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The map label for this gene is lldP [H]

Identifier: 23501607

GI number: 23501607

Start: 703160

End: 704833

Strand: Reverse

Name: lldP [H]

Synonym: BR0720

Alternate gene names: 23501607

Gene position: 704833-703160 (Counterclockwise)

Preceding gene: 23501610

Following gene: 23501605

Centisome position: 33.44

GC content: 58.36

Gene sequence:

>1674_bases
ATGCCCTGGAATCAAGTTTACGATCCCCTAGGCAGCATGTTCTGGTCAACATTGCTTGCCGCATTGCCCATCGTGGTACT
GCTCGGCGGAATCGGCATTTTCCACATAAAAGCACATATAGCCGCGATTCTCGGTTTGATTACCGCGCTCTTAATTGCGG
TGATCGGTTTTGGAATGCCCGCCGACATGGCGGGAGCCACAGCCGTTTACGGTGCAGCCTATGGCCTTCTGCCCATCGGC
TGGATCATTCTCAACGTGATCTTTCTGTATCGCCTGACGGAACAGACCGGGCAGTTCAACATCCTGCGTGATTCGATTGC
CGGGATAACCCCCGACCGTCGCTTGCAGCTTCTGTTCATCGCCTTTTCCTTTGGCGCGTTCTTTGAAGGTGCAGCCGGCT
TCGGAACACCCGTGGCCGTGACGGCAGCCATGCTGATGGGGCTTGGCTTTGCGCCGCTTCCCGCCGCTGGCCTGTCGCTG
ATCGCCAACACCGCGCCCGTCGCTTATGGCGCCTTGGGTACACCTGTTATCGCATTGTCTGCGGTGACGGGGATCGACCT
CTTGCAATTGTCAGGCATGATCGGTCATCAGCTTCCATTCTTCTCGGCCATCGTTCCATTCTGGCTCATCTGGGCCTTTG
CGGGCCGTAAAGGCATGATGGAAGTCTGGCCGGCACTGCTGGTTGCCGGTGTTTCGTTCGCCGTACCGCAATATGTAGTG
TCCAATTTCCATGGGCCATGGCTCGTCGATGTTATCGCCGCCATCTGCTCCATGGCAGCACTTGCCGCGTTCCTTCGCTT
CTGGCAGCCGCGTCGCATCTGGACGTCGACCGGCAAAGAGGGCGAAGAGACCAATGCACCGGTCCAGCCGCGCCACAGCC
ATTCCACGGGAGCGGTTTTCCGCGCATGGCTGCCATGGCTCGTTCTGTCGATCTTCGTGTTCTTGTGGGGCACACCGCAG
GTTCGCACATGGCTCGATTCGCTGTGGATCCGGAAAATGCAGGTTCCGCATCTGCATAACCTGGTCTTCAAGGTTCCGCC
GGTCGTTGCCGAAACCCATTCGGAAGCTGCGATCTTTACGCTGAACCTCCTGTCGGCCACAGGCACGGGCATCCTGCTTT
CCGCCGCCGTCGCGGGCTTTATCCTCGGCTTCAATCCGTTGAAGCTCGTGAAGGAATATTTCAAGACGGCCTATGTGGTG
CGCTTCTCGCTCATCACCATCTCTGCAATGCTCGCGCTCGGCTATGTCACCCGCTATTCGGGTACAGACGCGACCCTGGG
CCTTGCATTCGCACAGACGGGCTGGGTCTATCCGTTCTTCGGCGCGATGCTCGGCTGGCTGGGTGTGGCGCTGACGGGTT
CGGACACGGCTTCCAACGTCCTGTTCGGCGGGCTTCAGAAGATCACGGCTGAACAGCTTGGCCTTTCGCCGGTTCTGATG
GCAGCAGCCAATTCGTCTGGCGGTGTCATGGGCAAGATGATCGACGCCCAATCCATCGTCGTCGCCTCAACGGCAACCCA
GTGGTATGGACACGAATCGAAGATCCTTCGCTATGTGTTCTTCCATTCGATTGCGCTTGCCTGCCTTGTGGGCGTTCTGG
TTCTGGCGCAGGCCTATGTGCCGCCATTCACCTCCCTGGTGCCAGCGGAAACCTTGCCTTTAGTTGCTCATTAG

Upstream 100 bases:

>100_bases
GGAGAGGGCAGCGGAAGGGAATGTTTCCATTGGTCAGCCAAATCGGTGGAGCGAATTGGAGTGAAAAGGAAGAGATTTTA
ATCCAGGAGGGAGGACTTCG

Downstream 100 bases:

>100_bases
AGCGCGTTTCGATCTGATTGAATCAGATCGGCGCTCTAATCCTTTGCTTTGACGCGCATCTTTTCCGAAAACCGTTTCAC
ACTTTTCGGGATGCGCTCTA

Product: L-lactate permease

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 557; Mature: 556

Protein sequence:

>557_residues
MPWNQVYDPLGSMFWSTLLAALPIVVLLGGIGIFHIKAHIAAILGLITALLIAVIGFGMPADMAGATAVYGAAYGLLPIG
WIILNVIFLYRLTEQTGQFNILRDSIAGITPDRRLQLLFIAFSFGAFFEGAAGFGTPVAVTAAMLMGLGFAPLPAAGLSL
IANTAPVAYGALGTPVIALSAVTGIDLLQLSGMIGHQLPFFSAIVPFWLIWAFAGRKGMMEVWPALLVAGVSFAVPQYVV
SNFHGPWLVDVIAAICSMAALAAFLRFWQPRRIWTSTGKEGEETNAPVQPRHSHSTGAVFRAWLPWLVLSIFVFLWGTPQ
VRTWLDSLWIRKMQVPHLHNLVFKVPPVVAETHSEAAIFTLNLLSATGTGILLSAAVAGFILGFNPLKLVKEYFKTAYVV
RFSLITISAMLALGYVTRYSGTDATLGLAFAQTGWVYPFFGAMLGWLGVALTGSDTASNVLFGGLQKITAEQLGLSPVLM
AAANSSGGVMGKMIDAQSIVVASTATQWYGHESKILRYVFFHSIALACLVGVLVLAQAYVPPFTSLVPAETLPLVAH

Sequences:

>Translated_557_residues
MPWNQVYDPLGSMFWSTLLAALPIVVLLGGIGIFHIKAHIAAILGLITALLIAVIGFGMPADMAGATAVYGAAYGLLPIG
WIILNVIFLYRLTEQTGQFNILRDSIAGITPDRRLQLLFIAFSFGAFFEGAAGFGTPVAVTAAMLMGLGFAPLPAAGLSL
IANTAPVAYGALGTPVIALSAVTGIDLLQLSGMIGHQLPFFSAIVPFWLIWAFAGRKGMMEVWPALLVAGVSFAVPQYVV
SNFHGPWLVDVIAAICSMAALAAFLRFWQPRRIWTSTGKEGEETNAPVQPRHSHSTGAVFRAWLPWLVLSIFVFLWGTPQ
VRTWLDSLWIRKMQVPHLHNLVFKVPPVVAETHSEAAIFTLNLLSATGTGILLSAAVAGFILGFNPLKLVKEYFKTAYVV
RFSLITISAMLALGYVTRYSGTDATLGLAFAQTGWVYPFFGAMLGWLGVALTGSDTASNVLFGGLQKITAEQLGLSPVLM
AAANSSGGVMGKMIDAQSIVVASTATQWYGHESKILRYVFFHSIALACLVGVLVLAQAYVPPFTSLVPAETLPLVAH
>Mature_556_residues
PWNQVYDPLGSMFWSTLLAALPIVVLLGGIGIFHIKAHIAAILGLITALLIAVIGFGMPADMAGATAVYGAAYGLLPIGW
IILNVIFLYRLTEQTGQFNILRDSIAGITPDRRLQLLFIAFSFGAFFEGAAGFGTPVAVTAAMLMGLGFAPLPAAGLSLI
ANTAPVAYGALGTPVIALSAVTGIDLLQLSGMIGHQLPFFSAIVPFWLIWAFAGRKGMMEVWPALLVAGVSFAVPQYVVS
NFHGPWLVDVIAAICSMAALAAFLRFWQPRRIWTSTGKEGEETNAPVQPRHSHSTGAVFRAWLPWLVLSIFVFLWGTPQV
RTWLDSLWIRKMQVPHLHNLVFKVPPVVAETHSEAAIFTLNLLSATGTGILLSAAVAGFILGFNPLKLVKEYFKTAYVVR
FSLITISAMLALGYVTRYSGTDATLGLAFAQTGWVYPFFGAMLGWLGVALTGSDTASNVLFGGLQKITAEQLGLSPVLMA
AANSSGGVMGKMIDAQSIVVASTATQWYGHESKILRYVFFHSIALACLVGVLVLAQAYVPPFTSLVPAETLPLVAH

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=552, Percent_Identity=47.1014492753623, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1790031, Length=543, Percent_Identity=44.9355432780847, Blast_Score=439, Evalue=1e-124,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59541; Mature: 59410

Theoretical pI: Translated: 9.14; Mature: 9.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPWNQVYDPLGSMFWSTLLAALPIVVLLGGIGIFHIKAHIAAILGLITALLIAVIGFGMP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ADMAGATAVYGAAYGLLPIGWIILNVIFLYRLTEQTGQFNILRDSIAGITPDRRLQLLFI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCHHEEEHH
AFSFGAFFEGAAGFGTPVAVTAAMLMGLGFAPLPAAGLSLIANTAPVAYGALGTPVIALS
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHH
AVTGIDLLQLSGMIGHQLPFFSAIVPFWLIWAFAGRKGMMEVWPALLVAGVSFAVPQYVV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
SNFHGPWLVDVIAAICSMAALAAFLRFWQPRRIWTSTGKEGEETNAPVQPRHSHSTGAVF
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
RAWLPWLVLSIFVFLWGTPQVRTWLDSLWIRKMQVPHLHNLVFKVPPVVAETHSEAAIFT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHCCCCCCEEEE
LNLLSATGTGILLSAAVAGFILGFNPLKLVKEYFKTAYVVRFSLITISAMLALGYVTRYS
EEHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GTDATLGLAFAQTGWVYPFFGAMLGWLGVALTGSDTASNVLFGGLQKITAEQLGLSPVLM
CCCCHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHH
AAANSSGGVMGKMIDAQSIVVASTATQWYGHESKILRYVFFHSIALACLVGVLVLAQAYV
EECCCCCCCCEEHCCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PPFTSLVPAETLPLVAH
CCHHHHCCCCCCCCCCC
>Mature Secondary Structure 
PWNQVYDPLGSMFWSTLLAALPIVVLLGGIGIFHIKAHIAAILGLITALLIAVIGFGMP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ADMAGATAVYGAAYGLLPIGWIILNVIFLYRLTEQTGQFNILRDSIAGITPDRRLQLLFI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHCCCCCCCHHEEEHH
AFSFGAFFEGAAGFGTPVAVTAAMLMGLGFAPLPAAGLSLIANTAPVAYGALGTPVIALS
HHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHCCCCHHHCCCCCHHHHHH
AVTGIDLLQLSGMIGHQLPFFSAIVPFWLIWAFAGRKGMMEVWPALLVAGVSFAVPQYVV
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
SNFHGPWLVDVIAAICSMAALAAFLRFWQPRRIWTSTGKEGEETNAPVQPRHSHSTGAVF
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCCCCCCCCHHHH
RAWLPWLVLSIFVFLWGTPQVRTWLDSLWIRKMQVPHLHNLVFKVPPVVAETHSEAAIFT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHCCCCCCEEEE
LNLLSATGTGILLSAAVAGFILGFNPLKLVKEYFKTAYVVRFSLITISAMLALGYVTRYS
EEHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
GTDATLGLAFAQTGWVYPFFGAMLGWLGVALTGSDTASNVLFGGLQKITAEQLGLSPVLM
CCCCHHHHHHHHCCCCHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHCCCHHHH
AAANSSGGVMGKMIDAQSIVVASTATQWYGHESKILRYVFFHSIALACLVGVLVLAQAYV
EECCCCCCCCEEHCCCCCEEEEEHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PPFTSLVPAETLPLVAH
CCHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]