCACCGCCCTGCTCGAGCTGGC
GGCAAAGCTGAAAGCCGATAAGAAAAACGGTATCGAAGTCCAGAAACTGGCCGGAAAAAACATCGCGCTCATCTTCGAAA
AAGACTCAACCCGTACACGATGCTCTTTCGAAGTTGCCGCATACGATCAGGGCGCCCGCGTGACCTATCTGGGGCCCAGC
GGCAGCCAGATTGGCCATAAAGAGTCGATCAAGGACACCGCCCGCGTGCTCGGACGGATGTACGACGGCATTCAGTACCG
CGGCCACGGCCAGGAAGTGGTAGAGACCCTGGCGCAATACGCCGGCGTGCCGGTGTGGAACGGTCTCACCAACGAGTTCC
ACCCCACCCAGCTGCTGGCGGACCTGCTGACCATGAAAGAGCATCTGCCGGGCAAAGCCTTTAACCAGATGACGCTGGTC
TACGCCGGCGACGCGCGCAACAACATGGGCAATTCGATGCTGGAAGCCGCCGCGTTGACCGGTCTGGATCTGCGCCTGGT
GGCGCCATCGGCCTGCTGGCCGGAGGCCGCGCTGGTGGAGACCTGCACCGCGCTGGCCAAACAGCAGGGCGGCAACATCA
CCCTGACGGAAGATATCGCCGCGGGGGTGAAAGGCGCCGATTTTATCTATACCGACGTCTGGGTCTCAATGGGCGAGGCG
AAGGAAAAATGGGCCGAACGTATCGCCCTGCTGCGCGACTATCAGGTTAACAGCGCGATGCTGGCGCTCACCGGCAACCC
GCAGGTCAAGTTCCTCCACTGCCTGCCGGCGTTCCACGACGACCAGACCACGCTGGGCAAACAGATGGCTGCCGATTACG
GCCTGCACGGCGGCATGGAGGTGACTGACGAGGTGTTTGAGTCGGCGGCGAGCGTGGTCTTCGACCAGGCGGAAAACCGG
ATGCACACCATCAAAGCGGTGATGGTGGCGACGCTGAGCAAATAA

Upstream 100 bases:

>100_bases
CTTCTCAGTGAAAGATTTCGATCACAGACTTGCAAATGAATATTCATACATATAAATTGAATTTTAATTCAATTAGTGGC
CTATGCCAGGTGAGGGAACC

Downstream 100 bases:

>100_bases
CCCCTCGCTCGCGGCTGTCTCCCGGATGGCACGGCGTTCATCCGGGATTCGGTTCGCCATTTTACGCCATCAGCATCTTC
ACCACCGCTTTGCGCACCTT

Product: ornithine carbamoyltransferase

Products: NA

Alternate protein names: OTCase [H]

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MSAFYQKHFLKLLDFTPAEITALLELAAKLKADKKNGIEVQKLAGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPS
GSQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAQYAGVPVWNGLTNEFHPTQLLADLLTMKEHLPGKAFNQMTLV
YAGDARNNMGNSMLEAAALTGLDLRLVAPSACWPEAALVETCTALAKQQGGNITLTEDIAAGVKGADFIYTDVWVSMGEA
KEKWAERIALLRDYQVNSAMLALTGNPQVKFLHCLPAFHDDQTTLGKQMAADYGLHGGMEVTDEVFESAASVVFDQAENR
MHTIKAVMVATLSK

Sequences:

>Translated_334_residues
MSAFYQKHFLKLLDFTPAEITALLELAAKLKADKKNGIEVQKLAGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPS
GSQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAQYAGVPVWNGLTNEFHPTQLLADLLTMKEHLPGKAFNQMTLV
YAGDARNNMGNSMLEAAALTGLDLRLVAPSACWPEAALVETCTALAKQQGGNITLTEDIAAGVKGADFIYTDVWVSMGEA
KEKWAERIALLRDYQVNSAMLALTGNPQVKFLHCLPAFHDDQTTLGKQMAADYGLHGGMEVTDEVFESAASVVFDQAENR
MHTIKAVMVATLSK
>Mature_333_residues
SAFYQKHFLKLLDFTPAEITALLELAAKLKADKKNGIEVQKLAGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSG
SQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAQYAGVPVWNGLTNEFHPTQLLADLLTMKEHLPGKAFNQMTLVY
AGDARNNMGNSMLEAAALTGLDLRLVAPSACWPEAALVETCTALAKQQGGNITLTEDIAAGVKGADFIYTDVWVSMGEAK
EKWAERIALLRDYQVNSAMLALTGNPQVKFLHCLPAFHDDQTTLGKQMAADYGLHGGMEVTDEVFESAASVVFDQAENRM
HTIKAVMVATLSK

Specific function: Arginine biosynthesis; sixth step. [C]

COG id: COG0078

COG function: function code E; Ornithine carbamoyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family [H]

Homologues:

Organism=Homo sapiens, GI38788445, Length=328, Percent_Identity=36.890243902439, Blast_Score=187, Evalue=1e-47,
Organism=Homo sapiens, GI18105007, Length=332, Percent_Identity=25.6024096385542, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1790703, Length=334, Percent_Identity=89.2215568862275, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1786469, Length=334, Percent_Identity=88.0239520958084, Blast_Score=624, Evalue=1e-180,
Organism=Escherichia coli, GI48994908, Length=376, Percent_Identity=25.2659574468085, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI2367364, Length=151, Percent_Identity=37.7483443708609, Blast_Score=74, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322373, Length=329, Percent_Identity=31.6109422492401, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6322331, Length=286, Percent_Identity=26.9230769230769, Blast_Score=80, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24642586, Length=332, Percent_Identity=24.6987951807229, Blast_Score=74, Evalue=9e-14,

Paralogues:

None

Copy number: 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2066 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002292 [H]

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N [H]

EC number: =2.1.3.3 [H]

Molecular weight: Translated: 36478; Mature: 36347

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAFYQKHFLKLLDFTPAEITALLELAAKLKADKKNGIEVQKLAGKNIALIFEKDSTRTR
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCE
CSFEVAAYDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAQY
EEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHH
AGVPVWNGLTNEFHPTQLLADLLTMKEHLPGKAFNQMTLVYAGDARNNMGNSMLEAAALT
CCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHC
GLDLRLVAPSACWPEAALVETCTALAKQQGGNITLTEDIAAGVKGADFIYTDVWVSMGEA
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCEEEHHHHHHHHHH
KEKWAERIALLRDYQVNSAMLALTGNPQVKFLHCLPAFHDDQTTLGKQMAADYGLHGGME
HHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCH
VTDEVFESAASVVFDQAENRMHTIKAVMVATLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAFYQKHFLKLLDFTPAEITALLELAAKLKADKKNGIEVQKLAGKNIALIFEKDSTRTR
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCE
CSFEVAAYDQGARVTYLGPSGSQIGHKESIKDTARVLGRMYDGIQYRGHGQEVVETLAQY
EEEEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHH
AGVPVWNGLTNEFHPTQLLADLLTMKEHLPGKAFNQMTLVYAGDARNNMGNSMLEAAALT
CCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHC
GLDLRLVAPSACWPEAALVETCTALAKQQGGNITLTEDIAAGVKGADFIYTDVWVSMGEA
CCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHCCCCCCCEEEHHHHHHHHHH
KEKWAERIALLRDYQVNSAMLALTGNPQVKFLHCLPAFHDDQTTLGKQMAADYGLHGGME
HHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCH
VTDEVFESAASVVFDQAENRMHTIKAVMVATLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA