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The map label for this gene is ilvA [H]

Identifier: 238024865

GI number: 238024865

Start: 1909777

End: 1911420

Strand: Reverse

Name: ilvA [H]

Synonym: bglu_2g15050

Alternate gene names: 238024865

Gene position: 1911420-1909777 (Counterclockwise)

Preceding gene: 238024866

Following gene: 238024862

Centisome position: 67.61

GC content: 71.23

Gene sequence:

>1644_bases
ATGTCATCGCCGTCCCCCCGTCGTCCGGAATCCGTCACACCGCCGCGCGCGCGTTCGTCCGAGGCGTTGGCCATGCCGCC
GGCGGTGAAGCCGCCCGCGCAGCCGGCCGATTGCGCCGCCGCCGGCATCGATGCCTACCTGAAGAAGATCCTCACCGCGC
GCGTCTACGACGTGGCGGTCGAAACCGCGCTCGAGGCGGCCCGCAACCTGTCCGCGCGCGTGCACAACCGCGTGCTGCTC
AAGCGCGAGGACAACCAGCCGGTGTTCTCGTTCAAGCTGCGCGGCGCCTACAACCGCATGGCCCAGCTGGGCGCCGACGC
GCTCGCGCGCGGCGTGATCACCGCCTCGGCCGGCAACCACGCCCAGGGCGTCGCGTTCTCGGCCGCGCGCCTGGGCGTGA
AGGCGGTGATCATGGTGCCGGTCACCACCCCGCAGGTCAAGGTCGACGCGGTGCGCGCGCACGGCGGGCCGACCGTCGAG
GTGATCCAGGCCGGCGAATCGTTCAGCGACGCCTATGCCCACGCGCTCGAGCTGCAGCGCCAGCGCGAGCTGACCTTCGT
GCACCCGTTCGACGATCCCGAGGTGATCGCCGGCCAGGGCACCGTGGCGATGGAAGTGCTGCGCCAGCACCAGGGGCCGA
TCCACGCGATCTTCGTGCCGATCGGCGGCGGCGGGCTCGCGGCCGGCGTGGCCGCCTACGTGAAGGCGGTGCGCCCGGAG
ATCCGCGTGATCGGGGTGCAGACCGAGGACTCCTGCGCGATGGCGAAGTCGATCCGCGCCGGCGAGCGCGTGATGCTCGC
CGAGGTGGGCCTGTTCTCGGACGGCACGGCCGTGAAGCAGGTCGGCGAGGAAACGTTCCGGCTCTGCCGCGCGCTGCTCG
ACGAGGTGATCACGGTGGACACCGACGCGCTGTGCGCGGCGATCAAGGACGTGTTCCAGGACACGCGCAGCGTGCTGGAG
CCGGCCGGCGCGCTGGCCGTGGCGGGCGCCAAGCGCTACGCGGCGCGCACCGGCATCGAGGGCGAGACGCTGGTGGCGAT
CACCTCGGGCGCCAACATGAACTTCGACCGGATGCGCTTCGTGGCCGAGCGCGCCGAGGTGGGCGAGGCGCGCGAGGCGG
TGTTCGCGGTGACGATCCCCGAGGAGCGCGGCAGCTTCCGGCGCTTCTGCGAGCTGGTGGGCGAGCGCAGCGTGACGGAG
TTCAACTACCGGATCGCCGACGAGCGCGCCGCGCACATTTTCGTGGGCGTGCAGATCCGGCGCCGCGAGGAATCGGCCGA
GATCGCGGCGAACTTCGGCGCGCACGGCTTCGAGGCGGCCGACCTGACCGGCGACGAGCTGTCGAAGGACCACATTCGCT
ACATGGTGGGCGGGCGCTCGCCGCTCTCGCGCGACGAGCGGCTGTTCCGCTTCGAGTTTCCGGAGCGCCCGGGCGCGCTG
ATGAAGTTTCTCTCGGCGATGGCGCCGAACTGGAACATCAGCCTGTTCCACTACCGCAACCAGGGCGCGGACTACAGCTC
GATCCTGGTCGGGCTGCAGGTGCCCGGCGCCGATCACGCCACGTTCGACCGGTTCCTGGCCGCGCTCGGCTATCCCTATC
ACGAAGAGACCGCGAACCCGGCCTACCGGCTGTTCCTGGCCTAG

Upstream 100 bases:

>100_bases
AATGGTGGGTTAGCGCGCGCAGGAAGCCGACACGAAACCCGCCCCCGAGGCGGGTTTTTCGTATCCGTCTCCGGGCATGA
ATCCCAGCCAGGAGCCTCCG

Downstream 100 bases:

>100_bases
CGCCCGACGCCGGGCCGGGGCGCGGTGCGCCCGCCGGCGACGGCGCGGGCGCGCCCGCCGCGTTCACTCGAAGGCCGGGA
AGCCCGCGCGCCCCTGCGTG

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MSSPSPRRPESVTPPRARSSEALAMPPAVKPPAQPADCAAAGIDAYLKKILTARVYDVAVETALEAARNLSARVHNRVLL
KREDNQPVFSFKLRGAYNRMAQLGADALARGVITASAGNHAQGVAFSAARLGVKAVIMVPVTTPQVKVDAVRAHGGPTVE
VIQAGESFSDAYAHALELQRQRELTFVHPFDDPEVIAGQGTVAMEVLRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPE
IRVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQVGEETFRLCRALLDEVITVDTDALCAAIKDVFQDTRSVLE
PAGALAVAGAKRYAARTGIEGETLVAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTE
FNYRIADERAAHIFVGVQIRRREESAEIAANFGAHGFEAADLTGDELSKDHIRYMVGGRSPLSRDERLFRFEFPERPGAL
MKFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHATFDRFLAALGYPYHEETANPAYRLFLA

Sequences:

>Translated_547_residues
MSSPSPRRPESVTPPRARSSEALAMPPAVKPPAQPADCAAAGIDAYLKKILTARVYDVAVETALEAARNLSARVHNRVLL
KREDNQPVFSFKLRGAYNRMAQLGADALARGVITASAGNHAQGVAFSAARLGVKAVIMVPVTTPQVKVDAVRAHGGPTVE
VIQAGESFSDAYAHALELQRQRELTFVHPFDDPEVIAGQGTVAMEVLRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPE
IRVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQVGEETFRLCRALLDEVITVDTDALCAAIKDVFQDTRSVLE
PAGALAVAGAKRYAARTGIEGETLVAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTE
FNYRIADERAAHIFVGVQIRRREESAEIAANFGAHGFEAADLTGDELSKDHIRYMVGGRSPLSRDERLFRFEFPERPGAL
MKFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHATFDRFLAALGYPYHEETANPAYRLFLA
>Mature_546_residues
SSPSPRRPESVTPPRARSSEALAMPPAVKPPAQPADCAAAGIDAYLKKILTARVYDVAVETALEAARNLSARVHNRVLLK
REDNQPVFSFKLRGAYNRMAQLGADALARGVITASAGNHAQGVAFSAARLGVKAVIMVPVTTPQVKVDAVRAHGGPTVEV
IQAGESFSDAYAHALELQRQRELTFVHPFDDPEVIAGQGTVAMEVLRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPEI
RVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQVGEETFRLCRALLDEVITVDTDALCAAIKDVFQDTRSVLEP
AGALAVAGAKRYAARTGIEGETLVAITSGANMNFDRMRFVAERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTEF
NYRIADERAAHIFVGVQIRRREESAEIAANFGAHGFEAADLTGDELSKDHIRYMVGGRSPLSRDERLFRFEFPERPGALM
KFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHATFDRFLAALGYPYHEETANPAYRLFLA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=297, Percent_Identity=32.6599326599327, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI33469958, Length=317, Percent_Identity=28.391167192429, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1790207, Length=516, Percent_Identity=54.6511627906977, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1789505, Length=311, Percent_Identity=36.0128617363344, Blast_Score=165, Evalue=8e-42,
Organism=Caenorhabditis elegans, GI71991565, Length=318, Percent_Identity=29.559748427673, Blast_Score=132, Evalue=6e-31,
Organism=Caenorhabditis elegans, GI17537387, Length=385, Percent_Identity=30.6493506493506, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI17508781, Length=276, Percent_Identity=30.4347826086957, Blast_Score=121, Evalue=8e-28,
Organism=Saccharomyces cerevisiae, GI6320930, Length=516, Percent_Identity=48.062015503876, Blast_Score=472, Evalue=1e-134,
Organism=Saccharomyces cerevisiae, GI6322631, Length=306, Percent_Identity=32.0261437908497, Blast_Score=140, Evalue=7e-34,
Organism=Saccharomyces cerevisiae, GI6319788, Length=271, Percent_Identity=25.0922509225092, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI21355833, Length=314, Percent_Identity=28.9808917197452, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24645328, Length=255, Percent_Identity=27.4509803921569, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 59216; Mature: 59085

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00889 CNMP_BINDING_2 ; PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPSPRRPESVTPPRARSSEALAMPPAVKPPAQPADCAAAGIDAYLKKILTARVYDVAV
CCCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ETALEAARNLSARVHNRVLLKREDNQPVFSFKLRGAYNRMAQLGADALARGVITASAGNH
HHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECHHHHHHHHHCHHHHHHCEEEECCCCC
AQGVAFSAARLGVKAVIMVPVTTPQVKVDAVRAHGGPTVEVIQAGESFSDAYAHALELQR
CCCHHHHHHHCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHH
QRELTFVHPFDDPEVIAGQGTVAMEVLRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPE
HCCEEEECCCCCCCEEECCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHCCC
IRVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQVGEETFRLCRALLDEVITVD
EEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
TDALCAAIKDVFQDTRSVLEPAGALAVAGAKRYAARTGIEGETLVAITSGANMNFDRMRF
HHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHH
VAERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTEFNYRIADERAAHIFVGVQIR
HHHHHHCCCCCCEEEEEEECHHCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEEEE
RREESAEIAANFGAHGFEAADLTGDELSKDHIRYMVGGRSPLSRDERLFRFEFPERPGAL
ECCHHHHHHHHCCCCCCEECCCCCCCCCHHHHEEEECCCCCCCCCCCEEEEECCCCCCHH
MKFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHATFDRFLAALGYPYHEETANP
HHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHHHHHHHHHHHCCCCHHCCCCC
AYRLFLA
CEEEEEC
>Mature Secondary Structure 
SSPSPRRPESVTPPRARSSEALAMPPAVKPPAQPADCAAAGIDAYLKKILTARVYDVAV
CCCCCCCCCCCCCCCCCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
ETALEAARNLSARVHNRVLLKREDNQPVFSFKLRGAYNRMAQLGADALARGVITASAGNH
HHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECHHHHHHHHHCHHHHHHCEEEECCCCC
AQGVAFSAARLGVKAVIMVPVTTPQVKVDAVRAHGGPTVEVIQAGESFSDAYAHALELQR
CCCHHHHHHHCCEEEEEEEECCCCCEEEEEEECCCCCEEEEEECCCCHHHHHHHHHHHHH
QRELTFVHPFDDPEVIAGQGTVAMEVLRQHQGPIHAIFVPIGGGGLAAGVAAYVKAVRPE
HCCEEEECCCCCCCEEECCCHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHCCC
IRVIGVQTEDSCAMAKSIRAGERVMLAEVGLFSDGTAVKQVGEETFRLCRALLDEVITVD
EEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
TDALCAAIKDVFQDTRSVLEPAGALAVAGAKRYAARTGIEGETLVAITSGANMNFDRMRF
HHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHH
VAERAEVGEAREAVFAVTIPEERGSFRRFCELVGERSVTEFNYRIADERAAHIFVGVQIR
HHHHHHCCCCCCEEEEEEECHHCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEEEEEEEE
RREESAEIAANFGAHGFEAADLTGDELSKDHIRYMVGGRSPLSRDERLFRFEFPERPGAL
ECCHHHHHHHHCCCCCCEECCCCCCCCCHHHHEEEECCCCCCCCCCCEEEEECCCCCCHH
MKFLSAMAPNWNISLFHYRNQGADYSSILVGLQVPGADHATFDRFLAALGYPYHEETANP
HHHHHHHCCCCCEEEEEEECCCCCHHHEEEEEECCCCCHHHHHHHHHHHCCCCHHCCCCC
AYRLFLA
CEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA