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The map label for this gene is gltP [H]

Identifier: 238892569

GI number: 238892569

Start: 354441

End: 355769

Strand: Direct

Name: gltP [H]

Synonym: KP1_0344

Alternate gene names: 238892569

Gene position: 354441-355769 (Clockwise)

Preceding gene: 238892568

Following gene: 238892572

Centisome position: 6.75

GC content: 56.06

Gene sequence:

>1329_bases
TTGAGGAAGTCAGTAGTGAAGAAAACAAAAAAAGTCAGTCTGGCCTGGCAAATTTTGCTAGCCCTGGTGCTGGGTATCCT
TCTGGGCAGTTATCTGCATTACCACGCTGAAAGTCGCGATTGGTTAATTAGCAATTTGCTGACGCCGGCGGGCGATATCT
TTATCCATCTGATTAAAATGATCGTGGTCCCGATTGTCATTTCGACCCTGGTGGTCGGGATTGCCGGCGTGGGTGACGCC
AAACAGTTAGGGCGGATCGGTGCCAAAACCATTATCTATTTCGAAGTGATCACCACGGTGGCGATTGTGCTGGGTATCAC
CCTGGCCAACGTCTTCCAGCCGGGGACGGGCATTGATATGTCGCAGCTGGCGGCAGTTGATATTTCGAAATATCAGAACA
CCACCGCCGAAGTGCAGAGCCATGCGCACGGCCTGATGGGCACCATCCTGTCGCTGGTGCCGACCAATATCGTGGCATCG
ATGGCGAAAGGCGATATGCTGCCGATTATCTTCTTCTCGGTGCTGTTTGGCCTGGGGCTCTCCTCGCTGCCGGCGACCCA
CCGTGAGCCGCTGGTGACGGTCTTCCGCTCTATCTCCGAGACCATGTTTAAAGTCACCCATATGGTGATGCGCTATGCGC
CGGTCGGGGTATTCGCCCTGATTTCGGTAACCGTCGCCACCTTCGGTTTCGCCTCGCTGTGGCCGCTGGCCAAGCTAGTG
TTGCTGGTTTACTTTGCGATCCTGTTCTTCGCGCTGGTGGTGCTGGGGATTGTCGCGCGCCTGTGTGGTTTGAGCATCTG
GATCCTGATCCGCATCCTGAAAGATGAGCTGATTCTGGCTTATTCTACCGCCAGTTCGGAGAGCGTACTGCCGCGCATTA
TTGAGAAGATGGAAGCCTACGGCGCACCGGCGTCGATCACCAGCTTTGTGGTGCCGACCGGTTACTCCTTCAACCTCGAT
GGTTCAACGCTGTATCAGAGCATCGCGGCGATCTTTATCGCCCAGCTGTACGGTATTGACCTCTCTATCTGGCAGGAGAT
TACCTTGGTGCTGACCCTGATGGTGACCTCGAAAGGGATCGCCGGCGTGCCGGGCGTCTCTTTCGTGGTGCTGCTGGCCA
CCCTGGGTAGCGTCGGGATCCCGCTGGAAGGGCTTGCCTTTATTGCCGGCGTCGACCGTATCCTCGACATGGCGCGTACC
GCGCTGAACGTGGTGGGTAATGCGCTGGCGGTGCTGGTTATCGCCAAGTGGGAGCATAAGTTCGACCGCAAAAAAGCGCT
GGCGTATGAACGCGAAGTGCTGGGCAAGTTTGATAAAACCGCCCAATAA

Upstream 100 bases:

>100_bases
ATGATACTGATATTGCGCGTTAAATAACCCCACAAAGCAACGCAACACAATTCATACCCCCTGCAGTGGGTACCATGACG
AAAAGGAATGGTGCCTTTCA

Downstream 100 bases:

>100_bases
AACACAAAGCCCGGCGCGATAGCGCCGGGCTTTTTCTTATCCTTTACTAATCCGGTCAAACTCTTCGCAGCCGGTATCAA
ACCCCTCCAGGCAACTGACG

Product: glutamate/aspartate:proton symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 442; Mature: 442

Protein sequence:

>442_residues
MRKSVVKKTKKVSLAWQILLALVLGILLGSYLHYHAESRDWLISNLLTPAGDIFIHLIKMIVVPIVISTLVVGIAGVGDA
KQLGRIGAKTIIYFEVITTVAIVLGITLANVFQPGTGIDMSQLAAVDISKYQNTTAEVQSHAHGLMGTILSLVPTNIVAS
MAKGDMLPIIFFSVLFGLGLSSLPATHREPLVTVFRSISETMFKVTHMVMRYAPVGVFALISVTVATFGFASLWPLAKLV
LLVYFAILFFALVVLGIVARLCGLSIWILIRILKDELILAYSTASSESVLPRIIEKMEAYGAPASITSFVVPTGYSFNLD
GSTLYQSIAAIFIAQLYGIDLSIWQEITLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMART
ALNVVGNALAVLVIAKWEHKFDRKKALAYEREVLGKFDKTAQ

Sequences:

>Translated_442_residues
MRKSVVKKTKKVSLAWQILLALVLGILLGSYLHYHAESRDWLISNLLTPAGDIFIHLIKMIVVPIVISTLVVGIAGVGDA
KQLGRIGAKTIIYFEVITTVAIVLGITLANVFQPGTGIDMSQLAAVDISKYQNTTAEVQSHAHGLMGTILSLVPTNIVAS
MAKGDMLPIIFFSVLFGLGLSSLPATHREPLVTVFRSISETMFKVTHMVMRYAPVGVFALISVTVATFGFASLWPLAKLV
LLVYFAILFFALVVLGIVARLCGLSIWILIRILKDELILAYSTASSESVLPRIIEKMEAYGAPASITSFVVPTGYSFNLD
GSTLYQSIAAIFIAQLYGIDLSIWQEITLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMART
ALNVVGNALAVLVIAKWEHKFDRKKALAYEREVLGKFDKTAQ
>Mature_442_residues
MRKSVVKKTKKVSLAWQILLALVLGILLGSYLHYHAESRDWLISNLLTPAGDIFIHLIKMIVVPIVISTLVVGIAGVGDA
KQLGRIGAKTIIYFEVITTVAIVLGITLANVFQPGTGIDMSQLAAVDISKYQNTTAEVQSHAHGLMGTILSLVPTNIVAS
MAKGDMLPIIFFSVLFGLGLSSLPATHREPLVTVFRSISETMFKVTHMVMRYAPVGVFALISVTVATFGFASLWPLAKLV
LLVYFAILFFALVVLGIVARLCGLSIWILIRILKDELILAYSTASSESVLPRIIEKMEAYGAPASITSFVVPTGYSFNLD
GSTLYQSIAAIFIAQLYGIDLSIWQEITLVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMART
ALNVVGNALAVLVIAKWEHKFDRKKALAYEREVLGKFDKTAQ

Specific function: This carrier protein is part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=422, Percent_Identity=26.5402843601896, Blast_Score=142, Evalue=4e-34,
Organism=Homo sapiens, GI169790839, Length=451, Percent_Identity=28.159645232816, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI194239697, Length=469, Percent_Identity=26.865671641791, Blast_Score=138, Evalue=1e-32,
Organism=Homo sapiens, GI66773030, Length=477, Percent_Identity=28.0922431865828, Blast_Score=136, Evalue=4e-32,
Organism=Homo sapiens, GI21314632, Length=430, Percent_Identity=25.5813953488372, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI4827012, Length=423, Percent_Identity=28.8416075650118, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI5032093, Length=412, Percent_Identity=27.9126213592233, Blast_Score=116, Evalue=5e-26,
Organism=Homo sapiens, GI223468566, Length=278, Percent_Identity=28.7769784172662, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI223468564, Length=281, Percent_Identity=29.5373665480427, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI262359914, Length=392, Percent_Identity=26.7857142857143, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI301601644, Length=193, Percent_Identity=31.0880829015544, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1790514, Length=435, Percent_Identity=93.3333333333333, Blast_Score=813, Evalue=0.0,
Organism=Escherichia coli, GI1789947, Length=428, Percent_Identity=39.4859813084112, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1788024, Length=418, Percent_Identity=24.8803827751196, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1789473, Length=388, Percent_Identity=23.7113402061856, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71983106, Length=423, Percent_Identity=27.8959810874704, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17537407, Length=447, Percent_Identity=27.7404921700224, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI71983099, Length=423, Percent_Identity=27.8959810874704, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI193206505, Length=476, Percent_Identity=27.5210084033613, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71996953, Length=459, Percent_Identity=26.797385620915, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI193206654, Length=447, Percent_Identity=25.9507829977629, Blast_Score=122, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17541374, Length=422, Percent_Identity=25.5924170616114, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24583025, Length=460, Percent_Identity=24.3478260869565, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI17137668, Length=460, Percent_Identity=24.3478260869565, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24583023, Length=460, Percent_Identity=24.3478260869565, Blast_Score=128, Evalue=6e-30,
Organism=Drosophila melanogaster, GI281360481, Length=456, Percent_Identity=25.219298245614, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281360483, Length=466, Percent_Identity=25.7510729613734, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17137666, Length=466, Percent_Identity=25.7510729613734, Blast_Score=79, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 47693; Mature: 47693

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1971622; 1551855; 8265357; 9278503 [H]