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The map label for this gene is fabG [H]

Identifier: 23100128

GI number: 23100128

Start: 2743884

End: 2744651

Strand: Reverse

Name: fabG [H]

Synonym: OB2673

Alternate gene names: 23100128

Gene position: 2744651-2743884 (Counterclockwise)

Preceding gene: 23100129

Following gene: 23100127

Centisome position: 75.6

GC content: 38.93

Gene sequence:

>768_bases
GTGAATATAAATCAAATGACTGCAGTCGTTACAGGTGGTGCTTCCGGTTTAGGAGAAGCAACTGTGAGGAGACTACATAA
TCAAGGTGGTAAAGTAGCTATTTTTGATTTGAATAAAGAGAATGGAGAACGTCTCGCGACAGAGCTAGGCGATAATGTCG
ATTATTTTCAAGTTGATGTAACGGATGAAACTAGTGTTCAAAAGGCATTGGATAATGTCATGGAACAAAGTGACGGTATT
CATGCAGTTGTTAATTGTGCTGGTATTGCAATCGCAGAAAAAACGATTGGAAAAAAAGGCGTCCATTCATTACAACATTT
TTCAAACGTAATAGAAATCAACCTCATCGGTACATTCAATGTAATTCGACTTGCTGCTGAAAAAATGGCATTAAATAGTC
CAAACGATGAGGGAGAGCGCGGCGTTATCATTAATACTGCTTCTGTAGCTGCGTTTGAAGGTCAAATTGGACAGGCAGCA
TACAGTGCTTCAAAAGGAGGCGTTGCGGGAATGACCCTTCCGATTGCCAGAGACTTATCTACACTTGGAATTCGAGTTAT
GACCATTGCTCCTGGATTATTTTTAACTCCATTATTTGAAAAGTTACCAGATAAAGCAAAAGAAGAATTAGGAAAAATGA
CACCTTTTCCATCCAGATTAGGGAAGCCTATCGAATATGCAAAACTCGCACAAAGTATTATTGAAAACCCTATGTTAAAT
GGAGAAGTAATACGATTGGACGGAGCAATTCGAATGCAACCAAAGTAA

Upstream 100 bases:

>100_bases
ATGACAATAAGGGTAAGAAAGAAAAGCAAGAAATACTGGATCAAATGGCAGAATACCTATTAAATATATTAGCAAAGTAA
GGCAGAAAAGGAGAATGTTT

Downstream 100 bases:

>100_bases
TAAGAAAAGTGATAGCGTCCGAAAATCAACATTAAAATTCACCTTTTTTCAGAGGGTGATTTGACAATGGTTGCAAGTTA
AGAGTCAAGTGATAGACATG

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MNINQMTAVVTGGASGLGEATVRRLHNQGGKVAIFDLNKENGERLATELGDNVDYFQVDVTDETSVQKALDNVMEQSDGI
HAVVNCAGIAIAEKTIGKKGVHSLQHFSNVIEINLIGTFNVIRLAAEKMALNSPNDEGERGVIINTASVAAFEGQIGQAA
YSASKGGVAGMTLPIARDLSTLGIRVMTIAPGLFLTPLFEKLPDKAKEELGKMTPFPSRLGKPIEYAKLAQSIIENPMLN
GEVIRLDGAIRMQPK

Sequences:

>Translated_255_residues
MNINQMTAVVTGGASGLGEATVRRLHNQGGKVAIFDLNKENGERLATELGDNVDYFQVDVTDETSVQKALDNVMEQSDGI
HAVVNCAGIAIAEKTIGKKGVHSLQHFSNVIEINLIGTFNVIRLAAEKMALNSPNDEGERGVIINTASVAAFEGQIGQAA
YSASKGGVAGMTLPIARDLSTLGIRVMTIAPGLFLTPLFEKLPDKAKEELGKMTPFPSRLGKPIEYAKLAQSIIENPMLN
GEVIRLDGAIRMQPK
>Mature_255_residues
MNINQMTAVVTGGASGLGEATVRRLHNQGGKVAIFDLNKENGERLATELGDNVDYFQVDVTDETSVQKALDNVMEQSDGI
HAVVNCAGIAIAEKTIGKKGVHSLQHFSNVIEINLIGTFNVIRLAAEKMALNSPNDEGERGVIINTASVAAFEGQIGQAA
YSASKGGVAGMTLPIARDLSTLGIRVMTIAPGLFLTPLFEKLPDKAKEELGKMTPFPSRLGKPIEYAKLAQSIIENPMLN
GEVIRLDGAIRMQPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=60.3921568627451, Blast_Score=298, Evalue=4e-81,
Organism=Homo sapiens, GI83715985, Length=255, Percent_Identity=56.8627450980392, Blast_Score=272, Evalue=2e-73,
Organism=Homo sapiens, GI15277342, Length=234, Percent_Identity=35.042735042735, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI40254992, Length=246, Percent_Identity=28.0487804878049, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI31542939, Length=262, Percent_Identity=26.7175572519084, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI59889578, Length=209, Percent_Identity=32.5358851674641, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI150247226, Length=202, Percent_Identity=28.2178217821782, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI224922801, Length=177, Percent_Identity=29.3785310734463, Blast_Score=71, Evalue=8e-13,
Organism=Homo sapiens, GI22507405, Length=226, Percent_Identity=25.2212389380531, Blast_Score=68, Evalue=7e-12,
Organism=Homo sapiens, GI4504503, Length=231, Percent_Identity=26.8398268398268, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI10190704, Length=189, Percent_Identity=29.1005291005291, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1787335, Length=255, Percent_Identity=28.6274509803922, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI87082160, Length=194, Percent_Identity=32.9896907216495, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI2367175, Length=196, Percent_Identity=30.6122448979592, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=28.90625, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787820, Length=188, Percent_Identity=30.8510638297872, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI1789057, Length=215, Percent_Identity=30.6976744186047, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786812, Length=242, Percent_Identity=26.4462809917355, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=28.8, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=249, Percent_Identity=49.7991967871486, Blast_Score=227, Evalue=5e-60,
Organism=Caenorhabditis elegans, GI17555706, Length=222, Percent_Identity=33.3333333333333, Blast_Score=106, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI25147288, Length=223, Percent_Identity=32.7354260089686, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI32563809, Length=236, Percent_Identity=30.0847457627119, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17507613, Length=236, Percent_Identity=30.0847457627119, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17567345, Length=199, Percent_Identity=28.643216080402, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320089, Length=214, Percent_Identity=30.3738317757009, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322861, Length=247, Percent_Identity=26.3157894736842, Blast_Score=62, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17737361, Length=254, Percent_Identity=58.2677165354331, Blast_Score=288, Evalue=3e-78,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=32.258064516129, Blast_Score=104, Evalue=5e-23,
Organism=Drosophila melanogaster, GI24644339, Length=240, Percent_Identity=27.0833333333333, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI28571526, Length=231, Percent_Identity=25.974025974026, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21357041, Length=231, Percent_Identity=26.8398268398268, Blast_Score=65, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356301, Length=241, Percent_Identity=27.8008298755187, Blast_Score=64, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 27212; Mature: 27212

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNINQMTAVVTGGASGLGEATVRRLHNQGGKVAIFDLNKENGERLATELGDNVDYFQVDV
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEEEE
TDETSVQKALDNVMEQSDGIHAVVNCAGIAIAEKTIGKKGVHSLQHFSNVIEINLIGTFN
CCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCHHHHHHHHHHCCEEEEEEECHHH
VIRLAAEKMALNSPNDEGERGVIINTASVAAFEGQIGQAAYSASKGGVAGMTLPIARDLS
HHHHHHHHHHCCCCCCCCCCEEEEEECCEEECCCCCCHHHHHCCCCCCCCEEHHHHHHHH
TLGIRVMTIAPGLFLTPLFEKLPDKAKEELGKMTPFPSRLGKPIEYAKLAQSIIENPMLN
HHCEEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHCCCCC
GEVIRLDGAIRMQPK
CEEEEECCEEEECCC
>Mature Secondary Structure
MNINQMTAVVTGGASGLGEATVRRLHNQGGKVAIFDLNKENGERLATELGDNVDYFQVDV
CCCCCEEEEEECCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHCCCCCEEEEEE
TDETSVQKALDNVMEQSDGIHAVVNCAGIAIAEKTIGKKGVHSLQHFSNVIEINLIGTFN
CCCHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCHHHHHHHHHHCCEEEEEEECHHH
VIRLAAEKMALNSPNDEGERGVIINTASVAAFEGQIGQAAYSASKGGVAGMTLPIARDLS
HHHHHHHHHHCCCCCCCCCCEEEEEECCEEECCCCCCHHHHHCCCCCCCCEEHHHHHHHH
TLGIRVMTIAPGLFLTPLFEKLPDKAKEELGKMTPFPSRLGKPIEYAKLAQSIIENPMLN
HHCEEEEEECCCHHHHHHHHHCCHHHHHHHHCCCCCHHHHCCCHHHHHHHHHHHHCCCCC
GEVIRLDGAIRMQPK
CEEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]