| Definition | Burkholderia glumae BGR1 chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_012724 |
| Length | 3,906,507 |
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The map label for this gene is linX [H]
Identifier: 238028328
GI number: 238028328
Start: 3159049
End: 3159807
Strand: Direct
Name: linX [H]
Synonym: bglu_1g27890
Alternate gene names: 238028328
Gene position: 3159049-3159807 (Clockwise)
Preceding gene: 238028327
Following gene: 238028329
Centisome position: 80.87
GC content: 69.7
Gene sequence:
>759_bases ATGCGGCTTGCAGGCAAGACAGCGATCGTCACGGGCGGCGGCTCGGGCTTCGGCGAGGGCATCGCCAGGACCTACGCACG CGAGGGGGCGAACCTGGTCGTCAACGACCTGAACGGCGCGGCGGCCGAGCGCGTGGCCGGCGAGATCGCGATGGCGGGCG GGCGGGCGATCGCGATCGCCGGCGACGTCGCGAAGGGCGAGGACTGGCGCGCGCTGCTGGCCGCCGCCCTCGACGATTTC GGGCAGGTTCACGTGGTCGTCAACAATGCCGGCACCACGCACCGCAACAAGCCCGTGCTGGACGTGAGCGAGGCCGAGTA CGACCGCGTCTACGCCGTCAACATGAAAAGCCTGTTCTGGTGCGTGCAGACGCTGGTGCCGTATTTCCGCGAGGCGGGCG GCGGCGTGTTCGTCAACATCGCGTCCACCGCCGGGGTCCGGCCGCGCCCCGGCCTCGTCTGGTACAACAGCACGAAGGGC GCGATGATCACCGCCAGCAAGGCGCTCGCGGCCGAGCTCGGCGCCGACCGGATCCGCGTCAACTGCATCAACCCGGTGCT CGGCGAGACCGGCCTCATGACCGAATTCATGGGCGTCGACGACACGCCCGAGAACCGCCAGCGCTTCCTCGCCACGATTC CGCTCGGCCGGCTCTCGACGCCGCGCGACATCGCCAACGCGGCACTCTATCTGGCCTCCGACGAAGCCGAATTCATCACC GGCATCTGCCTGGAGGTGGACGGCGGCCGCTGCATCTGA
Upstream 100 bases:
>100_bases AGACCGTCGCGCTCAAACACGGCTGAGCCGCGCGGGCCGGCCGCGCGGCAGCCACGCAACCACTACCACCACCCGATCCG ACACGGACAAGGAGACAGCC
Downstream 100 bases:
>100_bases CGCACCTGACACACCTGACGCATCGGCGCGCGCCGCCACCACGCAATCGCGGCATCCTCGCGCCGCCGCCCCATACCAAG ACGACCGAACCATCCCGTAA
Product: 3-ketoacyl-(acyl-carrier-protein) reductase
Products: 3alpha12alpha-dihydroxy-oxobeta-cholanate; NADH [C]
Alternate protein names: 2,5-DDOL dehydrogenase [H]
Number of amino acids: Translated: 252; Mature: 252
Protein sequence:
>252_residues MRLAGKTAIVTGGGSGFGEGIARTYAREGANLVVNDLNGAAAERVAGEIAMAGGRAIAIAGDVAKGEDWRALLAAALDDF GQVHVVVNNAGTTHRNKPVLDVSEAEYDRVYAVNMKSLFWCVQTLVPYFREAGGGVFVNIASTAGVRPRPGLVWYNSTKG AMITASKALAAELGADRIRVNCINPVLGETGLMTEFMGVDDTPENRQRFLATIPLGRLSTPRDIANAALYLASDEAEFIT GICLEVDGGRCI
Sequences:
>Translated_252_residues MRLAGKTAIVTGGGSGFGEGIARTYAREGANLVVNDLNGAAAERVAGEIAMAGGRAIAIAGDVAKGEDWRALLAAALDDF GQVHVVVNNAGTTHRNKPVLDVSEAEYDRVYAVNMKSLFWCVQTLVPYFREAGGGVFVNIASTAGVRPRPGLVWYNSTKG AMITASKALAAELGADRIRVNCINPVLGETGLMTEFMGVDDTPENRQRFLATIPLGRLSTPRDIANAALYLASDEAEFIT GICLEVDGGRCI >Mature_252_residues MRLAGKTAIVTGGGSGFGEGIARTYAREGANLVVNDLNGAAAERVAGEIAMAGGRAIAIAGDVAKGEDWRALLAAALDDF GQVHVVVNNAGTTHRNKPVLDVSEAEYDRVYAVNMKSLFWCVQTLVPYFREAGGGVFVNIASTAGVRPRPGLVWYNSTKG AMITASKALAAELGADRIRVNCINPVLGETGLMTEFMGVDDTPENRQRFLATIPLGRLSTPRDIANAALYLASDEAEFIT GICLEVDGGRCI
Specific function: Catalyzes the degradation of 2,5-dichloro-2,5- cyclohexadiene-1,4-diol (2,5-DDOL) into 2,5-dichlorohydroquinone (2,5-DCHQ). LinX appears not to be involved in gamma-HCH degradation pathway [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=32.8, Blast_Score=125, Evalue=4e-29, Organism=Homo sapiens, GI5031737, Length=246, Percent_Identity=32.1138211382114, Blast_Score=112, Evalue=3e-25, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=30.0395256916996, Blast_Score=107, Evalue=9e-24, Organism=Homo sapiens, GI40254992, Length=245, Percent_Identity=30.6122448979592, Blast_Score=102, Evalue=3e-22, Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=31.9066147859922, Blast_Score=102, Evalue=4e-22, Organism=Homo sapiens, GI19923817, Length=261, Percent_Identity=28.735632183908, Blast_Score=102, Evalue=5e-22, Organism=Homo sapiens, GI7705925, Length=249, Percent_Identity=31.7269076305221, Blast_Score=101, Evalue=7e-22, Organism=Homo sapiens, GI33667109, Length=225, Percent_Identity=31.5555555555556, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI59889578, Length=229, Percent_Identity=32.3144104803493, Blast_Score=98, Evalue=9e-21, Organism=Homo sapiens, GI66933014, Length=254, Percent_Identity=30.3149606299213, Blast_Score=97, Evalue=2e-20, Organism=Homo sapiens, GI126723191, Length=185, Percent_Identity=31.8918918918919, Blast_Score=93, Evalue=2e-19, Organism=Homo sapiens, GI210032110, Length=193, Percent_Identity=31.0880829015544, Blast_Score=92, Evalue=6e-19, Organism=Homo sapiens, GI10190704, Length=250, Percent_Identity=31.6, Blast_Score=91, Evalue=1e-18, Organism=Homo sapiens, GI4504505, Length=213, Percent_Identity=30.5164319248826, Blast_Score=89, Evalue=4e-18, Organism=Homo sapiens, GI142976729, Length=194, Percent_Identity=26.8041237113402, Blast_Score=82, Evalue=4e-16, Organism=Homo sapiens, GI4758504, Length=257, Percent_Identity=30.3501945525292, Blast_Score=78, Evalue=8e-15, Organism=Homo sapiens, GI109715829, Length=248, Percent_Identity=28.6290322580645, Blast_Score=76, Evalue=3e-14, Organism=Homo sapiens, GI25282469, Length=219, Percent_Identity=26.027397260274, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI31542939, Length=248, Percent_Identity=26.2096774193548, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI40807363, Length=195, Percent_Identity=27.1794871794872, Blast_Score=72, Evalue=6e-13, Organism=Homo sapiens, GI310128830, Length=204, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI310115468, Length=204, Percent_Identity=27.9411764705882, Blast_Score=70, Evalue=1e-12, Organism=Homo sapiens, GI210032112, Length=193, Percent_Identity=27.4611398963731, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI40254986, Length=163, Percent_Identity=26.9938650306748, Blast_Score=69, Evalue=5e-12, Organism=Homo sapiens, GI302344755, Length=109, Percent_Identity=32.1100917431193, Blast_Score=67, Evalue=2e-11, Organism=Homo sapiens, GI83715985, Length=258, Percent_Identity=28.6821705426357, Blast_Score=65, Evalue=6e-11, Organism=Escherichia coli, GI1787905, Length=249, Percent_Identity=38.9558232931727, Blast_Score=148, Evalue=3e-37, Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=34.375, Blast_Score=129, Evalue=2e-31, Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=30.7086614173228, Blast_Score=110, Evalue=7e-26, Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=29.0322580645161, Blast_Score=110, Evalue=1e-25, Organism=Escherichia coli, GI1787335, Length=249, Percent_Identity=30.9236947791165, Blast_Score=109, Evalue=1e-25, Organism=Escherichia coli, GI87082160, Length=255, Percent_Identity=32.156862745098, Blast_Score=109, Evalue=2e-25, Organism=Escherichia coli, GI1790717, Length=254, Percent_Identity=29.5275590551181, Blast_Score=107, Evalue=7e-25, Organism=Escherichia coli, GI2367175, Length=248, Percent_Identity=31.4516129032258, Blast_Score=107, Evalue=1e-24, Organism=Escherichia coli, GI1786812, Length=257, Percent_Identity=28.7937743190661, Blast_Score=96, Evalue=2e-21, Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=28.8617886178862, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI1787526, Length=251, Percent_Identity=26.6932270916335, Blast_Score=69, Evalue=4e-13, Organism=Escherichia coli, GI1787820, Length=231, Percent_Identity=28.1385281385281, Blast_Score=68, Evalue=5e-13, Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=25.6704980842912, Blast_Score=67, Evalue=1e-12, Organism=Escherichia coli, GI2367365, Length=251, Percent_Identity=26.2948207171315, Blast_Score=64, Evalue=7e-12, Organism=Caenorhabditis elegans, GI17561402, Length=249, Percent_Identity=32.5301204819277, Blast_Score=130, Evalue=8e-31, Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=36.6935483870968, Blast_Score=120, Evalue=7e-28, Organism=Caenorhabditis elegans, GI115534694, Length=248, Percent_Identity=33.0645161290323, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=34, Blast_Score=114, Evalue=5e-26, Organism=Caenorhabditis elegans, GI25147288, Length=249, Percent_Identity=32.5301204819277, Blast_Score=112, Evalue=3e-25, Organism=Caenorhabditis elegans, GI17538480, Length=272, Percent_Identity=29.0441176470588, Blast_Score=107, Evalue=7e-24, Organism=Caenorhabditis elegans, GI71994600, Length=251, Percent_Identity=31.4741035856574, Blast_Score=107, Evalue=7e-24, Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=30.3030303030303, Blast_Score=106, Evalue=9e-24, Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=30.0751879699248, Blast_Score=103, Evalue=7e-23, Organism=Caenorhabditis elegans, GI17560676, Length=248, Percent_Identity=28.2258064516129, Blast_Score=103, Evalue=8e-23, Organism=Caenorhabditis elegans, GI17531453, Length=264, Percent_Identity=28.4090909090909, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17568967, Length=197, Percent_Identity=34.5177664974619, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17559104, Length=266, Percent_Identity=30.0751879699248, Blast_Score=100, Evalue=6e-22, Organism=Caenorhabditis elegans, GI17562904, Length=272, Percent_Identity=29.0441176470588, Blast_Score=100, Evalue=8e-22, Organism=Caenorhabditis elegans, GI17562910, Length=264, Percent_Identity=29.5454545454545, Blast_Score=99, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17544670, Length=265, Percent_Identity=26.4150943396226, Blast_Score=97, Evalue=8e-21, Organism=Caenorhabditis elegans, GI17560332, Length=266, Percent_Identity=28.9473684210526, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=26.9662921348315, Blast_Score=94, Evalue=5e-20, Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=27.1698113207547, Blast_Score=94, Evalue=7e-20, Organism=Caenorhabditis elegans, GI17538486, Length=266, Percent_Identity=27.0676691729323, Blast_Score=94, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17564282, Length=198, Percent_Identity=29.7979797979798, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=26.7175572519084, Blast_Score=92, Evalue=2e-19, Organism=Caenorhabditis elegans, GI17551412, Length=269, Percent_Identity=27.1375464684015, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17508895, Length=171, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI17560220, Length=263, Percent_Identity=26.615969581749, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17563726, Length=267, Percent_Identity=26.5917602996255, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI72000259, Length=266, Percent_Identity=25.9398496240602, Blast_Score=84, Evalue=7e-17, Organism=Caenorhabditis elegans, GI17538182, Length=257, Percent_Identity=30.7392996108949, Blast_Score=82, Evalue=3e-16, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=28.2051282051282, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17565030, Length=270, Percent_Identity=26.2962962962963, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI193203115, Length=191, Percent_Identity=28.7958115183246, Blast_Score=79, Evalue=2e-15, Organism=Caenorhabditis elegans, GI17508651, Length=245, Percent_Identity=23.6734693877551, Blast_Score=74, Evalue=7e-14, Organism=Caenorhabditis elegans, GI71982365, Length=197, Percent_Identity=26.3959390862944, Blast_Score=69, Evalue=2e-12, Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=27.6923076923077, Blast_Score=64, Evalue=9e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=190, Percent_Identity=32.6315789473684, Blast_Score=91, Evalue=1e-19, Organism=Saccharomyces cerevisiae, GI6323882, Length=239, Percent_Identity=25.1046025104602, Blast_Score=65, Evalue=1e-11, Organism=Drosophila melanogaster, GI24644339, Length=255, Percent_Identity=34.5098039215686, Blast_Score=137, Evalue=7e-33, Organism=Drosophila melanogaster, GI23397609, Length=252, Percent_Identity=34.1269841269841, Blast_Score=130, Evalue=9e-31, Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=35.0597609561753, Blast_Score=125, Evalue=2e-29, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=34.7826086956522, Blast_Score=125, Evalue=2e-29, Organism=Drosophila melanogaster, GI28571526, Length=250, Percent_Identity=33.6, Blast_Score=115, Evalue=3e-26, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=29.718875502008, Blast_Score=114, Evalue=7e-26, Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=30.952380952381, Blast_Score=108, Evalue=4e-24, Organism=Drosophila melanogaster, GI24640492, Length=192, Percent_Identity=33.3333333333333, Blast_Score=98, Evalue=5e-21, Organism=Drosophila melanogaster, GI18859837, Length=194, Percent_Identity=32.9896907216495, Blast_Score=96, Evalue=3e-20, Organism=Drosophila melanogaster, GI281364892, Length=197, Percent_Identity=33.502538071066, Blast_Score=94, Evalue=7e-20, Organism=Drosophila melanogaster, GI24644337, Length=254, Percent_Identity=31.496062992126, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI24649181, Length=188, Percent_Identity=32.4468085106383, Blast_Score=92, Evalue=3e-19, Organism=Drosophila melanogaster, GI21357673, Length=195, Percent_Identity=30.2564102564103, Blast_Score=84, Evalue=7e-17, Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=29.4117647058824, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI161076933, Length=189, Percent_Identity=30.1587301587302, Blast_Score=77, Evalue=9e-15, Organism=Drosophila melanogaster, GI24584748, Length=189, Percent_Identity=30.1587301587302, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI24584744, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI28574402, Length=183, Percent_Identity=30.6010928961749, Blast_Score=72, Evalue=4e-13, Organism=Drosophila melanogaster, GI21355631, Length=213, Percent_Identity=28.169014084507, Blast_Score=69, Evalue=2e-12, Organism=Drosophila melanogaster, GI24581726, Length=196, Percent_Identity=27.0408163265306, Blast_Score=66, Evalue=3e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: 1.1.1.159 [C]
Molecular weight: Translated: 26548; Mature: 26548
Theoretical pI: Translated: 5.12; Mature: 5.12
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 4.0 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRLAGKTAIVTGGGSGFGEGIARTYAREGANLVVNDLNGAAAERVAGEIAMAGGRAIAIA CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHEEECCCCEEEEE GDVAKGEDWRALLAAALDDFGQVHVVVNNAGTTHRNKPVLDVSEAEYDRVYAVNMKSLFW CCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCCCCCEEEEECHHHHHH CVQTLVPYFREAGGGVFVNIASTAGVRPRPGLVWYNSTKGAMITASKALAAELGADRIRV HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEEHHHHHHHCCCCEEEE NCINPVLGETGLMTEFMGVDDTPENRQRFLATIPLGRLSTPRDIANAALYLASDEAEFIT EECCCCCCCCCCHHHCCCCCCCCCCHHEEEEEECCCCCCCCHHHHHEEEEEECCCCCEEE GICLEVDGGRCI EEEEEECCCCCC >Mature Secondary Structure MRLAGKTAIVTGGGSGFGEGIARTYAREGANLVVNDLNGAAAERVAGEIAMAGGRAIAIA CCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHEEECCCCEEEEE GDVAKGEDWRALLAAALDDFGQVHVVVNNAGTTHRNKPVLDVSEAEYDRVYAVNMKSLFW CCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEECCCCCCCEEEEECHHHHHH CVQTLVPYFREAGGGVFVNIASTAGVRPRPGLVWYNSTKGAMITASKALAAELGADRIRV HHHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEEHHHHHHHCCCCEEEE NCINPVLGETGLMTEFMGVDDTPENRQRFLATIPLGRLSTPRDIANAALYLASDEAEFIT EECCCCCCCCCCHHHCCCCCCCCCCHHEEEEEECCCCCCCCHHHHHEEEEEECCCCCEEE GICLEVDGGRCI EEEEEECCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: 2-Mercaptoethanol; Dithiothreitol; NAD+; NADH [C]
Metal ions: CaCl2; KCl; MnCl2; NaCl [C]
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): 0.8 {cholic} 0.24 {taurochenodeoxycholic} 0.085 {glycochenodeoxycholic} 1 {glycocholic} 0.06 {chenodeoxycholic} [C]
Substrates: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate!; NAD [C]
Specific reaction: @ALPH01.txt*3alpha7alpha12alpha-Trihydroxybeta-cholanate! + NAD+ = 3alpha12alpha-dihydroxy-oxobeta-cholanate + NADH [C]
General reaction: Redox reaction [C]
Inhibitor: Ascorbicacid; BaCl2; CoCl2; CuCl2; EDTA; FeCl3; HgCl2; MgCl2; NH4Cl; Potassiumoxalate; Sodiumcitrate; Sodiumlaurylsulfate; Sodiumperchlorate; Sodiumperiodate; Sodiumpersulfate; TritonX-100; Tween; ZnCl2 [C]
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 7515041; 12450824 [H]