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The map label for this gene is soxR [H]

Identifier: 238892553

GI number: 238892553

Start: 336675

End: 337133

Strand: Direct

Name: soxR [H]

Synonym: KP1_0326

Alternate gene names: 238892553

Gene position: 336675-337133 (Clockwise)

Preceding gene: 238892551

Following gene: 238892554

Centisome position: 6.41

GC content: 59.69

Gene sequence:

>459_bases
ATGGAAAAGAAATCACCCCGCATCAAAATGCTGTTGACGCCTGGAGAAGTGGCAAAACGAACCGGCGTGGCGGTCTCGGC
CCTCCATTTTTATGAGAGTAAAGGATTGATCCACAGTCAGCGGAATGCCGGCAATCAGCGGCGCTACCGGCGTGACGTTC
TGCGCGCGGTGGCGATTATCAAAATTGCGCAACGTATTGGCATCCCGCTGGCCACTATCGGCGACGCGTTTGGCGTGCTG
CCGGAAGGGCACAATCTCAGCGCAAAAGAGTGGAAGATGCTGTCATCGCAGTGGCGTGAGGAGCTGGATCGGCGCATTCA
TACCCTGACGGCGCTACGCGACCAGCTCGACGGCTGTATCGGCTGCGGCTGTTTATCGCGACGCGACTGCCCGCTGCGCA
ACCCGGGCGATAAACTGGGGGAAGAGGGAACCGGCGCCCGGCTGCTGGAAGACGAGTGA

Upstream 100 bases:

>100_bases
TATCCTGATGGGACATAAAGCGGCCTCTCTCAATTCTCGATTCGTCGTTTTGTCTGCAGGCGAGTATAATTCCTCAAGTT
AACTTGAGGTAAAGCGCTTT

Downstream 100 bases:

>100_bases
TAAAACTAAAGCGCCACAACTGGGCGCTTTAGTTGTTTTCCGGTCTTGGTCTTTCGCATTATCTCGCTGGTTCGCGAGAG
GGTTTCCCCCGACGTCGACG

Product: redox-sensing activator of soxS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MEKKSPRIKMLLTPGEVAKRTGVAVSALHFYESKGLIHSQRNAGNQRRYRRDVLRAVAIIKIAQRIGIPLATIGDAFGVL
PEGHNLSAKEWKMLSSQWREELDRRIHTLTALRDQLDGCIGCGCLSRRDCPLRNPGDKLGEEGTGARLLEDE

Sequences:

>Translated_152_residues
MEKKSPRIKMLLTPGEVAKRTGVAVSALHFYESKGLIHSQRNAGNQRRYRRDVLRAVAIIKIAQRIGIPLATIGDAFGVL
PEGHNLSAKEWKMLSSQWREELDRRIHTLTALRDQLDGCIGCGCLSRRDCPLRNPGDKLGEEGTGARLLEDE
>Mature_152_residues
MEKKSPRIKMLLTPGEVAKRTGVAVSALHFYESKGLIHSQRNAGNQRRYRRDVLRAVAIIKIAQRIGIPLATIGDAFGVL
PEGHNLSAKEWKMLSSQWREELDRRIHTLTALRDQLDGCIGCGCLSRRDCPLRNPGDKLGEEGTGARLLEDE

Specific function: Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron-sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster i

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790498, Length=152, Percent_Identity=90.1315789473684, Blast_Score=281, Evalue=1e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR010211
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16971; Mature: 16971

Theoretical pI: Translated: 10.00; Mature: 10.00

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKSPRIKMLLTPGEVAKRTGVAVSALHFYESKGLIHSQRNAGNQRRYRRDVLRAVAII
CCCCCCCEEEEECCHHHHHHHCHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHH
KIAQRIGIPLATIGDAFGVLPEGHNLSAKEWKMLSSQWREELDRRIHTLTALRDQLDGCI
HHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCGCLSRRDCPLRNPGDKLGEEGTGARLLEDE
HCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MEKKSPRIKMLLTPGEVAKRTGVAVSALHFYESKGLIHSQRNAGNQRRYRRDVLRAVAII
CCCCCCCEEEEECCHHHHHHHCHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHHHHH
KIAQRIGIPLATIGDAFGVLPEGHNLSAKEWKMLSSQWREELDRRIHTLTALRDQLDGCI
HHHHHHCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GCGCLSRRDCPLRNPGDKLGEEGTGARLLEDE
HCCCCCCCCCCCCCCCHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]