Click here to switch to the map view.

The map label for this gene is dcm [C]

Identifier: 23100791

GI number: 23100791

Start: 3473289

End: 3474671

Strand: Reverse

Name: dcm [C]

Synonym: OB3336

Alternate gene names: 23100791

Gene position: 3474671-3473289 (Counterclockwise)

Preceding gene: 23100792

Following gene: 23100790

Centisome position: 95.71

GC content: 35.5

Gene sequence:

>1383_bases
ATGCATCAGATTTATTCAGCTACTTCAACTGATAAAAAGCTTCCTGAAGTTGTTGATTTATTTTCTGGGTGCGGAGGTTT
AGCTTTAGGGTTTCAACTGGCAGGATTTAATATACGTAAGGGAATAGAGCTAGATAGAGATGCTTCTGATGTCGCTTCTT
TCAATTTACATTGGAGACAAGGAAAACATGATAGGCATTTAAATAATGATATAACCTTATTAAGTGCAAATGAATTTTAT
AATGACCTAGATAGAAAAAATGATTTAATAGTAATCGGTGGTCCTCCTTGCCAAGCATATTCCAAAATTGGAAGGGCAAA
ACTTAAGTCTCTTGGTGAGGAGCGACGGCAAGAAAATGATGCCAGAGGAAAATTATATGAGAATTTTTTAGATTATGCTC
TGCATGTTGATGCAAATGTAATAGTTATGGAAAATGTTCCTGAAGCTGTCAACTATGGAGGAGTTAATATCCCGGATACT
GTTTGTGATATATTAATAAATAAGGGGTATGATGCAATTTGGACTGTCTTAAATGCAGCTGATTTCGGAGTTCCCCAAAC
AAGAGTGCGTTTATTCGTTATGGCAATAAAAAAGGATATTGGAAAGATAAAATTTATACCGGAACCGACCCATAAGCCTC
ATATAAATGTTAAGAGACAAAGTGTAAATGTTCGGTGGATGCAGTCTGAAATAAGAAACTCTAAATATTATAAACAGCCA
AATATCCCGGATGAGACCCTTTCTGATTGGGTGACTGTCGGCGATGCTATAGGAGATCTGCCAAATCTGTTCCCGGTTTA
TAATCAAAAATATAAGAATTATAAACCTATGATGATGAAAGAATATAAATCTCCACCTCAAAATACATTTCAAAAACTAA
TGAGGATTAACAATAAAGTAGACAAGGTTACAGGCAATATGTTTAGAAATACAAAGCGTGACTTTTCCATTTTTGACAAA
ATGGAAGAAGGAGATAATTACCTTGATGCTCACAATATAGCAATGTCACTTTTAAGGAAAGAAATGCGGAAGTCAGGAAT
TACAAAAGAAAATGAGTTTGAATACCGTTTATTAAAGGACAGAATTGTACCTCCATATTCAACTGAAAAATTTGTGGAGA
AATGGAGGAAATTATCTTCTGATAAACCATCACATACTTTAGTGGCTCATTTAAGTACTGATACATACAGCCATCTTCAC
CCTAGAGAGCCACGAGGTATTTCAGTTAGAGAAGCAGCCAGGCTACAGAGTTTTCCAGATGACTTTTTGTTTGATTGCAG
TATGGGTGCTGCTTTTAAACAAATAGGAAATGCTGTGCCCCCGTTATTAGCAAAAGCGATTGCTGAGGCGATGAAAAAAA
ATATACAAGGGGGATGTATATGA

Upstream 100 bases:

>100_bases
GATGGAGAAAACAGAAATTTGATTAGAAAAGTAATGAAACTGAATACAATTAGGTGCAAAATTATTGAACCTGAACTACA
TGATGGAGGAATTGATCAAT

Downstream 100 bases:

>100_bases
ACTATGTAAAGTTATTAAGAGAACAATACGAACTGTCTAACTATAATGCCGGGCCTTATTTTAGAATTGAATCAATTGAT
AATTCCAGTTTTCTCTTAAA

Product: cytosine-specific methyltransferase

Products: NA

Alternate protein names: Cytosine-specific methyltransferase; M.OihORF3336P

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MHQIYSATSTDKKLPEVVDLFSGCGGLALGFQLAGFNIRKGIELDRDASDVASFNLHWRQGKHDRHLNNDITLLSANEFY
NDLDRKNDLIVIGGPPCQAYSKIGRAKLKSLGEERRQENDARGKLYENFLDYALHVDANVIVMENVPEAVNYGGVNIPDT
VCDILINKGYDAIWTVLNAADFGVPQTRVRLFVMAIKKDIGKIKFIPEPTHKPHINVKRQSVNVRWMQSEIRNSKYYKQP
NIPDETLSDWVTVGDAIGDLPNLFPVYNQKYKNYKPMMMKEYKSPPQNTFQKLMRINNKVDKVTGNMFRNTKRDFSIFDK
MEEGDNYLDAHNIAMSLLRKEMRKSGITKENEFEYRLLKDRIVPPYSTEKFVEKWRKLSSDKPSHTLVAHLSTDTYSHLH
PREPRGISVREAARLQSFPDDFLFDCSMGAAFKQIGNAVPPLLAKAIAEAMKKNIQGGCI

Sequences:

>Translated_460_residues
MHQIYSATSTDKKLPEVVDLFSGCGGLALGFQLAGFNIRKGIELDRDASDVASFNLHWRQGKHDRHLNNDITLLSANEFY
NDLDRKNDLIVIGGPPCQAYSKIGRAKLKSLGEERRQENDARGKLYENFLDYALHVDANVIVMENVPEAVNYGGVNIPDT
VCDILINKGYDAIWTVLNAADFGVPQTRVRLFVMAIKKDIGKIKFIPEPTHKPHINVKRQSVNVRWMQSEIRNSKYYKQP
NIPDETLSDWVTVGDAIGDLPNLFPVYNQKYKNYKPMMMKEYKSPPQNTFQKLMRINNKVDKVTGNMFRNTKRDFSIFDK
MEEGDNYLDAHNIAMSLLRKEMRKSGITKENEFEYRLLKDRIVPPYSTEKFVEKWRKLSSDKPSHTLVAHLSTDTYSHLH
PREPRGISVREAARLQSFPDDFLFDCSMGAAFKQIGNAVPPLLAKAIAEAMKKNIQGGCI
>Mature_460_residues
MHQIYSATSTDKKLPEVVDLFSGCGGLALGFQLAGFNIRKGIELDRDASDVASFNLHWRQGKHDRHLNNDITLLSANEFY
NDLDRKNDLIVIGGPPCQAYSKIGRAKLKSLGEERRQENDARGKLYENFLDYALHVDANVIVMENVPEAVNYGGVNIPDT
VCDILINKGYDAIWTVLNAADFGVPQTRVRLFVMAIKKDIGKIKFIPEPTHKPHINVKRQSVNVRWMQSEIRNSKYYKQP
NIPDETLSDWVTVGDAIGDLPNLFPVYNQKYKNYKPMMMKEYKSPPQNTFQKLMRINNKVDKVTGNMFRNTKRDFSIFDK
MEEGDNYLDAHNIAMSLLRKEMRKSGITKENEFEYRLLKDRIVPPYSTEKFVEKWRKLSSDKPSHTLVAHLSTDTYSHLH
PREPRGISVREAARLQSFPDDFLFDCSMGAAFKQIGNAVPPLLAKAIAEAMKKNIQGGCI

Specific function: This methylase recognizes the double-stranded sequence ACCGGT, causes specific methylation on C-? on both strands, and protects the DNA from cleavage by a specific endonuclease (Potential)

COG id: COG0270

COG function: function code L; Site-specific DNA methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the C5-methyltransferase family

Homologues:

Organism=Homo sapiens, GI4503351, Length=294, Percent_Identity=27.5510204081633, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI195927037, Length=294, Percent_Identity=27.5510204081633, Blast_Score=82, Evalue=7e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MT36_OCEIH (Q8EL95)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_694258.1
- ProteinModelPortal:   Q8EL95
- SMR:   Q8EL95
- REBASE:   11861
- REBASE:   6390
- GeneID:   1018006
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB3336
- NMPDR:   fig|221109.1.peg.3340
- HOGENOM:   HBG301170
- OMA:   CITANLQ
- ProtClustDB:   CLSK482557
- BioCyc:   OIHE221109:OB3336-MONOMER
- BRENDA:   2.1.1.37
- InterPro:   IPR018117
- InterPro:   IPR001525
- PANTHER:   PTHR10629
- PRINTS:   PR00105
- TIGRFAMs:   TIGR00675

Pfam domain/function: PF00145 DNA_methylase

EC number: =2.1.1.37

Molecular weight: Translated: 52509; Mature: 52509

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00094 C5_MTASE_1; PS00095 C5_MTASE_2

Important sites: ACT_SITE 97-97

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHQIYSATSTDKKLPEVVDLFSGCGGLALGFQLAGFNIRKGIELDRDASDVASFNLHWRQ
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHEEECCCCCCCCCCCCCHHHHHHCCEEECC
GKHDRHLNNDITLLSANEFYNDLDRKNDLIVIGGPPCQAYSKIGRAKLKSLGEERRQEND
CCCCCCCCCCEEEEECHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCH
ARGKLYENFLDYALHVDANVIVMENVPEAVNYGGVNIPDTVCDILINKGYDAIWTVLNAA
HHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHH
DFGVPQTRVRLFVMAIKKDIGKIKFIPEPTHKPHINVKRQSVNVRWMQSEIRNSKYYKQP
HCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCC
NIPDETLSDWVTVGDAIGDLPNLFPVYNQKYKNYKPMMMKEYKSPPQNTFQKLMRINNKV
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCHH
DKVTGNMFRNTKRDFSIFDKMEEGDNYLDAHNIAMSLLRKEMRKSGITKENEFEYRLLKD
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RIVPPYSTEKFVEKWRKLSSDKPSHTLVAHLSTDTYSHLHPREPRGISVREAARLQSFPD
CCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHCCCCCCCCCCCHHHHHHHHCCCC
DFLFDCSMGAAFKQIGNAVPPLLAKAIAEAMKKNIQGGCI
HHHEECCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MHQIYSATSTDKKLPEVVDLFSGCGGLALGFQLAGFNIRKGIELDRDASDVASFNLHWRQ
CCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHEEECCCCCCCCCCCCCHHHHHHCCEEECC
GKHDRHLNNDITLLSANEFYNDLDRKNDLIVIGGPPCQAYSKIGRAKLKSLGEERRQEND
CCCCCCCCCCEEEEECHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCH
ARGKLYENFLDYALHVDANVIVMENVPEAVNYGGVNIPDTVCDILINKGYDAIWTVLNAA
HHHHHHHHHHHHHHCCCCCEEEECCCCHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHH
DFGVPQTRVRLFVMAIKKDIGKIKFIPEPTHKPHINVKRQSVNVRWMQSEIRNSKYYKQP
HCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCCCEEEECCCCHHHHHHHHCCCCCCCCC
NIPDETLSDWVTVGDAIGDLPNLFPVYNQKYKNYKPMMMKEYKSPPQNTFQKLMRINNKV
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHCCCHHHHHHHHHHHCCHH
DKVTGNMFRNTKRDFSIFDKMEEGDNYLDAHNIAMSLLRKEMRKSGITKENEFEYRLLKD
HHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
RIVPPYSTEKFVEKWRKLSSDKPSHTLVAHLSTDTYSHLHPREPRGISVREAARLQSFPD
CCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCHHCCCCCCCCCCCHHHHHHHHCCCC
DFLFDCSMGAAFKQIGNAVPPLLAKAIAEAMKKNIQGGCI
HHHEECCCCHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376