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The map label for this gene is ilvI [H]

Identifier: 238028157

GI number: 238028157

Start: 2971624

End: 2973387

Strand: Reverse

Name: ilvI [H]

Synonym: bglu_1g26080

Alternate gene names: 238028157

Gene position: 2973387-2971624 (Counterclockwise)

Preceding gene: 238028168

Following gene: 238028156

Centisome position: 76.11

GC content: 64.4

Gene sequence:

>1764_bases
ATGAACATGCCCAGCGCGGAATTCTCCACGTCGGAACCCGTTTCTGCCCCGTCGAGCGACTCGATCGGCGCCACCGTGCT
CATGAAGGCACTGGCCGACGAGAACGTCGAATTCATCTGGGGTTATCCCGGCGGCTCGGTTCTCTACATCTACGACGAAC
TCTACAAGCAGGACAAGGTCCAGCACGTGCTCGTGCGCCACGAACAGGCGGCGGTGCATGCGGCCGACGCCTACGCACGC
TCGACCGGCAACGTCGGCTGCTGCCTCGTCACGTCCGGCCCGGGCGTGACCAACGCCGTCACCGGCATCGCCACGGCCTA
CATGGATTCGGTGCCGCTCGTCGTGATCAGCGGCCAGGTGCCGACCGCGGCAATCGGCCAGGATGCGTTCCAGGAATGCG
ACACGGTCGGCATCACGCGCCCCTGCGTCAAGCACAACTTCCTCGTGAAGGACGTGCGCGAGCTGGCGGCAACCGTCAAG
AAGGCGTTCTTCATCGCCCGCACCGGCCGTCCCGGCCCCGTGCTGATCGACATTCCGAAGGACGTGTCGAAGATGCCGTG
CGAGTACGCGCCGGTCAAGAACGTCTCGCTGCGCTCGTACAACCCGGTCACCAAGGGCCATTCCGGCCAGATCCGCAAGG
CCGTGTCGCTGCTGCTGTCGGCCAAGCGCCCGTACATCTACACCGGCGGCGGCGTGATCCTGGCCGAGGCCGCGCGCGAG
CTGAACCAGTTCGCCGACCTGCTCGGCTACCCGGTCACCAACACGCTGATGGGGCTCGGCGGCTATCGCGCCTCCGATCC
GAAGTTTCTCGGCATGCTCGGCATGCACGGCACCTACGAAGCCAACATGGCGATGCAGCACTGCGACGTGCTGATCGCCA
TCGGCGCGCGCTTCGACGACCGCGTGATCGGCGACCCGGCGCACTTCTCGTCGCGTCCGCGCAAGATCATCCATATCGAC
ATCGATCCGTCGTCGATCAGCAAGCGCGTCAAGGTCGACATCCCGATCGTCGGCGACGTGAAGGAAGTGCTCAAGGAACT
GATCGAGCAGCTGCAGACGGCCGAGCACGGCCCGGACACCGAGGCGCTCGCGCAGTGGTGGAAGGACATCGAGGGCTGGC
GCGCCAAGGACTGCCTGAAGTACGACCGCGAGAGCGAGATCATCAAGCCGCAGCACGTGGTCGAGACGCTCTGGAGGCTC
ACGGGCGGCAATGCCTATGTCTGCTCGGACGTCGGCCAGCACCAGATGTGGGCCGCACAGTTCTACCGCTTCGACAAGCC
GCGCCGCTGGATCAACTCGGGCGGCCTCGGCACCATGGGCTTCGGCCTGCCCGCCGCGATGGGCGTCAAGATGGCTCATC
CGGACGACGACGTCGTCTGCATCACCGGCGAGGGCTCGATCCAGATGTGCATCCAGGAACTGTCGACCTGCAAGCAGTAC
GACACGCCCGTCAAGATCATCTCGCTGAACAACCGCTATCTCGGCATGGTTCGCCAGTGGCAGCAGATCGAATACAGCAA
GCGCTACTCGCATTCGTACATGGACGCGCTGCCCGATTTCGTGAAGCTCGCCGAGGCGTTCGGCCATGTCGGGATGCGCA
TCGAAAAAACCGCCGATGTGGAGCCGGCGCTGAAGGAAGCGCTGCGCCTCAAGGATCGCACCGTATTTCTCGACTTCCAG
ACCGATCCGACCGAGAACGTCTGGCCGATGGTCCAGGCCGGCAAGGGCATCACGGAGATGCTGCTCGGATCGGAAGATCT
GTAA

Upstream 100 bases:

>100_bases
AAGAAGCCAGCTCATCAACTGGACGCGCCGCTTGAACCCGGGCCACAAGTTCGGCAGAGAGCACCCGATCAATTTTTTGC
CGAAAATTCGAAAGGTCAAT

Downstream 100 bases:

>100_bases
CGGCGCCGCCGCACGCCGCGCCGCGCACCGCCGCCTTCACGAAGGGCGGCCGGTGCCGGGCGGCGCGCGCCGCGCATTCG
AACTGAATCAGTCGAGACCT

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MNMPSAEFSTSEPVSAPSSDSIGATVLMKALADENVEFIWGYPGGSVLYIYDELYKQDKVQHVLVRHEQAAVHAADAYAR
STGNVGCCLVTSGPGVTNAVTGIATAYMDSVPLVVISGQVPTAAIGQDAFQECDTVGITRPCVKHNFLVKDVRELAATVK
KAFFIARTGRPGPVLIDIPKDVSKMPCEYAPVKNVSLRSYNPVTKGHSGQIRKAVSLLLSAKRPYIYTGGGVILAEAARE
LNQFADLLGYPVTNTLMGLGGYRASDPKFLGMLGMHGTYEANMAMQHCDVLIAIGARFDDRVIGDPAHFSSRPRKIIHID
IDPSSISKRVKVDIPIVGDVKEVLKELIEQLQTAEHGPDTEALAQWWKDIEGWRAKDCLKYDRESEIIKPQHVVETLWRL
TGGNAYVCSDVGQHQMWAAQFYRFDKPRRWINSGGLGTMGFGLPAAMGVKMAHPDDDVVCITGEGSIQMCIQELSTCKQY
DTPVKIISLNNRYLGMVRQWQQIEYSKRYSHSYMDALPDFVKLAEAFGHVGMRIEKTADVEPALKEALRLKDRTVFLDFQ
TDPTENVWPMVQAGKGITEMLLGSEDL

Sequences:

>Translated_587_residues
MNMPSAEFSTSEPVSAPSSDSIGATVLMKALADENVEFIWGYPGGSVLYIYDELYKQDKVQHVLVRHEQAAVHAADAYAR
STGNVGCCLVTSGPGVTNAVTGIATAYMDSVPLVVISGQVPTAAIGQDAFQECDTVGITRPCVKHNFLVKDVRELAATVK
KAFFIARTGRPGPVLIDIPKDVSKMPCEYAPVKNVSLRSYNPVTKGHSGQIRKAVSLLLSAKRPYIYTGGGVILAEAARE
LNQFADLLGYPVTNTLMGLGGYRASDPKFLGMLGMHGTYEANMAMQHCDVLIAIGARFDDRVIGDPAHFSSRPRKIIHID
IDPSSISKRVKVDIPIVGDVKEVLKELIEQLQTAEHGPDTEALAQWWKDIEGWRAKDCLKYDRESEIIKPQHVVETLWRL
TGGNAYVCSDVGQHQMWAAQFYRFDKPRRWINSGGLGTMGFGLPAAMGVKMAHPDDDVVCITGEGSIQMCIQELSTCKQY
DTPVKIISLNNRYLGMVRQWQQIEYSKRYSHSYMDALPDFVKLAEAFGHVGMRIEKTADVEPALKEALRLKDRTVFLDFQ
TDPTENVWPMVQAGKGITEMLLGSEDL
>Mature_587_residues
MNMPSAEFSTSEPVSAPSSDSIGATVLMKALADENVEFIWGYPGGSVLYIYDELYKQDKVQHVLVRHEQAAVHAADAYAR
STGNVGCCLVTSGPGVTNAVTGIATAYMDSVPLVVISGQVPTAAIGQDAFQECDTVGITRPCVKHNFLVKDVRELAATVK
KAFFIARTGRPGPVLIDIPKDVSKMPCEYAPVKNVSLRSYNPVTKGHSGQIRKAVSLLLSAKRPYIYTGGGVILAEAARE
LNQFADLLGYPVTNTLMGLGGYRASDPKFLGMLGMHGTYEANMAMQHCDVLIAIGARFDDRVIGDPAHFSSRPRKIIHID
IDPSSISKRVKVDIPIVGDVKEVLKELIEQLQTAEHGPDTEALAQWWKDIEGWRAKDCLKYDRESEIIKPQHVVETLWRL
TGGNAYVCSDVGQHQMWAAQFYRFDKPRRWINSGGLGTMGFGLPAAMGVKMAHPDDDVVCITGEGSIQMCIQELSTCKQY
DTPVKIISLNNRYLGMVRQWQQIEYSKRYSHSYMDALPDFVKLAEAFGHVGMRIEKTADVEPALKEALRLKDRTVFLDFQ
TDPTENVWPMVQAGKGITEMLLGSEDL

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=589, Percent_Identity=25.8064516129032, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI21361361, Length=527, Percent_Identity=26.7552182163188, Blast_Score=152, Evalue=8e-37,
Organism=Escherichia coli, GI87081685, Length=571, Percent_Identity=57.968476357268, Blast_Score=681, Evalue=0.0,
Organism=Escherichia coli, GI1790104, Length=560, Percent_Identity=40.1785714285714, Blast_Score=406, Evalue=1e-114,
Organism=Escherichia coli, GI1786717, Length=534, Percent_Identity=34.4569288389513, Blast_Score=313, Evalue=3e-86,
Organism=Escherichia coli, GI1787096, Length=566, Percent_Identity=28.4452296819788, Blast_Score=202, Evalue=4e-53,
Organism=Escherichia coli, GI1788716, Length=554, Percent_Identity=24.3682310469314, Blast_Score=150, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17531301, Length=550, Percent_Identity=26.5454545454545, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17531299, Length=550, Percent_Identity=26.5454545454545, Blast_Score=162, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17542570, Length=517, Percent_Identity=27.852998065764, Blast_Score=144, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6323755, Length=580, Percent_Identity=42.4137931034483, Blast_Score=454, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6320816, Length=475, Percent_Identity=24.4210526315789, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320588, Length=587, Percent_Identity=23.5093696763203, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320123, Length=557, Percent_Identity=22.4416517055655, Blast_Score=92, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6321524, Length=530, Percent_Identity=21.6981132075472, Blast_Score=82, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323073, Length=497, Percent_Identity=22.3340040241449, Blast_Score=77, Evalue=6e-15,
Organism=Drosophila melanogaster, GI19922626, Length=564, Percent_Identity=25.177304964539, Blast_Score=176, Evalue=4e-44,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 64681; Mature: 64681

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNMPSAEFSTSEPVSAPSSDSIGATVLMKALADENVEFIWGYPGGSVLYIYDELYKQDKV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHH
QHVLVRHEQAAVHAADAYARSTGNVGCCLVTSGPGVTNAVTGIATAYMDSVPLVVISGQV
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCC
PTAAIGQDAFQECDTVGITRPCVKHNFLVKDVRELAATVKKAFFIARTGRPGPVLIDIPK
CCHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEECCC
DVSKMPCEYAPVKNVSLRSYNPVTKGHSGQIRKAVSLLLSAKRPYIYTGGGVILAEAARE
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCEEHHHHHHH
LNQFADLLGYPVTNTLMGLGGYRASDPKFLGMLGMHGTYEANMAMQHCDVLIAIGARFDD
HHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCEEEEECCCCCC
RVIGDPAHFSSRPRKIIHIDIDPSSISKRVKVDIPIVGDVKEVLKELIEQLQTAEHGPDT
CCCCCCHHCCCCCCEEEEEECCHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCH
EALAQWWKDIEGWRAKDCLKYDRESEIIKPQHVVETLWRLTGGNAYVCSDVGQHQMWAAQ
HHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FYRFDKPRRWINSGGLGTMGFGLPAAMGVKMAHPDDDVVCITGEGSIQMCIQELSTCKQY
HHHCCCCHHHHCCCCCCCCCCCCHHHHCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHC
DTPVKIISLNNRYLGMVRQWQQIEYSKRYSHSYMDALPDFVKLAEAFGHVGMRIEKTADV
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
EPALKEALRLKDRTVFLDFQTDPTENVWPMVQAGKGITEMLLGSEDL
CHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCHHHHHCCCCCC
>Mature Secondary Structure
MNMPSAEFSTSEPVSAPSSDSIGATVLMKALADENVEFIWGYPGGSVLYIYDELYKQDKV
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEHHHHHHHHH
QHVLVRHEQAAVHAADAYARSTGNVGCCLVTSGPGVTNAVTGIATAYMDSVPLVVISGQV
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEECCC
PTAAIGQDAFQECDTVGITRPCVKHNFLVKDVRELAATVKKAFFIARTGRPGPVLIDIPK
CCHHHCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCEEEECCC
DVSKMPCEYAPVKNVSLRSYNPVTKGHSGQIRKAVSLLLSAKRPYIYTGGGVILAEAARE
CHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCEEHHHHHHH
LNQFADLLGYPVTNTLMGLGGYRASDPKFLGMLGMHGTYEANMAMQHCDVLIAIGARFDD
HHHHHHHHCCCHHHHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHHCCEEEEECCCCCC
RVIGDPAHFSSRPRKIIHIDIDPSSISKRVKVDIPIVGDVKEVLKELIEQLQTAEHGPDT
CCCCCCHHCCCCCCEEEEEECCHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCH
EALAQWWKDIEGWRAKDCLKYDRESEIIKPQHVVETLWRLTGGNAYVCSDVGQHQMWAAQ
HHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHH
FYRFDKPRRWINSGGLGTMGFGLPAAMGVKMAHPDDDVVCITGEGSIQMCIQELSTCKQY
HHHCCCCHHHHCCCCCCCCCCCCHHHHCEEEECCCCCEEEEECCCHHHHHHHHHHHHHHC
DTPVKIISLNNRYLGMVRQWQQIEYSKRYSHSYMDALPDFVKLAEAFGHVGMRIEKTADV
CCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCC
EPALKEALRLKDRTVFLDFQTDPTENVWPMVQAGKGITEMLLGSEDL
CHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHCCCCHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]