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The map label for this gene is yyxA [H]

Identifier: 23100902

GI number: 23100902

Start: 3583245

End: 3584447

Strand: Reverse

Name: yyxA [H]

Synonym: OB3447

Alternate gene names: 23100902

Gene position: 3584447-3583245 (Counterclockwise)

Preceding gene: 23100903

Following gene: 23100898

Centisome position: 98.73

GC content: 40.15

Gene sequence:

>1203_bases
ATGGGATATTATGACCAATCTTACAGAAAAAAGAAACGAAAAAGTACCTGGATCGTTCCATTATTAACAGGTATTATACT
CGGTGGGATCGTGATGTTAGTTGTTGTCCCTGATATTTTTTTGAATCACGAAGATGGTCGGGATACGAATCAAGCGACCT
CTACGGACCAAACTAGCCCAGAAATAGAATCATCACCAAATGTTCAACCTTTACAAGTAGACGTATCCACGCAACTGACT
GACGTTGTTAGTGAAGTAACGCCGGCAGTAGTGGGGATTACGAATTTACAACGTGGGAATGATTTCTGGTCACAAGAGGA
AGGCGTTGAAGCAGGTACCGGTTCAGGCGTCATTTACAAGCTTGAAGGGGATACAGCTTACGTCGTTACAAATCATCATG
TTATTGAGGGAGCAGACACTGTAGAAGTAGTCATGCATGATGAAACACATATTGAAGCGGAAATTATCGGAAGCGATATA
TTTACGGATTTAGCCGTTCTAAGAATGGATGGATCGGAAGTAGATACAGTGATTGAAATGGGGACATCATCGACAATAAA
AGTAGGTGAGCCAGCAATCGCTATTGGAAATCCTCTTGGTTTATATCTTTCGAGTACAGTAACACAAGGTGTTATAAGTG
GTAAGGAACGTACCATTCCAATGGATTTTGATATGGATGGACGTGCGGATTGGCAAGCAGAAGTTATTCAGACAGATGCA
GCAATTAATCCTGGTAATAGCGGAGGAGCACTAATAAATATTAATGGACATCTAATCGGGATTAACTCGATGAAAATAAA
TGAAGACGCTGTGGAAGGTATTGGTTTTGCCATCCCTATCGATAGTGCGCTTCCTGTCATTGAAGAGCTTGAAACAACAG
GGGAAGTAACCCGTCCATATTTAGGGGTAGAAATTTACTCTTTAGAAGAGCTTCCACAATATGAGTGGAGAAATTCATTA
AATTTACCACAAGAAGTTACGGGTGGAGTCTACGTATGGACAGTAGAACGATTATCTCCAGCAGATAAAGCAGGCTTACA
AGAATTAGATGTTATCGTTGAAATGGATGGAGAGCCAATTCATAACATGATTGATTTGAGAAAAATATTATATCAAGAAA
AAGAAATTGGTGACGAAGTAGAGCTGACGATTTATCGAGATGGGCGTCAAATGAATACGACCATCACATTGGGAAGTCAA
TAA

Upstream 100 bases:

>100_bases
TTACGAAGTTGGTTAAGGTAGTGAATTGGGATTATGAGGGTTTATGTTTTACGATCTTTAGGGAATACTTAGGTATAGAA
ACCGATAAGGAGATCGATAT

Downstream 100 bases:

>100_bases
TAAGCTTGAAACTTAAATAATATAAAATTGGCGCTTATCTAGGGAAGTAATTGAAGCATTGGAATTCGTTCCAAGAGAAT
CTTCAAAGGATATACTCCCA

Product: serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MGYYDQSYRKKKRKSTWIVPLLTGIILGGIVMLVVVPDIFLNHEDGRDTNQATSTDQTSPEIESSPNVQPLQVDVSTQLT
DVVSEVTPAVVGITNLQRGNDFWSQEEGVEAGTGSGVIYKLEGDTAYVVTNHHVIEGADTVEVVMHDETHIEAEIIGSDI
FTDLAVLRMDGSEVDTVIEMGTSSTIKVGEPAIAIGNPLGLYLSSTVTQGVISGKERTIPMDFDMDGRADWQAEVIQTDA
AINPGNSGGALININGHLIGINSMKINEDAVEGIGFAIPIDSALPVIEELETTGEVTRPYLGVEIYSLEELPQYEWRNSL
NLPQEVTGGVYVWTVERLSPADKAGLQELDVIVEMDGEPIHNMIDLRKILYQEKEIGDEVELTIYRDGRQMNTTITLGSQ

Sequences:

>Translated_400_residues
MGYYDQSYRKKKRKSTWIVPLLTGIILGGIVMLVVVPDIFLNHEDGRDTNQATSTDQTSPEIESSPNVQPLQVDVSTQLT
DVVSEVTPAVVGITNLQRGNDFWSQEEGVEAGTGSGVIYKLEGDTAYVVTNHHVIEGADTVEVVMHDETHIEAEIIGSDI
FTDLAVLRMDGSEVDTVIEMGTSSTIKVGEPAIAIGNPLGLYLSSTVTQGVISGKERTIPMDFDMDGRADWQAEVIQTDA
AINPGNSGGALININGHLIGINSMKINEDAVEGIGFAIPIDSALPVIEELETTGEVTRPYLGVEIYSLEELPQYEWRNSL
NLPQEVTGGVYVWTVERLSPADKAGLQELDVIVEMDGEPIHNMIDLRKILYQEKEIGDEVELTIYRDGRQMNTTITLGSQ
>Mature_399_residues
GYYDQSYRKKKRKSTWIVPLLTGIILGGIVMLVVVPDIFLNHEDGRDTNQATSTDQTSPEIESSPNVQPLQVDVSTQLTD
VVSEVTPAVVGITNLQRGNDFWSQEEGVEAGTGSGVIYKLEGDTAYVVTNHHVIEGADTVEVVMHDETHIEAEIIGSDIF
TDLAVLRMDGSEVDTVIEMGTSSTIKVGEPAIAIGNPLGLYLSSTVTQGVISGKERTIPMDFDMDGRADWQAEVIQTDAA
INPGNSGGALININGHLIGINSMKINEDAVEGIGFAIPIDSALPVIEELETTGEVTRPYLGVEIYSLEELPQYEWRNSLN
LPQEVTGGVYVWTVERLSPADKAGLQELDVIVEMDGEPIHNMIDLRKILYQEKEIGDEVELTIYRDGRQMNTTITLGSQ

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=305, Percent_Identity=33.7704918032787, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI24308541, Length=297, Percent_Identity=31.986531986532, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI22129776, Length=312, Percent_Identity=30.7692307692308, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI7019477, Length=320, Percent_Identity=31.875, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1786356, Length=289, Percent_Identity=36.3321799307958, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1789629, Length=300, Percent_Identity=34.6666666666667, Blast_Score=157, Evalue=1e-39,
Organism=Escherichia coli, GI1789630, Length=390, Percent_Identity=32.8205128205128, Blast_Score=149, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24646839, Length=331, Percent_Identity=34.441087613293, Blast_Score=141, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43661; Mature: 43529

Theoretical pI: Translated: 3.98; Mature: 3.98

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGYYDQSYRKKKRKSTWIVPLLTGIILGGIVMLVVVPDIFLNHEDGRDTNQATSTDQTSP
CCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
EIESSPNVQPLQVDVSTQLTDVVSEVTPAVVGITNLQRGNDFWSQEEGVEAGTGSGVIYK
CCCCCCCCEEEEEEHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
LEGDTAYVVTNHHVIEGADTVEVVMHDETHIEAEIIGSDIFTDLAVLRMDGSEVDTVIEM
EECCEEEEEECCEEECCCCEEEEEEECCCEEEEEEECCHHHHCEEEEEECCCHHHHHEEC
GTSSTIKVGEPAIAIGNPLGLYLSSTVTQGVISGKERTIPMDFDMDGRADWQAEVIQTDA
CCCCEEEECCCEEEECCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEEECC
AINPGNSGGALININGHLIGINSMKINEDAVEGIGFAIPIDSALPVIEELETTGEVTRPY
CCCCCCCCCEEEEECCEEEEEECEEECHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCCE
LGVEIYSLEELPQYEWRNSLNLPQEVTGGVYVWTVERLSPADKAGLQELDVIVEMDGEPI
ECEEEEEHHHCCCHHHHCCCCCCHHHCCCEEEEEEECCCCCCCCCCCEEEEEEEECCCCH
HNMIDLRKILYQEKEIGDEVELTIYRDGRQMNTTITLGSQ
HHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEECCC
>Mature Secondary Structure 
GYYDQSYRKKKRKSTWIVPLLTGIILGGIVMLVVVPDIFLNHEDGRDTNQATSTDQTSP
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCC
EIESSPNVQPLQVDVSTQLTDVVSEVTPAVVGITNLQRGNDFWSQEEGVEAGTGSGVIYK
CCCCCCCCEEEEEEHHHHHHHHHHHHCCHHEEECCCCCCCCCCCCCCCCCCCCCCCEEEE
LEGDTAYVVTNHHVIEGADTVEVVMHDETHIEAEIIGSDIFTDLAVLRMDGSEVDTVIEM
EECCEEEEEECCEEECCCCEEEEEEECCCEEEEEEECCHHHHCEEEEEECCCHHHHHEEC
GTSSTIKVGEPAIAIGNPLGLYLSSTVTQGVISGKERTIPMDFDMDGRADWQAEVIQTDA
CCCCEEEECCCEEEECCCHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCEEEEEEECC
AINPGNSGGALININGHLIGINSMKINEDAVEGIGFAIPIDSALPVIEELETTGEVTRPY
CCCCCCCCCEEEEECCEEEEEECEEECHHHHHCCEEEEECCCCCHHHHHHHHCCCCCCCE
LGVEIYSLEELPQYEWRNSLNLPQEVTGGVYVWTVERLSPADKAGLQELDVIVEMDGEPI
ECEEEEEHHHCCCHHHHCCCCCCHHHCCCEEEEEEECCCCCCCCCCCEEEEEEEECCCCH
HNMIDLRKILYQEKEIGDEVELTIYRDGRQMNTTITLGSQ
HHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 8113162 [H]