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The map label for this gene is dcuA [H]

Identifier: 238892615

GI number: 238892615

Start: 402253

End: 403554

Strand: Reverse

Name: dcuA [H]

Synonym: KP1_0394

Alternate gene names: 238892615

Gene position: 403554-402253 (Counterclockwise)

Preceding gene: 238892616

Following gene: 238892614

Centisome position: 7.69

GC content: 59.06

Gene sequence:

>1302_bases
ATGTTTGGTGCAGAACTGGTTATTGTCCTGCTGGCGATTTATCTCGGCGCCCGGCTCGGCGGCATCGGTATCGGCTTTGC
CGGTGGCCTTGGCGTCCTTGTCCTGACGCTTATTTTTCAAATTAAACCGGGTGCGATCCCCTTCGACGTTATTGAAATCA
TTATGGCGGTGATTGCCGCTATCGCCGCCATGCAGGTCGCCGGCGGGATGGATTACCTGGTCAGCCTCGCCGAACGGATG
CTGCGCCGCCACCCGAAGTACATTACCTTCCTTGCCCCGCTGGTGACCTGGTTTATGACCGTGCTCGCTGGCACCGGCCA
TACCGCCTTCTCCACGCTGCCGGTGATCACCGAAGTTGCCAAAGAGCAAGGCATTCGTCCGTCTCGTCCACTGTCGATTG
CGGTGGTGGCCTCCCAGATAGCGATCACCGCCTCGCCCATTTCCGCCGCAGTGGTCTTTTTCGCAGGAATCCTTGAACCG
CTGGGCGTTAGCTATTTGACGCTGCTGGCCATCTGTATTCCGGTCACGCTGCTGGCGGTGATGCTCACCGCTATCGTCTG
CAACTTCCTCGGCTGCGAACTGAAAGACGATCCGGTTTACCAGGAGCGGCTGGCCAAGGGGGAAGTCAGACTGCGCGGCA
GCCAGGTATTTGAGCTGCAGCCGCACGCCAAACGCTCTGTCCTGCTGTTTTTGATCGGCATCGTGGCGGTGATGTTCTAC
GCCACGGCCATCAGCGATACCGTCGGCCTGATTAAGAACCCGGTGCTGCCGCGTAACGAGGCGATCGTGGTATTTATGCT
GACCATCGCCACCCTGATTAGCATCACCTGTAAGATCGACACTGGCGAAGTGCTGAACGCCAGCACCTTTAAGTCCGGGA
TGAGCGCCTGCGTCTGCGTCCTCGGCGTCGCCTGGCTGGGAGATACCTTCGTTAAAGCGCATATCAGCGACATCCAGGCC
GTGGCCGGCGATCTGCTGCATAATTACCCATGGCTGCTGGCGGTGGTACTGTTTTTCGCCGCCACGCTGCTCTACTCGCA
GGCAGCCACTACCAAGGCGTTGATGCCTGCCGCGCTGCTGCTGGGCGTCAGCCCGCTGACGGCTATCGCCTCGTTTGCCG
CGGTCTCGGCGCTGTTCGTTCTACCGACCTACCCAACCCTGCTGGCGGCGGTAGAGATGGACGACACCGGCTCAACCCGC
ATTGGTAAATATGTCTTTAACCACGCCTTCCTGATCCCCGGCGTTATCGCTATCACGCTGTGCGTGATCCTCGGCTTTAT
CTTTGGCGGGATTATGCTGTAA

Upstream 100 bases:

>100_bases
ATTCAAAGGCATGTCAGCGATGACATGCCTTTTTTGCTTTTTGGTTTTACTAAAATACAACAATTCAATATCAACTTGTT
AAAAAACAAGGAAGGCATAT

Downstream 100 bases:

>100_bases
ATACCGCTGGCGGCGGGCCCACTACGGGCCCGCCTTCCGTTGCCCTCACTTTCCCCGCTCGTTACGCTAATATCCCCGCA
TCTTGCGTGTTATAGTGCCT

Product: anaerobic C4-dicarboxylate transporter

Products: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MFGAELVIVLLAIYLGARLGGIGIGFAGGLGVLVLTLIFQIKPGAIPFDVIEIIMAVIAAIAAMQVAGGMDYLVSLAERM
LRRHPKYITFLAPLVTWFMTVLAGTGHTAFSTLPVITEVAKEQGIRPSRPLSIAVVASQIAITASPISAAVVFFAGILEP
LGVSYLTLLAICIPVTLLAVMLTAIVCNFLGCELKDDPVYQERLAKGEVRLRGSQVFELQPHAKRSVLLFLIGIVAVMFY
ATAISDTVGLIKNPVLPRNEAIVVFMLTIATLISITCKIDTGEVLNASTFKSGMSACVCVLGVAWLGDTFVKAHISDIQA
VAGDLLHNYPWLLAVVLFFAATLLYSQAATTKALMPAALLLGVSPLTAIASFAAVSALFVLPTYPTLLAAVEMDDTGSTR
IGKYVFNHAFLIPGVIAITLCVILGFIFGGIML

Sequences:

>Translated_433_residues
MFGAELVIVLLAIYLGARLGGIGIGFAGGLGVLVLTLIFQIKPGAIPFDVIEIIMAVIAAIAAMQVAGGMDYLVSLAERM
LRRHPKYITFLAPLVTWFMTVLAGTGHTAFSTLPVITEVAKEQGIRPSRPLSIAVVASQIAITASPISAAVVFFAGILEP
LGVSYLTLLAICIPVTLLAVMLTAIVCNFLGCELKDDPVYQERLAKGEVRLRGSQVFELQPHAKRSVLLFLIGIVAVMFY
ATAISDTVGLIKNPVLPRNEAIVVFMLTIATLISITCKIDTGEVLNASTFKSGMSACVCVLGVAWLGDTFVKAHISDIQA
VAGDLLHNYPWLLAVVLFFAATLLYSQAATTKALMPAALLLGVSPLTAIASFAAVSALFVLPTYPTLLAAVEMDDTGSTR
IGKYVFNHAFLIPGVIAITLCVILGFIFGGIML
>Mature_433_residues
MFGAELVIVLLAIYLGARLGGIGIGFAGGLGVLVLTLIFQIKPGAIPFDVIEIIMAVIAAIAAMQVAGGMDYLVSLAERM
LRRHPKYITFLAPLVTWFMTVLAGTGHTAFSTLPVITEVAKEQGIRPSRPLSIAVVASQIAITASPISAAVVFFAGILEP
LGVSYLTLLAICIPVTLLAVMLTAIVCNFLGCELKDDPVYQERLAKGEVRLRGSQVFELQPHAKRSVLLFLIGIVAVMFY
ATAISDTVGLIKNPVLPRNEAIVVFMLTIATLISITCKIDTGEVLNASTFKSGMSACVCVLGVAWLGDTFVKAHISDIQA
VAGDLLHNYPWLLAVVLFFAATLLYSQAATTKALMPAALLLGVSPLTAIASFAAVSALFVLPTYPTLLAAVEMDDTGSTR
IGKYVFNHAFLIPGVIAITLCVILGFIFGGIML

Specific function: Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane [H]

COG id: COG2704

COG function: function code R; Anaerobic C4-dicarboxylate transporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dcuA/dcuB transporter (TC 2.A.13.1) family [H]

Homologues:

Organism=Escherichia coli, GI1790580, Length=434, Percent_Identity=62.4423963133641, Blast_Score=518, Evalue=1e-148,
Organism=Escherichia coli, GI1790565, Length=402, Percent_Identity=37.3134328358209, Blast_Score=263, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004668 [H]

Pfam domain/function: PF03605 DcuA_DcuB [H]

EC number: NA

Molecular weight: Translated: 45813; Mature: 45813

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00549 BACTERIOFERRITIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGAELVIVLLAIYLGARLGGIGIGFAGGLGVLVLTLIFQIKPGAIPFDVIEIIMAVIAA
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
IAAMQVAGGMDYLVSLAERMLRRHPKYITFLAPLVTWFMTVLAGTGHTAFSTLPVITEVA
HHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KEQGIRPSRPLSIAVVASQIAITASPISAAVVFFAGILEPLGVSYLTLLAICIPVTLLAV
HHCCCCCCCCEEHEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLTAIVCNFLGCELKDDPVYQERLAKGEVRLRGSQVFELQPHAKRSVLLFLIGIVAVMFY
HHHHHHHHHHCCCCCCCCHHHHHHCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHH
ATAISDTVGLIKNPVLPRNEAIVVFMLTIATLISITCKIDTGEVLNASTFKSGMSACVCV
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHH
LGVAWLGDTFVKAHISDIQAVAGDLLHNYPWLLAVVLFFAATLLYSQAATTKALMPAALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVSPLTAIASFAAVSALFVLPTYPTLLAAVEMDDTGSTRIGKYVFNHAFLIPGVIAITL
HCCCHHHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
CVILGFIFGGIML
HHHHHHHHHHHCC
>Mature Secondary Structure
MFGAELVIVLLAIYLGARLGGIGIGFAGGLGVLVLTLIFQIKPGAIPFDVIEIIMAVIAA
CCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
IAAMQVAGGMDYLVSLAERMLRRHPKYITFLAPLVTWFMTVLAGTGHTAFSTLPVITEVA
HHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
KEQGIRPSRPLSIAVVASQIAITASPISAAVVFFAGILEPLGVSYLTLLAICIPVTLLAV
HHCCCCCCCCEEHEEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLTAIVCNFLGCELKDDPVYQERLAKGEVRLRGSQVFELQPHAKRSVLLFLIGIVAVMFY
HHHHHHHHHHCCCCCCCCHHHHHHCCCCEEECCCEEEEECCCHHHHHHHHHHHHHHHHHH
ATAISDTVGLIKNPVLPRNEAIVVFMLTIATLISITCKIDTGEVLNASTFKSGMSACVCV
HHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHHHHHHHHH
LGVAWLGDTFVKAHISDIQAVAGDLLHNYPWLLAVVLFFAATLLYSQAATTKALMPAALL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGVSPLTAIASFAAVSALFVLPTYPTLLAAVEMDDTGSTRIGKYVFNHAFLIPGVIAITL
HCCCHHHHHHHHHHHHHHHHHCCHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
CVILGFIFGGIML
HHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: C4-dicarboxylates [Periplasm]; C4-dicarboxylates [Periplasm] [C]

Specific reaction: C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] = C4-dicarboxylates [Periplasm] + C4-dicarboxylates [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11004174; 14500908; 8898907 [H]