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The map label for this gene is dmlR [H]

Identifier: 238027015

GI number: 238027015

Start: 1535463

End: 1536374

Strand: Direct

Name: dmlR [H]

Synonym: bglu_1g13930

Alternate gene names: 238027015

Gene position: 1535463-1536374 (Clockwise)

Preceding gene: 238027011

Following gene: 238027016

Centisome position: 39.31

GC content: 70.18

Gene sequence:

>912_bases
ATGGACCGCTTCAAGCAGATCGAGACGTTCGTGCGGGTGGCCGACGCGGGCAGTCTGGCCGCGGCGGCGCTCGAGGAGGG
GGTGTCGCCCGTCGTGCTGGGGCGGCGCATCGACGCGCTGGAGAAGCGCCTCGGCGTGAAGCTGATGTATCGCTCGACGC
GGCGGCTGGTGGTGAGCGAGGACGGCGCCGCGTTCCTCGAGCGCTGCCGCGGGCTGCTCGGCGACTGGCACCAGGCCGAG
AACGAACTCGCGGCCGGGCGCCGCGCGGTGAGCGGGCACCTGATCGTCTCGGCGCCGGCCGCGTTCGGCCGCAAGCACCT
CGCGCCGCTCGCGCCGGCCTTCGTCGCCGACAAGCCGGACCTGCAGCTCTCGTTCAACCTGACCGACCGCGTCGTGGATC
TGGTCCGCGAGGGCTACGACCTGTCGATCCGGATCGGCGGCGCGGTCGATCCGAACTTCGTGGCGGTGAAGCTGGCGAGC
AATCGCCGCGTGGTGTGCGGCACGCCTGATTATTTCCGCCGGCACGGGCGCCCGCAGTCGCTCGACGACCTGGCGAGGCA
CAACTGCCTCGCCTTCAACCTGCAAGGGGGACAGAACCGCGGCTGGTATTTCCGGCGCAACGGCAAGCTGGCGACGATCC
GCGTGACGGGCAACCTCGACTGCAACGACGGCGAACTGCTGCACCGCTGGGTCTCGGAAGGGCTTGGGCTCGGCTGGCGG
TCGACCTGGGAAATCGCGCGGCAACTGGAGACGGGCGAGCTCGAAACGGTGCTCGACGACCACGCGCTGCCCGACTACGA
CATCCTCGCCGTCTATCCGCAGCAGCGCTACGTGCCGGCGCGCGTGCGCTATTTCATCGATTACCTGCGCGACGCCTATG
CGCGGCCGGGTTACTGGAGCGCGCCGCGCTGA

Upstream 100 bases:

>100_bases
TTGATAAGATCGCCGCTCGTCGCTTATTTCGAAACTAAAAGTATCGAATGCCGTGTGGACAAGCGTCCGGCGCATCGATC
CAGGCACCGGGAGGCCGCCG

Downstream 100 bases:

>100_bases
CGCTGCCGCATGCCCGGCCGCCGCGGCGGACTCGGCCCGGCCCTCAAGTCGTTGAAAACACGGCCGATTCGGCGAACCGA
CGACGTGAAACCATTGCGCG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: D-malate degradation protein R [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MDRFKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSEDGAAFLERCRGLLGDWHQAE
NELAAGRRAVSGHLIVSAPAAFGRKHLAPLAPAFVADKPDLQLSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLAS
NRRVVCGTPDYFRRHGRPQSLDDLARHNCLAFNLQGGQNRGWYFRRNGKLATIRVTGNLDCNDGELLHRWVSEGLGLGWR
STWEIARQLETGELETVLDDHALPDYDILAVYPQQRYVPARVRYFIDYLRDAYARPGYWSAPR

Sequences:

>Translated_303_residues
MDRFKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSEDGAAFLERCRGLLGDWHQAE
NELAAGRRAVSGHLIVSAPAAFGRKHLAPLAPAFVADKPDLQLSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLAS
NRRVVCGTPDYFRRHGRPQSLDDLARHNCLAFNLQGGQNRGWYFRRNGKLATIRVTGNLDCNDGELLHRWVSEGLGLGWR
STWEIARQLETGELETVLDDHALPDYDILAVYPQQRYVPARVRYFIDYLRDAYARPGYWSAPR
>Mature_303_residues
MDRFKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSEDGAAFLERCRGLLGDWHQAE
NELAAGRRAVSGHLIVSAPAAFGRKHLAPLAPAFVADKPDLQLSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLAS
NRRVVCGTPDYFRRHGRPQSLDDLARHNCLAFNLQGGQNRGWYFRRNGKLATIRVTGNLDCNDGELLHRWVSEGLGLGWR
STWEIARQLETGELETVLDDHALPDYDILAVYPQQRYVPARVRYFIDYLRDAYARPGYWSAPR

Specific function: Transcriptional regulator required for the aerobic growth on D-malate as the sole carbon source. Induces the expression of dmlA in response to D-malate or L- or meso-tartrate. Negatively regulates its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081978, Length=291, Percent_Identity=36.426116838488, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1789440, Length=285, Percent_Identity=30.8771929824561, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=30.9027777777778, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1787128, Length=283, Percent_Identity=30.0353356890459, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789639, Length=297, Percent_Identity=25.9259259259259, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI145693193, Length=293, Percent_Identity=28.3276450511945, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1787589, Length=286, Percent_Identity=27.6223776223776, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1790011, Length=298, Percent_Identity=20.8053691275168, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34015; Mature: 34015

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRFKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSE
CCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHCEEEEEECCCEEEEEC
DGAAFLERCRGLLGDWHQAENELAAGRRAVSGHLIVSAPAAFGRKHLAPLAPAFVADKPD
CCHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCCEEEECCHHHCHHHCCCCCHHHHCCCCC
LQLSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLASNRRVVCGTPDYFRRHGRPQS
CEEEECHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCEEEECCCHHHHHCCCCCC
LDDLARHNCLAFNLQGGQNRGWYFRRNGKLATIRVTGNLDCNDGELLHRWVSEGLGLGWR
HHHHHHCCEEEEEECCCCCCCEEEEECCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCH
STWEIARQLETGELETVLDDHALPDYDILAVYPQQRYVPARVRYFIDYLRDAYARPGYWS
HHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
APR
CCC
>Mature Secondary Structure
MDRFKQIETFVRVADAGSLAAAALEEGVSPVVLGRRIDALEKRLGVKLMYRSTRRLVVSE
CCHHHHHHHHHHHHCCCHHHHHHHHHCCCCEEHHHHHHHHHHHHCEEEEEECCCEEEEEC
DGAAFLERCRGLLGDWHQAENELAAGRRAVSGHLIVSAPAAFGRKHLAPLAPAFVADKPD
CCHHHHHHHHHHHCCHHHHHHHHHHCCHHHCCCEEEECCHHHCHHHCCCCCHHHHCCCCC
LQLSFNLTDRVVDLVREGYDLSIRIGGAVDPNFVAVKLASNRRVVCGTPDYFRRHGRPQS
CEEEECHHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCEEEECCCHHHHHCCCCCC
LDDLARHNCLAFNLQGGQNRGWYFRRNGKLATIRVTGNLDCNDGELLHRWVSEGLGLGWR
HHHHHHCCEEEEEECCCCCCCEEEEECCEEEEEEEEECCCCCCHHHHHHHHHHHCCCCCH
STWEIARQLETGELETVLDDHALPDYDILAVYPQQRYVPARVRYFIDYLRDAYARPGYWS
HHHHHHHHHCCCCHHHHHHHCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
APR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]