Click here to switch to the map view.

The map label for this gene is aidB [H]

Identifier: 238892666

GI number: 238892666

Start: 456306

End: 457961

Strand: Direct

Name: aidB [H]

Synonym: KP1_0452

Alternate gene names: 238892666

Gene position: 456306-457961 (Clockwise)

Preceding gene: 238892665

Following gene: 238892669

Centisome position: 8.69

GC content: 65.22

Gene sequence:

>1656_bases
TTGATGGAGGGAGACACGATGCACTGGCAAACGCACACCGTTTTTAATCAACCCACCCCGCTGAATAACAGCAATCTGTT
TCTGTCCGATACCGCTCTGCGTGAAGCAGTGGTCCGCGAAGGCGCCGGCTGGGATGGCGATCTGCTCGCCAGCATTGGCC
AGCAGCTGGGGACAGCCGAATCGCTGGAGCTGGGACGCCTGGCCAACAGCAATCCGCCGGAGCTGCTGCGCTATGACGCC
ACCGGCGCCCGGCTGGACGACGTGCGCTTTCATCCTGCCTGGCACCTGCTGATGCAGGGGCTGTGCGCGAACCGGGTACA
TAACCTCGCCTGGCAGGAGGATGCCCGCGAAGGCGCGTTTGTCGCCCGCGCCGCCCGCTTTCTGCTCCATGCCCAGGTGG
AGGCCGGGACGTTGTGCCCGATTACCATGACCTTCGCCGCGACGCCCCTGCTGCAGCACGCCCTGCCCGCGCCCTTTCGC
GACTGGCTGTCGCCGCTGCTGAGCGACCGTTACGATCCGCACCTTGCGCCTGGCGGCCAGAAGCGCGGCCTGCTGATCGG
CATGGGGATGACCGAGAAGCAAGGGGGGTCTGATGTGCTGAGCAATACCACTCGCGCGGAGAAAACGGCGGAAGGGTTTT
ACCGACTGGTGGGACACAAGTGGTTCTTCTCGGTGCCGCAGAGCGATGCTCACCTGGTGCTGGCTCAGGCTCCGACGGGG
CTCTCATGCTTCTTTGTGCCGCGTCTGCTGCCCGACGGGCAGCGTAACGGCGTGCGTCTTGAACGCTTAAAAGAGAAGCT
CGGCAACCGCTCCAACGCCAGTAGCGAAGTGGAGTTTTATGAGGCCTGCGGCTGGCTGGTGGGCGACGAAGGCGACGGCG
TGCGGCAGATCCTCAGGATGGGCGGCCTGACCCGCTTTGACTGCGCGCTGGGCAGCCATGCCCTGATGCGTCGCGCCTTC
TCGGTGGCGCTGTATCACGCGCTACAGCGTCAGGCGTTTGGCAAAAACCTGGTCGAACAGCCGATGATGCGCCAGCTGCT
GGGGCAAATGGCGCTCCGTCTGGAGGGGCAGACCGCGTTTCTGTTTCGCCTGGCGCGGGCCTGGGACCGTCGGGATGATG
CCCGGGAAAGCGCCTGGGCGCGCCTGTTTACGCCTGCGGCCAAGTTTGCCATCTGTAAGGCCGGTATCCCGTTTGTCGCC
GAGGCGATGGAAGTGCTGGGCGGCATCGGCTATTGCGAGGAGAGCGAACTACCGCGGTTGTATCGCGAGATGCCGGTCAA
CAGCATCTGGGAAGGCTCCGGCAATATTATGTGCCTCGATGTGATGCGGGTGCTCAGCAAGCAGCCGGCGGCGATGGAGC
TGCTGGCCGCGGAGTGTGCGGAGGTGAAAGGGCAGAACCGCCATCTCGACCGCGCATGGCGTCAGCTGCAGCAACTGCTG
AAACGACCCGCCGAAGAGCAGGGGAGAGAGATTGCCCGGCTGGTCTATCGTCTTGGCGCGGGGGCGCAGATGCTGCGCCA
TGCTTCGCCGCCGCTGGCCGAAGCCTGGTGCCGGATGATGCTCGACACCCGCGGCGGCATACGTCTTGACGCGCCGACCC
TCGACGACCTGCTGCTGCGGGCTATGGGGCGCGGGCGCCAGGCGCCTCAGGCGTAG

Upstream 100 bases:

>100_bases
CCATCGACGAATCAAAAAAGCCATCCTCCGGGATGGCTTTTTTGTGACCGCTCTCGCGGGCGAGTATCCCTCCGGATAAC
CATACTTATGGCTATCGCCA

Downstream 100 bases:

>100_bases
AGAATGGCCTGCACGCGCCAGCTGTCCGGCTGTTGTTCCTCGTACATCTGAATAATGCGATACCAGGAGGCGCCTTGCTC
GTCTGCTTTGCGGGCAATGG

Product: isovaleryl CoA dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 551; Mature: 551

Protein sequence:

>551_residues
MMEGDTMHWQTHTVFNQPTPLNNSNLFLSDTALREAVVREGAGWDGDLLASIGQQLGTAESLELGRLANSNPPELLRYDA
TGARLDDVRFHPAWHLLMQGLCANRVHNLAWQEDAREGAFVARAARFLLHAQVEAGTLCPITMTFAATPLLQHALPAPFR
DWLSPLLSDRYDPHLAPGGQKRGLLIGMGMTEKQGGSDVLSNTTRAEKTAEGFYRLVGHKWFFSVPQSDAHLVLAQAPTG
LSCFFVPRLLPDGQRNGVRLERLKEKLGNRSNASSEVEFYEACGWLVGDEGDGVRQILRMGGLTRFDCALGSHALMRRAF
SVALYHALQRQAFGKNLVEQPMMRQLLGQMALRLEGQTAFLFRLARAWDRRDDARESAWARLFTPAAKFAICKAGIPFVA
EAMEVLGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVMRVLSKQPAAMELLAAECAEVKGQNRHLDRAWRQLQQLL
KRPAEEQGREIARLVYRLGAGAQMLRHASPPLAEAWCRMMLDTRGGIRLDAPTLDDLLLRAMGRGRQAPQA

Sequences:

>Translated_551_residues
MMEGDTMHWQTHTVFNQPTPLNNSNLFLSDTALREAVVREGAGWDGDLLASIGQQLGTAESLELGRLANSNPPELLRYDA
TGARLDDVRFHPAWHLLMQGLCANRVHNLAWQEDAREGAFVARAARFLLHAQVEAGTLCPITMTFAATPLLQHALPAPFR
DWLSPLLSDRYDPHLAPGGQKRGLLIGMGMTEKQGGSDVLSNTTRAEKTAEGFYRLVGHKWFFSVPQSDAHLVLAQAPTG
LSCFFVPRLLPDGQRNGVRLERLKEKLGNRSNASSEVEFYEACGWLVGDEGDGVRQILRMGGLTRFDCALGSHALMRRAF
SVALYHALQRQAFGKNLVEQPMMRQLLGQMALRLEGQTAFLFRLARAWDRRDDARESAWARLFTPAAKFAICKAGIPFVA
EAMEVLGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVMRVLSKQPAAMELLAAECAEVKGQNRHLDRAWRQLQQLL
KRPAEEQGREIARLVYRLGAGAQMLRHASPPLAEAWCRMMLDTRGGIRLDAPTLDDLLLRAMGRGRQAPQA
>Mature_551_residues
MMEGDTMHWQTHTVFNQPTPLNNSNLFLSDTALREAVVREGAGWDGDLLASIGQQLGTAESLELGRLANSNPPELLRYDA
TGARLDDVRFHPAWHLLMQGLCANRVHNLAWQEDAREGAFVARAARFLLHAQVEAGTLCPITMTFAATPLLQHALPAPFR
DWLSPLLSDRYDPHLAPGGQKRGLLIGMGMTEKQGGSDVLSNTTRAEKTAEGFYRLVGHKWFFSVPQSDAHLVLAQAPTG
LSCFFVPRLLPDGQRNGVRLERLKEKLGNRSNASSEVEFYEACGWLVGDEGDGVRQILRMGGLTRFDCALGSHALMRRAF
SVALYHALQRQAFGKNLVEQPMMRQLLGQMALRLEGQTAFLFRLARAWDRRDDARESAWARLFTPAAKFAICKAGIPFVA
EAMEVLGGIGYCEESELPRLYREMPVNSIWEGSGNIMCLDVMRVLSKQPAAMELLAAECAEVKGQNRHLDRAWRQLQQLL
KRPAEEQGREIARLVYRLGAGAQMLRHASPPLAEAWCRMMLDTRGGIRLDAPTLDDLLLRAMGRGRQAPQA

Specific function: May help to prevent alkylation damage by protecting DNA and destroying alkylating agents [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=319, Percent_Identity=26.0188087774295, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI187960098, Length=277, Percent_Identity=28.5198555956679, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4557231, Length=277, Percent_Identity=28.5198555956679, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI7656849, Length=273, Percent_Identity=29.6703296703297, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI226958412, Length=291, Percent_Identity=25.085910652921, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI226958414, Length=291, Percent_Identity=25.085910652921, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI4501859, Length=318, Percent_Identity=22.6415094339623, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082384, Length=537, Percent_Identity=78.7709497206704, Blast_Score=885, Evalue=0.0,
Organism=Escherichia coli, GI1786223, Length=329, Percent_Identity=24.9240121580547, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87081958, Length=262, Percent_Identity=25.9541984732824, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI86563383, Length=508, Percent_Identity=31.1023622047244, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI86563381, Length=508, Percent_Identity=31.1023622047244, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17538396, Length=290, Percent_Identity=27.5862068965517, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17508101, Length=265, Percent_Identity=24.1509433962264, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI71985184, Length=286, Percent_Identity=26.2237762237762, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17506239, Length=273, Percent_Identity=22.3443223443223, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17569725, Length=270, Percent_Identity=25.5555555555556, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17570075, Length=271, Percent_Identity=25.0922509225092, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356377, Length=327, Percent_Identity=23.2415902140673, Blast_Score=82, Evalue=9e-16,
Organism=Drosophila melanogaster, GI281363737, Length=290, Percent_Identity=24.8275862068966, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21355753, Length=283, Percent_Identity=26.8551236749117, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24646207, Length=314, Percent_Identity=22.6114649681529, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24660351, Length=273, Percent_Identity=26.3736263736264, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M [H]

EC number: NA

Molecular weight: Translated: 61300; Mature: 61300

Theoretical pI: Translated: 7.96; Mature: 7.96

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEGDTMHWQTHTVFNQPTPLNNSNLFLSDTALREAVVREGAGWDGDLLASIGQQLGTAE
CCCCCCEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHH
SLELGRLANSNPPELLRYDATGARLDDVRFHPAWHLLMQGLCANRVHNLAWQEDAREGAF
HHHHHHCCCCCCHHHEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VARAARFLLHAQVEAGTLCPITMTFAATPLLQHALPAPFRDWLSPLLSDRYDPHLAPGGQ
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
KRGLLIGMGMTEKQGGSDVLSNTTRAEKTAEGFYRLVGHKWFFSVPQSDAHLVLAQAPTG
CCCEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCHHEEECCCCCCEEEEEECCCC
LSCFFVPRLLPDGQRNGVRLERLKEKLGNRSNASSEVEFYEACGWLVGDEGDGVRQILRM
CEEEEHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCHHHHHHHHH
GGLTRFDCALGSHALMRRAFSVALYHALQRQAFGKNLVEQPMMRQLLGQMALRLEGQTAF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LFRLARAWDRRDDARESAWARLFTPAAKFAICKAGIPFVAEAMEVLGGIGYCEESELPRL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHH
YREMPVNSIWEGSGNIMCLDVMRVLSKQPAAMELLAAECAEVKGQNRHLDRAWRQLQQLL
HHHCCCCCEECCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
KRPAEEQGREIARLVYRLGAGAQMLRHASPPLAEAWCRMMLDTRGGIRLDAPTLDDLLLR
HCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHH
AMGRGRQAPQA
HHHCCCCCCCC
>Mature Secondary Structure
MMEGDTMHWQTHTVFNQPTPLNNSNLFLSDTALREAVVREGAGWDGDLLASIGQQLGTAE
CCCCCCEEEEEEECCCCCCCCCCCCEEEEHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHH
SLELGRLANSNPPELLRYDATGARLDDVRFHPAWHLLMQGLCANRVHNLAWQEDAREGAF
HHHHHHCCCCCCHHHEEECCCCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VARAARFLLHAQVEAGTLCPITMTFAATPLLQHALPAPFRDWLSPLLSDRYDPHLAPGGQ
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCC
KRGLLIGMGMTEKQGGSDVLSNTTRAEKTAEGFYRLVGHKWFFSVPQSDAHLVLAQAPTG
CCCEEEECCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCHHEEECCCCCCEEEEEECCCC
LSCFFVPRLLPDGQRNGVRLERLKEKLGNRSNASSEVEFYEACGWLVGDEGDGVRQILRM
CEEEEHHHHCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCEECCCCHHHHHHHHH
GGLTRFDCALGSHALMRRAFSVALYHALQRQAFGKNLVEQPMMRQLLGQMALRLEGQTAF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LFRLARAWDRRDDARESAWARLFTPAAKFAICKAGIPFVAEAMEVLGGIGYCEESELPRL
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCHHHH
YREMPVNSIWEGSGNIMCLDVMRVLSKQPAAMELLAAECAEVKGQNRHLDRAWRQLQQLL
HHHCCCCCEECCCCCEEHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHH
KRPAEEQGREIARLVYRLGAGAQMLRHASPPLAEAWCRMMLDTRGGIRLDAPTLDDLLLR
HCCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHCCCCCEECCCCHHHHHHH
AMGRGRQAPQA
HHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961409; 7610040; 9278503 [H]