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The map label for this gene is lrp [H]

Identifier: 238024799

GI number: 238024799

Start: 1837345

End: 1837827

Strand: Direct

Name: lrp [H]

Synonym: bglu_2g14370

Alternate gene names: 238024799

Gene position: 1837345-1837827 (Clockwise)

Preceding gene: 238024798

Following gene: 238024803

Centisome position: 64.99

GC content: 67.08

Gene sequence:

>483_bases
ATGTCAAGCCGCGAACGCGCTCCCCGCCAGCTCGACAGCCAGGACCGCAAGATCCTGCGCGCGCTGCAGGGCAATGCCCG
CCTGTCGAACGCCGAACTGGCCGAACAGGTCGGCATGTCGGCCACCGCCTGCTGGAACCGCACGCGCCAGCTGGAGGCCG
ACGGCTACATCGACGGCTATGTCGCGCTCGTCAACCAGCGCATGCTCGGTTTCGCCGATATCGTGATCCTCGAGGTCACG
CTCGACCGCCACGAGGACGACGCGCTCGCGCGCTTCGGCGCCGAACTGGCCGCGCTGCCCGAGGTGCTCGAGGCCTACCT
CGTGTCGGGCGAATACGACTACTGGATCAAGGTGGCCGTGGACGGCACCGCCGGCTACGAACGCTTCCTGCGCGAGAAGC
TCTACCGAATCTCGAGCATCCGCCACAGCCGCTCGATGTTCGCGCTGCGCTGCATGAAGGACGTGCCGTCGATGCAGGTG
TGA

Upstream 100 bases:

>100_bases
CGCAGGGCGGAAAAGGCTTTGCATTCTCCGGTAAATTCCGCGGAAAACCGGAAGCTTCTTCGGATAAAATCGCCATTCCC
TGAATAAGATTCCGATCACC

Downstream 100 bases:

>100_bases
CCCGGCGCCGGCCCCTGCTGGCGAACCACGCCGGCCCGCGCCGTCAGCGCGGCGATTGCGCCTGCGCCAGCGCGTCGAGC
GCCGCGCTGCGCGCCTGCAC

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 160; Mature: 159

Protein sequence:

>160_residues
MSSRERAPRQLDSQDRKILRALQGNARLSNAELAEQVGMSATACWNRTRQLEADGYIDGYVALVNQRMLGFADIVILEVT
LDRHEDDALARFGAELAALPEVLEAYLVSGEYDYWIKVAVDGTAGYERFLREKLYRISSIRHSRSMFALRCMKDVPSMQV

Sequences:

>Translated_160_residues
MSSRERAPRQLDSQDRKILRALQGNARLSNAELAEQVGMSATACWNRTRQLEADGYIDGYVALVNQRMLGFADIVILEVT
LDRHEDDALARFGAELAALPEVLEAYLVSGEYDYWIKVAVDGTAGYERFLREKLYRISSIRHSRSMFALRCMKDVPSMQV
>Mature_159_residues
SSRERAPRQLDSQDRKILRALQGNARLSNAELAEQVGMSATACWNRTRQLEADGYIDGYVALVNQRMLGFADIVILEVTL
DRHEDDALARFGAELAALPEVLEAYLVSGEYDYWIKVAVDGTAGYERFLREKLYRISSIRHSRSMFALRCMKDVPSMQV

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=153, Percent_Identity=37.2549019607843, Blast_Score=118, Evalue=2e-28,
Organism=Escherichia coli, GI87081742, Length=150, Percent_Identity=32, Blast_Score=90, Evalue=9e-20,
Organism=Escherichia coli, GI1790182, Length=140, Percent_Identity=32.8571428571429, Blast_Score=70, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 18163; Mature: 18032

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSRERAPRQLDSQDRKILRALQGNARLSNAELAEQVGMSATACWNRTRQLEADGYIDGY
CCCCCCCCHHCCHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHH
VALVNQRMLGFADIVILEVTLDRHEDDALARFGAELAALPEVLEAYLVSGEYDYWIKVAV
HHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
DGTAGYERFLREKLYRISSIRHSRSMFALRCMKDVPSMQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SSRERAPRQLDSQDRKILRALQGNARLSNAELAEQVGMSATACWNRTRQLEADGYIDGY
CCCCCCCHHCCHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHH
VALVNQRMLGFADIVILEVTLDRHEDDALARFGAELAALPEVLEAYLVSGEYDYWIKVAV
HHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEE
DGTAGYERFLREKLYRISSIRHSRSMFALRCMKDVPSMQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]