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The map label for this gene is ilvD [H]

Identifier: 238024904

GI number: 238024904

Start: 1957519

End: 1959303

Strand: Reverse

Name: ilvD [H]

Synonym: bglu_2g15490

Alternate gene names: 238024904

Gene position: 1959303-1957519 (Counterclockwise)

Preceding gene: 238024905

Following gene: 238024900

Centisome position: 69.3

GC content: 70.98

Gene sequence:

>1785_bases
ATGACGCAACACACCACGCGGCGGCTGCGCAGCCAGGAGTGGTTCGACGATCCGGCGCATGCCGACATGACGGCGCTCTA
TGTCGAGCGTTTCATGAACTACGGGCTCACGCGCGAGGAAATCCAGTCGGGCCGTCCGATCATCGGTATCGCGCAGACGG
GCAGCGACCTCGCGCCCTGCAACCGCCATCACATCGCGCTGGCCGAGCGGACCAAGGCCGGCATTCGCGACGCGGGCGGC
ATCCCGATGGAATTCCCCGTGCACCCGCTCGCCGAGCAGAGCCGCCGGCCCACCGCCGCGCTCGACCGCAACCTGGCCTA
TCTCGGCCTGGTGGAAGTGCTGCACGGCTTCCCGCTCGACGGTGTGGTGCTGACCACCGGCTGCGACAAGACCACGCCGG
CCTGCCTGATGGCAGCCGCGACCGTGGACATGCCGGCCATCGTGCTGTCGGGCGGGCCGATGCTCGACGGCTGGCACCAG
GGCAAGCGGGTCGGCTCGGGCACCGTGATCTGGCATGCGCGCAACCTGCTCGCGGCGGGCGAGATCGACTATGAGGGCTT
CATGGCGCTGGCCACCGCCTCGTCGCCGTCGATCGGCCACTGCAACACGATGGGCACCGCGCTGTCGATGAACAGCCTCG
CCGAGGCGCTCGGCATGTCGCTGCCGGGCTGCGCGAGCATCCCGGCCGCCTATCGCGAGCGCGGCCAGATGGCCTACGCC
ACCGGCAAGCGGATCGTCGGGCTGGTGCGCGAGGACGTGCGGCCGTCGCAGATCATGACCCGGGCGGCATTCGAGAACGC
GATCGTGATCGCCTCCGCGCTCGGCGCGTCCACCAACTGCCCGCCGCATCTGATCGCGATCGCGCGTCACCTCGGCGTGG
CGCTGTCGCTCGACGACTGGCAGCGCGTGGGCGAGGCGGTGCCGCTGATCGTCAACTGCATGCCGGCGGGCGACTATCTC
GGCGAGAGCTTCCACCGCGCGGGCGGCGTGCCGGCCGTGTTCCACGAGCTGTCGCGGGCAGGCCTCGTGCATCGCGACTG
CCTGACCGTGTCGGGCGAGACCATCGGCCAGATCGCGGACCGCTCGCCCACCTCGGAGCGCGACGTGATCCGCACCACCG
ACGCGCCGCTCAAGCACGGCGCCGGCTTCATGGTGCTGTCGGGCAACTTCTTCGACAGCGCGATCATGAAGATGTCGGTG
GTGGGCGAGGCGTTCCGCCAGACCTACCTGAGCGAGCCGGGCAGCGAGAACGCGTTCGAGGCGCGCGCCATCGTGTTCGA
CGGCCCCGAGGACTATCACGCGCGCATCAACGACCCCTCGCTCGAGATCGACCAGCACTGCATCCTGGTGATCCGCGGCG
CCGGCACGGTCGGCTATCCCGGCAGCGCCGAGGTGGTCAACATGGCGCCGCCCGCCGCGCTCGTGCGCGCCGGCATCGGC
TCGCTGCCCACGCTCGGCGACGGCCGCCAGAGCGGCACCTCGGCGAGCCCGTCGATCCTCAACATGTCGCCGGAGGCGGC
GGTGGGCGGCGGCCTCGCGCTGCTGCGCACGGGCGACCGGATCCGCGTGGACCTGAACGCGCGCAGGGTGGACGTGCTGG
TGGACGAGGCCGAGCTCGCGCGCCGCCGCGAGACGGCCGAGTTCTCGGTGCCGGTCTCGCAGACGCCGTGGCAGGAGCTG
TATCGGCAGACGGTCGGCCAGCTCTCGACGGGCGGCTGCCTGGAGCCGGCCACGCTGTACCTGAAGGTGATCGAGACGCA
CGGCAACCCGCGGCATTCGCACTGA

Upstream 100 bases:

>100_bases
GGCCGGAGCGGGCCGACGCGACGGCGCCGGCACCCATATCGAGAGGAGACGGTCGCGGCGCCGCGAGGCCGGGAGCGACC
AGGACACGGAGAACGGCAAG

Downstream 100 bases:

>100_bases
GCGCGCGGCCGCCGCGAGGCGGGATGGCGGCGCGGCACCGGGCGCGCCGCGCCGCCCGGCCGGGTGGCCTGGCCTGCCGC
TGCGTGCGTTACTTGAACTG

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 594; Mature: 593

Protein sequence:

>594_residues
MTQHTTRRLRSQEWFDDPAHADMTALYVERFMNYGLTREEIQSGRPIIGIAQTGSDLAPCNRHHIALAERTKAGIRDAGG
IPMEFPVHPLAEQSRRPTAALDRNLAYLGLVEVLHGFPLDGVVLTTGCDKTTPACLMAAATVDMPAIVLSGGPMLDGWHQ
GKRVGSGTVIWHARNLLAAGEIDYEGFMALATASSPSIGHCNTMGTALSMNSLAEALGMSLPGCASIPAAYRERGQMAYA
TGKRIVGLVREDVRPSQIMTRAAFENAIVIASALGASTNCPPHLIAIARHLGVALSLDDWQRVGEAVPLIVNCMPAGDYL
GESFHRAGGVPAVFHELSRAGLVHRDCLTVSGETIGQIADRSPTSERDVIRTTDAPLKHGAGFMVLSGNFFDSAIMKMSV
VGEAFRQTYLSEPGSENAFEARAIVFDGPEDYHARINDPSLEIDQHCILVIRGAGTVGYPGSAEVVNMAPPAALVRAGIG
SLPTLGDGRQSGTSASPSILNMSPEAAVGGGLALLRTGDRIRVDLNARRVDVLVDEAELARRRETAEFSVPVSQTPWQEL
YRQTVGQLSTGGCLEPATLYLKVIETHGNPRHSH

Sequences:

>Translated_594_residues
MTQHTTRRLRSQEWFDDPAHADMTALYVERFMNYGLTREEIQSGRPIIGIAQTGSDLAPCNRHHIALAERTKAGIRDAGG
IPMEFPVHPLAEQSRRPTAALDRNLAYLGLVEVLHGFPLDGVVLTTGCDKTTPACLMAAATVDMPAIVLSGGPMLDGWHQ
GKRVGSGTVIWHARNLLAAGEIDYEGFMALATASSPSIGHCNTMGTALSMNSLAEALGMSLPGCASIPAAYRERGQMAYA
TGKRIVGLVREDVRPSQIMTRAAFENAIVIASALGASTNCPPHLIAIARHLGVALSLDDWQRVGEAVPLIVNCMPAGDYL
GESFHRAGGVPAVFHELSRAGLVHRDCLTVSGETIGQIADRSPTSERDVIRTTDAPLKHGAGFMVLSGNFFDSAIMKMSV
VGEAFRQTYLSEPGSENAFEARAIVFDGPEDYHARINDPSLEIDQHCILVIRGAGTVGYPGSAEVVNMAPPAALVRAGIG
SLPTLGDGRQSGTSASPSILNMSPEAAVGGGLALLRTGDRIRVDLNARRVDVLVDEAELARRRETAEFSVPVSQTPWQEL
YRQTVGQLSTGGCLEPATLYLKVIETHGNPRHSH
>Mature_593_residues
TQHTTRRLRSQEWFDDPAHADMTALYVERFMNYGLTREEIQSGRPIIGIAQTGSDLAPCNRHHIALAERTKAGIRDAGGI
PMEFPVHPLAEQSRRPTAALDRNLAYLGLVEVLHGFPLDGVVLTTGCDKTTPACLMAAATVDMPAIVLSGGPMLDGWHQG
KRVGSGTVIWHARNLLAAGEIDYEGFMALATASSPSIGHCNTMGTALSMNSLAEALGMSLPGCASIPAAYRERGQMAYAT
GKRIVGLVREDVRPSQIMTRAAFENAIVIASALGASTNCPPHLIAIARHLGVALSLDDWQRVGEAVPLIVNCMPAGDYLG
ESFHRAGGVPAVFHELSRAGLVHRDCLTVSGETIGQIADRSPTSERDVIRTTDAPLKHGAGFMVLSGNFFDSAIMKMSVV
GEAFRQTYLSEPGSENAFEARAIVFDGPEDYHARINDPSLEIDQHCILVIRGAGTVGYPGSAEVVNMAPPAALVRAGIGS
LPTLGDGRQSGTSASPSILNMSPEAAVGGGLALLRTGDRIRVDLNARRVDVLVDEAELARRRETAEFSVPVSQTPWQELY
RQTVGQLSTGGCLEPATLYLKVIETHGNPRHSH

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=582, Percent_Identity=30.5841924398625, Blast_Score=193, Evalue=3e-50,
Organism=Escherichia coli, GI1788157, Length=447, Percent_Identity=31.5436241610738, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI2367371, Length=463, Percent_Identity=28.2937365010799, Blast_Score=129, Evalue=6e-31,
Organism=Escherichia coli, GI1786464, Length=490, Percent_Identity=29.1836734693878, Blast_Score=116, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322476, Length=525, Percent_Identity=28.3809523809524, Blast_Score=202, Evalue=8e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 63456; Mature: 63325

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHTTRRLRSQEWFDDPAHADMTALYVERFMNYGLTREEIQSGRPIIGIAQTGSDLAPC
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCCC
NRHHIALAERTKAGIRDAGGIPMEFPVHPLAEQSRRPTAALDRNLAYLGLVEVLHGFPLD
CCCEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCC
GVVLTTGCDKTTPACLMAAATVDMPAIVLSGGPMLDGWHQGKRVGSGTVIWHARNLLAAG
CEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCCCCEEEEEECCEEECC
EIDYEGFMALATASSPSIGHCNTMGTALSMNSLAEALGMSLPGCASIPAAYRERGQMAYA
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEH
TGKRIVGLVREDVRPSQIMTRAAFENAIVIASALGASTNCPPHLIAIARHLGVALSLDDW
HHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCEEEEHHHH
QRVGEAVPLIVNCMPAGDYLGESFHRAGGVPAVFHELSRAGLVHRDCLTVSGETIGQIAD
HHHHCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCEEHHEEEECCHHHHHHHC
RSPTSERDVIRTTDAPLKHGAGFMVLSGNFFDSAIMKMSVVGEAFRQTYLSEPGSENAFE
CCCCCCCCEEECCCCCHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
ARAIVFDGPEDYHARINDPSLEIDQHCILVIRGAGTVGYPGSAEVVNMAPPAALVRAGIG
EEEEEECCCCCCCEECCCCCCEECCEEEEEEECCCCCCCCCCCCEEECCCCHHHHHHCCC
SLPTLGDGRQSGTSASPSILNMSPEAAVGGGLALLRTGDRIRVDLNARRVDVLVDEAELA
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCEEEEEECCEEEEEEECHHHHH
RRRETAEFSVPVSQTPWQELYRQTVGQLSTGGCLEPATLYLKVIETHGNPRHSH
HHHCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHEEEEEEECCCCCCCCC
>Mature Secondary Structure 
TQHTTRRLRSQEWFDDPAHADMTALYVERFMNYGLTREEIQSGRPIIGIAQTGSDLAPC
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCHHHHHCCCCEEEEECCCCCCCCC
NRHHIALAERTKAGIRDAGGIPMEFPVHPLAEQSRRPTAALDRNLAYLGLVEVLHGFPLD
CCCEEEEHHHHHCCCCCCCCCCCCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHCCCCC
GVVLTTGCDKTTPACLMAAATVDMPAIVLSGGPMLDGWHQGKRVGSGTVIWHARNLLAAG
CEEEECCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHCCCCCCCCEEEEEECCEEECC
EIDYEGFMALATASSPSIGHCNTMGTALSMNSLAEALGMSLPGCASIPAAYRERGQMAYA
CCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHCCCEEEH
TGKRIVGLVREDVRPSQIMTRAAFENAIVIASALGASTNCPPHLIAIARHLGVALSLDDW
HHHHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCEEEEHHHH
QRVGEAVPLIVNCMPAGDYLGESFHRAGGVPAVFHELSRAGLVHRDCLTVSGETIGQIAD
HHHHCCCCEEEEEECCCHHHHHHHHHCCCCHHHHHHHHHCCCEEHHEEEECCHHHHHHHC
RSPTSERDVIRTTDAPLKHGAGFMVLSGNFFDSAIMKMSVVGEAFRQTYLSEPGSENAFE
CCCCCCCCEEECCCCCHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEE
ARAIVFDGPEDYHARINDPSLEIDQHCILVIRGAGTVGYPGSAEVVNMAPPAALVRAGIG
EEEEEECCCCCCCEECCCCCCEECCEEEEEEECCCCCCCCCCCCEEECCCCHHHHHHCCC
SLPTLGDGRQSGTSASPSILNMSPEAAVGGGLALLRTGDRIRVDLNARRVDVLVDEAELA
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCEEEEEECCEEEEEEECHHHHH
RRRETAEFSVPVSQTPWQELYRQTVGQLSTGGCLEPATLYLKVIETHGNPRHSH
HHHCCCEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]