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The map label for this gene is cobW [H]

Identifier: 238027450

GI number: 238027450

Start: 2030734

End: 2031801

Strand: Reverse

Name: cobW [H]

Synonym: bglu_1g18530

Alternate gene names: 238027450

Gene position: 2031801-2030734 (Counterclockwise)

Preceding gene: 238027454

Following gene: 238027449

Centisome position: 52.01

GC content: 69.01

Gene sequence:

>1068_bases
ATGCAAATGCGCAAAATTCCCGTGACCGTCGTCACGGGCTTCCTCGGCAGCGGCAAGACCACGCTGCTGCGTCACATTCT
CGAGAACGCGTCGGGCCGCCGGATCGCGGTGATCGTCAACGAATTCGGCGAACTCGGCATCGACGGCGAGATCCTGAAGG
GATGCGGCATCGGCTGCGAAGAGGGCGCGGAAGCGGCCGGCCAGCTCTACGAGCTCGCCAACGGCTGCCTGTGCTGCACG
GTGCAGGAGGAGTTCTATCCGGTGATGGAGGCGCTGGTCGAGCGCCGCGCCGAGATCGATCACGTGCTGATCGAGACCTC
GGGCCTCGCGCTGCCCAAGCCGCTCGTGCAGGCGTTCAACTGGCCGTCGATCAAGAACAGTTTTACCTGCGACGCGGTGC
TGACCGTGGTGGACGGCCCGGCCACCGCGGCCGGCCAGTTCGCCGACAACCCCGACGCCGTGGACGAGCAGCGCCGCGCC
GATCCGAACCTCGATCACGAATCGCCGCTGCACGAGCTGTTCGCCGACCAGCTCTCGTCGGCCGACCTGGTGATCGTCAA
CAAGACCGACCTGCTCGACGAGGCGCAATTCGCCTCGGTCGAGGCCACGATCCGCGAGGAAATCCCGGCCCACGTGAAGA
TCGTGCGGGCGCAGCGCGGCGAGCTCGACCTGGCCACGCTGATCGGCCTGAACGCGGCCTCGGAGGACAGCATCCACCTG
CGCCACGATCATCACGGCTCGGCCGACGACGCCGATCACCACCACGACGAGTTCGACTCGGTGGTGGTGCAGGCGCGCGT
GAGCTCGCGCGAGGCGACCGTCGCCGCGCTGCGCGCGCTGGTGGACGGCCACACGATCTACCGCGTGAAGGGCTTCGCGG
TGCTGCCCGGCACGCCGATGCGGCTGGTGATCCAGGGCGTGGGCGGACGCTTCGACAGCTACTTCGACCGCCGGCTGCGG
GACGGCGAGGACGAGGTCAGCCGCTTCGTGCTGATCGGCGAGGATCTCGACGCGGCCGCGCTGCAGCGCGCCTTCACGGC
CGCGCTCGGCGCCGCCCAGCCGGCCTGA

Upstream 100 bases:

>100_bases
CGGCGCGCTGTCCCGGGCCGCCGGCGTGGCGGCCCGTTTGCGATCGCTCCTGCCACGCGCCGATGGCATCATCCACCGAC
TCACCGACGGAATCCTTCCC

Downstream 100 bases:

>100_bases
CGCGCCGCGCGCCGCCATGCATCTGCTGCGCACCACCCCGGGCGGCTTCGTCGACGACACGCAGGGCGTGATCCGGATCG
ACCAGCGCCCCGCCGAGATC

Product: cobalamin biosynthesis protein CobW

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MQMRKIPVTVVTGFLGSGKTTLLRHILENASGRRIAVIVNEFGELGIDGEILKGCGIGCEEGAEAAGQLYELANGCLCCT
VQEEFYPVMEALVERRAEIDHVLIETSGLALPKPLVQAFNWPSIKNSFTCDAVLTVVDGPATAAGQFADNPDAVDEQRRA
DPNLDHESPLHELFADQLSSADLVIVNKTDLLDEAQFASVEATIREEIPAHVKIVRAQRGELDLATLIGLNAASEDSIHL
RHDHHGSADDADHHHDEFDSVVVQARVSSREATVAALRALVDGHTIYRVKGFAVLPGTPMRLVIQGVGGRFDSYFDRRLR
DGEDEVSRFVLIGEDLDAAALQRAFTAALGAAQPA

Sequences:

>Translated_355_residues
MQMRKIPVTVVTGFLGSGKTTLLRHILENASGRRIAVIVNEFGELGIDGEILKGCGIGCEEGAEAAGQLYELANGCLCCT
VQEEFYPVMEALVERRAEIDHVLIETSGLALPKPLVQAFNWPSIKNSFTCDAVLTVVDGPATAAGQFADNPDAVDEQRRA
DPNLDHESPLHELFADQLSSADLVIVNKTDLLDEAQFASVEATIREEIPAHVKIVRAQRGELDLATLIGLNAASEDSIHL
RHDHHGSADDADHHHDEFDSVVVQARVSSREATVAALRALVDGHTIYRVKGFAVLPGTPMRLVIQGVGGRFDSYFDRRLR
DGEDEVSRFVLIGEDLDAAALQRAFTAALGAAQPA
>Mature_355_residues
MQMRKIPVTVVTGFLGSGKTTLLRHILENASGRRIAVIVNEFGELGIDGEILKGCGIGCEEGAEAAGQLYELANGCLCCT
VQEEFYPVMEALVERRAEIDHVLIETSGLALPKPLVQAFNWPSIKNSFTCDAVLTVVDGPATAAGQFADNPDAVDEQRRA
DPNLDHESPLHELFADQLSSADLVIVNKTDLLDEAQFASVEATIREEIPAHVKIVRAQRGELDLATLIGLNAASEDSIHL
RHDHHGSADDADHHHDEFDSVVVQARVSSREATVAALRALVDGHTIYRVKGFAVLPGTPMRLVIQGVGGRFDSYFDRRLR
DGEDEVSRFVLIGEDLDAAALQRAFTAALGAAQPA

Specific function: Might be involved in cobalt reduction leading to cobalt(I) corrinoids [H]

COG id: COG0523

COG function: function code R; Putative GTPases (G3E family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cobW C-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI33469141, Length=361, Percent_Identity=29.0858725761773, Blast_Score=146, Evalue=2e-35,
Organism=Homo sapiens, GI126722884, Length=361, Percent_Identity=28.808864265928, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI148727351, Length=361, Percent_Identity=28.808864265928, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI223941779, Length=354, Percent_Identity=29.0960451977401, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI146231952, Length=361, Percent_Identity=28.5318559556787, Blast_Score=138, Evalue=6e-33,
Organism=Homo sapiens, GI223941776, Length=362, Percent_Identity=27.3480662983425, Blast_Score=125, Evalue=5e-29,
Organism=Homo sapiens, GI119120938, Length=159, Percent_Identity=36.4779874213836, Blast_Score=104, Evalue=1e-22,
Organism=Escherichia coli, GI87082430, Length=353, Percent_Identity=29.1784702549575, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1788499, Length=184, Percent_Identity=32.6086956521739, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324356, Length=379, Percent_Identity=26.1213720316623, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012824
- InterPro:   IPR003495
- InterPro:   IPR011629 [H]

Pfam domain/function: PF02492 cobW; PF07683 CobW_C [H]

EC number: NA

Molecular weight: Translated: 38375; Mature: 38375

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQMRKIPVTVVTGFLGSGKTTLLRHILENASGRRIAVIVNEFGELGIDGEILKGCGIGCE
CCCCCCCHHHEEECCCCCHHHHHHHHHHCCCCCEEEEEEECHHCCCCCCHHHHHCCCCCH
EGAEAAGQLYELANGCLCCTVQEEFYPVMEALVERRAEIDHVLIETSGLALPKPLVQAFN
HHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHCC
WPSIKNSFTCDAVLTVVDGPATAAGQFADNPDAVDEQRRADPNLDHESPLHELFADQLSS
CCCCCCCCCHHEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCC
ADLVIVNKTDLLDEAQFASVEATIREEIPAHVKIVRAQRGELDLATLIGLNAASEDSIHL
CCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEHHEECCCCCCCCEEE
RHDHHGSADDADHHHDEFDSVVVQARVSSREATVAALRALVDGHTIYRVKGFAVLPGTPM
EECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
RLVIQGVGGRFDSYFDRRLRDGEDEVSRFVLIGEDLDAAALQRAFTAALGAAQPA
EEEEECCCCCHHHHHHHHHCCCHHHHCEEEEECCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQMRKIPVTVVTGFLGSGKTTLLRHILENASGRRIAVIVNEFGELGIDGEILKGCGIGCE
CCCCCCCHHHEEECCCCCHHHHHHHHHHCCCCCEEEEEEECHHCCCCCCHHHHHCCCCCH
EGAEAAGQLYELANGCLCCTVQEEFYPVMEALVERRAEIDHVLIETSGLALPKPLVQAFN
HHHHHHHHHHHHHCCEEEEEEHHHHHHHHHHHHHHHHHHCEEEEECCCCCCCHHHHHHCC
WPSIKNSFTCDAVLTVVDGPATAAGQFADNPDAVDEQRRADPNLDHESPLHELFADQLSS
CCCCCCCCCHHEEEEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHCCC
ADLVIVNKTDLLDEAQFASVEATIREEIPAHVKIVRAQRGELDLATLIGLNAASEDSIHL
CCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEHHEECCCCCCCCEEE
RHDHHGSADDADHHHDEFDSVVVQARVSSREATVAALRALVDGHTIYRVKGFAVLPGTPM
EECCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEEEEEEEEECCCCCC
RLVIQGVGGRFDSYFDRRLRDGEDEVSRFVLIGEDLDAAALQRAFTAALGAAQPA
EEEEECCCCCHHHHHHHHHCCCHHHHCEEEEECCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]