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The map label for this gene is rnr [H]

Identifier: 238892664

GI number: 238892664

Start: 452954

End: 455386

Strand: Direct

Name: rnr [H]

Synonym: KP1_0450

Alternate gene names: 238892664

Gene position: 452954-455386 (Clockwise)

Preceding gene: 238892663

Following gene: 238892665

Centisome position: 8.63

GC content: 59.27

Gene sequence:

>2433_bases
ATGTCACAAGATCCATTCCAGGAACGCGAAGCTGAGAAGTACGCGAACCCTATCCCGAGCCGGGAATTTATCCTCGAACA
TTTAACTAAACGGGAAAAGCCTGCCAGCCGCGATGAGCTGGCCATCGAGTTAAATATCGAGGGCGAAGAGCAAACCGAAG
CGCTGCGCCGCCGCCTGCGCGCGATGGAGCGCGACGGTCAGCTGGTCTTCACCCGCCGCCAGTGCTATGCCCTGCCGGAA
CGCCTCGATCTCCTCAAAGGAACCGTTATTGGCCACCGCGATGGCTATGGTTTCCTGCGTGTTGAAGGGCGCAAAGACGA
TCTGTACCTGTCGTCAGAACAGATGAAAACCTGTATTCACGGCGACCAGGTGCTGGCTCAGCCGCTGGGCGCGGACCGTA
AGGGCCGCCGCGAAGCGCGCATCGTCCGCGTCCTCGTGCCGAAAACCAGCCAGATAGTTGGCCGTTACTTCACCGACGCT
GGCGTCGGCTTTGTCGTCCCGGACGACAGCCGCCTGAGCTTCGATATCCTGATCCCGCCGGAAGAGATAATGGGCGCGCG
GATGGGCTACGTGGTCGTGGTCGAGCTGACCCAGCGACCAACCCGCCGCACCAAAGCGGTGGGTAAAATCGTCGAAGTGC
TGGGCGACAACATGGGCACCGGCATGGCCGTCGATATGGCGCTGCGTACCCATGAAATTCCTTATGTCTGGCCGCCGGCG
GTGGAAAAACAGGTTTCCGGTCTCAAAGAACAGGTGCCGGAAGAGGCGAAGGCCGGACGCGTCGATTTACGCTCGCTGCC
GTTGGTTACCATTGACGGCGAAGATGCCCGCGACTTCGATGACGCGGTGTACTGCGAGAAGAAACGCGGCGGCGGCTGGC
GCCTGTGGGTAGCCATTGCCGACGTCAGCTACTACGTGCGCCCGGGGACGCCGCTGGATGCGGAAGCGCGCAGTCGTGGC
ACCTCGGTCTACTTCCCGTCGCAGGTAGTGCCGATGCTGCCGGAAGTGCTGTCTAACGGTCTATGCTCGCTGAACCCGCA
GGTCGATCGCCTGTGTATGGTGTGCGAGATGACGATTTCGTCAAAAGGCCGTCTGACCGGTTATAAATTCTATGAAGCGG
TGATGAGTTCACATGCTCGCCTGACCTATACCAAAGTGTGGCATATGCTGCAGGGTGACCAGGAACTGCGCGAACACTAC
GCGCCGCTGGTGAAGCACATTGAAGAGCTGCATAACCTCTACAAAGTGCTGGAGAGCGCCCGCGAAGAGCGCGGCGGTAT
CTCATTTGAAAGTGAAGAAGCTAAATTCATCTTCAATGCCGAACGCCGTATTGAGCGTATCGAACAGACTCAGCGTAACG
ATGCGCATAAGCTGATTGAAGAGTGCATGATCCTGGCGAACATCTCCGCCGCGCGCTTCGTTGAGAAGGCGCAGGAGCCG
GCGCTGTTCCGTATCCATGATAAGCCAACCACCGAAGCGATTACCTCCTTCCGTACCGTGCTGGCTGAGCTGGGACTGGA
GCTGCCTGGCGGCAACAAGCCGGAGCCGCGTGATTACGCCGAGCTGCTAACCTCCATCGCCGATCGCCCGGATGCGGAAA
TGCTGCAGACGATGCTCCTGCGCTCCATGAAGCAGGCGGTCTACGATCCGGAAAACCGCGGTCACTTTGGCCTGGCGCTG
CAGTCATACGCCCACTTCACCTCGCCGATTCGTCGTTACCCGGACCTGTCGCTGCACCGCGCTATCAAGTATCTGCTGGC
CAAAGAGCAGGGACATAAAGGCAACAGCACCGAGACCGGCGGCTGGCACTACAGCATGGAAGAGATGCTCCAGCTGGGTC
AGCACTGTTCGATGACCGAGCGCCGCGCCGACGAAGCGACGCGCGAAGTGTCTGACTGGCTGAAGTGCGACTTCATGCAG
GATCAGGTGGGCAACATCTTCTCCGGCGTGATCGCCAGCGTGACCGGCTTTGGCTTCTTCGTCCGCCTGAACGATCTGTT
TATCGACGGTCTGGTGCATGTTTCCAGCCTGGATAACGACTATTATCGTTTCGACCAGGTGGGGCAGCGTCTCATTGGTG
AGTCCGGCGGCCAGACCTATCGCCTGGGCGACCGCGTGGAAGTCCGTGTGGAAGCGGTCAACATGGACGAGCGGAAAATC
GACTTTACCCTGATCTCCAGCGAGCGTGCGCCGCGTAATGTCGGCAAGACCGCCCGTGAGAAAGCGAAAAAGAGTACCTC
TGGCAAGCCGGGCGGCCGTCGCCGCCAGGTGGGTAAGCAGGTAAACTTCGAGCCGGACAGCGCTTTCCGTAAAGAGAAAG
AGACCGCCCGACCGAAGAAAGAGAAAAAAGCGAAAAAACCGTCGGCGAAAACACAGAAAATCGCCGCCGCGACGAAAGCC
AAGCGCGCGGCAAAGAAGAAGATCGCCGAGTGA

Upstream 100 bases:

>100_bases
CTATACGCTGGCTGATTTGGTTGAGAAGAATCAACCGCTTTATAAATTATTGCTGGTGGAGTGACGCCACTCTGCCGGAG
ATGACAACGGAGGAACCGAT

Downstream 100 bases:

>100_bases
TTGACCTCCCTTCACCCTGAAGTCTGCTGACGCAGGATGGGGTGAAGGGGGCAGATAACAGAACCTAAAACGAGTACATC
AATGAGTGAAATGATTTACG

Product: exoribonuclease R

Products: NA

Alternate protein names: RNase R; Protein vacB [H]

Number of amino acids: Translated: 810; Mature: 809

Protein sequence:

>810_residues
MSQDPFQEREAEKYANPIPSREFILEHLTKREKPASRDELAIELNIEGEEQTEALRRRLRAMERDGQLVFTRRQCYALPE
RLDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIHGDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDA
GVGFVVPDDSRLSFDILIPPEEIMGARMGYVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYVWPPA
VEKQVSGLKEQVPEEAKAGRVDLRSLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPGTPLDAEARSRG
TSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISSKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQELREHY
APLVKHIEELHNLYKVLESAREERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMILANISAARFVEKAQEP
ALFRIHDKPTTEAITSFRTVLAELGLELPGGNKPEPRDYAELLTSIADRPDAEMLQTMLLRSMKQAVYDPENRGHFGLAL
QSYAHFTSPIRRYPDLSLHRAIKYLLAKEQGHKGNSTETGGWHYSMEEMLQLGQHCSMTERRADEATREVSDWLKCDFMQ
DQVGNIFSGVIASVTGFGFFVRLNDLFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKI
DFTLISSERAPRNVGKTAREKAKKSTSGKPGGRRRQVGKQVNFEPDSAFRKEKETARPKKEKKAKKPSAKTQKIAAATKA
KRAAKKKIAE

Sequences:

>Translated_810_residues
MSQDPFQEREAEKYANPIPSREFILEHLTKREKPASRDELAIELNIEGEEQTEALRRRLRAMERDGQLVFTRRQCYALPE
RLDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIHGDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDA
GVGFVVPDDSRLSFDILIPPEEIMGARMGYVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYVWPPA
VEKQVSGLKEQVPEEAKAGRVDLRSLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPGTPLDAEARSRG
TSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISSKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQELREHY
APLVKHIEELHNLYKVLESAREERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMILANISAARFVEKAQEP
ALFRIHDKPTTEAITSFRTVLAELGLELPGGNKPEPRDYAELLTSIADRPDAEMLQTMLLRSMKQAVYDPENRGHFGLAL
QSYAHFTSPIRRYPDLSLHRAIKYLLAKEQGHKGNSTETGGWHYSMEEMLQLGQHCSMTERRADEATREVSDWLKCDFMQ
DQVGNIFSGVIASVTGFGFFVRLNDLFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKI
DFTLISSERAPRNVGKTAREKAKKSTSGKPGGRRRQVGKQVNFEPDSAFRKEKETARPKKEKKAKKPSAKTQKIAAATKA
KRAAKKKIAE
>Mature_809_residues
SQDPFQEREAEKYANPIPSREFILEHLTKREKPASRDELAIELNIEGEEQTEALRRRLRAMERDGQLVFTRRQCYALPER
LDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIHGDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDAG
VGFVVPDDSRLSFDILIPPEEIMGARMGYVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYVWPPAV
EKQVSGLKEQVPEEAKAGRVDLRSLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIADVSYYVRPGTPLDAEARSRGT
SVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTISSKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQELREHYA
PLVKHIEELHNLYKVLESAREERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMILANISAARFVEKAQEPA
LFRIHDKPTTEAITSFRTVLAELGLELPGGNKPEPRDYAELLTSIADRPDAEMLQTMLLRSMKQAVYDPENRGHFGLALQ
SYAHFTSPIRRYPDLSLHRAIKYLLAKEQGHKGNSTETGGWHYSMEEMLQLGQHCSMTERRADEATREVSDWLKCDFMQD
QVGNIFSGVIASVTGFGFFVRLNDLFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKID
FTLISSERAPRNVGKTAREKAKKSTSGKPGGRRRQVGKQVNFEPDSAFRKEKETARPKKEKKAKKPSAKTQKIAAATKAK
RAAKKKIAE

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs. Required for the expression of virulence genes in enteroinvasive strains of E.coli [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=563, Percent_Identity=28.7744227353464, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI190014625, Length=563, Percent_Identity=28.7744227353464, Blast_Score=179, Evalue=9e-45,
Organism=Homo sapiens, GI134288890, Length=600, Percent_Identity=26, Blast_Score=172, Evalue=2e-42,
Organism=Homo sapiens, GI219521928, Length=525, Percent_Identity=25.9047619047619, Blast_Score=146, Evalue=9e-35,
Organism=Homo sapiens, GI19115966, Length=525, Percent_Identity=25.9047619047619, Blast_Score=145, Evalue=1e-34,
Organism=Escherichia coli, GI87082383, Length=795, Percent_Identity=91.8238993710692, Blast_Score=1494, Evalue=0.0,
Organism=Escherichia coli, GI1787542, Length=651, Percent_Identity=25.4992319508449, Blast_Score=168, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI212645896, Length=421, Percent_Identity=30.6413301662708, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17553506, Length=466, Percent_Identity=29.6137339055794, Blast_Score=172, Evalue=8e-43,
Organism=Saccharomyces cerevisiae, GI6324552, Length=557, Percent_Identity=26.9299820466786, Blast_Score=157, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6323943, Length=358, Percent_Identity=24.5810055865922, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24649634, Length=480, Percent_Identity=28.75, Blast_Score=177, Evalue=2e-44,
Organism=Drosophila melanogaster, GI19922976, Length=361, Percent_Identity=29.0858725761773, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24654597, Length=361, Percent_Identity=29.0858725761773, Blast_Score=144, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24654592, Length=361, Percent_Identity=29.0858725761773, Blast_Score=144, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805
- InterPro:   IPR013668 [H]

Pfam domain/function: PF08461 HTH_12; PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 91817; Mature: 91686

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: PS50126 S1 ; PS01175 RIBONUCLEASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDPFQEREAEKYANPIPSREFILEHLTKREKPASRDELAIELNIEGEEQTEALRRRLR
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
AMERDGQLVFTRRQCYALPERLDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIH
HHCCCCCEEEEHHHHHHCHHHHHHHHCCEEECCCCCEEEEEECCCCCEEECHHHHHHHHC
GDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDAGVGFVVPDDSRLSFDILIPP
CHHHHHHCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEECC
EEIMGARMGYVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYVWPPA
HHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCEECCCH
VEKQVSGLKEQVPEEAKAGRVDLRSLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIA
HHHHHHHHHHHCCHHHHCCCCCHHHCCEEEECCCCCCCCCHHHEEECCCCCCEEEEEEEE
DVSYYVRPGTPLDAEARSRGTSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTIS
CCEEEECCCCCCCHHHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
SKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQELREHYAPLVKHIEELHNLYKVLESA
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMILANISAARFVEKAQEP
HHHHCCCCCCCCCCCEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCC
ALFRIHDKPTTEAITSFRTVLAELGLELPGGNKPEPRDYAELLTSIADRPDAEMLQTMLL
CEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RSMKQAVYDPENRGHFGLALQSYAHFTSPIRRYPDLSLHRAIKYLLAKEQGHKGNSTETG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GWHYSMEEMLQLGQHCSMTERRADEATREVSDWLKCDFMQDQVGNIFSGVIASVTGFGFF
CEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
VRLNDLFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKI
EEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEEEEEECCCCCEE
DFTLISSERAPRNVGKTAREKAKKSTSGKPGGRRRQVGKQVNFEPDSAFRKEKETARPKK
EEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCH
EKKAKKPSAKTQKIAAATKAKRAAKKKIAE
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQDPFQEREAEKYANPIPSREFILEHLTKREKPASRDELAIELNIEGEEQTEALRRRLR
CCCCCHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
AMERDGQLVFTRRQCYALPERLDLLKGTVIGHRDGYGFLRVEGRKDDLYLSSEQMKTCIH
HHCCCCCEEEEHHHHHHCHHHHHHHHCCEEECCCCCEEEEEECCCCCEEECHHHHHHHHC
GDQVLAQPLGADRKGRREARIVRVLVPKTSQIVGRYFTDAGVGFVVPDDSRLSFDILIPP
CHHHHHHCCCCCCCCCCHHEEEEEECCCHHHHHHHHHHCCCCEEEECCCCCEEEEEEECC
EEIMGARMGYVVVVELTQRPTRRTKAVGKIVEVLGDNMGTGMAVDMALRTHEIPYVWPPA
HHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHCCCCEECCCH
VEKQVSGLKEQVPEEAKAGRVDLRSLPLVTIDGEDARDFDDAVYCEKKRGGGWRLWVAIA
HHHHHHHHHHHCCHHHHCCCCCHHHCCEEEECCCCCCCCCHHHEEECCCCCCEEEEEEEE
DVSYYVRPGTPLDAEARSRGTSVYFPSQVVPMLPEVLSNGLCSLNPQVDRLCMVCEMTIS
CCEEEECCCCCCCHHHHCCCCEEECCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHC
SKGRLTGYKFYEAVMSSHARLTYTKVWHMLQGDQELREHYAPLVKHIEELHNLYKVLESA
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REERGGISFESEEAKFIFNAERRIERIEQTQRNDAHKLIEECMILANISAARFVEKAQEP
HHHHCCCCCCCCCCCEEECHHHHHHHHHHHHCCHHHHHHHHHHHHHCCHHHHHHHHHCCC
ALFRIHDKPTTEAITSFRTVLAELGLELPGGNKPEPRDYAELLTSIADRPDAEMLQTMLL
CEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHH
RSMKQAVYDPENRGHFGLALQSYAHFTSPIRRYPDLSLHRAIKYLLAKEQGHKGNSTETG
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCC
GWHYSMEEMLQLGQHCSMTERRADEATREVSDWLKCDFMQDQVGNIFSGVIASVTGFGFF
CEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEE
VRLNDLFIDGLVHVSSLDNDYYRFDQVGQRLIGESGGQTYRLGDRVEVRVEAVNMDERKI
EEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEEEEEECCCCCEE
DFTLISSERAPRNVGKTAREKAKKSTSGKPGGRRRQVGKQVNFEPDSAFRKEKETARPKK
EEEEECCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCCHHHHHHHHHCCCCH
EKKAKKPSAKTQKIAAATKAKRAAKKKIAE
HHHHCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3058695; 1400189; 9603904 [H]