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The map label for this gene is mtlD

Identifier: 23100055

GI number: 23100055

Start: 2660210

End: 2661370

Strand: Reverse

Name: mtlD

Synonym: OB2600

Alternate gene names: 23100055

Gene position: 2661370-2660210 (Counterclockwise)

Preceding gene: 23100056

Following gene: 23100052

Centisome position: 73.31

GC content: 35.14

Gene sequence:

>1161_bases
ATGAAAACAGCAGTCCATTTTGGAGCAGGTAATATTGGCCGAGGATTTATCGGACTTTTACTTTATCAATCCGGTTATCA
AACCATTTTTATCGATGTAAATAATCAAGTTATTGATGAAATTAATAAACAAAAATCATATCATGTTTACCTAGCTGGAA
AGGAAAAACAAGAATTAACAGTAAATCATATTACTGGGATCAATAGTATAAAAGAGCCAGATGCTGTTACAGAAGCCATT
GTGAAGGCTGATGTCGTTACTACTGCAGTTGGACCTACAATTCTACCAGTTATTGCTAAGGCGATTTCTAAGGGATTACA
AGAAAGAACAAAGCAAAATAATAGCCCTCTCAATATTATTGCTTGTGAAAATATGGTTGGTGGAAGTTCATTACTCAAAG
AGCATGTTTTTGAGTCGCTTGAGGCTCATAAAATAGGGGAGTTTGATAGATTGTATGGCTTTCCCGATGCTGCAGTAGAT
CGTATCGTTCCTAATCAAACGAATAAGAATCTATTAGATGTGATGGTGGAACCTTATTATGAGTGGGTAGTTGAGAAAAA
AAAGATTGTCGGTGAAGTACCTCCAATTTTTGGCATTACGTATGTAGATGATCTTGCTCCTTATATTGAACGTAAATTGT
TTACGGTAAATACGGGACATGCTATTCCGGCTTACTTAGGAACACACTTGGGTTATGATACTATCGTAGAAGCTATGAAA
GATTTACGTATTGATGATACCATATACGGTGCTTTAGCTGAATCAGGAGAAGCATTAATTCATGCATATGGTTTTAATCG
CGAAATGCATCAAGAGTATGTGAGTAAAATTATTCAACGTTTTCAAAATCCATATATTTCAGATGATGTAAAGAGAGTTG
CGCGTGGTCCTATTCGAAAATTAGGAGCAAAGGATCGCTTAGTCAAACCAGCTTTAATGTATATTGAATATACAGGAAAA
ATCCCAGTATATTTAGCGAAGACAATTGCAGCAGCGTTATTATTTAATAATGATGAAGACAGAGAAGCGATAGAATTACA
GAAGAAAATTTCAGCTACTGGTTACCAACAAGCTTTTGTTGAAGTAAGTGGATGTGATAGTGATTCTATACTTACGAAGA
AAGTCATCGAGCAACTACGCTTATTACAAAATAAGAAGTAA

Upstream 100 bases:

>100_bases
CAAATTGCAATTATTTGTTCAGAAGTTGAGAATGTTGAGAAATTAGTAGCTGCAAGTTCTAAAGAAGAAGTTTTAGAACT
CCTCCAAGAGGTGAACTAAT

Downstream 100 bases:

>100_bases
AAAAAGCCTAGGATGAAGAACAGCATAATATCGCTGTTATCATTCTAGACTTTTTTATGAGGTAAAGAATTTTCATTCAT
CTTATCCTCTATGTGCGAGA

Product: mannitol-1-phosphate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 386; Mature: 386

Protein sequence:

>386_residues
MKTAVHFGAGNIGRGFIGLLLYQSGYQTIFIDVNNQVIDEINKQKSYHVYLAGKEKQELTVNHITGINSIKEPDAVTEAI
VKADVVTTAVGPTILPVIAKAISKGLQERTKQNNSPLNIIACENMVGGSSLLKEHVFESLEAHKIGEFDRLYGFPDAAVD
RIVPNQTNKNLLDVMVEPYYEWVVEKKKIVGEVPPIFGITYVDDLAPYIERKLFTVNTGHAIPAYLGTHLGYDTIVEAMK
DLRIDDTIYGALAESGEALIHAYGFNREMHQEYVSKIIQRFQNPYISDDVKRVARGPIRKLGAKDRLVKPALMYIEYTGK
IPVYLAKTIAAALLFNNDEDREAIELQKKISATGYQQAFVEVSGCDSDSILTKKVIEQLRLLQNKK

Sequences:

>Translated_386_residues
MKTAVHFGAGNIGRGFIGLLLYQSGYQTIFIDVNNQVIDEINKQKSYHVYLAGKEKQELTVNHITGINSIKEPDAVTEAI
VKADVVTTAVGPTILPVIAKAISKGLQERTKQNNSPLNIIACENMVGGSSLLKEHVFESLEAHKIGEFDRLYGFPDAAVD
RIVPNQTNKNLLDVMVEPYYEWVVEKKKIVGEVPPIFGITYVDDLAPYIERKLFTVNTGHAIPAYLGTHLGYDTIVEAMK
DLRIDDTIYGALAESGEALIHAYGFNREMHQEYVSKIIQRFQNPYISDDVKRVARGPIRKLGAKDRLVKPALMYIEYTGK
IPVYLAKTIAAALLFNNDEDREAIELQKKISATGYQQAFVEVSGCDSDSILTKKVIEQLRLLQNKK
>Mature_386_residues
MKTAVHFGAGNIGRGFIGLLLYQSGYQTIFIDVNNQVIDEINKQKSYHVYLAGKEKQELTVNHITGINSIKEPDAVTEAI
VKADVVTTAVGPTILPVIAKAISKGLQERTKQNNSPLNIIACENMVGGSSLLKEHVFESLEAHKIGEFDRLYGFPDAAVD
RIVPNQTNKNLLDVMVEPYYEWVVEKKKIVGEVPPIFGITYVDDLAPYIERKLFTVNTGHAIPAYLGTHLGYDTIVEAMK
DLRIDDTIYGALAESGEALIHAYGFNREMHQEYVSKIIQRFQNPYISDDVKRVARGPIRKLGAKDRLVKPALMYIEYTGK
IPVYLAKTIAAALLFNNDEDREAIELQKKISATGYQQAFVEVSGCDSDSILTKKVIEQLRLLQNKK

Specific function: Unknown

COG id: COG0246

COG function: function code G; Mannitol-1-phosphate/altronate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannitol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1790028, Length=383, Percent_Identity=46.2140992167102, Blast_Score=328, Evalue=3e-91,
Organism=Escherichia coli, GI1788497, Length=214, Percent_Identity=24.7663551401869, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1787823, Length=335, Percent_Identity=24.7761194029851, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790779, Length=286, Percent_Identity=23.4265734265734, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI48994885, Length=264, Percent_Identity=25, Blast_Score=62, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6324401, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6320765, Length=210, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MTLD_OCEIH (Q8EN87)

Other databases:

- EMBL:   BA000028
- RefSeq:   NP_693521.1
- ProteinModelPortal:   Q8EN87
- GeneID:   1017095
- GenomeReviews:   BA000028_GR
- KEGG:   oih:OB2600
- NMPDR:   fig|221109.1.peg.2599
- HOGENOM:   HBG568825
- OMA:   FTVNTGH
- ProtClustDB:   PRK02318
- BioCyc:   OIHE221109:OB2600-MONOMER
- BRENDA:   1.1.1.17
- HAMAP:   MF_00196
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR023028
- InterPro:   IPR000669
- InterPro:   IPR013118
- InterPro:   IPR023027
- InterPro:   IPR013131
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:1.10.1040.10
- PRINTS:   PR00084

Pfam domain/function: PF01232 Mannitol_dh; PF08125 Mannitol_dh_C; SSF48179 6DGDH_C_like

EC number: =1.1.1.17

Molecular weight: Translated: 43089; Mature: 43089

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00974 MANNITOL_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTAVHFGAGNIGRGFIGLLLYQSGYQTIFIDVNNQVIDEINKQKSYHVYLAGKEKQELT
CCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCEEEEEECCCCCCEE
VNHITGINSIKEPDAVTEAIVKADVVTTAVGPTILPVIAKAISKGLQERTKQNNSPLNII
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ACENMVGGSSLLKEHVFESLEAHKIGEFDRLYGFPDAAVDRIVPNQTNKNLLDVMVEPYY
EECCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHH
EWVVEKKKIVGEVPPIFGITYVDDLAPYIERKLFTVNTGHAIPAYLGTHLGYDTIVEAMK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCHHHHHHHHH
DLRIDDTIYGALAESGEALIHAYGFNREMHQEYVSKIIQRFQNPYISDDVKRVARGPIRK
HCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHH
LGAKDRLVKPALMYIEYTGKIPVYLAKTIAAALLFNNDEDREAIELQKKISATGYQQAFV
CCCCCHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHEE
EVSGCDSDSILTKKVIEQLRLLQNKK
EEECCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKTAVHFGAGNIGRGFIGLLLYQSGYQTIFIDVNNQVIDEINKQKSYHVYLAGKEKQELT
CCCEEEECCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCEEEEEECCCCCCEE
VNHITGINSIKEPDAVTEAIVKADVVTTAVGPTILPVIAKAISKGLQERTKQNNSPLNII
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
ACENMVGGSSLLKEHVFESLEAHKIGEFDRLYGFPDAAVDRIVPNQTNKNLLDVMVEPYY
EECCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHCCCCCCCCHHHHHHHHHHH
EWVVEKKKIVGEVPPIFGITYVDDLAPYIERKLFTVNTGHAIPAYLGTHLGYDTIVEAMK
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHCCHHHHHHHHH
DLRIDDTIYGALAESGEALIHAYGFNREMHQEYVSKIIQRFQNPYISDDVKRVARGPIRK
HCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCHHHH
LGAKDRLVKPALMYIEYTGKIPVYLAKTIAAALLFNNDEDREAIELQKKISATGYQQAFV
CCCCCHHHCCEEEEEEECCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHEE
EVSGCDSDSILTKKVIEQLRLLQNKK
EEECCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376