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The map label for this gene is ywrD [H]

Identifier: 23100722

GI number: 23100722

Start: 3403119

End: 3404732

Strand: Reverse

Name: ywrD [H]

Synonym: OB3267

Alternate gene names: 23100722

Gene position: 3404732-3403119 (Counterclockwise)

Preceding gene: 23100723

Following gene: 23100721

Centisome position: 93.78

GC content: 43.43

Gene sequence:

>1614_bases
ATGAATTTTTTTCATACCGAAACATATCCTTATACAAATCCAAGGCATGCAACCTATGCAAAAAATGGAATGGTGGCAAC
ATCGCAGCCACTTGCATCAGAAGCCGGACTGTCGATTCTAAAAAAAGGTGGTAATGCGATTGACGCTGCAATTGCTACAG
CGGCATGTTTAACAGTTGTCGAACCGACTTCGAATGGGATTGGCGGTGACGCTTTTGCGTTAGTATGGACAAAAGGTAAA
CTGCATGGACTTAATGCAAGTGGCCGTTCACCGCAATCCATCTCCATTGACAAAGTGAAAGAAACAGGAAAGGATCACAT
CCCAAAATATGGTTGGATTCCAGTTACGGTACCTGGAGCACCAAGTGCTTGGGCAGCATTATCCAAGAGGTTTGGCAAGC
TATCGTTACAAGAAGTATTGCAACCAGCGATTAATTACGCACGAGACGGGTATCCTTTGTCACCAACGTTAAGTAAGTTT
TGGAAAAAGGCATATACGGTTTTTAAAAAGGAATTATCGGATGATATGTTTCATGAATGGTTTGAGACCTTTGCTCCAAA
CGGTCGTGCTCCAGAAACAGGAGAGATGTGGCGCTCGCCTAATCATGCAAACACACTACAAGAAATTGCCGATACAGACG
GGGAATCATTTTACCGTGGAGAATTGGCGGCGAAAATAAGTGCATTCTCTGAAGCGAATGACGGATTTTTAACAGCAGAG
GACCTGGCAGCTCATCAACCAGAGTGGGTGGACCCGATTAAAGTAAATTACCGTGGCTATGATGTGTGGGAAATACCGCC
AAACGGACAAGGGATCATCGCTTTACAAGCATTAAATATCTTAAAAGGATATACATTTGATACGAAAGAAGTAACTGACA
CGTATCATAAGCAAATGGAAGCAATTAAACTTGCTTTTGCTGATGGGCAGGAACATGTGACAGAAAAAGATCATATGAAG
CATTCGGTGGAAGAATTATTGAGTGATTCCTATGGAGAGTATCGAAGAGGTCTGATTGGAGATGAAGCGATTCAACCAAA
AGCAGGCGAACCAGCGCTAAGCGGTACCGTATATTTAGCAACGGCAGACAATGAGGGGAATATGGTTTCCTTTATTCAAA
GTAATTATATGGGATTTGGTTCTGGCCTTGTGGTTCCTGGCACGGGAATTGCTCTGCAAAATCGCGGGCATAATTTTTCG
ATGGATCCGAATCATGTCAATGCATTAGCTGGAAATAAGCGAACATATCATACGATTATTCCTGGATTTTTAACAAAAGA
CGCAGAACCAATCGGTCCTTTTGGCGTGATGGGAGGATTTATGCAGCCTCAAGGTCATGTACAAGTAATTATGAATACCA
TTGATTTTCAGTTAAATCCGCAAGCAGCTTTAGATGCACCAAGGTGGCAATGGATGAAAGACAAACAAGTCGAAGTGGAA
AACACTTTCCCGCACCACATCGCAATGGATTTAGCGAAGAAAGGTCACAACATACGTATTCAATTAGAACCGAACAGTTT
TGGGCGCGGGCAGATCATTTGGAGAAATCCCGAAACAGGCGTACTGGTTGGCGGCACGGAATCCCGTACAGATGGTACGG
TAGCCGCTTGGTAA

Upstream 100 bases:

>100_bases
GTATTCATTACATACGTTCTGGTACGGGGAGCTACGCCGCCTCGAACTTCTCGGTCCTTTTCATCCTCCTTTTTGAACAC
GTAATAGAAAGGGAGATTTG

Downstream 100 bases:

>100_bases
GCAACAACAACAGCTCAGTAAAGGAATTTGCTATATGAGAACACATTGGAATATTTTTATCGCTTTTTTTCGCGTGGGTA
TGTTGGGATTTGGTGGAGGC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 537; Mature: 537

Protein sequence:

>537_residues
MNFFHTETYPYTNPRHATYAKNGMVATSQPLASEAGLSILKKGGNAIDAAIATAACLTVVEPTSNGIGGDAFALVWTKGK
LHGLNASGRSPQSISIDKVKETGKDHIPKYGWIPVTVPGAPSAWAALSKRFGKLSLQEVLQPAINYARDGYPLSPTLSKF
WKKAYTVFKKELSDDMFHEWFETFAPNGRAPETGEMWRSPNHANTLQEIADTDGESFYRGELAAKISAFSEANDGFLTAE
DLAAHQPEWVDPIKVNYRGYDVWEIPPNGQGIIALQALNILKGYTFDTKEVTDTYHKQMEAIKLAFADGQEHVTEKDHMK
HSVEELLSDSYGEYRRGLIGDEAIQPKAGEPALSGTVYLATADNEGNMVSFIQSNYMGFGSGLVVPGTGIALQNRGHNFS
MDPNHVNALAGNKRTYHTIIPGFLTKDAEPIGPFGVMGGFMQPQGHVQVIMNTIDFQLNPQAALDAPRWQWMKDKQVEVE
NTFPHHIAMDLAKKGHNIRIQLEPNSFGRGQIIWRNPETGVLVGGTESRTDGTVAAW

Sequences:

>Translated_537_residues
MNFFHTETYPYTNPRHATYAKNGMVATSQPLASEAGLSILKKGGNAIDAAIATAACLTVVEPTSNGIGGDAFALVWTKGK
LHGLNASGRSPQSISIDKVKETGKDHIPKYGWIPVTVPGAPSAWAALSKRFGKLSLQEVLQPAINYARDGYPLSPTLSKF
WKKAYTVFKKELSDDMFHEWFETFAPNGRAPETGEMWRSPNHANTLQEIADTDGESFYRGELAAKISAFSEANDGFLTAE
DLAAHQPEWVDPIKVNYRGYDVWEIPPNGQGIIALQALNILKGYTFDTKEVTDTYHKQMEAIKLAFADGQEHVTEKDHMK
HSVEELLSDSYGEYRRGLIGDEAIQPKAGEPALSGTVYLATADNEGNMVSFIQSNYMGFGSGLVVPGTGIALQNRGHNFS
MDPNHVNALAGNKRTYHTIIPGFLTKDAEPIGPFGVMGGFMQPQGHVQVIMNTIDFQLNPQAALDAPRWQWMKDKQVEVE
NTFPHHIAMDLAKKGHNIRIQLEPNSFGRGQIIWRNPETGVLVGGTESRTDGTVAAW
>Mature_537_residues
MNFFHTETYPYTNPRHATYAKNGMVATSQPLASEAGLSILKKGGNAIDAAIATAACLTVVEPTSNGIGGDAFALVWTKGK
LHGLNASGRSPQSISIDKVKETGKDHIPKYGWIPVTVPGAPSAWAALSKRFGKLSLQEVLQPAINYARDGYPLSPTLSKF
WKKAYTVFKKELSDDMFHEWFETFAPNGRAPETGEMWRSPNHANTLQEIADTDGESFYRGELAAKISAFSEANDGFLTAE
DLAAHQPEWVDPIKVNYRGYDVWEIPPNGQGIIALQALNILKGYTFDTKEVTDTYHKQMEAIKLAFADGQEHVTEKDHMK
HSVEELLSDSYGEYRRGLIGDEAIQPKAGEPALSGTVYLATADNEGNMVSFIQSNYMGFGSGLVVPGTGIALQNRGHNFS
MDPNHVNALAGNKRTYHTIIPGFLTKDAEPIGPFGVMGGFMQPQGHVQVIMNTIDFQLNPQAALDAPRWQWMKDKQVEVE
NTFPHHIAMDLAKKGHNIRIQLEPNSFGRGQIIWRNPETGVLVGGTESRTDGTVAAW

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI153266885, Length=510, Percent_Identity=25.6862745098039, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI153266901, Length=511, Percent_Identity=25.8317025440313, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI73915092, Length=519, Percent_Identity=25.0481695568401, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI73915090, Length=519, Percent_Identity=25.0481695568401, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI73915096, Length=519, Percent_Identity=25.0481695568401, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI73915094, Length=519, Percent_Identity=25.0481695568401, Blast_Score=137, Evalue=4e-32,
Organism=Homo sapiens, GI113429324, Length=514, Percent_Identity=24.124513618677, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI153266907, Length=508, Percent_Identity=25, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI113429326, Length=514, Percent_Identity=23.7354085603113, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI109148539, Length=504, Percent_Identity=24.8015873015873, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1789856, Length=545, Percent_Identity=29.9082568807339, Blast_Score=198, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI193208245, Length=509, Percent_Identity=25.147347740668, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI193208247, Length=505, Percent_Identity=24.950495049505, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17506189, Length=512, Percent_Identity=25.78125, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI212646519, Length=500, Percent_Identity=25.8, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI72000294, Length=500, Percent_Identity=25.8, Blast_Score=115, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI17542894, Length=517, Percent_Identity=23.4042553191489, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24642670, Length=512, Percent_Identity=25.78125, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI24642666, Length=512, Percent_Identity=25.78125, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI45551474, Length=512, Percent_Identity=25.78125, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI161077880, Length=512, Percent_Identity=25.78125, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI161077878, Length=512, Percent_Identity=25.78125, Blast_Score=146, Evalue=3e-35,
Organism=Drosophila melanogaster, GI161077496, Length=511, Percent_Identity=23.4833659491194, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI18859893, Length=429, Percent_Identity=24.2424242424242, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI18859741, Length=305, Percent_Identity=24.2622950819672, Blast_Score=82, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58950; Mature: 58950

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFFHTETYPYTNPRHATYAKNGMVATSQPLASEAGLSILKKGGNAIDAAIATAACLTVV
CCCCCCCCCCCCCCCCCEECCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHEEE
EPTSNGIGGDAFALVWTKGKLHGLNASGRSPQSISIDKVKETGKDHIPKYGWIPVTVPGA
CCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHCCHHCCCCCCCEEEECCCC
PSAWAALSKRFGKLSLQEVLQPAINYARDGYPLSPTLSKFWKKAYTVFKKELSDDMFHEW
CHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FETFAPNGRAPETGEMWRSPNHANTLQEIADTDGESFYRGELAAKISAFSEANDGFLTAE
HHHHCCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEHH
DLAAHQPEWVDPIKVNYRGYDVWEIPPNGQGIIALQALNILKGYTFDTKEVTDTYHKQME
HHHCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHH
AIKLAFADGQEHVTEKDHMKHSVEELLSDSYGEYRRGLIGDEAIQPKAGEPALSGTVYLA
HHEEEECCCHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE
TADNEGNMVSFIQSNYMGFGSGLVVPGTGIALQNRGHNFSMDPNHVNALAGNKRTYHTII
EECCCCCEEEEEHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCHHHHHCCCCEEEEEEC
PGFLTKDAEPIGPFGVMGGFMQPQGHVQVIMNTIDFQLNPQAALDAPRWQWMKDKQVEVE
CHHHCCCCCCCCCHHHHCCCCCCCCCEEEEEEECCEEECCHHHCCCCCCCCCCCCCEEEC
NTFPHHIAMDLAKKGHNIRIQLEPNSFGRGQIIWRNPETGVLVGGTESRTDGTVAAW
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCEECC
>Mature Secondary Structure
MNFFHTETYPYTNPRHATYAKNGMVATSQPLASEAGLSILKKGGNAIDAAIATAACLTVV
CCCCCCCCCCCCCCCCCEECCCCEEECCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHEEE
EPTSNGIGGDAFALVWTKGKLHGLNASGRSPQSISIDKVKETGKDHIPKYGWIPVTVPGA
CCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCCHHHHHHCCHHCCCCCCCEEEECCCC
PSAWAALSKRFGKLSLQEVLQPAINYARDGYPLSPTLSKFWKKAYTVFKKELSDDMFHEW
CHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
FETFAPNGRAPETGEMWRSPNHANTLQEIADTDGESFYRGELAAKISAFSEANDGFLTAE
HHHHCCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEEHH
DLAAHQPEWVDPIKVNYRGYDVWEIPPNGQGIIALQALNILKGYTFDTKEVTDTYHKQME
HHHCCCCCCCCCEEEEECCEEEEECCCCCCCEEEEEEHHHHHCCCCCHHHHHHHHHHHHH
AIKLAFADGQEHVTEKDHMKHSVEELLSDSYGEYRRGLIGDEAIQPKAGEPALSGTVYLA
HHEEEECCCHHHCCHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCEEEEE
TADNEGNMVSFIQSNYMGFGSGLVVPGTGIALQNRGHNFSMDPNHVNALAGNKRTYHTII
EECCCCCEEEEEHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCHHHHHCCCCEEEEEEC
PGFLTKDAEPIGPFGVMGGFMQPQGHVQVIMNTIDFQLNPQAALDAPRWQWMKDKQVEVE
CHHHCCCCCCCCCHHHHCCCCCCCCCEEEEEEECCEEECCHHHCCCCCCCCCCCCCEEEC
NTFPHHIAMDLAKKGHNIRIQLEPNSFGRGQIIWRNPETGVLVGGTESRTDGTVAAW
CCCCHHHHHHHHHCCCEEEEEECCCCCCCCEEEEECCCCCEEECCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]