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The map label for this gene is mmlH [H]

Identifier: 238025234

GI number: 238025234

Start: 2375961

End: 2377259

Strand: Reverse

Name: mmlH [H]

Synonym: bglu_2g19060

Alternate gene names: 238025234

Gene position: 2377259-2375961 (Counterclockwise)

Preceding gene: 238025239

Following gene: 238025233

Centisome position: 84.08

GC content: 71.67

Gene sequence:

>1299_bases
ATGCGCTGGTACCGGGACATCCCACCCGCCGAGAAACGCACGCTCCGGGCCTGCTTCGCGGGCTGGGCGGTGGACGCGGC
CGATACGCAGATCTTTTCGCTGGTGATCCCGACGCTGCTGACGGTATGGGGCATCAGCAAGGGGCAGGCCGGCCTGATCG
GCGGCGCCACGCTGGTGGCCGGCGCGCTGGGCGGGCTGCTGGCCGGCATGCTGTCGGATCGGGTGGGCCGCGTGCGCGCG
CTGCAGGTCACCGTGCTCTGGTTTTCGCTGTTCACCTTCCTGAGCGCGTTCGCGCAGAACTTCGAGCAGTTGCTCGCGCT
GAAGGCGCTGCAGGGCATCGGCTTCGGCGGCGAATGGACGGCCGGTGCGGTGCTGCTCAGCGAAACCATCGACGCGCGGC
ATCGCGGCAAGGCGATGGGCATCGTGCAGAGCGCCTGGGGCTTCGGCTGGGGCGCCGCGGTGCTGCTCTATACGGCGATG
TTCTCGTTCGTCTCGCAGGAGTGGGCGTGGCGGCTGCTGTTCGCGGTGGGCGTGGCGCCCGCGCTGCTGGTGCTGTATCT
GCGCCGCAAGGTGGCCGAGCCGCCGCGCGAGCGGGCCGCCGCGCGCGAGGCCGGGCGGCCCGGCGTGCTGGCGACGGCGG
CCGGCATCTTCGCGCCGGCGGTGCTGCGCACGACGGTGGTGGGCGGGCTGATCGGGCTGGGCGCGCATGGCGGCTATTAC
GCGGTCACCACCTGGCTGCCGACCTACCTGAAGACCGAGCGCCATCTGTCGGTGCTCGGCACGGGCGGCTACCTGGCGGT
GGTGATCGTCGCGTTCATCGCCGGCTGCTTCGCGAGCGCCTGGCTGCAGGACCGCATCGGCCGCCGCCGGACCGTGATCG
TGTTCGCGATCGGCTGCACGGTGATGGTCAATCTCTACACGCGCCTGCCGATCGGTGACACCGCCATGCTGATCCTGAGC
TTCCCGCTTGGGCTGCTTTCGGCCGGCATCCCGGCCGCGCTCGGCGCGCTGTTCAACGAACTCTATCCGCAGGGCGTGCG
CGGCACCGGCGTGGGTTTTTGCTACAACTTCGGGCGCATCGTCTCGGCCGGCTTTCCGGTCCTGATCGGCCACATGAGCA
GCACGATGTCGCTCGGCACCGCGCTTGGCATCGATGCCGGCCTGGCCTATGGGCTGGTCGTGGTCGCCGCGCTGCTGCTG
CCCGAGACGCGCGGGCGCCGCATCGCCGCGCCGCTGCCCGGCGGCTCGCGCGCCGGCCCGCAAGGCGCGAGCCCCGCCAC
GCCGGTCGAACCCACCTGA

Upstream 100 bases:

>100_bases
ATAGTATGCACGGCACTGCGTCCCGCACCAGAATGCGTACCATCATTCAATCGCGGTCGGGCGCCGGCGTGCCGCCACGA
TACGCACAAGGAGACGAGTC

Downstream 100 bases:

>100_bases
TCGCGAATACATGAAGACGACGCATCCGGCTTTGCCGCCGCTTGCCGAGGCCGGCCTGTCGGCCGCGGGCGCGGCCTGGC
TCGCCGCCGGCGCGCCGGCC

Product: major facilitator superfamily transporter

Products: Proton [Cytoplasm]; N-acetylneuraminate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 432; Mature: 432

Protein sequence:

>432_residues
MRWYRDIPPAEKRTLRACFAGWAVDAADTQIFSLVIPTLLTVWGISKGQAGLIGGATLVAGALGGLLAGMLSDRVGRVRA
LQVTVLWFSLFTFLSAFAQNFEQLLALKALQGIGFGGEWTAGAVLLSETIDARHRGKAMGIVQSAWGFGWGAAVLLYTAM
FSFVSQEWAWRLLFAVGVAPALLVLYLRRKVAEPPRERAAAREAGRPGVLATAAGIFAPAVLRTTVVGGLIGLGAHGGYY
AVTTWLPTYLKTERHLSVLGTGGYLAVVIVAFIAGCFASAWLQDRIGRRRTVIVFAIGCTVMVNLYTRLPIGDTAMLILS
FPLGLLSAGIPAALGALFNELYPQGVRGTGVGFCYNFGRIVSAGFPVLIGHMSSTMSLGTALGIDAGLAYGLVVVAALLL
PETRGRRIAAPLPGGSRAGPQGASPATPVEPT

Sequences:

>Translated_432_residues
MRWYRDIPPAEKRTLRACFAGWAVDAADTQIFSLVIPTLLTVWGISKGQAGLIGGATLVAGALGGLLAGMLSDRVGRVRA
LQVTVLWFSLFTFLSAFAQNFEQLLALKALQGIGFGGEWTAGAVLLSETIDARHRGKAMGIVQSAWGFGWGAAVLLYTAM
FSFVSQEWAWRLLFAVGVAPALLVLYLRRKVAEPPRERAAAREAGRPGVLATAAGIFAPAVLRTTVVGGLIGLGAHGGYY
AVTTWLPTYLKTERHLSVLGTGGYLAVVIVAFIAGCFASAWLQDRIGRRRTVIVFAIGCTVMVNLYTRLPIGDTAMLILS
FPLGLLSAGIPAALGALFNELYPQGVRGTGVGFCYNFGRIVSAGFPVLIGHMSSTMSLGTALGIDAGLAYGLVVVAALLL
PETRGRRIAAPLPGGSRAGPQGASPATPVEPT
>Mature_432_residues
MRWYRDIPPAEKRTLRACFAGWAVDAADTQIFSLVIPTLLTVWGISKGQAGLIGGATLVAGALGGLLAGMLSDRVGRVRA
LQVTVLWFSLFTFLSAFAQNFEQLLALKALQGIGFGGEWTAGAVLLSETIDARHRGKAMGIVQSAWGFGWGAAVLLYTAM
FSFVSQEWAWRLLFAVGVAPALLVLYLRRKVAEPPRERAAAREAGRPGVLATAAGIFAPAVLRTTVVGGLIGLGAHGGYY
AVTTWLPTYLKTERHLSVLGTGGYLAVVIVAFIAGCFASAWLQDRIGRRRTVIVFAIGCTVMVNLYTRLPIGDTAMLILS
FPLGLLSAGIPAALGALFNELYPQGVRGTGVGFCYNFGRIVSAGFPVLIGHMSSTMSLGTALGIDAGLAYGLVVVAALLL
PETRGRRIAAPLPGGSRAGPQGASPATPVEPT

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=439, Percent_Identity=25.5125284738041, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI213021148, Length=439, Percent_Identity=24.6013667425968, Blast_Score=73, Evalue=6e-13,
Organism=Homo sapiens, GI4507005, Length=443, Percent_Identity=24.6049661399549, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI87082231, Length=459, Percent_Identity=26.1437908496732, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI87082404, Length=383, Percent_Identity=22.1932114882507, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082159, Length=333, Percent_Identity=29.1291291291291, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1790550, Length=393, Percent_Identity=26.2086513994911, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081723, Length=398, Percent_Identity=27.8894472361809, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1786229, Length=388, Percent_Identity=23.7113402061856, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1788292, Length=372, Percent_Identity=25, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32564663, Length=438, Percent_Identity=24.6575342465753, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19922874, Length=377, Percent_Identity=22.2811671087533, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45389; Mature: 45389

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: PS50850 MFS ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; N-acetylneuraminate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + N-acetylneuraminate [Periplasm] = Proton [Cytoplasm] + N-acetylneuraminate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]