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The map label for this gene is cusC [C]

Identifier: 238026853

GI number: 238026853

Start: 1326920

End: 1328386

Strand: Direct

Name: cusC [C]

Synonym: bglu_1g12190

Alternate gene names: 238026853

Gene position: 1326920-1328386 (Clockwise)

Preceding gene: 238026852

Following gene: 238026854

Centisome position: 33.97

GC content: 63.8

Gene sequence:

>1467_bases
ATGTCACGATTCACCATGCTTGTCTTGTCGATTGCCTCGCTGGGCGTTGCGGGATGCGGGACGCTGACGCGCACGGCATG
GACGCAGCCGGAGCTTACGGTTCCACCGCATTGGCAGGCAGGGGCCGCCGCCGCAGGGGGGACAGCTGCGTCCGCGACAG
CTGGGAATCCCTATACGCAGCGTGACGCTCCCGGCTCGTCCAAGCCTCTGCCGGCGGAGGCCGAAGCGAAGTCGGGCAGT
GACGCGGACATCGACCCCTGGTGGCAGGCATTTGGCGATCCGGAACTGAGCCGGCTTGTCGAACGGGCTTTGGCCGGCAA
TCATGATCTGAAGACGGCGGTCGCCAACCTGCGCGCGGCGCAATTCGCCGTCGATCTCGCACGCGCGAATCAATTGCCCG
CGATTAGCGCAAGTGCGGGACTGTCGAATTCTCACTCGCTGCGCGGCACGCAAGTCGCGTCACATGCGAAATCACTTCTC
GCATCGGCCAGCTATGTCGTCGACTTGTGGGGGACACTGGCGAGTTCGGTCGACGCAGCACGCTGGGAGAAACAGGCAAC
CGAGCAGGACGAACGGACCGTCGAGATGGCCGTCGCATCGTCGGTTGCCGGCGACTACTGGTTACTCGCCCTGCTAACCG
AGCAGATCGAACAGAGCGACGCGTCGATTCGTTACGGCGAACAGACCCTGGCGTTGGCGAATGCCCGGTATACGTCGGGC
GCGGTGGCCGCGGTGGATCTGCTAGCCGCTCGTCGATCGCTCGCGTCGCTACGCGCGTCGCGCTATGTTCTGCTGGCGCA
GCAAACACAAGCTGAAAATGCGCTTGCCATCCTGCTCGGTCAACCACCGGGCGAAGTCTTCGCGGTTTCTTCGGCGCGGC
TGATGACTCCGCTGCCCGCCGTTTCTCCGGGGGTGCCAGCCTCCGTACTCGCTCGCCGTCCGGACGTGAAGGCGGCGGAA
TTGCGAACGCGAAGCACGCTCGCGAATGTCGATGCGACACGAACCAGCTTTTACCCCAGCTTCACGTTGACGGGCTCGGC
CGGTGCCGCGAGCGACGCGTTGCGCGATTTATTGCAAAACCCGCTCGGTACGATCGCAGCCAATGTCGCAGCCCCGTTTC
TGAATTTCAGGACGATGAAAGCGCGGGTTGGCTCGGCGCAGACAGCCTACGATGCTGCGGCGGTCGCGTTTGCCAAGACG
TTCTATCAGGCGCTCGCCGATGTGGAGAATGCCCTTGCTGCACGTTCCGACTACCAGGCCGAGATCACGCAATGGGCGGA
CGCGCTCGAAGCTGCACGACAAAGCGAGCAGCGCATCGGCTGGCAATACCGCGCAGGCTCCGTACCGCTACAGAACTGGC
TCGACGCGCAGCAGGCGACTCGTGATGCCGATGCCGAACTCGCAAGCGTGCGCTATGCGACTCTCACCAATCAGGTGGCG
CTTTATGTTGCGCTCGGCGGACGCTAG

Upstream 100 bases:

>100_bases
GCCCGGCAGAAGCGCTGACCCGCGAATGAAAAAGCTCCCTCGCTCACCGCATGCGGTTTCGCCACGCACTGTCTCATGGC
GGGTTGGAAGGCCGAAATCG

Downstream 100 bases:

>100_bases
CCTAAAGAACGATTCCATCAAGGCCGCTGAAAGCTGTTGCAGCGGAGGGGAGCGCCTCGTGAATCCGGCATACCGTCCGA
ATTGGATGCGAAGACACCGA

Product: NodT family RND efflux system outer membrane lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSRFTMLVLSIASLGVAGCGTLTRTAWTQPELTVPPHWQAGAAAAGGTAASATAGNPYTQRDAPGSSKPLPAEAEAKSGS
DADIDPWWQAFGDPELSRLVERALAGNHDLKTAVANLRAAQFAVDLARANQLPAISASAGLSNSHSLRGTQVASHAKSLL
ASASYVVDLWGTLASSVDAARWEKQATEQDERTVEMAVASSVAGDYWLLALLTEQIEQSDASIRYGEQTLALANARYTSG
AVAAVDLLAARRSLASLRASRYVLLAQQTQAENALAILLGQPPGEVFAVSSARLMTPLPAVSPGVPASVLARRPDVKAAE
LRTRSTLANVDATRTSFYPSFTLTGSAGAASDALRDLLQNPLGTIAANVAAPFLNFRTMKARVGSAQTAYDAAAVAFAKT
FYQALADVENALAARSDYQAEITQWADALEAARQSEQRIGWQYRAGSVPLQNWLDAQQATRDADAELASVRYATLTNQVA
LYVALGGR

Sequences:

>Translated_488_residues
MSRFTMLVLSIASLGVAGCGTLTRTAWTQPELTVPPHWQAGAAAAGGTAASATAGNPYTQRDAPGSSKPLPAEAEAKSGS
DADIDPWWQAFGDPELSRLVERALAGNHDLKTAVANLRAAQFAVDLARANQLPAISASAGLSNSHSLRGTQVASHAKSLL
ASASYVVDLWGTLASSVDAARWEKQATEQDERTVEMAVASSVAGDYWLLALLTEQIEQSDASIRYGEQTLALANARYTSG
AVAAVDLLAARRSLASLRASRYVLLAQQTQAENALAILLGQPPGEVFAVSSARLMTPLPAVSPGVPASVLARRPDVKAAE
LRTRSTLANVDATRTSFYPSFTLTGSAGAASDALRDLLQNPLGTIAANVAAPFLNFRTMKARVGSAQTAYDAAAVAFAKT
FYQALADVENALAARSDYQAEITQWADALEAARQSEQRIGWQYRAGSVPLQNWLDAQQATRDADAELASVRYATLTNQVA
LYVALGGR
>Mature_487_residues
SRFTMLVLSIASLGVAGCGTLTRTAWTQPELTVPPHWQAGAAAAGGTAASATAGNPYTQRDAPGSSKPLPAEAEAKSGSD
ADIDPWWQAFGDPELSRLVERALAGNHDLKTAVANLRAAQFAVDLARANQLPAISASAGLSNSHSLRGTQVASHAKSLLA
SASYVVDLWGTLASSVDAARWEKQATEQDERTVEMAVASSVAGDYWLLALLTEQIEQSDASIRYGEQTLALANARYTSGA
VAAVDLLAARRSLASLRASRYVLLAQQTQAENALAILLGQPPGEVFAVSSARLMTPLPAVSPGVPASVLARRPDVKAAEL
RTRSTLANVDATRTSFYPSFTLTGSAGAASDALRDLLQNPLGTIAANVAAPFLNFRTMKARVGSAQTAYDAAAVAFAKTF
YQALADVENALAARSDYQAEITQWADALEAARQSEQRIGWQYRAGSVPLQNWLDAQQATRDADAELASVRYATLTNQVAL
YVALGGR

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=408, Percent_Identity=27.6960784313726, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI2367348, Length=298, Percent_Identity=27.1812080536913, Blast_Score=77, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 51346; Mature: 51215

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRFTMLVLSIASLGVAGCGTLTRTAWTQPELTVPPHWQAGAAAAGGTAASATAGNPYTQ
CCHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RDAPGSSKPLPAEAEAKSGSDADIDPWWQAFGDPELSRLVERALAGNHDLKTAVANLRAA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
QFAVDLARANQLPAISASAGLSNSHSLRGTQVASHAKSLLASASYVVDLWGTLASSVDAA
HHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWEKQATEQDERTVEMAVASSVAGDYWLLALLTEQIEQSDASIRYGEQTLALANARYTSG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCHHHEECCCCCCCC
AVAAVDLLAARRSLASLRASRYVLLAQQTQAENALAILLGQPPGEVFAVSSARLMTPLPA
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEECCCCCEEEECCCHHHCCCCC
VSPGVPASVLARRPDVKAAELRTRSTLANVDATRTSFYPSFTLTGSAGAASDALRDLLQN
CCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCHHHHHHHHHHC
PLGTIAANVAAPFLNFRTMKARVGSAQTAYDAAAVAFAKTFYQALADVENALAARSDYQA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
EITQWADALEAARQSEQRIGWQYRAGSVPLQNWLDAQQATRDADAELASVRYATLTNQVA
HHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEE
LYVALGGR
EEEEECCC
>Mature Secondary Structure 
SRFTMLVLSIASLGVAGCGTLTRTAWTQPELTVPPHWQAGAAAAGGTAASATAGNPYTQ
CHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RDAPGSSKPLPAEAEAKSGSDADIDPWWQAFGDPELSRLVERALAGNHDLKTAVANLRAA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHH
QFAVDLARANQLPAISASAGLSNSHSLRGTQVASHAKSLLASASYVVDLWGTLASSVDAA
HHHHHHHHCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RWEKQATEQDERTVEMAVASSVAGDYWLLALLTEQIEQSDASIRYGEQTLALANARYTSG
HHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCHHHEECCCCCCCC
AVAAVDLLAARRSLASLRASRYVLLAQQTQAENALAILLGQPPGEVFAVSSARLMTPLPA
HHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCEEEEEEECCCCCEEEECCCHHHCCCCC
VSPGVPASVLARRPDVKAAELRTRSTLANVDATRTSFYPSFTLTGSAGAASDALRDLLQN
CCCCCCHHHHHCCCCCCHHHHHHHHHHHCCCCHHHCCCCCEEEECCCCCHHHHHHHHHHC
PLGTIAANVAAPFLNFRTMKARVGSAQTAYDAAAVAFAKTFYQALADVENALAARSDYQA
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
EITQWADALEAARQSEQRIGWQYRAGSVPLQNWLDAQQATRDADAELASVRYATLTNQVA
HHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEE
LYVALGGR
EEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]