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The map label for this gene is mtlA [H]

Identifier: 23100058

GI number: 23100058

Start: 2663935

End: 2665395

Strand: Reverse

Name: mtlA [H]

Synonym: OB2603

Alternate gene names: 23100058

Gene position: 2665395-2663935 (Counterclockwise)

Preceding gene: 23100059

Following gene: 23100057

Centisome position: 73.42

GC content: 37.71

Gene sequence:

>1461_bases
ATGTCTGAAGAACAATCTGGCTTTCGTGCAAAAGTACAGAAATTTGGTAGTTATCTAAGTGGGATGATTATGCCAAACAT
CGGTGCTTTTATTGCATGGGGAATTATTACAGCTTTATTTATACCAGACGGTTGGTGGCCAAATGAAGATTTGGCGGGAT
TGGTAGATCCGATGATCTTATATCTATTGCCATTATTAATTGGTTTTACTGGTGGACGTATGGTTTACGATATTCGTGGA
GGAGTCGTTGGTGCAACTGCAACAATGGGGGTAATCGTTGGAGCGGATGCCCCGATGTTTTTAGGTGCAATGTTAATGGG
TCCATTAGCTGCTTACTTGATGAAGAAGTTTGATGGAGTGTTCCAACACAGAATTCGTCAAGGATTTGAAATGTTATACA
ATAACTTTTCAGCGGGTATATTAGCGGCAATCATGGCAATTATTGCACTAAAAGCAATTGGTCCAATTGTATCAGGATTG
AACGCCGCACTTGCTGCTGGAGTGGAAGTAATTGTTAATGCCGGTTTATTGCCACTGGCAAATATCATTATTGAACCAGC
AAAAATCTTATTCCTTAATAATGCAATTAACCATGGAATTTTAACTCCATTAGGTGCTGACCAGGCATCAGAGATTGGAA
AATCAATTTTATTTCTAATGGAAGCTAACCCAGGGCCTGGACTAGGAATTTTACTGGCATTTGCTATTTTTGGTAAAGGA
GTTTCTAAAGCCTCTGCACCAGGTGCTGCAATAATTCAATTTTTAGGTGGTATTCATGAGATTTATTTCCCATATGTTCT
AATGAAACCAATGCTTATCTTAGCTGCAATTGGTGGTGGGGTTACAGGAGTATTCACACTGCAATTATTTGATGCCGGAT
TACGTGCGGCGGCGTCTCCAGGTAGTATTTTTGCAGTATTAGCTATGGCAGCTTCTGATAGTTATATGGGAGTTATTTTA
AGTGTAATATTAGCAACCGCTGTTTCCTTTACTATTGCTGCAATTATATTGAAATCATCGAAATCGGATGATGAAGGAGA
TTTAAGTGCTTCTACAGAAAAAATGGAAGCGATGAAAGGAAAAGAAAGCAGTGTTGCTGGTTCGTTAAAAGGGAATCAAA
ATAATCCTGGAGAAGTAAATGATCAAGATGTCGTACCAGAAACACCTGTAAAAGATGCATCACAAGTAGATAAAATAATT
TTTGCATGTGATGCTGGAATGGGTTCTAGCGCTATGGGTGCATCGTTATTAAAGAATAAATTTAAGAAGAGCGATATTAA
TATCGATGTTACCAATAAAGCGATCAATGAAATACCTGAAGATGCCGATATTGTAATTACTCAAAAAACATTAACAAATC
GTGCTAAAGCTAAACTTCCGACTGCAGAGCATATTTCAGTGGAGAATTTCTTGAATAGTCCTAAATATGATGAACTGGTG
GAACGTTTGAAAAATAAATAA

Upstream 100 bases:

>100_bases
TTGCCAAAGTCACATTAAGATAGTGTTGTAAGCGGATTCCTGATTGCCATAAAATAAATGTAGATACAATAAATATAGAA
AGTGAAAGGGGAGTTTGTTC

Downstream 100 bases:

>100_bases
TATTAATGGAGGTGAATGGTCTTGTATCTTTCCAGTCGTGAACGACATATACTGAAGATTCTTTTAGAGGCAGAAAAGCA
CATGTCAGTAAAAGAAATTG

Product: PTS system mannitol-specific enzyme II BC component

Products: NA

Alternate protein names: EIICB-Mtl; EII-Mtl; Mannitol permease IIC component; PTS system mannitol-specific EIIC component; Mannitol-specific phosphotransferase enzyme IIB component; PTS system mannitol-specific EIIB component [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MSEEQSGFRAKVQKFGSYLSGMIMPNIGAFIAWGIITALFIPDGWWPNEDLAGLVDPMILYLLPLLIGFTGGRMVYDIRG
GVVGATATMGVIVGADAPMFLGAMLMGPLAAYLMKKFDGVFQHRIRQGFEMLYNNFSAGILAAIMAIIALKAIGPIVSGL
NAALAAGVEVIVNAGLLPLANIIIEPAKILFLNNAINHGILTPLGADQASEIGKSILFLMEANPGPGLGILLAFAIFGKG
VSKASAPGAAIIQFLGGIHEIYFPYVLMKPMLILAAIGGGVTGVFTLQLFDAGLRAAASPGSIFAVLAMAASDSYMGVIL
SVILATAVSFTIAAIILKSSKSDDEGDLSASTEKMEAMKGKESSVAGSLKGNQNNPGEVNDQDVVPETPVKDASQVDKII
FACDAGMGSSAMGASLLKNKFKKSDINIDVTNKAINEIPEDADIVITQKTLTNRAKAKLPTAEHISVENFLNSPKYDELV
ERLKNK

Sequences:

>Translated_486_residues
MSEEQSGFRAKVQKFGSYLSGMIMPNIGAFIAWGIITALFIPDGWWPNEDLAGLVDPMILYLLPLLIGFTGGRMVYDIRG
GVVGATATMGVIVGADAPMFLGAMLMGPLAAYLMKKFDGVFQHRIRQGFEMLYNNFSAGILAAIMAIIALKAIGPIVSGL
NAALAAGVEVIVNAGLLPLANIIIEPAKILFLNNAINHGILTPLGADQASEIGKSILFLMEANPGPGLGILLAFAIFGKG
VSKASAPGAAIIQFLGGIHEIYFPYVLMKPMLILAAIGGGVTGVFTLQLFDAGLRAAASPGSIFAVLAMAASDSYMGVIL
SVILATAVSFTIAAIILKSSKSDDEGDLSASTEKMEAMKGKESSVAGSLKGNQNNPGEVNDQDVVPETPVKDASQVDKII
FACDAGMGSSAMGASLLKNKFKKSDINIDVTNKAINEIPEDADIVITQKTLTNRAKAKLPTAEHISVENFLNSPKYDELV
ERLKNK
>Mature_485_residues
SEEQSGFRAKVQKFGSYLSGMIMPNIGAFIAWGIITALFIPDGWWPNEDLAGLVDPMILYLLPLLIGFTGGRMVYDIRGG
VVGATATMGVIVGADAPMFLGAMLMGPLAAYLMKKFDGVFQHRIRQGFEMLYNNFSAGILAAIMAIIALKAIGPIVSGLN
AALAAGVEVIVNAGLLPLANIIIEPAKILFLNNAINHGILTPLGADQASEIGKSILFLMEANPGPGLGILLAFAIFGKGV
SKASAPGAAIIQFLGGIHEIYFPYVLMKPMLILAAIGGGVTGVFTLQLFDAGLRAAASPGSIFAVLAMAASDSYMGVILS
VILATAVSFTIAAIILKSSKSDDEGDLSASTEKMEAMKGKESSVAGSLKGNQNNPGEVNDQDVVPETPVKDASQVDKIIF
ACDAGMGSSAMGASLLKNKFKKSDINIDVTNKAINEIPEDADIVITQKTLTNRAKAKLPTAEHISVENFLNSPKYDELVE
RLKNK

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: COG2213

COG function: function code G; Phosphotransferase system, mannitol-specific IIBC component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-2 domain [H]

Homologues:

Organism=Escherichia coli, GI1790027, Length=479, Percent_Identity=58.455114822547, Blast_Score=525, Evalue=1e-150,
Organism=Escherichia coli, GI1789301, Length=483, Percent_Identity=48.4472049689441, Blast_Score=446, Evalue=1e-126,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013011
- InterPro:   IPR003501
- InterPro:   IPR003352
- InterPro:   IPR013014
- InterPro:   IPR004718 [H]

Pfam domain/function: PF02378 PTS_EIIC; PF02302 PTS_IIB [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 51069; Mature: 50937

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS51099 PTS_EIIB_TYPE_2 ; PS51104 PTS_EIIC_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEEQSGFRAKVQKFGSYLSGMIMPNIGAFIAWGIITALFIPDGWWPNEDLAGLVDPMIL
CCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
YLLPLLIGFTGGRMVYDIRGGVVGATATMGVIVGADAPMFLGAMLMGPLAAYLMKKFDGV
HHHHHHHCCCCCCEEEEECCCEEEHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
FQHRIRQGFEMLYNNFSAGILAAIMAIIALKAIGPIVSGLNAALAAGVEVIVNAGLLPLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
NIIIEPAKILFLNNAINHGILTPLGADQASEIGKSILFLMEANPGPGLGILLAFAIFGKG
HHHHCCHHHEEECCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCC
VSKASAPGAAIIQFLGGIHEIYFPYVLMKPMLILAAIGGGVTGVFTLQLFDAGLRAAASP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
GSIFAVLAMAASDSYMGVILSVILATAVSFTIAAIILKSSKSDDEGDLSASTEKMEAMKG
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
KESSVAGSLKGNQNNPGEVNDQDVVPETPVKDASQVDKIIFACDAGMGSSAMGASLLKNK
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHH
FKKSDINIDVTNKAINEIPEDADIVITQKTLTNRAKAKLPTAEHISVENFLNSPKYDELV
HHHCCCCEEECHHHHHHCCCCCCEEEEHHHHHHHHHHCCCCHHHCCHHHHHCCCCHHHHH
ERLKNK
HHHHCC
>Mature Secondary Structure 
SEEQSGFRAKVQKFGSYLSGMIMPNIGAFIAWGIITALFIPDGWWPNEDLAGLVDPMIL
CCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
YLLPLLIGFTGGRMVYDIRGGVVGATATMGVIVGADAPMFLGAMLMGPLAAYLMKKFDGV
HHHHHHHCCCCCCEEEEECCCEEEHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
FQHRIRQGFEMLYNNFSAGILAAIMAIIALKAIGPIVSGLNAALAAGVEVIVNAGLLPLA
HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
NIIIEPAKILFLNNAINHGILTPLGADQASEIGKSILFLMEANPGPGLGILLAFAIFGKG
HHHHCCHHHEEECCCCCCCCCCCCCCCHHHHHHHHEEEEEECCCCCCHHHHHHHHHHHCC
VSKASAPGAAIIQFLGGIHEIYFPYVLMKPMLILAAIGGGVTGVFTLQLFDAGLRAAASP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
GSIFAVLAMAASDSYMGVILSVILATAVSFTIAAIILKSSKSDDEGDLSASTEKMEAMKG
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCC
KESSVAGSLKGNQNNPGEVNDQDVVPETPVKDASQVDKIIFACDAGMGSSAMGASLLKNK
CCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCHHHHHHHHHHH
FKKSDINIDVTNKAINEIPEDADIVITQKTLTNRAKAKLPTAEHISVENFLNSPKYDELV
HHHCCCCEEECHHHHHHCCCCCCEEEEHHHHHHHHHHCCCCHHHCCHHHHHCCCCHHHHH
ERLKNK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8824601 [H]