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The map label for this gene is lacR [H]

Identifier: 238024874

GI number: 238024874

Start: 1918502

End: 1919314

Strand: Reverse

Name: lacR [H]

Synonym: bglu_2g15150

Alternate gene names: 238024874

Gene position: 1919314-1918502 (Counterclockwise)

Preceding gene: 238024875

Following gene: 238024873

Centisome position: 67.88

GC content: 69.25

Gene sequence:

>813_bases
ATGAAAGTAGCCCGCCGCCGTGAAGCCATGCTCCAGGCCGTTCTCTCCGGCATGACCGAAGTGTCCGAGTTGTGCGAACA
CTTCGGCATGTCCGAGGCCACCGTGCGCCGAGATCTGCGTGCGCTCGCCGACGAGCGGCTGATCCTGCGCACCTATGGCG
GCGCGGCTTCGGTGAGCACGCACGCGCCCGAGGAGTCGCTCGAACAGCGGCGCCGGAGCTTTCAGGCGGAAAAGGACGCC
ATCGGTCACGCGGCCGCCGCGCACGTGCAAGCGGGCGACACGATCTTTCTCGACAGCGGCACCACCACGGCCGCCCTTGC
GCGCGCGCTCGCCGGGGCGGGCCGTCACAACGTGCGCGTGGTCACCAACAACCTGCTGGTCGTGCAGGCGCTCGCCGCGA
GCAACGTGCCGCTCACGCTGATCGGCGGTGAGGTGCGCGAGTCGAGCATGAGCACGCTCGGCCCCATCGCCCAGCTCGCG
CTCACGCGCGTGACCGTCGATAAGGCGTTTCTCGGCGCCGACGGCGTCGTGCCCGGACGCGGCCTGTGCGAAGCCACCGC
CGACCAGGCCTACCTCAAGGAATGCTTGATGCGCCAGGCCGCGCGCCTCTATGTGCTGGTGACCGCCGACAAGCTCAACC
GCGACAGCCAGCAGCACTGGGCGCCCATCGACAAGCCGTGGACGCTGATCACCGACGCGAGTGCCTCGCACGCCGAATTG
CAGGCGTTTCGCGAATTGACGGGCGTGACGATCGAGCCGGTCGCGGTCATGGCCAGCGCGGCGGGTGGGCCGGGCGCCTT
GCAATCGCACTGA

Upstream 100 bases:

>100_bases
CAGGCGACGGAAAATAATGGATACACTACGTGCGCGCCGGATCGTCCGCGCCGCTTGCCTCGCTGCGGGGCGACGTCCCG
AACCCAACCCCGAATCGCCC

Downstream 100 bases:

>100_bases
CATCGCGCTCATGGACAACGCACTGCCGCAACGTTTTGTCGTCACGGGCGCAAGCTCGGGTATCGGTTACGCGATCGCGC
GGCACTTGCTCGACGCCGGC

Product: DeoR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MKVARRREAMLQAVLSGMTEVSELCEHFGMSEATVRRDLRALADERLILRTYGGAASVSTHAPEESLEQRRRSFQAEKDA
IGHAAAAHVQAGDTIFLDSGTTTAALARALAGAGRHNVRVVTNNLLVVQALAASNVPLTLIGGEVRESSMSTLGPIAQLA
LTRVTVDKAFLGADGVVPGRGLCEATADQAYLKECLMRQAARLYVLVTADKLNRDSQQHWAPIDKPWTLITDASASHAEL
QAFRELTGVTIEPVAVMASAAGGPGALQSH

Sequences:

>Translated_270_residues
MKVARRREAMLQAVLSGMTEVSELCEHFGMSEATVRRDLRALADERLILRTYGGAASVSTHAPEESLEQRRRSFQAEKDA
IGHAAAAHVQAGDTIFLDSGTTTAALARALAGAGRHNVRVVTNNLLVVQALAASNVPLTLIGGEVRESSMSTLGPIAQLA
LTRVTVDKAFLGADGVVPGRGLCEATADQAYLKECLMRQAARLYVLVTADKLNRDSQQHWAPIDKPWTLITDASASHAEL
QAFRELTGVTIEPVAVMASAAGGPGALQSH
>Mature_270_residues
MKVARRREAMLQAVLSGMTEVSELCEHFGMSEATVRRDLRALADERLILRTYGGAASVSTHAPEESLEQRRRSFQAEKDA
IGHAAAAHVQAGDTIFLDSGTTTAALARALAGAGRHNVRVVTNNLLVVQALAASNVPLTLIGGEVRESSMSTLGPIAQLA
LTRVTVDKAFLGADGVVPGRGLCEATADQAYLKECLMRQAARLYVLVTADKLNRDSQQHWAPIDKPWTLITDASASHAEL
QAFRELTGVTIEPVAVMASAAGGPGALQSH

Specific function: Repressor of the lactose catabolism operon. Galactose-6- phosphate is the inducer [H]

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789829, Length=237, Percent_Identity=31.2236286919831, Blast_Score=104, Evalue=8e-24,
Organism=Escherichia coli, GI1789519, Length=247, Percent_Identity=31.1740890688259, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1789059, Length=249, Percent_Identity=30.5220883534137, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787540, Length=252, Percent_Identity=27.7777777777778, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788069, Length=225, Percent_Identity=30.6666666666667, Blast_Score=91, Evalue=7e-20,
Organism=Escherichia coli, GI226510968, Length=230, Percent_Identity=31.304347826087, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082344, Length=196, Percent_Identity=31.6326530612245, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789170, Length=236, Percent_Identity=26.6949152542373, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790753, Length=211, Percent_Identity=26.0663507109005, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1790635, Length=262, Percent_Identity=25.1908396946565, Blast_Score=61, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 28673; Mature: 28673

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS00894 HTH_DEOR_1 ; PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVARRREAMLQAVLSGMTEVSELCEHFGMSEATVRRDLRALADERLILRTYGGAASVST
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCC
HAPEESLEQRRRSFQAEKDAIGHAAAAHVQAGDTIFLDSGTTTAALARALAGAGRHNVRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEE
VTNNLLVVQALAASNVPLTLIGGEVRESSMSTLGPIAQLALTRVTVDKAFLGADGVVPGR
EECCEEEEEHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GLCEATADQAYLKECLMRQAARLYVLVTADKLNRDSQQHWAPIDKPWTLITDASASHAEL
CCHHHHHHHHHHHHHHHHHHHHEEEEEEHHHCCCCCHHHCCCCCCCEEEEECCCCCHHHH
QAFRELTGVTIEPVAVMASAAGGPGALQSH
HHHHHHHCCEECHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKVARRREAMLQAVLSGMTEVSELCEHFGMSEATVRRDLRALADERLILRTYGGAASVST
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCC
HAPEESLEQRRRSFQAEKDAIGHAAAAHVQAGDTIFLDSGTTTAALARALAGAGRHNVRV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCCCEEE
VTNNLLVVQALAASNVPLTLIGGEVRESSMSTLGPIAQLALTRVTVDKAFLGADGVVPGR
EECCEEEEEHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
GLCEATADQAYLKECLMRQAARLYVLVTADKLNRDSQQHWAPIDKPWTLITDASASHAEL
CCHHHHHHHHHHHHHHHHHHHHEEEEEEHHHCCCCCHHHCCCCCCCEEEEECCCCCHHHH
QAFRELTGVTIEPVAVMASAAGGPGALQSH
HHHHHHHCCEECHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2120234; 1901863 [H]