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The map label for this gene is treA [H]

Identifier: 238025136

GI number: 238025136

Start: 2249636

End: 2251261

Strand: Reverse

Name: treA [H]

Synonym: bglu_2g18010

Alternate gene names: 238025136

Gene position: 2251261-2249636 (Counterclockwise)

Preceding gene: 238025139

Following gene: 238025133

Centisome position: 79.62

GC content: 70.3

Gene sequence:

>1626_bases
ATGCTCGTGCTCGCGGCCGCGTTCGTGTCGTTGCCCGCCTGCTCCGACATGAACACGGCGCAGTCGGCCACGCCGGCGGC
CGCGCGTGCCGCCGGTACCGACGCCGCGGCGGCCGCCGCGCAGCCTGCCGGCCTGCTGCCGCCGCCGAGCCAGCTCTATG
GCGACCTGTTCGTGGCCGTGCAGACCGCGCAGCTGTTTCCGGATCAGAAGACCTTCGTCGATTCGACGCCCGACGCCGAT
CCGTCCACGATCGTGCAGTTCTACGCGCAGCAGAAGGATGCGCCGGGCTTTTCGCTGCGCGAGTTCGTCGCCAAGCACTT
CACGCCGCCGGTGGACAGCGTGGTCACGCCGCCCGCGAACCAGACGCTGCGCGCCCACATCGACTGGCTGTGGCCGCGCC
TGACGCGCAACACCGACGGCGCGCCGCGCTACGGCTCGCTGATCGCGCTGCCCAAGCCATACGTGGTGCCGGGCGGCCGC
TTCCGCGAAGGCTACTACTGGGACAGCTACTTCACGATGCTCGGCCTGCAGGACGCCGGGCGCGAGGATCTGGTCGACGC
GATGCTCGACAACTTCGCCTACCTGATCGATACGGTCGGCCACGTGCCGAACGGCAATCGCACCTACTACGCGAGCCGCT
CGCAGCCGCCGTTCTTCGCCTACATGGTCGAGCTGGCCGCGAAGAAGGAGGGCAACGGCGTCTACCAGAAGTATCTGCCG
GCGCTGCGCAAGGAATATGCTTACTGGATGCAGGGTGAAGCGAGCACGCCGCGCGGCAGCGCGTCGGCGCACGTGGTGGC
GATGCCCGACGGCGCGATCCTGAACCGCTACTGGGATGCGAGCGCGACGCCGCGCGACGAATCCTACCTCGAGGACGTGC
AGACTGCGCGCGCGGCCACGGGCCGGCCCGCGGCCGAGGTGTGGCGCGACCTGCGCGCCGGTGCCGAGAGCGGCTGGGAC
TACAGCTCGCGCTGGCTCGGCGACGGCCGCACGCTCGCCACCATCCGCACCACCGCGATCGTGCCGGTCGACCTGAACAG
CCTGATGTACCACCTGGAGAAGACCATCGTGAAGGGCTGCGGCGTCACGCACGATGTCGCCTGCGTGGCCGATTTTTCCG
CGCGCGCCGCGCGCCGCGACGCCGCGATCAACCGCTATCTGTGGAATCCGGCCGGCTATTACGGCGACTATGACTGGCAG
CTCGGCAAGCCGCGTGACGGACTCAGCGCGGCCGCGCTCTACCCGCTCTACGCCGGCGCGGCCACCCCCGAGCACGCGAT
CTCCACCGCCCAGCACGTGCGCGACACGCTGCTGCAGCCGGGCGGCCTCGCCACCACCACCCGCAACACCGGCCAGCAGT
GGGATGCGCCGAACGGCTGGGCTCCGCTGCAATGGATCGCGATCCAGGGGCTCACGCGCTACGGCGAACGCCCGCTCGCC
GACGAGATCGGCAAGCGTTTCCTGGCCGACGTGAAGGGCGTGTACGCGCGCGAGGGCAAGCTCGTCGAGAAGTACGTGGT
GGAGGGGGCCGGCGTGGGCGGCGGCGGCGGGGAGTACCCGCTGCAGGACGGCTTCGGCTGGACCAACGGCGTGACCGCGA
AGCTGCTCGACCGCTACGGACAGTAA

Upstream 100 bases:

>100_bases
GGCCCAAGCCCGCCGCGCGTTGCGCGTCAGCTCTACGAAAACCGTGGCCGTGGCGGCACGGCGCCGTGCACGGCACGCCC
TCGGCCATCGCGCGGGCTCC

Downstream 100 bases:

>100_bases
TGAAACCGGCCCGCCGCCGGATTCCGGCGACGGGCCGCTCGCGCGCAGCGGCGCTCAGAGGAACGCGTGCGATACCTGCG
CGCCCGGTTGCGGCATGCGG

Product: Neutral trehalase

Products: NA

Alternate protein names: Alpha,alpha-trehalase; Alpha,alpha-trehalose glucohydrolase [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MLVLAAAFVSLPACSDMNTAQSATPAAARAAGTDAAAAAAQPAGLLPPPSQLYGDLFVAVQTAQLFPDQKTFVDSTPDAD
PSTIVQFYAQQKDAPGFSLREFVAKHFTPPVDSVVTPPANQTLRAHIDWLWPRLTRNTDGAPRYGSLIALPKPYVVPGGR
FREGYYWDSYFTMLGLQDAGREDLVDAMLDNFAYLIDTVGHVPNGNRTYYASRSQPPFFAYMVELAAKKEGNGVYQKYLP
ALRKEYAYWMQGEASTPRGSASAHVVAMPDGAILNRYWDASATPRDESYLEDVQTARAATGRPAAEVWRDLRAGAESGWD
YSSRWLGDGRTLATIRTTAIVPVDLNSLMYHLEKTIVKGCGVTHDVACVADFSARAARRDAAINRYLWNPAGYYGDYDWQ
LGKPRDGLSAAALYPLYAGAATPEHAISTAQHVRDTLLQPGGLATTTRNTGQQWDAPNGWAPLQWIAIQGLTRYGERPLA
DEIGKRFLADVKGVYAREGKLVEKYVVEGAGVGGGGGEYPLQDGFGWTNGVTAKLLDRYGQ

Sequences:

>Translated_541_residues
MLVLAAAFVSLPACSDMNTAQSATPAAARAAGTDAAAAAAQPAGLLPPPSQLYGDLFVAVQTAQLFPDQKTFVDSTPDAD
PSTIVQFYAQQKDAPGFSLREFVAKHFTPPVDSVVTPPANQTLRAHIDWLWPRLTRNTDGAPRYGSLIALPKPYVVPGGR
FREGYYWDSYFTMLGLQDAGREDLVDAMLDNFAYLIDTVGHVPNGNRTYYASRSQPPFFAYMVELAAKKEGNGVYQKYLP
ALRKEYAYWMQGEASTPRGSASAHVVAMPDGAILNRYWDASATPRDESYLEDVQTARAATGRPAAEVWRDLRAGAESGWD
YSSRWLGDGRTLATIRTTAIVPVDLNSLMYHLEKTIVKGCGVTHDVACVADFSARAARRDAAINRYLWNPAGYYGDYDWQ
LGKPRDGLSAAALYPLYAGAATPEHAISTAQHVRDTLLQPGGLATTTRNTGQQWDAPNGWAPLQWIAIQGLTRYGERPLA
DEIGKRFLADVKGVYAREGKLVEKYVVEGAGVGGGGGEYPLQDGFGWTNGVTAKLLDRYGQ
>Mature_541_residues
MLVLAAAFVSLPACSDMNTAQSATPAAARAAGTDAAAAAAQPAGLLPPPSQLYGDLFVAVQTAQLFPDQKTFVDSTPDAD
PSTIVQFYAQQKDAPGFSLREFVAKHFTPPVDSVVTPPANQTLRAHIDWLWPRLTRNTDGAPRYGSLIALPKPYVVPGGR
FREGYYWDSYFTMLGLQDAGREDLVDAMLDNFAYLIDTVGHVPNGNRTYYASRSQPPFFAYMVELAAKKEGNGVYQKYLP
ALRKEYAYWMQGEASTPRGSASAHVVAMPDGAILNRYWDASATPRDESYLEDVQTARAATGRPAAEVWRDLRAGAESGWD
YSSRWLGDGRTLATIRTTAIVPVDLNSLMYHLEKTIVKGCGVTHDVACVADFSARAARRDAAINRYLWNPAGYYGDYDWQ
LGKPRDGLSAAALYPLYAGAATPEHAISTAQHVRDTLLQPGGLATTTRNTGQQWDAPNGWAPLQWIAIQGLTRYGERPLA
DEIGKRFLADVKGVYAREGKLVEKYVVEGAGVGGGGGEYPLQDGFGWTNGVTAKLLDRYGQ

Specific function: Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system [H]

COG id: COG1626

COG function: function code G; Neutral trehalase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 37 family [H]

Homologues:

Organism=Homo sapiens, GI116284412, Length=536, Percent_Identity=35.0746268656716, Blast_Score=272, Evalue=5e-73,
Organism=Escherichia coli, GI1787447, Length=492, Percent_Identity=55.0813008130081, Blast_Score=544, Evalue=1e-156,
Organism=Escherichia coli, GI1789936, Length=508, Percent_Identity=51.9685039370079, Blast_Score=502, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17542196, Length=534, Percent_Identity=32.9588014981273, Blast_Score=258, Evalue=4e-69,
Organism=Caenorhabditis elegans, GI25148109, Length=574, Percent_Identity=29.9651567944251, Blast_Score=236, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI25141398, Length=539, Percent_Identity=31.1688311688312, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI17565078, Length=519, Percent_Identity=32.7552986512524, Blast_Score=229, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71987755, Length=441, Percent_Identity=29.2517006802721, Blast_Score=185, Evalue=5e-47,
Organism=Saccharomyces cerevisiae, GI6320204, Length=440, Percent_Identity=30.2272727272727, Blast_Score=147, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6319473, Length=428, Percent_Identity=31.7757009345794, Blast_Score=147, Evalue=4e-36,
Organism=Drosophila melanogaster, GI24656680, Length=538, Percent_Identity=32.1561338289963, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24656675, Length=538, Percent_Identity=32.1561338289963, Blast_Score=246, Evalue=3e-65,
Organism=Drosophila melanogaster, GI24656661, Length=538, Percent_Identity=32.1561338289963, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI17933716, Length=538, Percent_Identity=32.1561338289963, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24656670, Length=538, Percent_Identity=32.1561338289963, Blast_Score=246, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24656685, Length=496, Percent_Identity=32.4596774193548, Blast_Score=230, Evalue=2e-60,
Organism=Drosophila melanogaster, GI22024178, Length=532, Percent_Identity=29.5112781954887, Blast_Score=213, Evalue=3e-55,
Organism=Drosophila melanogaster, GI45551104, Length=372, Percent_Identity=31.1827956989247, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI28573474, Length=297, Percent_Identity=28.6195286195286, Blast_Score=116, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008928
- InterPro:   IPR001661
- InterPro:   IPR018232 [H]

Pfam domain/function: PF01204 Trehalase [H]

EC number: =3.2.1.28 [H]

Molecular weight: Translated: 58841; Mature: 58841

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00927 TREHALASE_1 ; PS00928 TREHALASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVLAAAFVSLPACSDMNTAQSATPAAARAAGTDAAAAAAQPAGLLPPPSQLYGDLFVAV
CEEEEEHHHHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
QTAQLFPDQKTFVDSTPDADPSTIVQFYAQQKDAPGFSLREFVAKHFTPPVDSVVTPPAN
HHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHCCCCCCC
QTLRAHIDWLWPRLTRNTDGAPRYGSLIALPKPYVVPGGRFREGYYWDSYFTMLGLQDAG
CHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEECCCCCCCCCEEEHHHHHHHCCCCCC
REDLVDAMLDNFAYLIDTVGHVPNGNRTYYASRSQPPFFAYMVELAAKKEGNGVYQKYLP
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHH
ALRKEYAYWMQGEASTPRGSASAHVVAMPDGAILNRYWDASATPRDESYLEDVQTARAAT
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
GRPAAEVWRDLRAGAESGWDYSSRWLGDGRTLATIRTTAIVPVDLNSLMYHLEKTIVKGC
CCCHHHHHHHHHHCCCCCCCCCHHCCCCCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHC
GVTHDVACVADFSARAARRDAAINRYLWNPAGYYGDYDWQLGKPRDGLSAAALYPLYAGA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
ATPEHAISTAQHVRDTLLQPGGLATTTRNTGQQWDAPNGWAPLQWIAIQGLTRYGERPLA
CCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
DEIGKRFLADVKGVYAREGKLVEKYVVEGAGVGGGGGEYPLQDGFGWTNGVTAKLLDRYG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHC
Q
C
>Mature Secondary Structure
MLVLAAAFVSLPACSDMNTAQSATPAAARAAGTDAAAAAAQPAGLLPPPSQLYGDLFVAV
CEEEEEHHHHCCCCCCCCCCCCCCCHHHHHCCCCHHHHHCCCCCCCCCHHHHHHHHHHHH
QTAQLFPDQKTFVDSTPDADPSTIVQFYAQQKDAPGFSLREFVAKHFTPPVDSVVTPPAN
HHHHHCCCCHHHCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHCCCCCCC
QTLRAHIDWLWPRLTRNTDGAPRYGSLIALPKPYVVPGGRFREGYYWDSYFTMLGLQDAG
CHHHHHHHHHHHHHHCCCCCCCCCCCEEECCCCEECCCCCCCCCEEEHHHHHHHCCCCCC
REDLVDAMLDNFAYLIDTVGHVPNGNRTYYASRSQPPFFAYMVELAAKKEGNGVYQKYLP
HHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHH
ALRKEYAYWMQGEASTPRGSASAHVVAMPDGAILNRYWDASATPRDESYLEDVQTARAAT
HHHHHHHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHCC
GRPAAEVWRDLRAGAESGWDYSSRWLGDGRTLATIRTTAIVPVDLNSLMYHLEKTIVKGC
CCCHHHHHHHHHHCCCCCCCCCHHCCCCCCEEEEEEEEEEEEECHHHHHHHHHHHHHHHC
GVTHDVACVADFSARAARRDAAINRYLWNPAGYYGDYDWQLGKPRDGLSAAALYPLYAGA
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
ATPEHAISTAQHVRDTLLQPGGLATTTRNTGQQWDAPNGWAPLQWIAIQGLTRYGERPLA
CCHHHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHH
DEIGKRFLADVKGVYAREGKLVEKYVVEGAGVGGGGGEYPLQDGFGWTNGVTAKLLDRYG
HHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHC
Q
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]