Click here to switch to the map view.

The map label for this gene is fepA [H]

Identifier: 238892535

GI number: 238892535

Start: 318496

End: 320754

Strand: Direct

Name: fepA [H]

Synonym: KP1_0306

Alternate gene names: 238892535

Gene position: 318496-320754 (Clockwise)

Preceding gene: 238892534

Following gene: 238892540

Centisome position: 6.07

GC content: 56.13

Gene sequence:

>2259_bases
ATGAAATACACGTCTCACTTCCCGCTGGGGATCGTCATTCCTCTGCTCGCCTGTAGCGTGCCGCTGCAGGCGGCAGAGAA
CATGACCGAACAATCGACGCCTGACGAGAGCGCCGCCACTGCCGAAAATCACGAGGAGACGATGGTCATAACCGCCGCCA
GGCAGAACCTGCAGGCGCCGGGCGTGTCGACCATCACCGCAGAAGAGATCCGCAAACATCCCCCCGCCCGCGATGTGTCG
GAGTTAATTCGTACGCAGCCCGGGGTAAACCTGACCGGCAACTCCACCAGCGGGCAGCGCGGCAACAACCGGCAAATTGA
TATCCGTGGCATGGGGCCCGAGAATACGCTGGTGCTGGTCGATGGTAAACCGGTGACCAGCCGTAACTCGGTGCGGTATG
GCTGGCGCGGCGATCGTGACTCCCGCGGCGATACCAGTTGGGTGCCAGCGGAGATGATCGATCATATCGATGTGATCCGC
GGCCCGGCGGCGGCGCGCTATGGTAATGGCGCGATGGGCGGGGTCGTCAACATCGTGACCAAACCGACCACGCGAGAATG
GCACGGGTCGTGGAATACCTATATGAATGCTCCGCAGCACCGTAAAGAAGGGGCGACGAAACGTACTAACTTTAGCCTCA
ATGGTCCGCTGTCGGACAGTGTCAGCTTCAATCTCTGGGGTAATCTGAGTAAAACCCAGGCCGATGCACAGGATATTAAC
GCCGGGCATGAAGCGGAACGTACCGGTTCCTACGCCGGTTCTTATCCCGCCGGACGTGAAGGGGTGGTGAACAAAGATAT
TCACAGTAAGCTGCGCTGGGAGTTTGCCCCGATGCAGGCCCTGGAGTTTGAGGCCGGTTACAGCCGCCAGGGTAATCTCT
ATGCCGGCGACACACAAAACACCAATACCAGTACGCTGGTGAAGAGTATGTACGGGAAAGAGACCAACCGTCTCTACCGG
CAAACTTACGGCGTAACATGGACCGGCGGCTGGGATAATGGCGTGACCAGCAACAGCTATGCCCAGTACGAACACACCCG
TAACTCGCGAATGGATGAAGGGCTGGCGGGCGGTACGGAAGGGATCTTCTCCAGTAGCGAGTTTTCAGATATCGATCTGG
CCGATGTCCTGCTACATAGTGAAGTGAATATTCCGTTTACGCTGGGGGTCGATCAGAATCTGACGCTGGGGGCAGAATGG
AATCAGCAGCGGATGAAAGATGGCGTATCGACAACCCAGGCGCTCTCTTATGGCACTATCGATGGCGTATCGGCTACCGG
TCGTAGCCCGTACTCCAGTGCCGAGATCTTCTCGCTGTTTACCGAAGATAATATGGCGCTAACGGACAGCACCATGCTGA
CACCCGCTCTGCGCTTCGATCACCACAGCATCGTCGGCAATAACTGGAGCCCCTCACTGAACCTGTCTCAGGAGCTGACG
GACGACTGGACGCTGAAGCTGGGCATTGCCCGTGCTTACAAGGCGCCTAACCTCTACCAGTTGAACCCGAACTATATTCT
CTACAGCAACGGTCAAGGCTGTTACGCCAGTAGTTCCGCCTGCTATCTGATGGGGAATAGCGATCTGAAAGCGGAGACCA
GCGTTAATAAAGAGATTGGTCTTGAGTACAAGCATGATGGCTATCAGGCGGGGATCACCTGGTTCCGTAACGACTATCAC
AATAAGATTGAGTCAGGGTATGCGGCGGTGGGTACCGCCAGCAACGGCACCACCAATATCTATCAGTGGGAAAACGTACC
AAAGGCGTTAGTGGAAGGCCTGGAAGGAACGCTGAATCTGCCGGTGGGGGAGGCGGTTAACTGGAGCAATAACCTGACCT
GGATGCTGCAGAGCAAGAATAAGACGACCGGCGACCGGCTGTCAGTGATCCCGCAGTTTACCCTGAACTCGACTTTGAGC
TGGCAGGTTCGTGAAGATCTCTCCCTGCAGAGCACCTTTACCTGGTATGGCCGACAGAAACCAAAACGCTTCAATTATAA
GGGCGAGGCGGTCAGCGGCAGCGAACTAAACGAAGTCAGCCCATACAGCATTGTCGGCCTCAGTGCGACCTGGGATGTGA
ACAAAAATCTGAGCTTCACCAGCGGGATAGATAACCTGTTTGATATTCGCCACTACCGGGCAGGGAATGCGCAAACGACC
GGCAACGCGACGACGGGAGCTTATCTGTATGGCGCGGGTGCCGAGACCTATAACGAATCGGGGCGGACCTTCTTTATGAG
CGTTAATACTCATTTCTGA

Upstream 100 bases:

>100_bases
CCAAAATCTGGCGACGCGCTGAGGCAAGTATTTTATCCCATTGTTTTTTCAATTGGGGAAGGCGTTATGCCCGACAGCAA
CAGAAAACAGGGCATATTCT

Downstream 100 bases:

>100_bases
TGATCCTGATGAGGAGTAAACCGGGTGCAATGCGACCCGGTTTTTTTATTTCAGATGAGAGCGGAGGAGGCGGTTATAAA
TCGTGACAAAATCTTCACGC

Product: outer membrane receptor FepA

Products: NA

Alternate protein names: Enterobactin outer-membrane receptor [H]

Number of amino acids: Translated: 752; Mature: 752

Protein sequence:

>752_residues
MKYTSHFPLGIVIPLLACSVPLQAAENMTEQSTPDESAATAENHEETMVITAARQNLQAPGVSTITAEEIRKHPPARDVS
ELIRTQPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLVLVDGKPVTSRNSVRYGWRGDRDSRGDTSWVPAEMIDHIDVIR
GPAAARYGNGAMGGVVNIVTKPTTREWHGSWNTYMNAPQHRKEGATKRTNFSLNGPLSDSVSFNLWGNLSKTQADAQDIN
AGHEAERTGSYAGSYPAGREGVVNKDIHSKLRWEFAPMQALEFEAGYSRQGNLYAGDTQNTNTSTLVKSMYGKETNRLYR
QTYGVTWTGGWDNGVTSNSYAQYEHTRNSRMDEGLAGGTEGIFSSSEFSDIDLADVLLHSEVNIPFTLGVDQNLTLGAEW
NQQRMKDGVSTTQALSYGTIDGVSATGRSPYSSAEIFSLFTEDNMALTDSTMLTPALRFDHHSIVGNNWSPSLNLSQELT
DDWTLKLGIARAYKAPNLYQLNPNYILYSNGQGCYASSSACYLMGNSDLKAETSVNKEIGLEYKHDGYQAGITWFRNDYH
NKIESGYAAVGTASNGTTNIYQWENVPKALVEGLEGTLNLPVGEAVNWSNNLTWMLQSKNKTTGDRLSVIPQFTLNSTLS
WQVREDLSLQSTFTWYGRQKPKRFNYKGEAVSGSELNEVSPYSIVGLSATWDVNKNLSFTSGIDNLFDIRHYRAGNAQTT
GNATTGAYLYGAGAETYNESGRTFFMSVNTHF

Sequences:

>Translated_752_residues
MKYTSHFPLGIVIPLLACSVPLQAAENMTEQSTPDESAATAENHEETMVITAARQNLQAPGVSTITAEEIRKHPPARDVS
ELIRTQPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLVLVDGKPVTSRNSVRYGWRGDRDSRGDTSWVPAEMIDHIDVIR
GPAAARYGNGAMGGVVNIVTKPTTREWHGSWNTYMNAPQHRKEGATKRTNFSLNGPLSDSVSFNLWGNLSKTQADAQDIN
AGHEAERTGSYAGSYPAGREGVVNKDIHSKLRWEFAPMQALEFEAGYSRQGNLYAGDTQNTNTSTLVKSMYGKETNRLYR
QTYGVTWTGGWDNGVTSNSYAQYEHTRNSRMDEGLAGGTEGIFSSSEFSDIDLADVLLHSEVNIPFTLGVDQNLTLGAEW
NQQRMKDGVSTTQALSYGTIDGVSATGRSPYSSAEIFSLFTEDNMALTDSTMLTPALRFDHHSIVGNNWSPSLNLSQELT
DDWTLKLGIARAYKAPNLYQLNPNYILYSNGQGCYASSSACYLMGNSDLKAETSVNKEIGLEYKHDGYQAGITWFRNDYH
NKIESGYAAVGTASNGTTNIYQWENVPKALVEGLEGTLNLPVGEAVNWSNNLTWMLQSKNKTTGDRLSVIPQFTLNSTLS
WQVREDLSLQSTFTWYGRQKPKRFNYKGEAVSGSELNEVSPYSIVGLSATWDVNKNLSFTSGIDNLFDIRHYRAGNAQTT
GNATTGAYLYGAGAETYNESGRTFFMSVNTHF
>Mature_752_residues
MKYTSHFPLGIVIPLLACSVPLQAAENMTEQSTPDESAATAENHEETMVITAARQNLQAPGVSTITAEEIRKHPPARDVS
ELIRTQPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLVLVDGKPVTSRNSVRYGWRGDRDSRGDTSWVPAEMIDHIDVIR
GPAAARYGNGAMGGVVNIVTKPTTREWHGSWNTYMNAPQHRKEGATKRTNFSLNGPLSDSVSFNLWGNLSKTQADAQDIN
AGHEAERTGSYAGSYPAGREGVVNKDIHSKLRWEFAPMQALEFEAGYSRQGNLYAGDTQNTNTSTLVKSMYGKETNRLYR
QTYGVTWTGGWDNGVTSNSYAQYEHTRNSRMDEGLAGGTEGIFSSSEFSDIDLADVLLHSEVNIPFTLGVDQNLTLGAEW
NQQRMKDGVSTTQALSYGTIDGVSATGRSPYSSAEIFSLFTEDNMALTDSTMLTPALRFDHHSIVGNNWSPSLNLSQELT
DDWTLKLGIARAYKAPNLYQLNPNYILYSNGQGCYASSSACYLMGNSDLKAETSVNKEIGLEYKHDGYQAGITWFRNDYH
NKIESGYAAVGTASNGTTNIYQWENVPKALVEGLEGTLNLPVGEAVNWSNNLTWMLQSKNKTTGDRLSVIPQFTLNSTLS
WQVREDLSLQSTFTWYGRQKPKRFNYKGEAVSGSELNEVSPYSIVGLSATWDVNKNLSFTSGIDNLFDIRHYRAGNAQTT
GNATTGAYLYGAGAETYNESGRTFFMSVNTHF

Specific function: This protein is involved in the initial step of iron uptake by binding ferrienterobactin (Fe-ENT), an iron chelatin siderophore that allows E.coli to extract iron from the environment. FepA also acts as a receptor for colicins B and D [H]

COG id: COG4771

COG function: function code P; Outer membrane receptor for ferrienterochelin and colicins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tonB-dependent receptor family [H]

Homologues:

Organism=Escherichia coli, GI1786798, Length=724, Percent_Identity=71.9613259668508, Blast_Score=1100, Evalue=0.0,
Organism=Escherichia coli, GI1788478, Length=773, Percent_Identity=29.6248382923674, Blast_Score=262, Evalue=6e-71,
Organism=Escherichia coli, GI1790405, Length=739, Percent_Identity=23.2746955345061, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1787723, Length=167, Percent_Identity=31.7365269461078, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012910
- InterPro:   IPR000531
- InterPro:   IPR010916
- InterPro:   IPR010917
- InterPro:   IPR010105 [H]

Pfam domain/function: PF07715 Plug; PF00593 TonB_dep_Rec [H]

EC number: NA

Molecular weight: Translated: 82711; Mature: 82711

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS01156 TONB_DEPENDENT_REC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYTSHFPLGIVIPLLACSVPLQAAENMTEQSTPDESAATAENHEETMVITAARQNLQAP
CCCCCCCCHHHHHHHHHHCCCHHHHHCCHHCCCCCCHHCCCCCCCCEEEEEEECCCCCCC
GVSTITAEEIRKHPPARDVSELIRTQPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLVLV
CCCEEEHHHHHCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCEEEEEECCCCCEEEEE
DGKPVTSRNSVRYGWRGDRDSRGDTSWVPAEMIDHIDVIRGPAAARYGNGAMGGVVNIVT
CCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCEEEEEE
KPTTREWHGSWNTYMNAPQHRKEGATKRTNFSLNGPLSDSVSFNLWGNLSKTQADAQDIN
CCCCCCCCCCCHHHCCCCHHHHCCCCCCCCEEECCCCCCCEEEEEECCCCHHHCCHHHCC
AGHEAERTGSYAGSYPAGREGVVNKDIHSKLRWEFAPMQALEFEAGYSRQGNLYAGDTQN
CCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHEEEECCCEEEEECCCCCCCCCEEECCCCC
TNTSTLVKSMYGKETNRLYRQTYGVTWTGGWDNGVTSNSYAQYEHTRNSRMDEGLAGGTE
CCHHHHHHHHHCCHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC
GIFSSSEFSDIDLADVLLHSEVNIPFTLGVDQNLTLGAEWNQQRMKDGVSTTQALSYGTI
CCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCCEEECCCCCHHHHHCCCCHHHHHCCCCC
DGVSATGRSPYSSAEIFSLFTEDNMALTDSTMLTPALRFDHHSIVGNNWSPSLNLSQELT
CCCCCCCCCCCCCCEEEEEEECCCEEEECCHHCCHHHHCCCCEECCCCCCCCCCCHHHCC
DDWTLKLGIARAYKAPNLYQLNPNYILYSNGQGCYASSSACYLMGNSDLKAETSVNKEIG
CCEEEEEEEHHHHCCCCEEEECCCEEEEECCCCCEECCCEEEEECCCCCCCCCCCCHHHC
LEYKHDGYQAGITWFRNDYHNKIESGYAAVGTASNGTTNIYQWENVPKALVEGLEGTLNL
CEECCCCEEECHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCHHHHHHCCCCEEEC
PVGEAVNWSNNLTWMLQSKNKTTGDRLSVIPQFTLNSTLSWQVREDLSLQSTFTWYGRQK
CCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCEEEEECCCCC
PKRFNYKGEAVSGSELNEVSPYSIVGLSATWDVNKNLSFTSGIDNLFDIRHYRAGNAQTT
CCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHCCCHHHHHHHHCCCCCCCCC
GNATTGAYLYGAGAETYNESGRTFFMSVNTHF
CCCCCCEEEEECCCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MKYTSHFPLGIVIPLLACSVPLQAAENMTEQSTPDESAATAENHEETMVITAARQNLQAP
CCCCCCCCHHHHHHHHHHCCCHHHHHCCHHCCCCCCHHCCCCCCCCEEEEEEECCCCCCC
GVSTITAEEIRKHPPARDVSELIRTQPGVNLTGNSTSGQRGNNRQIDIRGMGPENTLVLV
CCCEEEHHHHHCCCCHHHHHHHHHCCCCCEECCCCCCCCCCCCCEEEEEECCCCCEEEEE
DGKPVTSRNSVRYGWRGDRDSRGDTSWVPAEMIDHIDVIRGPAAARYGNGAMGGVVNIVT
CCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHCCCCCCCCCEEEEEE
KPTTREWHGSWNTYMNAPQHRKEGATKRTNFSLNGPLSDSVSFNLWGNLSKTQADAQDIN
CCCCCCCCCCCHHHCCCCHHHHCCCCCCCCEEECCCCCCCEEEEEECCCCHHHCCHHHCC
AGHEAERTGSYAGSYPAGREGVVNKDIHSKLRWEFAPMQALEFEAGYSRQGNLYAGDTQN
CCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHEEEECCCEEEEECCCCCCCCCEEECCCCC
TNTSTLVKSMYGKETNRLYRQTYGVTWTGGWDNGVTSNSYAQYEHTRNSRMDEGLAGGTE
CCHHHHHHHHHCCHHHHHHHHHCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCC
GIFSSSEFSDIDLADVLLHSEVNIPFTLGVDQNLTLGAEWNQQRMKDGVSTTQALSYGTI
CCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCCEEECCCCCHHHHHCCCCHHHHHCCCCC
DGVSATGRSPYSSAEIFSLFTEDNMALTDSTMLTPALRFDHHSIVGNNWSPSLNLSQELT
CCCCCCCCCCCCCCEEEEEEECCCEEEECCHHCCHHHHCCCCEECCCCCCCCCCCHHHCC
DDWTLKLGIARAYKAPNLYQLNPNYILYSNGQGCYASSSACYLMGNSDLKAETSVNKEIG
CCEEEEEEEHHHHCCCCEEEECCCEEEEECCCCCEECCCEEEEECCCCCCCCCCCCHHHC
LEYKHDGYQAGITWFRNDYHNKIESGYAAVGTASNGTTNIYQWENVPKALVEGLEGTLNL
CEECCCCEEECHHHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCHHHHHHCCCCEEEC
PVGEAVNWSNNLTWMLQSKNKTTGDRLSVIPQFTLNSTLSWQVREDLSLQSTFTWYGRQK
CCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEECCCEEEEEECCCCCCCEEEEECCCCC
PKRFNYKGEAVSGSELNEVSPYSIVGLSATWDVNKNLSFTSGIDNLFDIRHYRAGNAQTT
CCCCCCCCCCCCCCCCCCCCCEEEEEEEEEECCCCCCCHHCCCHHHHHHHHCCCCCCCCC
GNATTGAYLYGAGAETYNESGRTFFMSVNTHF
CCCCCCEEEEECCCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3015941; 8905232; 9278503; 2974033; 2526281; 2201687; 9886293 [H]