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The map label for this gene is mscM [H]

Identifier: 238024771

GI number: 238024771

Start: 1800753

End: 1801988

Strand: Direct

Name: mscM [H]

Synonym: bglu_2g14090

Alternate gene names: 238024771

Gene position: 1800753-1801988 (Clockwise)

Preceding gene: 238024770

Following gene: 238024773

Centisome position: 63.69

GC content: 67.56

Gene sequence:

>1236_bases
ATGAATGCATCCTGGTTTTCGCCGCTCGTCGGCTGTCTGATCCTGCTGGCCGTGTCGTGCGCGATCGGCGCGGCCGTGCG
CTACCTGCTGTTCCGCGTGGTCGCGAAGTTCGCGCAGCGCTCGCCGACGCGCTTGGACGACGTGCTGTTCCAGTTCGGCG
CGTTCAAGTGGCTGTCGCGGCTGGTGCCGTTCGTGGTGTTCCAGCTCGGTTTCCGCGCCGTGCCGAACATCCCCGAACCG
GCCGCGCAGCTGGTCGACAAGGTGCTGTTCGCGATCGTGGTGCTGCTCGTCACGCTGCTGGTCAGCGCGGTGCTGTCGGC
CGTCGAGCATCTGCACCGCACCACCCGCACACGGCCGGCGCTCTCGCTCAAGGGCGCCGTGCAGCTCGTCAAGCTCGCGA
TGTTCATCACCGCCACGCTGGTGGTGATCGGCACCGTCACCGGCAAGCAGATCGGGCTGCTGCTGTCGGGCATCGGCGCG
ATGTCGGCGGTGCTGATGCTGATCTTCAAGGACACCATCCTCGGCCTGGTGGCCGGCGTGCAGCTCTCCTCGAACGACAT
GCTGCGGATCGGCGACTGGATCACGATGCCGAGCGCGGGCGCCGACGGCGACGTGATCGACATCACGCTCAACACCGTGA
AGGTGTCGAACTTCGACCGCACCATCATCACGATTCCCACCTGGAAGCTGATCACCGAGAGCTACCAGAACTGGCGCGGC
ATGACCGAGTCGGGCGGGCGGCGCATCAAGCGCTCGCTGTTCATCGACGCCACCAGCGTGCGCTTCCTCGCCCACGACGA
GATCGAGCGGCTCGAGCGCTTCCGGCTGCTGAAGGCGTACCTGGCGAGCAAGCTCGACACGCTGGCCGAATGGAACGGCT
CGCTCGGCGCCGACGGCGAATGGATGGGCAACCGCCGGCAGCTCACCAACCTCGGCACGTTCCGCGCCTATTGCGACAAC
TACCTGCAGCAGCACCCGCGCATCCACCGCGGCATGACCTGCATGGCGCGCCAGCTGCCGCCCACCGCCGAGGGCATCCC
GCTGGAACTCTACTGCTTCACCGACACCACCACCTGGCTCGACTACGAGACGATTCAGGGCGACATCTTCGACCACCTGC
TGGCCGTGCTGCCGGAGTTCGGGCTGCGCGTCTACCAGCATCCGTCCGGGTTCGACCTGCGCGGCATGGTCGAGGCCGGC
GCCGCGCGCGGCGCCGAGCCCGCCCTGCCGGCCTGA

Upstream 100 bases:

>100_bases
CGCGCAGTCGATTACGGATGGCCTTCGTTGCCGCGCCGCGCGCCCCGGCCCGGTTCGCCGCGTCGGTCCCCTCCGTTTCC
TTCGTTTCGATAGCAAGCCA

Downstream 100 bases:

>100_bases
GCGTCGACGGTTGTCCCCGCAACCGGTTGGGCACCCGTCCGCGCCGCTGGCCGCCGTCTCCGGCGCATCGGCCCGCGTTC
AGCGGGCGCCCGTGGCCGCG

Product: Mechanosensitive ion channel protein MscS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MNASWFSPLVGCLILLAVSCAIGAAVRYLLFRVVAKFAQRSPTRLDDVLFQFGAFKWLSRLVPFVVFQLGFRAVPNIPEP
AAQLVDKVLFAIVVLLVTLLVSAVLSAVEHLHRTTRTRPALSLKGAVQLVKLAMFITATLVVIGTVTGKQIGLLLSGIGA
MSAVLMLIFKDTILGLVAGVQLSSNDMLRIGDWITMPSAGADGDVIDITLNTVKVSNFDRTIITIPTWKLITESYQNWRG
MTESGGRRIKRSLFIDATSVRFLAHDEIERLERFRLLKAYLASKLDTLAEWNGSLGADGEWMGNRRQLTNLGTFRAYCDN
YLQQHPRIHRGMTCMARQLPPTAEGIPLELYCFTDTTTWLDYETIQGDIFDHLLAVLPEFGLRVYQHPSGFDLRGMVEAG
AARGAEPALPA

Sequences:

>Translated_411_residues
MNASWFSPLVGCLILLAVSCAIGAAVRYLLFRVVAKFAQRSPTRLDDVLFQFGAFKWLSRLVPFVVFQLGFRAVPNIPEP
AAQLVDKVLFAIVVLLVTLLVSAVLSAVEHLHRTTRTRPALSLKGAVQLVKLAMFITATLVVIGTVTGKQIGLLLSGIGA
MSAVLMLIFKDTILGLVAGVQLSSNDMLRIGDWITMPSAGADGDVIDITLNTVKVSNFDRTIITIPTWKLITESYQNWRG
MTESGGRRIKRSLFIDATSVRFLAHDEIERLERFRLLKAYLASKLDTLAEWNGSLGADGEWMGNRRQLTNLGTFRAYCDN
YLQQHPRIHRGMTCMARQLPPTAEGIPLELYCFTDTTTWLDYETIQGDIFDHLLAVLPEFGLRVYQHPSGFDLRGMVEAG
AARGAEPALPA
>Mature_411_residues
MNASWFSPLVGCLILLAVSCAIGAAVRYLLFRVVAKFAQRSPTRLDDVLFQFGAFKWLSRLVPFVVFQLGFRAVPNIPEP
AAQLVDKVLFAIVVLLVTLLVSAVLSAVEHLHRTTRTRPALSLKGAVQLVKLAMFITATLVVIGTVTGKQIGLLLSGIGA
MSAVLMLIFKDTILGLVAGVQLSSNDMLRIGDWITMPSAGADGDVIDITLNTVKVSNFDRTIITIPTWKLITESYQNWRG
MTESGGRRIKRSLFIDATSVRFLAHDEIERLERFRLLKAYLASKLDTLAEWNGSLGADGEWMGNRRQLTNLGTFRAYCDN
YLQQHPRIHRGMTCMARQLPPTAEGIPLELYCFTDTTTWLDYETIQGDIFDHLLAVLPEFGLRVYQHPSGFDLRGMVEAG
AARGAEPALPA

Specific function: Mechanosensitive channel of miniconductance that confers protection against mild hypoosmotic shock. Overexpression confers protection against severe shocks [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1786791, Length=311, Percent_Identity=52.0900321543408, Blast_Score=334, Evalue=5e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 45411; Mature: 45411

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNASWFSPLVGCLILLAVSCAIGAAVRYLLFRVVAKFAQRSPTRLDDVLFQFGAFKWLSR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LVPFVVFQLGFRAVPNIPEPAAQLVDKVLFAIVVLLVTLLVSAVLSAVEHLHRTTRTRPA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSLKGAVQLVKLAMFITATLVVIGTVTGKQIGLLLSGIGAMSAVLMLIFKDTILGLVAGV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QLSSNDMLRIGDWITMPSAGADGDVIDITLNTVKVSNFDRTIITIPTWKLITESYQNWRG
EECCCCCEEECCEEECCCCCCCCCEEEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHCC
MTESGGRRIKRSLFIDATSVRFLAHDEIERLERFRLLKAYLASKLDTLAEWNGSLGADGE
CCHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
WMGNRRQLTNLGTFRAYCDNYLQQHPRIHRGMTCMARQLPPTAEGIPLELYCFTDTTTWL
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEE
DYETIQGDIFDHLLAVLPEFGLRVYQHPSGFDLRGMVEAGAARGAEPALPA
EHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNASWFSPLVGCLILLAVSCAIGAAVRYLLFRVVAKFAQRSPTRLDDVLFQFGAFKWLSR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LVPFVVFQLGFRAVPNIPEPAAQLVDKVLFAIVVLLVTLLVSAVLSAVEHLHRTTRTRPA
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LSLKGAVQLVKLAMFITATLVVIGTVTGKQIGLLLSGIGAMSAVLMLIFKDTILGLVAGV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QLSSNDMLRIGDWITMPSAGADGDVIDITLNTVKVSNFDRTIITIPTWKLITESYQNWRG
EECCCCCEEECCEEECCCCCCCCCEEEEEEEEEEECCCCCEEEECCCHHHHHHHHHHHCC
MTESGGRRIKRSLFIDATSVRFLAHDEIERLERFRLLKAYLASKLDTLAEWNGSLGADGE
CCHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
WMGNRRQLTNLGTFRAYCDNYLQQHPRIHRGMTCMARQLPPTAEGIPLELYCFTDTTTWL
CCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCEE
DYETIQGDIFDHLLAVLPEFGLRVYQHPSGFDLRGMVEAGAARGAEPALPA
EHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 7813889 [H]