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The map label for this gene is qacH [H]

Identifier: 23501812

GI number: 23501812

Start: 901277

End: 901609

Strand: Reverse

Name: qacH [H]

Synonym: BR0928

Alternate gene names: 23501812

Gene position: 901609-901277 (Counterclockwise)

Preceding gene: 23501813

Following gene: 23501810

Centisome position: 42.78

GC content: 55.56

Gene sequence:

>333_bases
ATGCCGGTTTATACTTTTCTCGCCATTGCAATCTTTTCCGAAGTCATCGGCACACTAAGCCTCAAGGCATCGGAAGGGTT
TTCGCGCCTTGGCCCATCCATCGTGGTGGTGGTCGCCTATGGCCTCGCCTTCTATTTCCTGTCACTAACGCTGAAAACAA
TCCCGGTCGGTGTCGCCTATGCGATCTGGTCCGGCGTTGGCGTAACGCTGGTGGCGCTCATCGGCTGGCTGGTATTCGGG
CAGAAGCTGGATCTTCCCGCAATTGTCGGCATGGGCCTCATCATCGCGGGCGTGATCGTCTTGAATTTGCTTTCCAACAC
CGCTCAGCATTAG

Upstream 100 bases:

>100_bases
GCTTACCAGATTTGCGACGCCTCATCCGGCGGGCTGCCCGCCGGATTTTTTATAGTATTATTATTTAACAATCTTTTCCC
CCGTTATTCGAGAGCGCGCC

Downstream 100 bases:

>100_bases
GGCCTAACAGGAACGCCGCCGGAAACGGGCTTGTCGCAGCCCGTCGTGGAGGGATAGGTGAGCGGCAGGCCGCAAAGCGA
ACGCACTGCAAGATAGGCCC

Product: quaternary ammonium compound-resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Quaternary ammonium determinant F [H]

Number of amino acids: Translated: 110; Mature: 109

Protein sequence:

>110_residues
MPVYTFLAIAIFSEVIGTLSLKASEGFSRLGPSIVVVVAYGLAFYFLSLTLKTIPVGVAYAIWSGVGVTLVALIGWLVFG
QKLDLPAIVGMGLIIAGVIVLNLLSNTAQH

Sequences:

>Translated_110_residues
MPVYTFLAIAIFSEVIGTLSLKASEGFSRLGPSIVVVVAYGLAFYFLSLTLKTIPVGVAYAIWSGVGVTLVALIGWLVFG
QKLDLPAIVGMGLIIAGVIVLNLLSNTAQH
>Mature_109_residues
PVYTFLAIAIFSEVIGTLSLKASEGFSRLGPSIVVVVAYGLAFYFLSLTLKTIPVGVAYAIWSGVGVTLVALIGWLVFGQ
KLDLPAIVGMGLIIAGVIVLNLLSNTAQH

Specific function: Multidrug exporter. Is implicated for the resistance to bacteriocidal quaternary ammonium compounds [H]

COG id: COG2076

COG function: function code P; Membrane transporters of cations and cationic drugs

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the small multidrug resistance (SMR) protein family [H]

Homologues:

Organism=Escherichia coli, GI1786755, Length=110, Percent_Identity=54.5454545454545, Blast_Score=123, Evalue=3e-30,
Organism=Escherichia coli, GI87082378, Length=103, Percent_Identity=34.9514563106796, Blast_Score=65, Evalue=8e-13,
Organism=Escherichia coli, GI1787884, Length=107, Percent_Identity=33.6448598130841, Blast_Score=65, Evalue=1e-12,
Organism=Escherichia coli, GI1787883, Length=99, Percent_Identity=37.3737373737374, Blast_Score=62, Evalue=7e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000390 [H]

Pfam domain/function: PF00893 Multi_Drug_Res [H]

EC number: NA

Molecular weight: Translated: 11538; Mature: 11407

Theoretical pI: Translated: 8.95; Mature: 8.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVYTFLAIAIFSEVIGTLSLKASEGFSRLGPSIVVVVAYGLAFYFLSLTLKTIPVGVAY
CCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGVGVTLVALIGWLVFGQKLDLPAIVGMGLIIAGVIVLNLLSNTAQH
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PVYTFLAIAIFSEVIGTLSLKASEGFSRLGPSIVVVVAYGLAFYFLSLTLKTIPVGVAY
CHHHHHHHHHHHHHHHHHHHHCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIWSGVGVTLVALIGWLVFGQKLDLPAIVGMGLIIAGVIVLNLLSNTAQH
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9756755 [H]