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The map label for this gene is rnd [H]

Identifier: 23501637

GI number: 23501637

Start: 736411

End: 737568

Strand: Reverse

Name: rnd [H]

Synonym: BR0750

Alternate gene names: 23501637

Gene position: 737568-736411 (Counterclockwise)

Preceding gene: 23501639

Following gene: 23501634

Centisome position: 34.99

GC content: 60.28

Gene sequence:

>1158_bases
ATGCAACTCATCACGACCACCGAGGCCCTTGAAGAGGCCGTATTCGCCCTTGCCAAATCCGATTTCGTCACGGTTGACAC
GGAGTTCATCCGTGAAACGACCTTCTGGCCGGAATTGTGCCTGATCCAGATGGCCTCACCTGACCATACGGCGCTGGTGG
ATGCGCTGGCGCCGGGGTTGGACCTTGCGCCCTTCTTCCGCCTGATGGCCGATGAGGAAATCGTCAAGGTCTTCCATGCC
GCCCGGCAGGATATCGAGATTGTCTTTCATCTGGGCAATCTGATCCCCTCGCCAGTTTTCGACACGCAGGTGGCGGCAAT
GGTCTGCGGCTTTGGCGATGCGATTTCCTATGACCAGCTCGTGCAGAAGGTTACGGGCAAGCACCTCGACAAGTCCTCGC
GGTTTACCGACTGGCGCCGCCGCCCGCTTTCCGACAAGCAACTCGATTATGCGCTGGCGGACGTGACCTATCTGCGCGAC
ATCTACCTCTATCTGAAGGAAGAGCTTCAAAAAGAAGGGCGCAGCGAGTGGGTGAACGAGGAAATGGCGGTGCTGACCGC
GCGCCAAACTTACGATCTTCATCCTGATGACGCATGGCGGCGCGTGAAGGCGCGTGTGCGTAAACCACTTGAGCTTGCCA
TCGTGCAGGCCGTTGCCGCCTGGCGCGAGCGCGAGGCGCGCGAACGCAATGTGCCGCGCGGGCGCATCATCAAGGACGAC
ACGATTGCCGAAATCGCACAGCAGCAGCCGCGTGACGCCGAGGCGCTCGGTCGCCTTCGTTCCATCCCCAAGGGTTGGGA
GCGTTCCGCACAGGCGGCAGGCCTTGTCACGGCGATCCAGTCGGCGCTTGCAATCGCGAAGGAAGACCTTCCCAAATCGC
CAAAGCCATCCCACTCACCGGAAGGCAGCGCCGCCGCTGCGGATATCCTGAAAGTCCTGCTCAAGCTGGTGACGGAAGAA
CATGGCGTGGCAGCCAAGATCGTCGCCAATTCCGACGATATTGAAAAGATCGCCGCGGAGGGCGACAAGGCGAACGTCCC
TGCCCTGCACGGCTGGCGACGCGAGGTTTTCGGCCAGAAGGCACTCGATCTCATCGACGGCAAGATCGGCATCAAGTTTG
AGAACCGACGGATCAGAGCGGTGGAGTTAAGGGAGTAA

Upstream 100 bases:

>100_bases
GACGCAACGTATCGACAAAAAATACAATTTGCACTTGTTATGCTACGGGTTTTGCGCATTCTTTCGCGACAATCGATGTC
GCTTTGTCTAAAAGAAAACC

Downstream 100 bases:

>100_bases
GGGAGTAAGGGAGTAAGGGAAAAAATCACCCTTTTTCAGTCAAGGCAAATATTTTACTTGCCTTGTCCACCACCTGCCCG
CACCCTATTCCCCTATTCCC

Product: ribonuclease D

Products: NA

Alternate protein names: RNase D [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MQLITTTEALEEAVFALAKSDFVTVDTEFIRETTFWPELCLIQMASPDHTALVDALAPGLDLAPFFRLMADEEIVKVFHA
ARQDIEIVFHLGNLIPSPVFDTQVAAMVCGFGDAISYDQLVQKVTGKHLDKSSRFTDWRRRPLSDKQLDYALADVTYLRD
IYLYLKEELQKEGRSEWVNEEMAVLTARQTYDLHPDDAWRRVKARVRKPLELAIVQAVAAWREREARERNVPRGRIIKDD
TIAEIAQQQPRDAEALGRLRSIPKGWERSAQAAGLVTAIQSALAIAKEDLPKSPKPSHSPEGSAAAADILKVLLKLVTEE
HGVAAKIVANSDDIEKIAAEGDKANVPALHGWRREVFGQKALDLIDGKIGIKFENRRIRAVELRE

Sequences:

>Translated_385_residues
MQLITTTEALEEAVFALAKSDFVTVDTEFIRETTFWPELCLIQMASPDHTALVDALAPGLDLAPFFRLMADEEIVKVFHA
ARQDIEIVFHLGNLIPSPVFDTQVAAMVCGFGDAISYDQLVQKVTGKHLDKSSRFTDWRRRPLSDKQLDYALADVTYLRD
IYLYLKEELQKEGRSEWVNEEMAVLTARQTYDLHPDDAWRRVKARVRKPLELAIVQAVAAWREREARERNVPRGRIIKDD
TIAEIAQQQPRDAEALGRLRSIPKGWERSAQAAGLVTAIQSALAIAKEDLPKSPKPSHSPEGSAAAADILKVLLKLVTEE
HGVAAKIVANSDDIEKIAAEGDKANVPALHGWRREVFGQKALDLIDGKIGIKFENRRIRAVELRE
>Mature_385_residues
MQLITTTEALEEAVFALAKSDFVTVDTEFIRETTFWPELCLIQMASPDHTALVDALAPGLDLAPFFRLMADEEIVKVFHA
ARQDIEIVFHLGNLIPSPVFDTQVAAMVCGFGDAISYDQLVQKVTGKHLDKSSRFTDWRRRPLSDKQLDYALADVTYLRD
IYLYLKEELQKEGRSEWVNEEMAVLTARQTYDLHPDDAWRRVKARVRKPLELAIVQAVAAWREREARERNVPRGRIIKDD
TIAEIAQQQPRDAEALGRLRSIPKGWERSAQAAGLVTAIQSALAIAKEDLPKSPKPSHSPEGSAAAADILKVLLKLVTEE
HGVAAKIVANSDDIEKIAAEGDKANVPALHGWRREVFGQKALDLIDGKIGIKFENRRIRAVELRE

Specific function: Cleaves multimeric tRNA precursor at the spacer region. Contribute to the 3' maturation of several stable RNAs [H]

COG id: COG0349

COG function: function code J; Ribonuclease D

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4505917, Length=264, Percent_Identity=25.3787878787879, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI50301240, Length=264, Percent_Identity=25.3787878787879, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1788105, Length=371, Percent_Identity=30.7277628032345, Blast_Score=171, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI17531757, Length=188, Percent_Identity=29.2553191489362, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324574, Length=167, Percent_Identity=29.3413173652695, Blast_Score=66, Evalue=8e-12,
Organism=Drosophila melanogaster, GI161078302, Length=267, Percent_Identity=24.7191011235955, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002562
- InterPro:   IPR002121
- InterPro:   IPR010997
- InterPro:   IPR006292
- InterPro:   IPR012337 [H]

Pfam domain/function: PF01612 3_5_exonuc; PF00570 HRDC [H]

EC number: =3.1.13.5 [H]

Molecular weight: Translated: 43203; Mature: 43203

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLITTTEALEEAVFALAKSDFVTVDTEFIRETTFWPELCLIQMASPDHTALVDALAPGL
CCCCCHHHHHHHHHHHHHHCCEEEECHHHHHHHCCCHHHHEEEECCCCHHHHHHHHCCCC
DLAPFFRLMADEEIVKVFHAARQDIEIVFHLGNLIPSPVFDTQVAAMVCGFGDAISYDQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHH
VQKVTGKHLDKSSRFTDWRRRPLSDKQLDYALADVTYLRDIYLYLKEELQKEGRSEWVNE
HHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
EMAVLTARQTYDLHPDDAWRRVKARVRKPLELAIVQAVAAWREREARERNVPRGRIIKDD
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCH
TIAEIAQQQPRDAEALGRLRSIPKGWERSAQAAGLVTAIQSALAIAKEDLPKSPKPSHSP
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
EGSAAAADILKVLLKLVTEEHGVAAKIVANSDDIEKIAAEGDKANVPALHGWRREVFGQK
CCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ALDLIDGKIGIKFENRRIRAVELRE
HHHHHCCCEEEEECCCEEEEEECCC
>Mature Secondary Structure
MQLITTTEALEEAVFALAKSDFVTVDTEFIRETTFWPELCLIQMASPDHTALVDALAPGL
CCCCCHHHHHHHHHHHHHHCCEEEECHHHHHHHCCCHHHHEEEECCCCHHHHHHHHCCCC
DLAPFFRLMADEEIVKVFHAARQDIEIVFHLGNLIPSPVFDTQVAAMVCGFGDAISYDQL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHH
VQKVTGKHLDKSSRFTDWRRRPLSDKQLDYALADVTYLRDIYLYLKEELQKEGRSEWVNE
HHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
EMAVLTARQTYDLHPDDAWRRVKARVRKPLELAIVQAVAAWREREARERNVPRGRIIKDD
HHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEECCH
TIAEIAQQQPRDAEALGRLRSIPKGWERSAQAAGLVTAIQSALAIAKEDLPKSPKPSHSP
HHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
EGSAAAADILKVLLKLVTEEHGVAAKIVANSDDIEKIAAEGDKANVPALHGWRREVFGQK
CCCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
ALDLIDGKIGIKFENRRIRAVELRE
HHHHHCCCEEEEECCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3041371; 9097040; 9278503; 8107670 [H]