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The map label for this gene is mntH [H]

Identifier: 238024774

GI number: 238024774

Start: 1804476

End: 1805816

Strand: Direct

Name: mntH [H]

Synonym: bglu_2g14120

Alternate gene names: 238024774

Gene position: 1804476-1805816 (Clockwise)

Preceding gene: 238024773

Following gene: 238024781

Centisome position: 63.82

GC content: 75.32

Gene sequence:

>1341_bases
ATGCCCAACCCGACGATGCCCACCCTGCCCTCGCCCGTGCGCCGCCTGCGCCCGCCCACTGCGTGGACCCGCTACGCCGG
CGCCGGCGCGCTGGTGGCGGTCGGCTACATGGACCCGGGCAACTGGGCCACCGCGCTGGCGGGCGGCGCGCAGTTCGGCT
ACCGCCTGCTCGGCGTGGTGGCGCTGGCAAGCCTGATCGCCGTGCTGCTGCAATGGGTGGCGGCGCGGCTGGGCGTGGTG
ACCGGGCGCGATCTGGCCGAGCTGTGCAGGGCACGGCTCTCGCCGCGCGCCGCGCTGGCCCTCTGGCTCGCCACCGAGGC
CGCCATCATCGCCTGCGACGTGGCCGAGGTGGTGGGCTGCGCGGTGGCGTTGCAGATGCTGCTGCACGTGCCGCTGCTGG
CCGGCGTGCTGATCTCGGCGGTCGGCACCTTCGCGATGCTCGCGCTGCAGCGGCGCGGCCATCGCACGCTCGAGGCCTGC
GTGGCCGCGCTGATCCTGTTCGTCGCGCTCTGCTTCGTGGCCGAGGTCGCGCTCGCGCAGCCCGACTGGGCCGCGGCGCT
CGGCGGCTTCGCGCCGTCCGCCGAGCTGGTCCGCAACGCCGGCATGGTCTGGCTCGCGGCCGGCATCGTCGGCGCCACGG
TGATGCCGCACAACCTCTATCTGCACTCGGCGCTCGTCAAGCGCCACGCGCCGCCCGCCGGCAGCGCCCGCGGCGGCCGG
CGCGGGCACCACGGCGCCGCGGCGCGCCGCGAGCGCGACGCCGAGATCGCCGGCACGATGCGCGGCGTGGGCTTCGACAC
CTTCTTCTCGCTCGGGTTCGCGTTCGTCGTCAACGCGGCGCTGCTGACCGTGGCCGCGGCGGCGTTCCACGCGAGCGGCC
ACACCGGCGTGGACGACCTCGCCGACGCCCACCGGCTGCTCGCGCCGCTGGTCGGCAGCCACTGGGCGAGCCTGCTGTTC
GCCGCCGCGCTGCTCGCCTGCGGGCTCAACGCCACCGTGACCGGCACGCTCGCCGGGCAGATCGTGATGGAGGGTTTCCT
GAAGCTGCGCATCTCGCCCACGCGGCGCGCGATCCTCACGCGCGCGCTCGCGATCGGGCCGGCGCTGGTGGCCGTGGCCG
CGTTCGGCAATCACGGTTCCGCGCAACTGCTGGTGGCGAGCCAGGTCGTGCTGAGCCTGCAACTGCCGCTGGCCGTGATC
CCGCTGGTGCGCTTCGCCGCCGACCCGGCGCTGATGGGCCGCTGGCGCATCCGCGGCTGGGTGCACGCGGCGGCCTGGGC
GGCCACCGCCTTGATTCTGGTGCTCAACCTCGCGCTGCTCTGGCAGCTCTGGGCCGACTGA

Upstream 100 bases:

>100_bases
TCGGTTTTTTTCATTGTCAAATGCAAACGAGAATAATTATCATTTATAAAAGATGCCATGGCGTCTCGCTATTCTTCAGA
TCACCGCCGGATCACGACCG

Downstream 100 bases:

>100_bases
GCCCGGCAGGTGCCGCGCTCGCCGGCGCCGCCTGGCTGCGCGACGCCGCCGGGGGCGCGCGTCTCAGCGCGCCGTCCAGC
GCGCCTGCGTCACGTCGAGC

Product: Manganese/iron transporter, NRAMP family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MPNPTMPTLPSPVRRLRPPTAWTRYAGAGALVAVGYMDPGNWATALAGGAQFGYRLLGVVALASLIAVLLQWVAARLGVV
TGRDLAELCRARLSPRAALALWLATEAAIIACDVAEVVGCAVALQMLLHVPLLAGVLISAVGTFAMLALQRRGHRTLEAC
VAALILFVALCFVAEVALAQPDWAAALGGFAPSAELVRNAGMVWLAAGIVGATVMPHNLYLHSALVKRHAPPAGSARGGR
RGHHGAAARRERDAEIAGTMRGVGFDTFFSLGFAFVVNAALLTVAAAAFHASGHTGVDDLADAHRLLAPLVGSHWASLLF
AAALLACGLNATVTGTLAGQIVMEGFLKLRISPTRRAILTRALAIGPALVAVAAFGNHGSAQLLVASQVVLSLQLPLAVI
PLVRFAADPALMGRWRIRGWVHAAAWAATALILVLNLALLWQLWAD

Sequences:

>Translated_446_residues
MPNPTMPTLPSPVRRLRPPTAWTRYAGAGALVAVGYMDPGNWATALAGGAQFGYRLLGVVALASLIAVLLQWVAARLGVV
TGRDLAELCRARLSPRAALALWLATEAAIIACDVAEVVGCAVALQMLLHVPLLAGVLISAVGTFAMLALQRRGHRTLEAC
VAALILFVALCFVAEVALAQPDWAAALGGFAPSAELVRNAGMVWLAAGIVGATVMPHNLYLHSALVKRHAPPAGSARGGR
RGHHGAAARRERDAEIAGTMRGVGFDTFFSLGFAFVVNAALLTVAAAAFHASGHTGVDDLADAHRLLAPLVGSHWASLLF
AAALLACGLNATVTGTLAGQIVMEGFLKLRISPTRRAILTRALAIGPALVAVAAFGNHGSAQLLVASQVVLSLQLPLAVI
PLVRFAADPALMGRWRIRGWVHAAAWAATALILVLNLALLWQLWAD
>Mature_445_residues
PNPTMPTLPSPVRRLRPPTAWTRYAGAGALVAVGYMDPGNWATALAGGAQFGYRLLGVVALASLIAVLLQWVAARLGVVT
GRDLAELCRARLSPRAALALWLATEAAIIACDVAEVVGCAVALQMLLHVPLLAGVLISAVGTFAMLALQRRGHRTLEACV
AALILFVALCFVAEVALAQPDWAAALGGFAPSAELVRNAGMVWLAAGIVGATVMPHNLYLHSALVKRHAPPAGSARGGRR
GHHGAAARRERDAEIAGTMRGVGFDTFFSLGFAFVVNAALLTVAAAAFHASGHTGVDDLADAHRLLAPLVGSHWASLLFA
AALLACGLNATVTGTLAGQIVMEGFLKLRISPTRRAILTRALAIGPALVAVAAFGNHGSAQLLVASQVVLSLQLPLAVIP
LVRFAADPALMGRWRIRGWVHAAAWAATALILVLNLALLWQLWAD

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=446, Percent_Identity=35.8744394618834, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI295293167, Length=430, Percent_Identity=35.8139534883721, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI295293178, Length=430, Percent_Identity=35.8139534883721, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI295293175, Length=430, Percent_Identity=35.8139534883721, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI295293173, Length=430, Percent_Identity=35.8139534883721, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI10835169, Length=430, Percent_Identity=35.8139534883721, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI295293171, Length=430, Percent_Identity=35.8139534883721, Blast_Score=190, Evalue=3e-48,
Organism=Homo sapiens, GI295293169, Length=430, Percent_Identity=35.8139534883721, Blast_Score=190, Evalue=3e-48,
Organism=Escherichia coli, GI1788736, Length=418, Percent_Identity=38.5167464114833, Blast_Score=247, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI71999499, Length=448, Percent_Identity=31.0267857142857, Blast_Score=193, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17569473, Length=422, Percent_Identity=32.9383886255924, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI193210616, Length=461, Percent_Identity=31.236442516269, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI71993856, Length=244, Percent_Identity=36.8852459016393, Blast_Score=142, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6323062, Length=412, Percent_Identity=38.3495145631068, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6321841, Length=428, Percent_Identity=36.214953271028, Blast_Score=216, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6324450, Length=423, Percent_Identity=34.9881796690307, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI45553443, Length=428, Percent_Identity=32.9439252336449, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24648607, Length=428, Percent_Identity=32.9439252336449, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI281362176, Length=428, Percent_Identity=32.9439252336449, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI24648609, Length=428, Percent_Identity=32.9439252336449, Blast_Score=184, Evalue=9e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 46434; Mature: 46303

Theoretical pI: Translated: 11.07; Mature: 11.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNPTMPTLPSPVRRLRPPTAWTRYAGAGALVAVGYMDPGNWATALAGGAQFGYRLLGVV
CCCCCCCCCCCHHHHCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHH
ALASLIAVLLQWVAARLGVVTGRDLAELCRARLSPRAALALWLATEAAIIACDVAEVVGC
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
AVALQMLLHVPLLAGVLISAVGTFAMLALQRRGHRTLEACVAALILFVALCFVAEVALAQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
PDWAAALGGFAPSAELVRNAGMVWLAAGIVGATVMPHNLYLHSALVKRHAPPAGSARGGR
CCHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCC
RGHHGAAARRERDAEIAGTMRGVGFDTFFSLGFAFVVNAALLTVAAAAFHASGHTGVDDL
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
ADAHRLLAPLVGSHWASLLFAAALLACGLNATVTGTLAGQIVMEGFLKLRISPTRRAILT
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHEECCHHHHHHHH
RALAIGPALVAVAAFGNHGSAQLLVASQVVLSLQLPLAVIPLVRFAADPALMGRWRIRGW
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
VHAAAWAATALILVLNLALLWQLWAD
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PNPTMPTLPSPVRRLRPPTAWTRYAGAGALVAVGYMDPGNWATALAGGAQFGYRLLGVV
CCCCCCCCCCHHHHCCCCCHHHHHCCCCCEEEEEECCCCCHHHHHHCCHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]