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The map label for this gene is metC [H]

Identifier: 23501626

GI number: 23501626

Start: 723569

End: 724738

Strand: Reverse

Name: metC [H]

Synonym: BR0739

Alternate gene names: 23501626

Gene position: 724738-723569 (Counterclockwise)

Preceding gene: 23501633

Following gene: 23501625

Centisome position: 34.38

GC content: 56.24

Gene sequence:

>1170_bases
GTGGCTAAGCAGCAGTTGAAGACAGAGAAGTTGGGCATAAACACGCGGCTTGCTCATGACGGTTATTGCCCCGGCGACTA
TCACGGCTTTGTCAACCCGCCCGTCGTGCGCGCATCGACCGTGCTTTTTCCCGATGCAGAAACCATGGCAAGCAACGGCC
AGAAATATACCTATGGCACACGCGGCACGCCCACAAGCGAAGCGCTTTGCAAAGCCATAGACGCGCTGGAGGGCTCTGCG
GGAACGGTTTGCGTTCCATCGGGGCTAGCGGCCATAACCGTTCCGCTGCTGGGATTTCTTTCACCCGGCGATCATGCGCT
TCTTGTCGATTCGATTTATTACCCGACCCGCCACTTCGCCAATACGATCCTGAAACGCATGGGTGTGGACGTCGAATATT
ACGATCCGGAAATCGGTGCGGACATTGCAAAGCTGATGCGCCCGAACACCAAGGTCGTGTTTACGGAATCACCCGCCTCC
AACACATTCGAGATACAGGATATTCCTGCCATCGCTGAAGCCGCCCACAAGGGCAATGCCATCGTCATGATGGACAATAC
CTGGGCGACACCGCTTTATTTCCGGGCGCTCGATTTCGGCGTGGACATCAGCATTCACGCCGCAACCAAATATCCCTCCG
GCCATTCCGACATTCTTTTCGGCACCATTTCGACCAATGAGAAATGCTGGCCGCAATTGCTGGAAACACACGGCACGATG
GGCCTTTGTGCCGGGCCTGACGACACCTACCAGATCTTGCGCGGACTGCGCACCATGGGCATCCGGCTGGAACATCATCG
CAAAAGCGCACTGGAGATTGCCCGCTGGCTGGAAAATCATCCAATGGTGGAACGCGTTCTGCATCCAGCCCTCGAAAGCC
ATCCCGGCCATGAAATCTGGAAACGCGATTTTTCCGGTTCGTCCGGCATTTTCTCCTTTGTTCTGGCAAAGGGCGGACAT
GCGCAAGCGAGCGCCTTCCTCAACGCGCTGGAGATTTTCGGCCTCGGCTATTCGTGGGGTGGCTATCAAAGCCTTGCGCT
TGAAGTGAAGCTTGGCGACCGCACCGTTTCGAAGAACGATTATGCCGGGCCGGTCATCCGCCTTCAGATCGGTCTGGAAG
ACGTGCTCGACCTCATCGCCGATCTCGAAAGAGGTTTTGCTGCAATCTGA

Upstream 100 bases:

>100_bases
CGAAGCTCTTTTTGCCGAAGCCAATCTTGTACCCAGCCGGCAGAATCACGTCTTTCGAGAATCTGTGGAACAGCACGCAA
CATGGTCTGGAGGCATTTTC

Downstream 100 bases:

>100_bases
TTACTTAGGGCAGTTCCTGTTTAATTCAGGCAACCGCGCCATAAGGAAGATCATGATGACTTGGGTATTCATAATACAGG
GCGTTATGGCGATCGGCCTT

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MAKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSA
GTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPAS
NTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTM
GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGGH
AQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKNDYAGPVIRLQIGLEDVLDLIADLERGFAAI

Sequences:

>Translated_389_residues
MAKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSA
GTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPAS
NTFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTM
GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGGH
AQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKNDYAGPVIRLQIGLEDVLDLIADLERGFAAI
>Mature_388_residues
AKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGTRGTPTSEALCKAIDALEGSAG
TVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFANTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASN
TFEIQDIPAIAEAAHKGNAIVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTMG
LCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIWKRDFSGSSGIFSFVLAKGGHA
QASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKNDYAGPVIRLQIGLEDVLDLIADLERGFAAI

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=365, Percent_Identity=34.2465753424658, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI299473759, Length=365, Percent_Identity=31.2328767123288, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI25453487, Length=364, Percent_Identity=30.2197802197802, Blast_Score=154, Evalue=2e-37,
Organism=Escherichia coli, GI1789383, Length=390, Percent_Identity=46.6666666666667, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1790375, Length=370, Percent_Identity=31.0810810810811, Blast_Score=176, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI17560056, Length=330, Percent_Identity=36.3636363636364, Blast_Score=204, Evalue=5e-53,
Organism=Caenorhabditis elegans, GI71980708, Length=398, Percent_Identity=32.6633165829146, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17538055, Length=295, Percent_Identity=36.6101694915254, Blast_Score=196, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6321170, Length=333, Percent_Identity=46.5465465465465, Blast_Score=318, Evalue=1e-87,
Organism=Saccharomyces cerevisiae, GI6319307, Length=377, Percent_Identity=31.2997347480106, Blast_Score=160, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6323333, Length=385, Percent_Identity=25.974025974026, Blast_Score=111, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321254, Length=388, Percent_Identity=25.2577319587629, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321904, Length=368, Percent_Identity=26.3586956521739, Blast_Score=103, Evalue=5e-23,
Organism=Drosophila melanogaster, GI19922554, Length=384, Percent_Identity=35.9375, Blast_Score=234, Evalue=6e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42387; Mature: 42256

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGT
CCHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEECCC
RGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFA
CCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCEEEEECHHCCHHHHH
NTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNA
HHHHHHHCCCEEEECCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHCCCCE
IVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTM
EEEECCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHCCCE
GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIW
EEECCCCHHHHHHHHHHHHCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHH
KRDFSGSSGIFSFVLAKGGHAQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKND
HHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCEEECCCC
YAGPVIRLQIGLEDVLDLIADLERGFAAI
CCCCEEEEEECHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKQQLKTEKLGINTRLAHDGYCPGDYHGFVNPPVVRASTVLFPDAETMASNGQKYTYGT
CHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCHHHHHCCCCEEECCC
RGTPTSEALCKAIDALEGSAGTVCVPSGLAAITVPLLGFLSPGDHALLVDSIYYPTRHFA
CCCCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHCCCCCCEEEEECHHCCHHHHH
NTILKRMGVDVEYYDPEIGADIAKLMRPNTKVVFTESPASNTFEIQDIPAIAEAAHKGNA
HHHHHHHCCCEEEECCHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCHHHHHHCCCCE
IVMMDNTWATPLYFRALDFGVDISIHAATKYPSGHSDILFGTISTNEKCWPQLLETHGTM
EEEECCCCCCCCEEEEECCCCEEEEEEEECCCCCCCCEEEEEECCCCHHHHHHHHHCCCE
GLCAGPDDTYQILRGLRTMGIRLEHHRKSALEIARWLENHPMVERVLHPALESHPGHEIW
EEECCCCHHHHHHHHHHHHCEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHH
KRDFSGSSGIFSFVLAKGGHAQASAFLNALEIFGLGYSWGGYQSLALEVKLGDRTVSKND
HHCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEEEEEEECCEEECCCC
YAGPVIRLQIGLEDVLDLIADLERGFAAI
CCCCEEEEEECHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]