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The map label for this gene is guaA [H]

Identifier: 238026928

GI number: 238026928

Start: 1421794

End: 1423413

Strand: Direct

Name: guaA [H]

Synonym: bglu_1g13000

Alternate gene names: 238026928

Gene position: 1421794-1423413 (Clockwise)

Preceding gene: 238026927

Following gene: 238026929

Centisome position: 36.4

GC content: 66.23

Gene sequence:

>1620_bases
ATGCACGACAAAATCCTGATCCTCGACTTCGGTTCGCAAGTCACCCAACTGATTGCGCGGCGGGTTCGCGAAGCGCACGT
CTATTGCGAGATTCATCCGAACGATGTCAGCGACGAATTCGTCCGCGAGTTCGCGCCGAAGGGCGTGATCCTGTCGGGCA
GCCATGCGAGCACCTACGAGGACCACCAGCTGCGCGCGCCGCAGGCCGTCTGGGATCTCGGGGTGCCGGTGCTCGGCATC
TGCTACGGGATGCAGACCATGGCCGTGCAGCTCGGCGGCAAGGTGGAGTGGAGCGATCACCGCGAATTCGGCTATGCCGA
AGTGCGCGCCCATGGCCACACGCGCCTGCTCGACGGCATCGAGGATTTCCGTACCGAGGAAGGCCACGGCATGCTGAAGG
TGTGGATGAGTCACGGCGACAAGGTGGGCGAGCTGCCGCCCGGCTTCAAGCTGATGGCGTCCACGCCGAGCTGCCCGATC
GCCGCGATGGCCGACGAGGCGCGCGGCTATTACGCCGTGCAGTTCCATCCGGAAGTGACGCATACCGTGAAGGGCCGCCA
GCTGCTCGAGCGCTTCGTGCTCGAGATCGCTGCCGCCAAGCCGGACTGGGTGATGCGCGACCATATCGAGGAGGCCGTCG
CGCTGATTCGCGAGCAGGTGGGCAGCGAGGAGGTGATCCTCGGCCTGTCGGGCGGCGTGGATTCGAGCGTGGCCGCGGCG
CTGATCCATCGCGCGATCGGCGACCAGCTCACCTGCGTGTTCGTCGACCATGGCCTGCTGCGCCTGAACGAAGGGCAAAT
GGTGCTCGACATGTTCGCAGGGCGGCTGCATGCGAAGGTCGTCCACGTCGACGCGTCGGAGCAGTTCCTCGGCCAGCTGG
CCGGCGTGACCGACCCGGAGGCGAAGCGCAAGATCATCGGCCGCGAGTTCGTCGAGGTGTTTCAGGCCGAGGCGAGGAAG
CTCGGCAACGCGAAGTGGCTCGCGCAGGGCACGATCTACCCGGACGTGATCGAATCGGGCGGCGCGAAGACGAAGAAGGC
GACGACGATCAAGAGCCACCACAACGTGGGCGGGCTGCCCGAGACGCTGGGGCTGAAACTGCTCGAACCGCTGCGCGACC
TGTTCAAGGACGAGGTGCGCGAGCTGGGCGTGGCGCTCGGCCTGCCGCCCGAGATGGTGTATCGCCATCCGTTCCCGGGG
CCGGGCCTGGGGGTGCGGATCCTGGGCGAGGTGAAGCGCGATTACGCGGACCTGCTGCGCCGCGCCGACGCGATCTTCAT
CGAGGAACTGCGCGGCACGATCGCGAACGAGCAGGATGCGGCGGCGGGGATCTGCGAGGCGTCGCAGGTCGGAAAGTCGT
GGTATGACCTCACCAGCCAGGCGTTCGCGGTGTTCCTGCCGGTGAAGTCGGTGGGGGTGATGGGGGACGGGCGCACCTAC
GACTACGTGACCGCGCTGCGCGCGGTGCAGACCACCGACTTCATGACGGCGCATTGGGCACATCTGCCGTATGCGCTGCT
GGGGCGCGTTTCGAATCGCATCATCAACGAGGTTCGGGGCATCAATCGGGTGGTTTATGACGTGTCGGGGAAGCCGCCGG
CGACGATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
GGGCGCTTGCCGGGCATGGCGCCCGGACCATTTTCCGACTCAGATGCAGCGCCGCGTGCGCTGCTTTTCTTACCTGCCTG
TACTCATCCCGTAGCCTGCC

Downstream 100 bases:

>100_bases
GCCCCAGCCCGCCGAGCCGGCACGGCTCGATGCCCGCAGGGGCCGATGCCACGCATTCCCGCCGGCCCCCGCGCATCGGT
TCCGCACCGCTGTCGGCAGC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGIEDFRTEEGHGMLKVWMSHGDKVGELPPGFKLMASTPSCPI
AAMADEARGYYAVQFHPEVTHTVKGRQLLERFVLEIAAAKPDWVMRDHIEEAVALIREQVGSEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFAGRLHAKVVHVDASEQFLGQLAGVTDPEAKRKIIGREFVEVFQAEARK
LGNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKRDYADLLRRADAIFIEELRGTIANEQDAAAGICEASQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKPPATIEWE

Sequences:

>Translated_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGIEDFRTEEGHGMLKVWMSHGDKVGELPPGFKLMASTPSCPI
AAMADEARGYYAVQFHPEVTHTVKGRQLLERFVLEIAAAKPDWVMRDHIEEAVALIREQVGSEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFAGRLHAKVVHVDASEQFLGQLAGVTDPEAKRKIIGREFVEVFQAEARK
LGNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKRDYADLLRRADAIFIEELRGTIANEQDAAAGICEASQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKPPATIEWE
>Mature_539_residues
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKGVILSGSHASTYEDHQLRAPQAVWDLGVPVLGI
CYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGIEDFRTEEGHGMLKVWMSHGDKVGELPPGFKLMASTPSCPI
AAMADEARGYYAVQFHPEVTHTVKGRQLLERFVLEIAAAKPDWVMRDHIEEAVALIREQVGSEEVILGLSGGVDSSVAAA
LIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFAGRLHAKVVHVDASEQFLGQLAGVTDPEAKRKIIGREFVEVFQAEARK
LGNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLPETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPG
PGLGVRILGEVKRDYADLLRRADAIFIEELRGTIANEQDAAAGICEASQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain [H]

Homologues:

Organism=Homo sapiens, GI4504035, Length=563, Percent_Identity=34.2806394316163, Blast_Score=271, Evalue=8e-73,
Organism=Escherichia coli, GI1788854, Length=536, Percent_Identity=63.9925373134328, Blast_Score=689, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71992717, Length=580, Percent_Identity=34.8275862068965, Blast_Score=284, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=580, Percent_Identity=34.8275862068965, Blast_Score=284, Evalue=9e-77,
Organism=Caenorhabditis elegans, GI71992710, Length=580, Percent_Identity=34.8275862068965, Blast_Score=284, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6323873, Length=548, Percent_Identity=47.8102189781022, Blast_Score=495, Evalue=1e-141,
Organism=Drosophila melanogaster, GI281365319, Length=560, Percent_Identity=35.8928571428571, Blast_Score=292, Evalue=4e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 59470; Mature: 59470

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKGVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCHHHHHHH
EDFRTEEGHGMLKVWMSHGDKVGELPPGFKLMASTPSCPIAAMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHCCCCEEEEEECCCHH
HTVKGRQLLERFVLEIAAAKPDWVMRDHIEEAVALIREQVGSEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFAGRLHAKVVHVDASEQFLGQLAGVTDPE
HHHHHHCCCEEEEEEECCEEEECCCCCHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCH
AKRKIIGREFVEVFQAEARKLGNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCCCCHHHEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKRDYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRGTIANEQDAAAGICEASQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEECC
>Mature Secondary Structure
MHDKILILDFGSQVTQLIARRVREAHVYCEIHPNDVSDEFVREFAPKGVILSGSHASTYE
CCCCEEEEECCHHHHHHHHHHHHHCEEEEEECCCCCCHHHHHHHCCCCEEEECCCCCCCC
DHQLRAPQAVWDLGVPVLGICYGMQTMAVQLGGKVEWSDHREFGYAEVRAHGHTRLLDGI
CCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHCCCHHHHHHH
EDFRTEEGHGMLKVWMSHGDKVGELPPGFKLMASTPSCPIAAMADEARGYYAVQFHPEVT
HHHCCCCCCCEEEEEECCCCCCCCCCCCCEEEECCCCCCCHHHHHCCCCEEEEEECCCHH
HTVKGRQLLERFVLEIAAAKPDWVMRDHIEEAVALIREQVGSEEVILGLSGGVDSSVAAA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHH
LIHRAIGDQLTCVFVDHGLLRLNEGQMVLDMFAGRLHAKVVHVDASEQFLGQLAGVTDPE
HHHHHHCCCEEEEEEECCEEEECCCCCHHHHHHCCCEEEEEEECCHHHHHHHHCCCCCCH
AKRKIIGREFVEVFQAEARKLGNAKWLAQGTIYPDVIESGGAKTKKATTIKSHHNVGGLP
HHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCCCCCHHHEECCCCCCCCCC
ETLGLKLLEPLRDLFKDEVRELGVALGLPPEMVYRHPFPGPGLGVRILGEVKRDYADLLR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHH
RADAIFIEELRGTIANEQDAAAGICEASQVGKSWYDLTSQAFAVFLPVKSVGVMGDGRTY
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCHHHHHHHHHHEEEEEEHHHHCCCCCCCCH
DYVTALRAVQTTDFMTAHWAHLPYALLGRVSNRIINEVRGINRVVYDVSGKPPATIEWE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA