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The map label for this gene is dacC [H]

Identifier: 23501950

GI number: 23501950

Start: 1043218

End: 1044450

Strand: Reverse

Name: dacC [H]

Synonym: BR1072

Alternate gene names: 23501950

Gene position: 1044450-1043218 (Counterclockwise)

Preceding gene: 23501951

Following gene: 23501949

Centisome position: 49.55

GC content: 57.91

Gene sequence:

>1233_bases
ATGCCCTCTTCGCGCATTCGTAATTTTCTGCGAGCTATCATGTTGAAATCGTCGTCCCGTATTTCGCGTTTCTTTGCGTC
CGTCGTATTTGGAACAGCCGTTCTTTGTGCGTCAGGCGCAATGGCGAGCACATCATGGGTTGTGTTCGATGCGGATAGCG
GGCGGATGCTGGGGCAGGACGATGCAAGCGCGCAGCACGCGCCAGCCTCACTTGCCAAGATGATGACGCTCTATCTCACT
TTCGAGGCCTTGAAGACTGGCCGGTTGCATTGGGACGATGCGCTGCCGATTTCAAAAAATGCGGCTTCCAAGGTTCGGAT
GAAGCTGTGGCTGAAGGCCGGCGACACGATTTCTACCCGCGATGCAGTCAACGGGATGATTATCGTCTCGGCAAATGATG
CTGCGACTGTCATGGGCGAATATCTTGCCGGCTCGGAGGCCGCTTTTGCGCGCCTGATGACACAGCGCGCGCGCCAGATC
GGCATGAAAAGCACCATTTTCGCCAATCCTTCGGGGCTGACCGCGAATGTCAGCCAGTTGACGACTGCACGCGACATGGC
GGTGCTGGGCATGGCTCTTCGGCGAGATTTCCCGGAAGAATATGCGTTGTTTTCGCAGCGCTCCTTCACTTTTCGCGGGC
GCGTCTATAACGGGCACAACAACCTGATGTACCGCTATGCGGGTGTGGATGGCATCAAGACCGGCTATACAAATGTATCC
GGCTATAATTTGGTGTCGTCGGCCTATATCAACAACAGGCATCTGGTGGGCGTGGTTCTGGGCGCAGGCTCTGCCGGGCA
GCGCGATGGCCAGAAGGCGAAACTTCTGACGCGCTTTGGCGGTGTCGATAATGGCAAGGCCGCGCCTCTGGTTGCCATGG
CGAAGCCGCAGGCGGTTACTGCGAAACTGAAGCCGGATGTGGTTGCCGATCTGATCGACGATACCCAGATCGAGCAGGGG
GATGGCGGCTATCCAGTGACTTCCGGCAGATCGAACTGGCGCATTCAGCTGGCGGCAACGCCAAGCCGTGCGGGTGCCAG
CGAATTGCAGGAGAAATATGCACCCGTGGTTTCCAGGATCGTGCCCGGCGCAAAGGGCGAAATCTCGCCTTCGCCCAAGG
GTCGCAAAGTCTATCGCGTGCGTTTTTCCGGCGTCAGGGATTCGGCTGCCGCAAGCAAGGCCTGCGTGCAGCTCAAACGC
CAGCAAATCGCCTGCCTGGCTATTCAGAACTAG

Upstream 100 bases:

>100_bases
TTTACGTTAAATGAATATAATTCATTAACCATCGCTGCGTTTTATAGCTCCTTGATATTAAGGCGTTGCCCTGTCCATTT
TTGGGCCGCAATTTGCCTGC

Downstream 100 bases:

>100_bases
AGAGCGTTTCGATCTGATTGAATCAGATCGGCGCTATAATCCTTTTTTTGACGCGCATTTTTTCCGAAAACCGTTTCACA
CTTTTCGGGATGCGTTCTAG

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MPSSRIRNFLRAIMLKSSSRISRFFASVVFGTAVLCASGAMASTSWVVFDADSGRMLGQDDASAQHAPASLAKMMTLYLT
FEALKTGRLHWDDALPISKNAASKVRMKLWLKAGDTISTRDAVNGMIIVSANDAATVMGEYLAGSEAAFARLMTQRARQI
GMKSTIFANPSGLTANVSQLTTARDMAVLGMALRRDFPEEYALFSQRSFTFRGRVYNGHNNLMYRYAGVDGIKTGYTNVS
GYNLVSSAYINNRHLVGVVLGAGSAGQRDGQKAKLLTRFGGVDNGKAAPLVAMAKPQAVTAKLKPDVVADLIDDTQIEQG
DGGYPVTSGRSNWRIQLAATPSRAGASELQEKYAPVVSRIVPGAKGEISPSPKGRKVYRVRFSGVRDSAAASKACVQLKR
QQIACLAIQN

Sequences:

>Translated_410_residues
MPSSRIRNFLRAIMLKSSSRISRFFASVVFGTAVLCASGAMASTSWVVFDADSGRMLGQDDASAQHAPASLAKMMTLYLT
FEALKTGRLHWDDALPISKNAASKVRMKLWLKAGDTISTRDAVNGMIIVSANDAATVMGEYLAGSEAAFARLMTQRARQI
GMKSTIFANPSGLTANVSQLTTARDMAVLGMALRRDFPEEYALFSQRSFTFRGRVYNGHNNLMYRYAGVDGIKTGYTNVS
GYNLVSSAYINNRHLVGVVLGAGSAGQRDGQKAKLLTRFGGVDNGKAAPLVAMAKPQAVTAKLKPDVVADLIDDTQIEQG
DGGYPVTSGRSNWRIQLAATPSRAGASELQEKYAPVVSRIVPGAKGEISPSPKGRKVYRVRFSGVRDSAAASKACVQLKR
QQIACLAIQN
>Mature_409_residues
PSSRIRNFLRAIMLKSSSRISRFFASVVFGTAVLCASGAMASTSWVVFDADSGRMLGQDDASAQHAPASLAKMMTLYLTF
EALKTGRLHWDDALPISKNAASKVRMKLWLKAGDTISTRDAVNGMIIVSANDAATVMGEYLAGSEAAFARLMTQRARQIG
MKSTIFANPSGLTANVSQLTTARDMAVLGMALRRDFPEEYALFSQRSFTFRGRVYNGHNNLMYRYAGVDGIKTGYTNVSG
YNLVSSAYINNRHLVGVVLGAGSAGQRDGQKAKLLTRFGGVDNGKAAPLVAMAKPQAVTAKLKPDVVADLIDDTQIEQGD
GGYPVTSGRSNWRIQLAATPSRAGASELQEKYAPVVSRIVPGAKGEISPSPKGRKVYRVRFSGVRDSAAASKACVQLKRQ
QIACLAIQN

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=270, Percent_Identity=37.037037037037, Blast_Score=161, Evalue=9e-41,
Organism=Escherichia coli, GI1786851, Length=240, Percent_Identity=36.6666666666667, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI87082022, Length=243, Percent_Identity=36.2139917695473, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI87082054, Length=271, Percent_Identity=28.4132841328413, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 44022; Mature: 43891

Theoretical pI: Translated: 10.68; Mature: 10.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSRIRNFLRAIMLKSSSRISRFFASVVFGTAVLCASGAMASTSWVVFDADSGRMLGQD
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCC
DASAQHAPASLAKMMTLYLTFEALKTGRLHWDDALPISKNAASKVRMKLWLKAGDTISTR
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHEEEEEEEECCCCCCCH
DAVNGMIIVSANDAATVMGEYLAGSEAAFARLMTQRARQIGMKSTIFANPSGLTANVSQL
HHHCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
TTARDMAVLGMALRRDFPEEYALFSQRSFTFRGRVYNGHNNLMYRYAGVDGIKTGYTNVS
HHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCC
GYNLVSSAYINNRHLVGVVLGAGSAGQRDGQKAKLLTRFGGVDNGKAAPLVAMAKPQAVT
CCCHHHHHEECCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEE
AKLKPDVVADLIDDTQIEQGDGGYPVTSGRSNWRIQLAATPSRAGASELQEKYAPVVSRI
EECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
VPGAKGEISPSPKGRKVYRVRFSGVRDSAAASKACVQLKRQQIACLAIQN
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCEEEEEECC
>Mature Secondary Structure 
PSSRIRNFLRAIMLKSSSRISRFFASVVFGTAVLCASGAMASTSWVVFDADSGRMLGQD
CHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCC
DASAQHAPASLAKMMTLYLTFEALKTGRLHWDDALPISKNAASKVRMKLWLKAGDTISTR
CCCCCCCHHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCCCHHHEEEEEEEECCCCCCCH
DAVNGMIIVSANDAATVMGEYLAGSEAAFARLMTQRARQIGMKSTIFANPSGLTANVSQL
HHHCEEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
TTARDMAVLGMALRRDFPEEYALFSQRSFTFRGRVYNGHNNLMYRYAGVDGIKTGYTNVS
HHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEEEEECCCCEEEEEECCCCCCCCCCCCC
GYNLVSSAYINNRHLVGVVLGAGSAGQRDGQKAKLLTRFGGVDNGKAAPLVAMAKPQAVT
CCCHHHHHEECCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCEEEECCCCEEE
AKLKPDVVADLIDDTQIEQGDGGYPVTSGRSNWRIQLAATPSRAGASELQEKYAPVVSRI
EECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHH
VPGAKGEISPSPKGRKVYRVRFSGVRDSAAASKACVQLKRQQIACLAIQN
CCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]