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The map label for this gene is yphC [C]

Identifier: 238024814

GI number: 238024814

Start: 1851679

End: 1852719

Strand: Reverse

Name: yphC [C]

Synonym: bglu_2g14520

Alternate gene names: 238024814

Gene position: 1852719-1851679 (Counterclockwise)

Preceding gene: 238024816

Following gene: 238024812

Centisome position: 65.53

GC content: 64.27

Gene sequence:

>1041_bases
ATGAAAGCCGTCATGTTCGAATCCTTCGGTGAACGCCCCAAGCTCGTCAGCCTGCGTGATCCTTCACCGGAAACGCATGG
GGTCGTCATCAAGGTGCAGGCGACCGGCGTTTGCCGCAGCGACTGGCATGGCTGGGTCGGCCACGATACCGACATCGAGC
TGCCCCACGTTCCCGGCCATGAACTGGCCGGCACCATTGAAGCCGTCGGCAAGGATGTCAGCCAATGGCAGGTCGGCGAC
CGCGTGACCGTTCCTTTCGTCGGCGGCTGCGGTTCATGTCCCGAGTGCCATGCCGGCCATCAGCAGGTCTGCCACTCCCA
GTTTCAGCCAGGCTTCACGCATTGGGGCTCCTTCGCGGAATACGTGTCGATCCACCGGGCGGACCTCAATCTCGTGGCGC
TGCCCGAGTCCATCACCTTCGCCACGGCGGCCTCGCTCGGCTGCCGGTTCGTGACGTCCTTCCGCGCCGTCGTCGATCAG
GGCAAGGTGACTGCTGGCCAATGGGTGGCCGTGCACGGCTGCGGCGGGGTGGGCCTCTCGGCGATCATGATCGCGAATGC
GCTGGGCGCCAACGTCGTGGCGGTAGACATTGCCGAAGACAAGCTCGCGCTGGCCAAGCGCCTGGGCGCCGCAGCCACCA
TCGATGCCAAATCCGTGGCCGATGTGCCCGAGGCCGTGATGGAGGTCACGGGAGGCGGCGCGCACGTCTCGCTCGATGCG
CTCGGCTCACCCGTGACCTGTTTCAATTCGATTCAGAACCTGCGTCGCCGCGGCAAGCACGTACAGGTGGGCTTGATGCT
GGGTGAGCACAGCACGCCCTCGGTGCCGATGAGCAAGATCGTGGGGTGGGAGCTGGAGGTGCTCGGCAGCCACGGCATGC
AGGCTCATCGTTACGATGCGATGATGCCGATGATCCTCGCGGGCAAGCTGAAGCCGGAGCTGTTGGTCGGCAAGGAGATC
AGCCTTGAGGAGTCGATCGATGCGCTGATGTCCATGGACAAGTTCCAAGGCACCGGCACTACCGTTGTCACCCGGTTTTA
G

Upstream 100 bases:

>100_bases
CAATATCAAAAATTGGCCTGATGCGAGAGGATTCGGCAAGACAATTTTTTTCTGCCGGTCGATAATGAGCGGACCCAAGC
CCGCCACGTCAGGAGCACCC

Downstream 100 bases:

>100_bases
CCCCCGCATCCGCAGGAGCCAAGGTCTGCGGCCGATTGCCGACGCGCACTGGCAGCGCGCCATGCACGTACCCGGCGATC
ACGCGCTCGATGTGCGCACG

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: ADH-HT [H]

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKAVMFESFGERPKLVSLRDPSPETHGVVIKVQATGVCRSDWHGWVGHDTDIELPHVPGHELAGTIEAVGKDVSQWQVGD
RVTVPFVGGCGSCPECHAGHQQVCHSQFQPGFTHWGSFAEYVSIHRADLNLVALPESITFATAASLGCRFVTSFRAVVDQ
GKVTAGQWVAVHGCGGVGLSAIMIANALGANVVAVDIAEDKLALAKRLGAAATIDAKSVADVPEAVMEVTGGGAHVSLDA
LGSPVTCFNSIQNLRRRGKHVQVGLMLGEHSTPSVPMSKIVGWELEVLGSHGMQAHRYDAMMPMILAGKLKPELLVGKEI
SLEESIDALMSMDKFQGTGTTVVTRF

Sequences:

>Translated_346_residues
MKAVMFESFGERPKLVSLRDPSPETHGVVIKVQATGVCRSDWHGWVGHDTDIELPHVPGHELAGTIEAVGKDVSQWQVGD
RVTVPFVGGCGSCPECHAGHQQVCHSQFQPGFTHWGSFAEYVSIHRADLNLVALPESITFATAASLGCRFVTSFRAVVDQ
GKVTAGQWVAVHGCGGVGLSAIMIANALGANVVAVDIAEDKLALAKRLGAAATIDAKSVADVPEAVMEVTGGGAHVSLDA
LGSPVTCFNSIQNLRRRGKHVQVGLMLGEHSTPSVPMSKIVGWELEVLGSHGMQAHRYDAMMPMILAGKLKPELLVGKEI
SLEESIDALMSMDKFQGTGTTVVTRF
>Mature_346_residues
MKAVMFESFGERPKLVSLRDPSPETHGVVIKVQATGVCRSDWHGWVGHDTDIELPHVPGHELAGTIEAVGKDVSQWQVGD
RVTVPFVGGCGSCPECHAGHQQVCHSQFQPGFTHWGSFAEYVSIHRADLNLVALPESITFATAASLGCRFVTSFRAVVDQ
GKVTAGQWVAVHGCGGVGLSAIMIANALGANVVAVDIAEDKLALAKRLGAAATIDAKSVADVPEAVMEVTGGGAHVSLDA
LGSPVTCFNSIQNLRRRGKHVQVGLMLGEHSTPSVPMSKIVGWELEVLGSHGMQAHRYDAMMPMILAGKLKPELLVGKEI
SLEESIDALMSMDKFQGTGTTVVTRF

Specific function: Thermophilic NAD(+)-dependent alcohol dehydrogenase. Bears mainly an ethanol-dehydrogenase activity [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=341, Percent_Identity=29.9120234604106, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI34577061, Length=341, Percent_Identity=30.2052785923754, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI4501929, Length=341, Percent_Identity=29.9120234604106, Blast_Score=113, Evalue=3e-25,
Organism=Homo sapiens, GI71565154, Length=244, Percent_Identity=31.1475409836066, Blast_Score=111, Evalue=9e-25,
Organism=Homo sapiens, GI71565152, Length=247, Percent_Identity=29.5546558704453, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI156523966, Length=247, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=4e-23,
Organism=Homo sapiens, GI4501939, Length=247, Percent_Identity=30.7692307692308, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI262073058, Length=245, Percent_Identity=30.2040816326531, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI71743840, Length=245, Percent_Identity=30.2040816326531, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI194239674, Length=351, Percent_Identity=28.4900284900285, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI13236495, Length=351, Percent_Identity=28.4900284900285, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI194239676, Length=283, Percent_Identity=28.6219081272085, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI156627571, Length=357, Percent_Identity=27.1708683473389, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI22538446, Length=274, Percent_Identity=28.1021897810219, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI22538444, Length=274, Percent_Identity=28.1021897810219, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI87082125, Length=264, Percent_Identity=31.0606060606061, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1788075, Length=337, Percent_Identity=26.7062314540059, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1787863, Length=349, Percent_Identity=27.7936962750716, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081918, Length=272, Percent_Identity=33.8235294117647, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI226510992, Length=304, Percent_Identity=29.2763157894737, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1786825, Length=384, Percent_Identity=26.5625, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788073, Length=322, Percent_Identity=25.1552795031056, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790045, Length=328, Percent_Identity=26.219512195122, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1788407, Length=269, Percent_Identity=31.5985130111524, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI1786552, Length=364, Percent_Identity=25.5494505494505, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1786518, Length=280, Percent_Identity=27.5, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1790718, Length=340, Percent_Identity=24.4117647058824, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71988145, Length=267, Percent_Identity=32.9588014981273, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17562582, Length=267, Percent_Identity=32.2097378277154, Blast_Score=122, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17562584, Length=271, Percent_Identity=32.1033210332103, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI25146526, Length=249, Percent_Identity=31.7269076305221, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71997431, Length=251, Percent_Identity=31.8725099601594, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17565904, Length=279, Percent_Identity=30.1075268817204, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=330, Percent_Identity=28.1818181818182, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=346, Percent_Identity=27.7456647398844, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=268, Percent_Identity=31.7164179104478, Blast_Score=132, Evalue=6e-32,
Organism=Saccharomyces cerevisiae, GI6324486, Length=345, Percent_Identity=29.8550724637681, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6323729, Length=268, Percent_Identity=31.7164179104478, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6323961, Length=347, Percent_Identity=30.2593659942363, Blast_Score=127, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6320033, Length=298, Percent_Identity=28.1879194630872, Blast_Score=113, Evalue=4e-26,
Organism=Saccharomyces cerevisiae, GI6322619, Length=346, Percent_Identity=28.3236994219653, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319955, Length=346, Percent_Identity=28.3236994219653, Blast_Score=97, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6323099, Length=336, Percent_Identity=26.4880952380952, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319257, Length=371, Percent_Identity=25.8760107816712, Blast_Score=80, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6323980, Length=205, Percent_Identity=33.1707317073171, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319949, Length=256, Percent_Identity=30.078125, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=336, Percent_Identity=26.7857142857143, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI17737895, Length=329, Percent_Identity=28.8753799392097, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI17137530, Length=334, Percent_Identity=27.5449101796407, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI17737897, Length=338, Percent_Identity=25.7396449704142, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221457811, Length=186, Percent_Identity=30.6451612903226, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550770, Length=186, Percent_Identity=30.6451612903226, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551930, Length=186, Percent_Identity=30.6451612903226, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 36720; Mature: 36720

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVMFESFGERPKLVSLRDPSPETHGVVIKVQATGVCRSDWHGWVGHDTDIELPHVPGH
CCCEECHHHCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCH
ELAGTIEAVGKDVSQWQVGDRVTVPFVGGCGSCPECHAGHQQVCHSQFQPGFTHWGSFAE
HHHHHHHHHCCCHHHEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
YVSIHRADLNLVALPESITFATAASLGCRFVTSFRAVVDQGKVTAGQWVAVHGCGGVGLS
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHH
AIMIANALGANVVAVDIAEDKLALAKRLGAAATIDAKSVADVPEAVMEVTGGGAHVSLDA
HHHHHHHCCCCEEEEEECHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCCEEEHHC
LGSPVTCFNSIQNLRRRGKHVQVGLMLGEHSTPSVPMSKIVGWELEVLGSHGMQAHRYDA
CCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHH
MMPMILAGKLKPELLVGKEISLEESIDALMSMDKFQGTGTTVVTRF
HHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MKAVMFESFGERPKLVSLRDPSPETHGVVIKVQATGVCRSDWHGWVGHDTDIELPHVPGH
CCCEECHHHCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEECCCCCCH
ELAGTIEAVGKDVSQWQVGDRVTVPFVGGCGSCPECHAGHQQVCHSQFQPGFTHWGSFAE
HHHHHHHHHCCCHHHEECCCEEEEEEECCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
YVSIHRADLNLVALPESITFATAASLGCRFVTSFRAVVDQGKVTAGQWVAVHGCGGVGLS
HHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHH
AIMIANALGANVVAVDIAEDKLALAKRLGAAATIDAKSVADVPEAVMEVTGGGAHVSLDA
HHHHHHHCCCCEEEEEECHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHCCCCCEEEHHC
LGSPVTCFNSIQNLRRRGKHVQVGLMLGEHSTPSVPMSKIVGWELEVLGSHGMQAHRYDA
CCCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCHHHHCCCEEEEECCCCCCHHHHHH
MMPMILAGKLKPELLVGKEISLEESIDALMSMDKFQGTGTTVVTRF
HHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8020473 [H]